1,197 research outputs found
マウス四塩化炭素およびカルバマゼピン肝障害モデルにおける肝臓内プロスタグランジンE2量の調節因子に関する研究
No full text主査：川畑篤史 教授 学内授与番号：薬第177号
Hiroaki Shimada, Ryota Hashimoto, Aya Aoki, Saya Yamada, Ken-Ichi Oba, Atsushi Kawase, Takeo Nakanishi, Masahiro Iwaki "The regulatory mechanism involved in the prostaglandin E2 disposition in carbon tetrachloride-induced liver injury" Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume155, April 2020, 102081
https://doi.org/10.1016/j.plefa.2020.102081 掲載
Ken-ichi Oba, Hiroaki Shimada, Ryota Hashimoto, Atsushi Kawase, Takeo Nakanishi, Masahiro Iwaki "Assessment of hepatic prostaglandin E2 level in carbamazepine induced liver injury" Endocr Regul. 2022 Feb 18;56(1):22-30.
doi:10.2478/enr-2022-0003 掲載application/pd
The regulatory factors of hepatic prostaglandin E2 levels in carbon tetrachloride- and carbamazepine-induced liver injury model mice
No full text近畿大学Kindai University博士（薬科学）主査：川畑篤史 教授 学内授与番号：薬第177号
Hiroaki Shimada, Ryota Hashimoto, Aya Aoki, Saya Yamada, Ken-Ichi Oba, Atsushi Kawase, Takeo Nakanishi, Masahiro Iwaki "The regulatory mechanism involved in the prostaglandin E2 disposition in carbon tetrachloride-induced liver injury" Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume155, April 2020, 102081
https://doi.org/10.1016/j.plefa.2020.102081 掲載
Ken-ichi Oba, Hiroaki Shimada, Ryota Hashimoto, Atsushi Kawase, Takeo Nakanishi, Masahiro Iwaki "Assessment of hepatic prostaglandin E2 level in carbamazepine induced liver injury" Endocr Regul. 2022 Feb 18;56(1):22-30.
doi:10.2478/enr-2022-0003 掲載application/pdfdoctoral thesi
Neoadjuvant Treatment in Pancreatic Cancer
No full text: Thanks to the development of modern chemotherapeutic regimens, survival after surgery for pancreatic ductal adenocarcinoma (PDAC) has improved and pancreatologists worldwide agree that the treatment of PDAC demands a multidisciplinary approach. Neoadjuvant treatment (NAT) plays a major role in the treatment of PDAC since only about 20% of patients are considered resectable at the time of diagnosis. Moreover, increasing data demonstrating the benefits of NAT for borderline resectable/locally advanced PDAC are driving a shift from up-front surgery to NAT in the multidisciplinary treatment of even resectable PDAC. Our understanding of the role of NAT in PDAC has evolved from tumor shrinkage to controlling potential micrometastases and selecting patients who may benefit from radical resection. The present review gives an overview on the current literature of NAT concepts for BR/LA PDAC and resectable PDAC
Gestão do trabalho e participação: Chega de oba-oba?
No full textThis article aims at investigating the work management in the advertising agencies in the city of
Belo Horizonte. The scope for the analysis was the work developed by Meir (2005) in the book “End
of the fun”. The repercussion aroused by the considerations in the book was the reason to choose
this author, because she proposes a return to the old fashion way of managing the work. The
authors discusses that the forms of managing work are not suitable for the advertisement agencies
and the professional that work for them. She believes that the office cannot be an extension of the
home and the leisure. The qualitative research developed for this investigation presents data
related to the ways of working of these organizations and corroborates with the author’s
statements. It was observed that the employees of the agencies fall into two categories of workers:
a rigid group, that works under strict and well definite rules, and the other group that performs the
tasks in accordance with the demands of the client’s advertising campaign. The results point out to
other issues such as “the lack of creativity toward the administrative procedures” and the clear
division of the work relations in only one organization.Esse artigo tem por finalidade investigar a gestão do trabalho nas agências de publicidade do município de Belo Horizonte. O escopo para a análise da pesquisa foi o trabalho desenvolvido por Meir (2005), no livro “Chega de oba-oba”. A escolha pela autora foi proveniente da repercussão causada por suas considerações, visto que ela propõe um retorno às estruturas antigas nas formas de gerir o trabalho. A autora argumenta que as novas formas de gerir o trabalho não são adequadas para as agências e nem para os profissionais que nelas trabalham. Isto porque acredita que o local de trabalho não pode ser uma extensão do lar e do lazer. A pesquisa de cunho qualitativo, desenvolvida para essa investigação, apresenta dados sobre as formas de se trabalhar e corrobora com as teses da autora. Observou-se que os empregados das agências se enquadram em dois grupos de trabalhadores: um rígido, que trabalha sob regras muito definidas, e um outro que desempenha suas funções em acordo com as exigências demandadas pelas campanhas publicitárias dos clientes da organização. Os resultados apontam para outras questões tais como a “falta de criatividade dos procedimentos administrativos” e da nítida divisão das relações de trabalho nas empresas
Role of chemotherapy for advanced/recurrent gastric cancer: an individual-patient-data meta-analysis
No full textRole of chemotherapy for advanced/recurrent gastric cancer: an individual-patient-data meta-analysis.
GASTRIC (Global Advanced/Adjuvant Stomach Tumor Research International Collaboration) Group1, Oba K, Paoletti X, Bang YJ, Bleiberg H, Burzykowski T, Fuse N, Michiels S, Morita S, Ohashi Y, Pignon JP, Rougier P, Sakamoto J, Sargent D, Sasako M, Shitara K, Tsuburaya A, Van Cutsem E, Buyse M.
Collaborators (54)
Buyse M, Michiels S, Oba K, Paoletti X, Rougier P, Yamamoto S, Nakamura K, Bang YJ, Bleiberg H, Burzykowski T, Buyse M, Delbaldo C, Michiels S, Morita S, Oba K, Ohashi Y, Paoletti X, Pignon JP, Rougier P, Sakamoto J, Sargent D, Sasako M, Van Cutsem E, Ajani J, Boku N, Barone C, Borner M, Bouche O, Bugat R, Coombes C, Cullinan S, Dank M, Douglass H, Fuse N, Glimelius B, Hawkins R, Kanzler S, Koizumi W, Kim TW, Lordick F, Moehler M, Nio Y, Ohtsu A, Pozzo C, Reichardt P, Roth A, Schumacher C, Shitara K, Thuss-Patience P, Tsuburaya A, Van Cutsem E, Vanhoefer U, Wils J, Yamamura Y.
Author information
Abstract
We conducted an individual-patient-data meta-analysis of the efficacy of chemotherapy on overall survival (OS) and progression-free survival (PFS) in advanced/recurrent gastric cancer (AGC). Our primary research question was whether the experimental arms of the trials included in the meta-analysis showed a benefit as compared with their corresponding control arms. MEDLINE (up to 2010), Cochrane Central Register of Controlled Trials, National Institutes of Health (NIH) trial registry and proceedings of major oncologic and gastrointestinal cancer meetings were searched. Randomised controlled trials for AGC closed to patient accrual before the end of 2006 were eligible. As of December 2010, individual patient data were available from 22 trials (4245 patients, representing 47% of the targeted data) of 55 eligible trials. The overall comparison of experimental arms with the corresponding control arms showed statistically significant differences in terms of both OS and PFS. Hazard ratio was 0.88 (95% confidence interval 0.82-0.94, P<0.0001) for OS and 0.81 (0.76-0.88, P<0.0001) for PFS. The results of the sub-analysis of adding a given chemotherapeutic agent to any chemotherapy confirm the results of the overall analysis, with a hazard reduction of 11% for OS (P<0.01) and 26% for PFS (P<0.0001). This meta-analysis of individual patient data shows that the additions of experimental chemotherapeutic agents to pre-existing control or standard regimens have produced a modest improvement in OS and PFS. Median survival remained below 1 year for all investigated chemotherapy regimens and none emerged as a clear standard
Erratum: The Operative management in Bariatric Acute abdomen (OBA) Survey: Long-term complications of bariatric surgery and the emergency surgeon's point of view (World J Emerg Surg (2020) 15 (2) DOI: 10.1186/s13017-019-0281-y)
No full textThe original article [1] contained an error in authorship whereby author, Fausto Catena was mistakenly listed as part of the institutional authorship of the OBA trial supporters instead of in the correct position of final author. As such, the original article has since been corrected to reflect the correct authorship. Furthermore, this error was mistakenly introduced by the production team handling this article and, as such was not the fault of the authors
Subversions of Gender and Power in Oba Minako's "Yamamba no Bisho"
No full textBeginning as early as Genji Monogatari and continuing to the present, women writers have had a significant impact on Japanese canon. Their perspectives present a critical view of the social structure and its effects on the lives of women, both in fiction and in factual biographical accounts. This essay posits that many female authors from modern Japan defied gender stereotypes and wrote about the difficulties that women faced. To illustrate this point further, Oba Minako (1930-2007) is introduced as an exemplary author who succeeded in her career despite many potential obstacles. Oba's writing combines imagery of women's power in the literary tradition as well as motifs from Japanese mythology to express a deep-seated anxiety with regard to the individuation process. Her short story "Yamamba no Bisho" examines this theme from the perspective of a psychic witch haunted by her supernatural abilities. Through an analysis of this story, the author will theorize that these abilities embody women's dual desire to both conform to the existing power structure and to reject it.9KJ00010002479departmental bulletin pape
Clutch interval of hermit crab
No full textInterval between reproductive events is an important factor for iteroparous animals because it determines the number of clutches throughout life. This study examined whether female size, clutch size, shell size and prenuptial molting affected the clutch interval in the hermit crab Pagurus nigrivittatus. Precopulatory guarding pairs of P. nigrivittatus were sampled in the field and kept in the laboratory until the female extruded eggs. The clutch interval of each female was assessed as one of two types of relatively "short" and "long" intervals by checking whether the guarded female had eggs and/or egg cases from the preceding brood or not when the guarding pair was collected. The clutch interval was longer in females with prenuptial molting than those without molting and these females usually grew larger at the prenuptial molt. This suggests that female P. nigrivittatus with a long interval might allocate energy into growth at the expense of the number of clutches during the current reproductive season. The allocation to growth is theoretically predicted to decrease with female size. Gastropod shell size is also known to affect the reproductive activity in hermit crabs. However, female size did not significantly affect the clutch interval in P. nigrivittatus, and the effect of gastropod shell size on clutch interval was not consistent with previous empirical studies. These results may be caused by differences in the gastropod species of shell occupied by the females of P. nigrivittatus
Comparing neoadjuvant chemotherapy with or without radiation therapy for pancreatic ductal adenocarcinoma: National Cancer Database cohort analysis
No full textBackground: Neoadjuvant treatment is important for improving the rate of R0 surgical resection and overall survival outcome in treating patients with pancreatic ductal adenocarcinoma (PDAC). However, the true efficacy of radiotherapy (RT) for neoadjuvant treatment of PDAC is uncertain. This retrospective study evaluated the treatment outcome of neoadjuvant RT in the treatment of PDAC. Methods: Collected from the National Cancer Database, information on patients with PDAC who underwent neoadjuvant chemotherapy (NAC) and pancreatectomy between 2010 to 2016 was used in this study. Short- and long-term outcomes were compared between patients who received neoadjuvant chemoradiotherapy (NACRT) and NAC. Results: The study included 6936 patients, of whom 3185 received NACRT and 3751 NAC. The groups showed no difference in overall survival (NACRT 16.1 months versus NAC 17.4 months; P = 0.054). NACRT is associated with more frequent margin negative resection (86.1 versus 80.0 per cent; P < 0.001) but a more unfavourable 90-day mortality than NAC (6.4 versus 3.6 per cent; P < 0.001). The odds of 90-day mortality were higher in the radiotherapy group (odds ratio 1.81; P < 0.001), even after adjusting for significant covariates. Patients who received NACRT received single-agent chemotherapy more often than those who received NAC (31.5 versus 10.7 per cent; P < 0.001). Conclusion: This study failed to show a survival benefit for NACRT over NAC alone, despite its association with negative margin resection. The significantly higher mortality in NACRT warrants further investigation into its efficacy in the treatment of pancreatic cancer
The Worldview and the Author´s (Self)Reflection in Czech Contemporary Historiography
No full textCílem studie je představit možnosti, jak na základě publikovaných autorských textů zkoumat světový názor historiků a historiček, zejména v oboru soudobých dějin, kde lze předpokládat vliv jejich hodnotového horizontu na interpretaci relativně nedávné minulosti. Autor nejprve vymezuje pojetí světového názoru vzhledem ke stanovenému záměru a zdůvodňuje analytické užití tohoto pojmu v historiografickém textu, v daném kontextu se také zamýšlí nad vztahem paměti, dějin a historiografie. Konstatuje, že poměrně málo českých historiků a historiček dosud reflektuje vztah (individuální či kolektivní) paměti a práce dějepisce, zvláště s ohledem na jeho pozici v současné společnosti, která bývá často redukována na roli objektivního „objevitele historické pravdy“. Taková (sebe)reflexe předpokládá přiznání vlivu individuálního světového názoru historika (komplexu názorů a postojů formovaných výchovou, vzděláním, vzpomínkami, generační příslušností a podobně) na jeho vědeckou činnost. Autor studie nabízí dvě možné a vzájemně se doplňující cesty k poznání historikova světového názoru: jednak prostřednictvím vlastních svědectví a prohlášení z jeho osobněji laděných textů a egodokumentů (eseje, rozhovory, vzpomínky, příspěvky na sociálních sítích), jednak analýzou jeho vědeckých textů (časopiseckých studií, knižních monografií, recenzí). Oba přístupy autor dokumentuje na konkrétních příkladech z produkce historiků a historiček českých soudobých dějin. V závěru studie pak nastiňuje cíle a smysl zkoumání historikova světového názoru.The aim of this study is to present the opportunities for research into the worldview of historians, especially historians focused on contemporary history, where it can be assumed that their set of values may influence their interpretation of the rela-tively recent past. The author first defines the notion of worldview and justifies the analytical use of this concept in historiographical texts. He also considers the relationship between memory, history and historiography in the given context. The author states that not many Czech historians have so far reflected on the relationship between (individual and collective) memory and the work of the historian, especially with regard to his or her position in contemporary society, which is often reduced to the role of an objective “discoverer of historical truth”. Such (self)reflection presupposes the acknowledgement of the influence of the historian’s individual worldview (a complex of opinions and attitudes shaped by upbringing, education, memories, generational affiliation and so on) on his or her scholarly activity. The author of the study offers two possible and complementary ways to learn about the historian’s worldview: first, through his or her own testimonies and statements from more personal texts and ego-documents (essays, interviews, memoirs or social me-dia posts), and second, through the analysis of his or her scholarly texts (journal studies, monographs and book reviews). The author demonstrates both approaches with concrete examples of works by historians of Czech contemporary history and concludes by outlining the aims and purpose of examining the historian’s worldview. © 2022, Institute of Contemporary History of the Czech Academy of Sciences. All rights reserved
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