83 research outputs found
RNA editing alterations define manifestation of prion diseases
No full textPrion diseases are fatal neurodegenerative disorders caused by misfolding of the normal prion protein into an infectious cellular pathogen. Clinically characterized by rapidly progressive dementia and accounting for 85% of human prion disease cases, sporadic Creutzfeldt–Jakob disease (sCJD) is the prevalent human prion disease. Although sCJD neuropathological hallmarks are well-known, associated molecular alterations are elusive due to rapid progression and absence of preclinical stages. To investigate transcriptome alterations during disease progression, we utilized tg340- PRNP 129MM mice infected with postmortem material from sCJD patients of the most susceptible genotype (MM1 subtype), a sCJD model that faithfully recapitulates the molecular and pathological alterations of the human disease. Here we report that transcriptomic analyses from brain cortex in the context of disease progression, reveal epitranscriptomic alterations (specifically altered RNA edited pathway profiles, eg., ER stress, lysosome) that are characteristic and possibly protective mainly for preclinical and clinical disease stages. Our results implicate regulatory epitranscriptomic mechanisms in prion disease neuropathogenesis, whereby RNA-editing targets in a humanized sCJD mouse model were confirmed in pathological human autopsy material
Exploring Historical Monuments and Learning History through an Augmented Reality Enhanced Serious Game
No full textTheoretical subjects, such as history, usually do not attract the interest of students and as a result educational games and serious games that use augmented reality (AR) are increasingly used as a means of supporting education. It is believed that these games can make the lesson more engaging and contribute to improving student performance. However, relevant research is limited. The present research presents the AR-enhanced serious game “Exploring Ancient Greece” that aims at supporting 10- to 14-year-old students in learning the history of Ancient Greece. It consists of three levels that include: a presentation of archaeological sites with AR that gives students the chance to explore places of historical interest; a trivia game that includes an AR presentation of a monument or piece of art somewhere in the physical surroundings of the students; and an escape room where the player is trapped in an archaeological site and tries to solve riddles to find the exit. To evaluate the game, an empirical study was conducted involving students between the ages of 10 and 14 who answered knowledge questions before and after playing the game, completed a questionnaire including questions based on the System Usability Scale (SUS), as well as questions for evaluating their experience, and answered oral questions. Based on the results of this study, students improved their knowledge of history, evaluated the game positively and stated that they prefer the use of serious games and AR in education
SIMULASI BERKENDARA LALU LINTAS DENGAN MEDIA BARANG BEKAS UNTUK MENINGKATKAN DISIPLIN SEJAK USIA DINI DI TK QILPI AL JIHAD SURABAYA
No full textThis study aims to determine the effectiveness of traffic driving simulations at Qilpi Al Jihad Kindergarten in Surabaya. The author uses a qualitative descriptive method. The author focuses on applying traffic driving simulations with used media to improve discipline in children from an early age. The author observes 4 times meetings. Each of their meetings plays a different role but with the same content. Media used materials used are available at school and have been adapted to the material being taught. The research subjects were the Qilpi Al Jihad Surabaya Kindergarten which numbered 14 students. All students use media from used materials at each meeting for 30 minutes. The results showed that learning media through varied media used materials will make children more enthusiastic and enthusiastic to learn because it is not boring. However, for children who do not understand the traffic signs and regulations that have been explained by the teacher, they will experience difficulties and confusion.
Keywords: driving simulation, training discipline in early childhood, gross motoricPenelitian ini bertujuan untuk mengetahui keefektifitasan simulasi berkendara lalu lintas di TK Qilpi Al Jihad Surabaya. Penulis menggunakan metode deskriptif kualitatif. Penulis fokus bagaimana menerapkan simulasi berkendara lalu lintas dengan media barang bekas untuk meningkatkan disiplin pada anak sejak usia dini. Penulis melakukan observasi selama 4x pertemuan. Setiap pertemuan mereka memainkan peran yang berbeda namun dengan isi materi yang sama. Media bahan bekas yang dipakai sudah tersedia di sekolah dan sudah disesuaikan dengan materi yang diajarkan. Subjek penelitian adalah TK Qilpi Al Jihad Surabaya yang berjumlah 14 siswa. Seluruh siswa menggunakan media dari bahan bekas di setiap pertemuan selama 30 menit. Hasil penelitian menunjukkan bahwa media pembelajaran melalui media bahan bekas yang bervariasi dalam suatu pembelajaran akan membuat anak-anak semakin bersemangat dan antusias untuk belajar karena tidak membosankan. Namun, bagi anak-anak yang kurang memahami rambu-rambu dan peraturan lalu lintas yang telah dijelaskan oleh guru, mereka akan mengalami kesulitan dan kebingungan.
Kata Kunci: simulasi berkendara, melatih kedisiplinan anak usia dini, motorik kasa
DINAMIKA KOMUNITAS PEDAGANG BESI BEKAS ASAL PANJALU DI PASAR JATAYU BANDUNG TAHUN 1957-2000
No full textSkripsi ini berjudul Dinamika Komunitas Pedagang Besi Bekas Asal Panjalu di Pasar Jatayu Bandung Tahun 1957-2000. Penelitian ini bertujuan untuk mendeskripsikan kajian historis mengenai dinamika yang terjadi pada komunitas pedagang besi bekas asal Panjalu yang berdagang di Pasar Jatayu Bandung pada kurun waktu 1957 hingga tahun 2000. Masih ditemukannya penelitian yang secara khusus mengkaji mengenai komunitas urban asal Panjalu yang bermata pencaharian sebagai pedagang besi bekas di Kota Bandung menjadi alasan penulis untuk melakukan penelitian ini. Melalui penelitian ini diharapkan mampu memperkaya khazanah penulisan sejarah lokal mengenai salah satu komunitas urban yang berasal dari Panjalu yang bergerak dalam usaha jual beli besi bekas. Metode penelitian yang digunakan adalah metode historis yang memiliki tahapan heursitik, kritik, interpretasi, dan historiografi. Berdasarkan hasil penelitian, eksistensi Pasar Jatayu sebagai pasar besi sejak diresmikannya pada tahun 1957 hingga masa kejayaannya pada tahun 2000 tidak terlepas dari peran komunitas pedagang besi bekas asal Panjalu selaku pihak yang ‘menghidupkan’ pasar. Pasar Jatayu juga di sisi lain telah menjadi wadah aktivitas ekonomi dan sumber penghidupan bagi para urbanisan asal Panjalu yang tergabung ke dalam komunitas pedagang besi bekas. Komunitas pedagang besi bekas asal Panjalu di Pasar Jatayu dalam perkembangannya telah membuktikan bahwa praktek jual-beli besi bekas yang seringkali dianggap kurang menarik bagi sebagian orang untuk dijadikan sebuah komoditas usaha, ternyata mampu mengantarkan komunitas ini ke tingkatan sosial yang lebih tinggi. Upaya pengembangan usaha besi bekas yang dilakukan komunitas ini secara terus menerus dan melibatkan beberapa generasi telah menjadi contoh sukses komunitas urban yang bermukim di kota Bandung.;--This research is entitled Dynamics of the Community of Used Iron Traders from Panjalu at Jatayu Market Bandung City in 1957-2000. This study aims to describe a historical study of the dynamics that occurred in the community of used iron traders from Panjalu who traded at Jatayu Market Bandung City in the period 1957 to 2000. It is still difficult to find research that specifically examines the urban community from Panjalu, whose livelihood as a scrap metal trader in the city of Bandung is the reason for the author to conduct this research. Through this research, it is hoped that it can enrich the treasures of local history writing about one of the urban communities originating from Panjalu, which is engaged in the business of buying and selling scrap metal. The research method used is a historical method that has heuritic stages, criticism, interpretation, and historiography. Based on the results of the study, the existence of the Jatayu Market as an iron market since its inauguration in 1957 until its heyday in 2000 was inseparable from the role of the community of scrap iron traders from Panjalu as a party that 'enlivens' the market. Jatayu Market, on the other hand, has become a place for economic activity and a source of livelihood for urbanists from Panjalu who are members of the scrap metal traders community. The community of scrap iron traders from Panjalu in Jatayu Market in its development has proven that the practice of buying and selling used iron, which is often considered to be less attractive to some people as a business commodity, turns out to deliver this community to a higher social level. The efforts to develop scrap metal business carried out by this community continuously and involving several generations have become successful examples of urban communities in the city of Bandung
Ethics of Regulation of Claims by Companies and Consumers
No full textThe purpose of this article is to present the state of business and consumer debt on the basis of information materials and reports published by the National Debt Register. The analyzed data shows that many companies and consumers do not pay their obligations on time. Entrepreneurs govern their duties until three months after the due date. The article shows how the public perceive unreliable companies and individuals that do not regulate within its obligations. The author also tries to find the factors influencing fulfillment of financial obligations by individuals and firms
PELAKSANAAN PENDAFTARAN TANAH BEKAS HAK MILIK ADAT DI KECAMATAN JATI ASIH-BEKASI
No full textThe warranty endowment of certainty of law in land area
needs the availability of the complete and explicit
written law appliances and effective land registration
implementation. Article 19 UUPA affirming that to
warrant certainty of law by government to be held the
land registration in all Indonesia Republic regions.
People will get a warranty through land registration on
its land because he/she procure a certificate
prevailing as the fervent proof appliance. However, in
fact, it is still many lands which not yet registered.
In Jatiasih-Bekasi regions, for example, there are
former custom property lands which not be registered by
its owner, of course, it is very risky because it will
raise a problem in the future. Moreover, it is also
open opportunity to other parties to exploit a change
to get the land; in which resident did not have enough
fervent proof stating that they are the actually land
owner. Considering about the important of certificate
as a proof appliance, then Author is interested to make
this thesis by title “The Registration Implementation
of Former Custom Property Land in Sub-district of
Jatiasih-Bekasi. The metode that used based on
empirical juridical approach method which rest on
primary data (result of research in area). The research
purpose is to know the registration implementation of
former custom property land, especially in Sub-district
of Jatisari-Bekasi region is held as according to the
prevailed regulation, that is, Governmental Regulation
No. 24 1997 and PMNA No. 3 1997. More than half of
former custom property lands in the region are not yet
registered or uncertificated. The expense problem
become a main constraint within the certificating
process, beside other constraints such as the problems
of medium, time, human resource, society prosperity
level, and the minimal of society knowledge about the
importance of Property Certificate.
Pemberian jaminan kepastian hukum di bidang pertanahan
memerlukan tersedianya perangkat hukum tertulis yang
lengkap dan jelas serta penyelenggaraan pendaftaran tanah
yang efektif. Pasal 19 UUPA menegaskan bahwa untuk
menjamin kepastian hukum oleh pemerintah diadakan
pendaftaran tanah di seluruh wilayah Republik Indonesia.
Melalui pendaftaran tanah orang akan memperoleh jaminan
kepastian hukum atas tanahnya karena memperoleh
sertipikat yang berlaku sebagai alat bukti yang kuat.
Namun dalam kenyataannya masih banyak tanah-tanah yang
belum didaftarkan. Di wilayah Jatiasih-Bekasi contohnya
banyak tanah-tanah bekas hak milik adat yang tidak
didaftarkan oleh pemlikinya, tentunya hal ini sangat
riskan karena akan menimbulkan masalah di kemudian hari
selain itu juga membuka peluang bagi pihak lain untuk
memanfaatkan kesempatan memperoleh tanah tersebut, dimana
penduduk tidak mempunyai bukti yang cukup kuat yang
menyatakan bahwa mereka adalah pemilik tanah yang
sebenarnya. Mengingat pentingnya surat tanda bukti hak
tanah (sertipikat) sebagai alat bukti yang kuat bagi
pemiliknya, maka Penulis tertarik untuk membuat tesis
“Pelaksanaan Pendaftaran Tanah Bekas Hak Milik Adat Di
Kecamatan Jatiasih-Bekasi. Metode yang digunakan adalah
berdasarkan metode pendekatan yuridis empiris yang
bertumpu pada data primer (hasil dari penelitian di
lapangan). Tujuan penelitian ini adalah untuk mengetahui
pelaksanaan pendaftaran tanah bekas hak milik adat di
wilayah Kecamatan Jatiasih-Bekasi dan hambatan serta
penyelesaiannya dalam pelaksanaan pendaftaran tanah.
Hasil penelitian bahwa Pelaksanaan Pendaftaran Tanah
bekas hak milik adat, khususnya di wilayah Kecamatan
Jatiasih-Bekasi diselenggarakan sesuai dengan peraturan
yang berlaku, yaitu PP No.24/1997 dan PMNA No.3/1997.
Lebih dari setengah tanah-tanah bekas hak milik adat di
wilayah tersebut belum didaftarkan atau tidak
bersertipikat. Masalah biaya menjadi kendala yang utama
dalam proses pembuatan sertipikat ini, disamping kendala
lain seperti masalah waktu dan sarana, sumber daya
manusia, tingkat kesejahteraan warga masyarakat, serta
minimnya pengetahuan masyarakat akan pentingnya
Sertipikat Hak Milik
Pengembangan Aplikasi Inovatif dengan Transparansi Informasi Untuk Jual Beli Mobil Bekas Menggunakan Metodologi Design Thinking
No full textTesis ini membahas penelitian mengenai pengembangan aplikasi sebagai inovasi dalam industri jual beli mobil bekas yang fokus pada peningkatan transparansi informasi. Saat ini, industri jual beli mobil bekas menghadapi tantangan serius dalam hal transparansi informasi yang dapat menghambat proses transaksi dan mengurangi tingkat kepercayaan antara penjual dan pembeli. Dalam upaya untuk mengatasi masalah ini, penelitian ini mengusulkan solusi yang inovatif dengan menerapkan prinsip-prinsip Design Thinking. Penelitian ini dimulai dengan menganalisis aplikasi jual beli mobil bekas yang ada saat ini dan mengidentifikasi masalah utama yang dihadapi oleh pengguna. Pada tahap ini, penulis menyadari masih terdapat kekurangan pada aplikasi yang sedang dikembangkan, sehingga perlu dilakukan penyempurnaan dengan melengkapi fitur-fitur yang memenuhi aspek transparansi informasi dengan menggunakan metodologi Design Thinking untuk menghasilkan aplikasi yang lebih berkualitas. Selain itu, kurangnya pemahaman mendalam tentang kebutuhan pengguna juga menjadi masalah yang perlu diatasi. Selanjutnya, penelitian ini menerapkan pendekatan Design Thinking untuk merancang dan mengembangkan aplikasi jual beli mobil bekas. Pendekatan ini melibatkan pemahaman mendalam terhadap pengguna, kolaborasi dengan para pemangku kepentingan, serta iterasi berulang dalam perancangan dan pengembangan aplikasi. Hasil penelitian ini diharapkan dapat menjadi solusi bagi bisnis jual beli mobil bekas secara online dengan memberikan detail informasi mobil yang transparan tentang kondisi mobil, riwayat perawatan, latar belakang, harga yang sesuai dukungan data dari pihak ketiga yang akurat dapat mempermudah dalam proses pengambilan keputusan
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This thesis discusses research regarding application development as an innovation in the used car buying and selling industry which focuses on increasing information transparency. Currently, the used car buying and selling industry faces serious challenges in terms of information transparency which can hamper the transaction process and reduce the level of trust between sellers and buyers. In an effort to overcome this problem, this research proposes an innovative solution by applying the principles of Design Thinking. This research began by analyzing existing used car buying and selling applications and identifying the main problems faced by users. At this stage, the author realizes that there are still shortcomings in the application being developed, so improvements need to be made by completing features that meet the information transparency aspect using the Design Thinking methodology to produce a higher quality application. Additionally, a lack of in-depth understanding of user needs is also a problem that needs to be addressed. Furthermore, this research applies a Design Thinking approach to designing and developing a used car buying and selling application. This approach involves deep understanding of users, collaboration with stakeholders, and repeated iterations in application design and development. It is hoped that the results of this research can be a solution for the online used car buying and selling business by providing detailed, transparent car information about the condition of the car, maintenance history, background, appropriate prices, supported by accurate third party data that can make the decision making process easier
Komparasi Algoritma K-Nearest Neighbors dan Random Forest Pada Prediksi Harga Mobil Bekas
No full textAlong with the development of the era of production of motorized vehicles, especially cars today, has experienced a very significant increase, companies are competing with each other in issuing the latest series. This has an impact on the abundance of used or used cars on the market, retail companies are demanded to be selective in determining the selling price and purchase price of the cars to be purchased and those to be resold, by utilizing technology, especially Data Mining, which is expected to assist the car selection process. which will be purchased quickly and accurately. Used car price predictions are influenced by several factors, including the type of car, fuel, distance traveled, year of production, and transmission. With these problems, the author tries to compare the K-Nearest Neighbors and Random Forest algorithms as the basis for making machine learning models that can predict the price of used cars according to existing specifications. The results of this study indicate that the Random Forest Algorithm has a smaller error value and better accuracy than K-Nearest Neighbors, Random Forest has an accuracy of 96.38% and K-Nearest Neighbors 59.17%, the error value obtained is calculated using the MSE (Mean Squared Error) evaluation metric by calculating the average difference between the actual value and the predicted value.Seiring dengan perkembangan zaman produksi pada kendaraan bermotor khususnya mobil dewasa ini mengalami peningkatan yang sangat signifikan, perusahaan saling berlomba-lomba dalam mengeluarkan seri terbarunya. Hal ini berdampak pada melimpahnya mobil seken atau bekas pakai di pasaran, perusahaan retail di tuntut selektif dalam menentukan harga jual dan harga beli dari mobil yang akan di beli serta yang akan diperjual belikan kembali, dengan memanfaatkan teknologi khususnya Data Mining diharapkan dapat membantu proses seleksi mobil yang akan di beli dengan cepat serta akurat. Prediksi harga mobil bekas dipengaruhi beberapa faktor antara lain jenis mobil, bahan bakar, jarak tempuh, tahun produksi, serta transmisi. Dengan adanya permasalahan tersebut, penulis mencoba memkomparasi algoritma K-Nearest Neighbors dan Random Forest sebagai dasar pembuatan model machine learning yang dapat memprediksi harga mobil bekas yang sesuai dengan spesifikasi yang ada. Hasil pada penelitian ini menunjukkan Algoritma Random Forest mendapat nilai error yang lebih kecil serta akurasi yang lebih baik dibandingkan K-Nearest Neighbors, Random Forest mendapat akurasi 96.38 % dan K-Nearest Neighbors 59.17 %, nilai error yang diperoleh dihitung menggunakan metrik evaluasi MSE(Mean Squared Error) dengan menghitung selisih rata-rata nilai sebenarnya dengan nilai prediksi
Perlindungan Konsumen atas Penyalahgunaan Swab Antigen Bekas yang Telah Didaur Ulang Berdasarkan Undang-Undang Republik Indonesia Nomor 8 Tahun 1999 tentang Perlindungan Konsumen (Studi Kasus : Putusan Nomor 1981/Pid.Sus/2021/PN Lbp)
No full textPerlindungan konsumen sangat penting. Salah satu bentuk penipuan konsumen terstruktur selama pandemi Covid-19 adalah tindak pidana stik antigen bekas yang didaur ulang. Rumusan masalah dalam penulisan skripsi ini adalah apakah pertimbangan hakim dalam putusan Nomor 1981/Pid.Sus/2021/PN Lbp sudah sesuai berdasarkan teori pemidanaan dan bagaimana pertanggungjawaban pelaku usaha terhadap penyalahgunaan stik
antigen bekas yang didaur ulang pada putusan Nomor 1981/Pid.Sus/2021/PN Lbp. Dalam penulisan ini, penulis menggunakan penelitian kepustakaan yuridis normatif. Data yang digunakan adalah data primer dari undang-undang, data
sekunder yang diperoleh melalui buku, artikel dalam jurnal hukum, dan data tersier dari kamus-kamus hukum. Dalam penelitian ini, dari hasil yang diperoleh penulis dapat disimpulkan bahwa penjatuhan hukum pidana dalam putusan Nomor 1981/Pid.Sus/2021/PN Lbp terlalu ringan dan kurang efektif bagi pelaku karena terbukti secara sah dan sengaja menggunakan stik antigen bekas yang didaur ulang. Penulis juga menyimpulkan bahwa kepastian hukum harus dilaksanakan dengan baik sebagai tanggung jawab pelaku usaha.
Kata Kunci : Perlindungan Konsumen, Swab Antigen, Daur Ulang, Hukuman Pidana. / Consumer protection is very important. One form of structured consumer
fraud during the Covid-19 pandemic is the criminal act of recycled used antigen
sticks. The formulation of the problem in writing this thesis is whether the
judge's consideration in Decision Number 1981/Pid.Sus/2021/PN Lbp is
appropriate based on the theory of punishment and how the liability of business
actors for the misuse of recycled used antigen sticks in Decision Number
1981/Pid.Sus/2021/PN Lbp.
In this paper, the author uses normative juridical literature research. The
data used are primary data from laws, secondary data obtained through books,
articles in legal journals, and tertiary data from legal dictionaries.
In this study, from the results obtained by the author, it can be concluded
that the imposition of criminal law in Decision Number 1981/Pid.Sus/2021/PN
Lbp is too light and ineffective for the perpetrator because it is proven that he
legally and intentionally used recycled used antigen sticks. The author also
concludes that legal certainty must be implemented properly as the
responsibility of business actors. Keywords : Consumer Protection, Swab Antigen,
Recycling, Criminal Punishmen
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