741 research outputs found
Elastic behavior of model membranes with antimicrobial peptides depends on lipid specificity and d-enantiomers
No full textIn an effort to provide new treatments for the global crisis of bacterial resistance to current antibiotics, we have used a rational approach to design several new antimicrobial peptides (AMPs). The present study focuses on 24-mer WLBU2 and its derivative, D8, with the amino acid sequence, RRWVRRVRRWVRRVVRVVRRWVRR. In D8, all of the valines are the Denantiomer. We use X-ray low- and wide-angle diffuse scattering data to measure elasticity and lipid chain order. We show a good correlation between in vitro bacterial killing efficiency and both bending and chain order behavior in bacterial lipid membrane mimics; our results suggest that AMP-triggered domain formation could be the mechanism of bacterial killing in both Grampositive and Gram-negative bacteria. In red blood cell lipid mimics, D8 stiffens and orders the membrane, while WLBU2 softens and disorders it, which correlate with D8’s harmless vs. WLBU2’s toxic behavior in hemolysis tests. These results suggest that elasticity and chain order behavior can be used to predict mechanisms of bactericidal action and toxicity of new AMPs.Fil: Kumagai, Akari. University of Carnegie Mellon; Estados UnidosFil: Dupuy, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; ArgentinaFil: Arsov, Zoran. Jožef Stefan Institute; EsloveniaFil: Elhady, Yasmene. University of Carnegie Mellon; Estados UnidosFil: Moody, Diamond. University of Carnegie Mellon; Estados UnidosFil: Erns, Robert. University of Maryland; Estados UnidosFil: Deslouches, Berthony. University of Pittsburgh; Estados UnidosFil: Montelaro, Ronald. University of Pittsburgh; Estados UnidosFil: Di, Yuanpu Peter. University of Pittsburgh; Estados UnidosFil: Tristram-Nagle, Stephanie. University of Carnegie Mellon; Estados Unido
Un'incursione nel thriller: Poslednja knjiga di Zoran Živković
No full textThe contribution will analyze some of the original features of Poslednja Knjiga (The last book) by Zoran Živković, who does not follow the strict tradition of crime - novels, on the contrary, wishing to transcend reality, the writer overcomes the restrictions of logic and scientifically proved, in order to venture into dimension of the imagery, surreal, dreamy. Živković sets his crime story in a library in Belgrade: inspector Dejan Lukić is entrusted with the case of mysterious deaths, but the investigation, with dramatic turns of events, ends up in a complete nonsense. The truth does not lie in the detection of the murderer (the last book), it is elsewhere, in the mind of the almighty creator - the Author himself, who manipulates the ephemeral lives of his characters. Rich in meta-crime elements, the crime story reveals the complex interaction between the writer's and his creatures' universe
Zoran Kravar's encyclopedic text
No full textU članku se opisuje i komentira izbor iz enciklopedijskoga rada književnoga povjesnika i teoretičara Zorana Kravara. Naglasak je na natuknicama pisanima za potrebe Krležijane. Na početku će se prezentirati glavne teze koje je sam autor iznio u povodu analize vlastita leksikografskoga posla na višegodišnjim enciklopedijskim projektima. Potom se analiziraju karakteristična mjesta u natuknicama koja oprimjeruju Kravarovu leksikografsku metodu te tumače njegova stajališta o nizu prominentnih književnopovijesnih, kulturnopovijesnih i političkopovijesnih tema, u historiografiji i danas relevantnih. Zaključno se vraćamo manje istaknutim mjestima Kravarove leksikografske ispovijesti, na kojima nastojimo dokazati da njegova metaleksikografska promišljanja imaju težinu domišljene metode, komplementarne s pristupom i tezama kojih se držao i u književnopovijesnom radu te su natuknice koje je sastavio o hrvatskoj književnosti važan i integralan dio njegova ukupna prinosa istraživanjima u povijesti hrvatske književnosti.The article describes and comments the selection from the encyclopedic work of the literary historian and theoretician Zoran Kravar. The emphasis is on the notes written for the needs of Krležijana. Initially, the main theses presented by the author himself will be presented in connection with the analysis of his own lexicographical work on multi-year encyclopedic projects. Characteristic places in the entries that exemplify Kravarʼs lexicographic method are then analyzed, but also interpret his views on a number of important literary-historical, cultural-historical and political-historical topics, which are still relevant in historiography. In conclusion, we return to the less prominent parts of Kravarʼs lexicographic confession, where we try to prove that his metalexicographic reflections have the weight of an invented method, complementary to the approach and theses he presented in his literary historical work, and the notes he compiled on Croatian literature are an important part of his total contribution to research in the history of Croatian literature
Zoran Vidojević question: Where the globalization is directed to?: Answer: Democracy on the wane
No full textIn this scientific review we discuss the attitude of the respected Serbian sociologist Zoran Vidojević toward the direction and the trends of globalisation as a process, about the ideas of globalism, liberal totalitarianism, American 'new world order' and transitional post-socialist societies. The author concludes that Vidojević, through his scientific oeuvre, especially through his last two scientific monographs, proved to be a truly engaged intellectual that, demonstrating it by the example of his attitude towards the problem of Kosovo and Metohija, works from the standpoint formulated by Santiago Ramon y Cajal about patriotism as one of the basic principles of the methodology of scientific research
Res judicata – The remarks on the Court of Justice of the EU judgment on Zoran Spasic case
No full textThe significance of the ne bis in idem principle is determined by its essence. In view of enhanced international cooperation this principle acquires a new meaning and the scope of its validity becomes redefined. EU Court of Justice referred to the ne bis principle – inter alia – on Zoran Spasic case. The author of this paper presents the most unconventional aspects of that important judgment. The Court found that reasons of safety and widely understood efficiency of functioning of cross-border prosecutions is more vital than understanding of the res judicata principle established in the literature
Fluorescence Microspectroscopy with Nanometer Peak Position Resolution: Novel Applications of Environment-Sensitive Probes
No full textChapter Six Application of Spin-Labeling EPR and ATR-FTIR Spectroscopies to the Study of Membrane Heterogeneity
No full textZoran Đinđić: From Anarchist to Barbarogenius
No full textZoran Đinđić bio je prvi (i do sada jedini) srbijanski premijer sa doktorskom diplomom filozofa i objavljenim knjigama koje su, u celosti ilidelimično, bile posvećene filozofiji politike. Otuda se nameće pitanjeda li je postojao uticaj njegovih ranih filozofskih stavova na kasnijebavljenje politikom. U članku se autor bavi onim što misli da je bioglavni diskontinuitet i glavni kontinuitet u misli Zorana Đinđića. Glavni diskontinuitet pojavio se u oblasti filozofije istorije: u suprotnostisa njegovom ranom kritikom filozofije istorije on je, dok je bio navlasti, formulisao svoju „filozofiju srpske istorije”. Na drugoj strani, ukritici prosvetiteljstva (shvaćenog kao totalitarnog) bio je dosledando kraja svog života. Štaviše, vernost mladalačkom anarhizmu izgleda da je došla do izražaja u poslednjim mesecima Đinđićevog života,kada je počeo da poprima crte Barbarogenija, onako kako ga je svojevremeno opisao Ljubomir Micić.Zoran Đinđić was the first (and so far only) Serbian prime minister with a PhD in philosophy and publications entirely or partially devoted to the philosophy of politics.Therefore, it is worth asking whether there was any impact of his early philosophicalviews on his later politics. The author is dealing with what he considers to be the maindiscontinuity and the main continuity in Đinđić’s thought. The former one marks thefield of philosophy of history: in contrast to his early critique of philosophy of history,once in power Đinđić formulated his own „philosophy of Serbian history”. The latterone, his critique of Enlightement as totalitarian, proved to be persistent throughouthis life. In the last months of his life Đinđić began to take on the features of a Barbarogenius, as Ljubomir Micić once described himself
Johann Albrecht von Reiswitz (1899-1962)
No full textInstitut za evropske studije je u saradnji sa Arhivom Vojvodine objavio je ovo zanimljivo izdanje. U pitanju je prva monografija o Johanu Albrehtu fon Rajsvicu, čiji je autor Andreas Rot. Ovo je nešto skraćeno izdanje voluminozne knjige gospodina Rota, koji je dao dozvolu da za naše tržište prevedemo one delove koji se odnose sa njegov rad i boravak u Jugoslaviji i okupiranoj Srbiji. Zahtevan posao prevoda i priređivanja ovog dela za naše tržište uradio je doktor Zoran Janjetović, u koordinaciji sa samim Rotom.
Fon Rajsvic, potomak stare pruske porodice, doktor filozofije, areholog, istoričar umetnosti i administrativac za pitanje istorijskih i kulturnih artefakata, predstavlja vrlo zanimljivu i za naše prostore važnu ličnost. Između dva rata boravio je u raznim misijama, da bi nakon okupacije došao kao oficir pod čijim nadleštvom su bile institucije kulture, muzeji, arhivi itd. Autor, koji je ovoj problematici posvetio višegodišnje istraživanje, donosi mnoštvo materijala, svedočenja i daje uravnotežen i objektivan pregled delovanja Fon Rajsvica na našim prostorima.The Institute of European Studies, in cooperation with the Archives of Vojvodina, published this intriguing edition. This is the first monograph on Johann Albrecht von Reiswitz, authored by Andreas Roth. It is a somewhat abridged version of Mr Roth’s extensive book, and he granted permission to translate for our market those parts related to his work and his stay in Yugoslavia and occupied Serbia. The challenging task of translating and editing this work for our market was undertaken by Dr Zoran Janjetović, in consultation with Andreas Roth himself. Von Reiswitz is a fascinating and significant figure for our region. He is a doctor of philosophy, an archaeologist, an art historian, a descendant of an old Prussian family, and an administrator for the issue of historical and cultural artefacts. He served in a number of missions during the two wars, and following the occupation, he became an officer in charge of cultural institutions, museums, archives, etc. The author, who spent many years researching this topic, provides a thorough and impartial summary of Von Reiswitz's activities in our area along with a wealth of materials and testimonies.Prevod dela: Johann Albrecht von Reiswitz (1899-1962) / Andreas Rot
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