74 research outputs found
Meet Edem Awumey
No full textEdem Awumey is an awarded author from Togo who has written short stories and two novels. The central theme in his works is the exile.</p
Les espaces anonymes, entre voyage et exil. Entretien avec l'écrivain Edem Awumey
No full textA l’occasion de la Foire du Livre 2010 consacrée à la littérature africaine, l'Institut français de Stockholm avait le privilège d’accueillir le 25 septembre l’écrivain togolais Edem Awumey. Edem Awumey, qui réside actuellement au Québec, est né au Togo et a fait ses études en France, notamment à l’Université de Cergy-Pontoise, où il a soutenu, en 2005, un doctorat de littérature francophone. Il est l’auteur d’un grand nombre de nouvelles et de deux romans : "Les Pieds Sales", 2009, Seuil, sélectionné pour le prix Goncourt de la même année et "Port-Mélo", 2006, Gallimard, Grand Prix Littéraire de l’Afrique Noire 2006
A journey without destination : the meaningless experience of migration in Dirty Feet of Edem Awumey
No full textIf Edem Awumey can be classified as a writer belonging to the ”migrant literature” in Canada, his work is overwhelmed with characters wandering without knowing where they go. It is the case in one of his novels entitled Dirty Feet (Les Pieds Sales in French). According to Daniel Chartier, ”migrant writing” – unlike ethnic literature, immigration or immigrant literature – can be defined thematically by hybridity and by its frequent use of autobiography. The genre of migrant literature refers to literature from authors who are between two cultures and who focus on the journey, the odyssée. The story of the journey is the central part of this literary genre as it is a composition of cultural fragments. The aim of the presentation is to illustrate the characteristics of this genre through the novel of Edem Awumey, Les Pieds Sales. How are the characters and the locations presented in the novel? The analysis will be done with the help of Memory studies that primarily focus on the symbolic relevance of objects, characters and places
Targeting EDEM protects against ER stress and improves development and survival in C. elegans
No full textEDEM-1, EDEM-2 and EDEM-3 are key players for the quality control of newly synthesized proteins in the endoplasmic reticulum (ER) by accelerating disposal and degradation of misfolded proteins through ER Associated Degradation (ERAD). Although many previous studies reported the role of individual ERAD components especially in cell-based systems, still little is known about the consequences of ERAD dysfunction under physiological and ER stress conditions in the context of a multicellular organism. Here we report the first individual and combined characterization and functional interplay of EDEM proteins in Caenorhabditis elegans using single, double, and triple mutant combinations. We found that EDEM-2 has a major role in the clearance of misfolded proteins from ER under physiological conditions, whereas EDEM-1 and EDEM-3 roles become prominent under acute ER stress. In contrast to SEL-1 loss, the loss of EDEMs in an intact organism induces only a modest ER stress under physiological conditions. In addition, chronic impairment of EDEM functioning attenuated both XBP-1 activation and up-regulation of the stress chaperone GRP78/BiP, in response to acute ER stress. We also show that pre-conditioning to EDEM loss in acute ER stress restores ER homeostasis and promotes survival by activating ER hormesis. We propose a novel role for EDEM in fine-tuning the ER stress responsiveness that affects ER homeostasis and survival.[Author summary] ER stress and UPRER malfunctions have been implicated in the pathogenesis of neurodegeneration, metabolic and inflammatory diseases as well as tumor progression and diabetes, whereby disturbed ER homeostasis negatively influences the pathology of the disease. Under ER stress conditions, the cells either activate UPRER-dependent cytoprotective mechanisms when ER stress is at subtoxic levels or, in case of an excessive ER stress, the cytotoxic response stimulates cell death. Here, we used Caenorhabditis elegans to study the cellular responses to ER stress at organismal level. We show that EDEMs respond differently to ER stress stimuli, and moreover, EDEMs deficiencies activate an XBP-1 independent adaptive program to promote organism survival under acute ER stress. Corroborated with the fact that loss of EDEM-2 and EDEM-3 induces resistance to acute ER stress in an intact organism, our data implicate EDEM proteins in a broader response to ER stress than previously established, which opens a new avenue for understanding the regulation of ER stress with implications for clinical and therapeutic investigations.This research was funded by Unitatea Executivă pentru Finanțarea Învățământului Superior, a Cercetării, Dezvoltării și Inovării (https://uefiscdi.gov.ro/) grant number PN-II-ID-PCE-2012-4-0350 to SMP. SG is grateful for the support from European Social Fund for Sectorial Operational Program Human Resources Development 2007-2013 grant number POSDRU/89/1.5/S/60746. RT is grateful for the support from the National Authority for Scientific Research and Innovation (https://www.research.gov.ro), and from the Ministry of European Funds(https://mfe.gov.ro/), through the Competitiveness Operational Programme 2014-2020, POC-A.1-A.1.1.4-E-2015 [Grant number: 40/02.09.2016, ID: P_37_778, to RT]. SMP, SG, MC and RT were supported by the Romanian Academy(https://acad.ro/) Projects 1 and 3.Peer reviewe
Les espaces anonymes, entre voyage et exil. Entretien avec l’écrivain Edem Awumey [Elektronisk resurs]
No full text
IBPP Research Associates: Zambia
No full textThe following article - 10 years...and the show must go on, by Edem Djokotoe - was posted in the August 1, 2001 Issue of The Post (Zambia). Copyright permissions for the article were not available, and it is not available for download.
The article discusses the struggles of the author and The Post (Zambia) to remain in journalism business
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