9 research outputs found
Comunicazioni e notificazioni, processo di cognizione, procedimenti speciali, separazione e divorzio, rito speciale in materia di infortunistica stradale: D. L. 14 marzo 2005, n. 35 convertito con modificazioni nella L. 14 maggio 2005, n. 80 ; L. 28 dicembre 2005, n. 262 ; L. 28 dicembre 2005, n. 263 ; L. 8 febbraio 2006, n. 54 e L. 21 febbraio 2006, n. 102
No full textSAR and Anti-Mycobacterial Activity of Quinolones and Triazoloquinolones: An Update
No full textFluoroquinolones (FQ) are an important family of synthetic antimicrobial agents being clinically used over the
past thirty years. Currently some FQ are under investigation for the treatment of multidrug-resistant tuberculosis (MDRTB),
defined as resistance to at least isoniazid and rifampicin, and are under investigation as first-line drugs. Their main
biological target in Mycobacterium tuberculosis is the DNA gyrase, a topoisomerase II encoded by gyrA and gyrB that is
essential to maintain the DNA supercoil. It has been demonstrated that mutations in short regions of DNA gyrase are associated
with quinolone resistance or hypersusceptibility and take place in several MDR clinical isolates of M. tuberculosis.
In this article we update§ our previous review (Carta et al. Anti-infective agents, 2008, 7, 134-147) about the anti mycobacterial
properties, mode of action and structure activity relationship (SAR) studies of the known quinolone derivatives. Furthermore,
we update the synthesis and activity of 3,9-disubstituted-6-oxo-6,9-dihydro-3H-[1,2,3]-triazolo[4,5-
h,g]quinolone-carboxylic acids and their esters as a new class of potent and selective anti-mycobacterial agents, coupled
with absence of cytotoxicity. Furthermore, particularly interesting is their activity against MDR M. tuberculosis
Processo di esecuzione: D.L. 14 marzo 2005, n. 35 convertito con modificazioni nella L. 14 maggio 2005, n. 80; L. 28 dicembre 2005, n. 263; L. 24 febbraio 2006, n. 52
No full textA morte na unidade de terapia intensiva: um estudo de caso
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas. Programa de Pós-graduação em Sociologia PolíticaEsta pesquisa buscou descrever como é #o morrer# em uma Unidade de Terapia Intensiva (UTI) e explicar como esta morte condiciona os pacientes e impacta o trabalho dos profissionais de saúde. Foi realizada em uma UTI de adultos, no Estado de Santa Catarina. Adotou uma visão interdisciplinar que incorporou, em maior espaço, os aspectos sócioantropológicos da morte e do morrer. A observação sistemática foi a técnica utilizada para a coleta de dados, possibilitando a identificação dos fenômenos e o companhamento do processo de morrer em cada momento de suas inseparáveis etapas. A influência da morte sobre o comportamento/sentimento da equipe foi percebida nas falas de interlocutores-chaves que vivenciam cotidianamente a morte na UTI, como parte de suas profissões. A análise dos dados foi ancorada na sociologia clássica weberiana e apoiada no pensamento foucaultiano para compreender as relações de poder que se estabelecem e se entrecruzam na UTI, aqui vista como um não-lugar, incorporando a percepção da sociologia e antropologia, especialmente em Augé. Estão presentes, também, alguns recortes da sociologia da técnica, sem deixar de lado a sociologia das emoções ao tratar do luto e da morte digna. A concepção de modernidade tardia de Giddens dá o referente da contemporaneidade, onde os valores consagrados são questionados pela incorporação tecnológica presente na UTI, que não discute nem percebe o ser humano, mas o corpo objetificado. A morte que acontece na UTI é como se fosse um desligamento silencioso da vida, uma saída #à francesa# sem despedidas. Não é como a morte domesticada descrita por Ariès, mas uma morte esquecida por todos, no isolamento do seu espaço/leito, com exceção dos que morrem passando mal e mobilizam a equipe para um embate com a morte tentando mantê-lo vivo. Não há outra forma de morrer: ou no silêncio da solidão ou no fragor da luta, na arena do embate quando a equipe é #derrotada#, permanecendo na interface cinzenta entre a luz e as trevas, entre vida e morte, até a consumação do fato. O doente em situação terminal é olhado no Panópticon da UTI, mas não é visto nem percebido por esses olhares da equipe de saúde. Os que deveriam olhá-lo, os que estão lá fora, seus familiares, parentes e amigos, só saberão de sua morte após o evento ter-se concluído. A morte por mim observada não é a única morte que acontece na UTI, outras mortes antecedem, desde a entrada na UTI quando ocorre o desligamento do doente do lugar social onde vive para ser colocado em um não-lugar. Sua identidade será um número no prontuário formalizando uma morte social. A sua relação com o outro será reduzida à uma espetacularização na tela do monitor onde os gráficos e números falarão por ele, ainda mais quando sedado e intubado. Ocorre, assim, o que chamo de morte familiar, pois para muitas famílias ele já está praticamente morto, pois não pode conversar, apenas olhar, acariciar e monologar no sussurro quase choroso do desespero. This study sought to describe how #death# is in an Intensive Care Unit (ICU) (Unidade de Terapia Intensiva - UTI) and to explain how death conditions the patients, as well as impacts the work of health care professionals. The study was carried out in an ICU in the state of Santa Catarina, Brazil. It adopted an interdisciplinary perspective which incorporated to a greater degree the socio-anthropological aspects of death and dying. The technique utilized for data collection was systematic observation, making it possible to identify phenomenon and accompaniment of the death process in each moment of its inseparable stages. The influence of death on team behavior/sentiment was perceived in the speech of key speakers who lived death as a daily part of their professional practice in the ICU. The data analysis was anchored in classic Weberian sociology and supported by Foucault thinking in order to comprehend power relationships that are established and mix together in the ICU, seen thus as a non-place, incorporating such sociological and anthropological perception, especially in Augé. Some extracts of the technique of sociology are present here, without ignoring the sociology of emotions when dealing with grieving and dignified death. Giddens# conception of delayed modernity gives reference to contemporarily, where consecrated values are questioned through the incorporation of technology present in the ICU, which does not discuss or perceive the human being, but an objectified body. Death which occurs in the ICU is like a silent disconnection from life, a #French# exit with no goodbyes. It is not like the domesticated death described by Aries, but a death forgotten by all in the isolation of their space/bed, with the exception of those who die under duress and thus mobilize the team in a conflict with death, attempting to keep the patient alive. There is no time or way to die: either there is silence of solitude or the din of a fight in the arena of such conflict when the health care team is #beaten#, remaining in the grey interface between the light and the darkness, between life and death, until the fact is consummated. The terminally ill are observed in the Panopticon of the ICU, but is not seen nor perceived by these glances from health care team members. Those who should see them, those who are outside, their family members, relatives, and friends will only learn of the patient#s death after the event has passed. Death as observed by the author is not the only death which occurs in the ICU. Other deaths come before it, since entering the ICU, the patient is disconnected from the social place in which they live and placed in a non-place. His/her identity will be a number on a hospital chart, formalizing a social death. His/her relationship with others will be reduced to a spectacularization on the monitor screen where graphs and numbers will speak for him/her, all the more when sedated and on life support. Thus, what I call familiar death occurs, for to many families the patient is practically dead already, without the ability to converse; just able to look, caress, and monologue in a desperate almost crying whisper
Status of MagAO and review of astronomical science with visible light adaptive optics
No full textWe review astronomical results in the visible (λ<1μm) with adaptive optics and note the status the MagAO system and the recent upgrade to visible camera's Simultaneous/Spectra Differential Imager (SDI+) mode. Since mid- 2013 there has been a rapid increase visible AO with over 50 refereed science papers published in just 2015-2016 timeframe. Currently there are productive small (D < 2 m) visible light AO telescopes like the UV-LGS Robo-AO system (Baranec, et al. 2016). The largest (D=8m) telescope to achieve regular visible AO science is SPHERE/ZIMPOL. ZIMPOL is a polarimeter fed by the 1.2 kHz SPHERE ExAO system (Fusco et al. 2016). ZIMPOL's ability to differentiate scattered polarized light from starlight allows the sensitive detection of circumstellar disks, stellar surfaces, and envelopes of evolved AGB stars. The main focus of this paper is another large (D=6.5m Magellan telescope) AO system (MagAO) which has been very productive in the visible as well (particularly at the H-alpha emission line). MagAO is an advanced Adaptive Secondary Mirror (ASM) AO system at the Magellan in Chile. This ASM secondary has 585 actuators with < 1 msec response times (0.7 ms typically). MagAO utilizes a 1 kHz pyramid wavefront sensor (PWFS). The relatively small actuator pitch ( 22 cm/subap, 300 modes, upgraded to 30 pix dia. PWFS) allows moderate Strehls to be obtained in the visible (0.63-1.05 microns). Long exposures (60s) achieve <30mas resolutions and 30% Strehls at 0.62 microns (r') with the VisAO camera (0.5-1.0 μm) in 0.5" seeing with bright R <= 9 mag stars ( 10% Strehls can be obtained on fainter R 12 mag guide stars). Differential Spectral Imaging (SDI) at H-alpha has been very important for accreting exoplanet detection. There is also a 1-5micron science camera (Clio; Morzinski et al. 2016). These capabilities have led to over 35 MagAO refereed science publications. Here we review the key steps to having good performance in the visible and review the exciting new AO visible science opportunities and science results in the fields of: exoplanet detection; circumstellar and protoplanetary disks; young stars; AGB stars; emission line jets; and stellar surfaces. The recent rapid increase in the scientific publications and power of visible AO is due to the maturity of the next-generation of AO systems and our new ability probe circumstellar regions with very high (10-30 mas) spatial resolutions that would otherwise require much larger (<10m) diameter telescopes in the infrared
Optimisation and Operation of Residential Micro Combined Heat and Power (μCHP) Systems
No full textIn response to growing concerns regarding global warming and climate change, reduction of CO2 emissions becomes a priority for many countries, especially the developed ones such as the UK. Residential applications are considered among the most important areas for substantial reduction of CO2 emissions because they represent a major part of the total consumed energy in those countries. For instance, in the UK, residential applications are currently accountable for about 150 Mt CO2 emissions, which represents approximately 25% of the whole CO2 emissions [1-2]. In order to achieve a significant CO2 reduction, many strategies must be adopted in the policy of these countries. One of these strategies is to introduce micro combined heat and power (μCHP) systems into residential energy systems, since they offer several advantages over traditional systems. A significant amount of research has been carried out in this field; however, in terms of integrating such systems into residential energy systems, significant work is yet to be conducted. This is because of the complexity of these systems and their interdependency on many uncertain variables, energy demand of a house is a case in point.
In order to achieve such integration, this research focuses on the optimisation and operation of μCHP systems in residential energy systems as essential steps towards integration of these systems, so it deals with the optimisation and operation of a μCHP system within a building taking into account that the system is grid-connected in order to export or import electricity in certain cases. A comprehensive review that summarises key points that outline the trend of previous research in this field has been carried out. The reviewed areas include: technologies used as residential μCHP units, modelling of the μCHP systems, sizing of μCHP systems and operation strategies used for such systems.
To further this, a generic model for sizing of μCHP system’s components to meet different residential application has been developed by the author. Two different online operation strategies of residential μCHP systems, namely: an online linear programming optimiser (LPO) and a real time fuzzy logic operation strategy (FLOS) have been developed. The performance of the novel online operation strategies, in terms of their ability to reduce operation costs, has been evaluated. Both the LPO and the FLOS were found to have their advantages when compared with the traditional operation strategies of μCHP systems in terms of operation costs and CO2 emissions. This research should therefore be useful in informing design and operation decisions during developing and implementing μCHP technologies in residential applications, especially single dwellings
Society and the inquisition in Malta 1743-1798
No full textThe thesis falls into two main sections. It endeavours to analyse the major aspects of Maltese society in the second half of the eighteenth century as they emerge from a close scrutiny of the Archives of the Inquisition in Malta. The approach is mainly that of the ethnologist, a social history written 'from below'. The ultimate purpose was to try to arrive at as clear and accurate a picture of the Maltese mentalite as the archives permitted. Unfortunately, the Archives of the Inquisition in Malta have hardly ever been seriously studied by the social historian. Their richness and diversity not only cast enormous insight into the mental habits and frame of mind of a wide cross-section of Maltese society; they even shed sufficient light on a wide range of the social life of the Maltese. The subject is also approached from the point of view of the legal historian. The Inquisition was a Tribunal of Faith set up to stop the onslaught of Protestantism, as well as to reform the superstitious accretions to popular religion practised by the remaining part of the Catholic Church. The thesis examines the events leading to the charge and possibly arrest of the accused. Most of the reports were self-accusations and those arrested were taken into custody only after much deliberation. If the Inquisitors did make use of torture the accused was assisted by the defence counsel and produced his own witnesses. No instance of death sentences are encountered with in the second half of the eighteenth century and those found guilty were kindly dealt with, the Inquisitors being only after their conversion
The Enhanced Resolution Imager and Spectrograph for the VLT
No full textISSN:0004-6361ISSN:1432-0746ISSN:1432-074
Turn down the heat
No full textThis report provides a snapshot of recent scientific literature and new analyses of likely impacts and risks that would be associated with a 4° Celsius warming within this century. It is a rigorous attempt to outline a range of risks, focusing on developing countries and especially the poor. A 4°C world would be one of unprecedented heat waves, severe drought, and major floods in many regions, with serious impacts on ecosystems and associated services. But with action, a 4°C world can be avoided and we can likely hold warming below 2°C.
Without further commitments and action to reduce greenhouse gas emissions, the world is likely to warm by more than 3°C above the preindustrial climate. Even with the current mitigation commitments and pledges fully implemented, there is roughly a 20 percent likelihood of exceeding 4°C by 2100.
If they are not met, a warming of 4°C could occur as early as the 2060s. Such a warming level and associated sea-level rise of 0.5 to 1 meter, or more, by 2100 would not be the end point: a further warming to levels over 6°C, with several meters of sea-level rise, would likely occur over the following centuries
