20 research outputs found
Accurate omnidirectional multi-camera embedded structure from motion
No full textTrajectory estimation and 3D scene reconstruction from multiple cameras (also referred as Structure from Motion, SfM) will have a central role in the future of automotive industry. Typical appliance fields will be: autonomous navigation/guidance, collisions avoidance against static or moving objects (in particular pedestrians), parking assisted maneuvers and many more. The work exposed in this paper had mainly two different goals: (1) to describe the implementation of a real time embedded SfM modular pipeline featuring a dedicated optimized HW/SW system partitioning. It included also nonlinear optimizations such as local and global bundle adjustment at different stages of the pipeline; (2) to demonstrate quantitatively its performances on a synthetic test space specifically designed for its characterization. In order to make the system reliable and effective, providing the driver or the autonomous vehicle with a prompt response, the data rates and low latency of the 5G communication systems appear to make this choice the most promising communication solution
Erratum: Alcoholic and nonalcoholic liver disease: Diagnostic assessment and therapeutic perspectives (BioMed Research International (2019) 2019 (8691502) DOI: 10.1155/2019/8691502)
No full textIn the article titled “Alcoholic and Nonalcoholic Liver Disease: Diagnostic Assessment and Therapeutic Perspectives” [1], the affiliation “University of Valencia, Hospital La Fe, Valencia, Spain” was incorrectly assigned to the author Dr. Marina Berenguer. The correct affiliations for this author are shown below, and they have been added as affiliations 6, 7, and 8 in the author information above: CIBER-EHD, Instituto de Salud Carlos III, Madrid, Spain Hepatology and Liver Transplantation Unit, IIS La Fe, Hospital Universitario y Politécnico La Fe, Valencia, Spain Faculty of Medicine, University of Valencia, Valencia, Spain
Stima visiva di traiettoria di tipo structure from motion in un contesto multicamera
No full textLAUREA MAGISTRAL
Tumor suppressor role of the CL2/DRO1/CCDC80 gene in thyroid carcinogenesis
No full textContext: Thyroid carcinoma is one of the mostcommonmalignancies of the endocrine system, and, despite the high frequency of oncogene activation in thyroid neoplastic lesions, the tumor suppressor genes involved in thyroid carcinogenesis remain unidentified.Ourprevious data implicated a link between the CL2/CCDC80 gene and thyroid cancer. Objective: The objective of the study was to examine the expression of the CL2/CCDC80 gene in human thyroid carcinomas in the attempt to determine whether it plays a role in thyroid carcinogenesis. Design: Weevaluated the expression of CL2/CCDC80 in a large number of thyroid neoplastic tissue samples differing in degree of malignancy. We also investigated the effects of its restoration in 2 human thyroid carcinoma cell lines characterized by very low levels of CL2/CCDC80 expression. Results: CL2/CCDC80 expression was much lower in almost all the thyroid carcinomas analyzed than in normal thyroid tissues and was lowest in follicular variants of papillary carcinomas. Loss of heterozygosity partially accounted for CL2/CCDC80 down-regulation in thyroid carcinoma samples. Restoration of CL2/CCDC80 expression in the 2 human thyroid anaplastic carcinoma cell lines resulted in a higher susceptibility to apoptosis and suppression of the malignant phenotype. CL2/CCDC80 expression positively regulated the expression of E-cadherin, thereby halting cancer progression. Conclusions: These results indicate that CL2/CCDC80 is a putative tumor suppressor gene in thyroid carcinogenesis. Copyright © 2013 by The Endocrine Society
State-of-the-Art and Upcoming Innovations in Pancreatic Cancer Care: A Step Forward to Precision Medicine
No full textSimple Summary Pancreatic cancer remains a major therapeutic challenge despite medical advances. The incidence of pancreatic cancer is increasing, and this disease is associated with a high mortality and morbidity rate. The poor prognosis of pancreatic cancer can be attributed to several factors, including the difficulty of early diagnosis due to the lack of specific symptoms and biomarkers in the early stages, the aggressiveness of the disease, and its resistance to systemic therapies. However, recent advances in the field have led to promising new therapeutic strategies, and endoscopists have assumed a key role in the multidisciplinary management of this disease. The aim of this article is to provide a comprehensive literature review focused on examining existing treatments for various stages of pancreatic cancer, with an emphasis on new and innovative therapeutic approaches. Pancreatic cancer remains a social and medical burden despite the tremendous advances that medicine has made in the last two decades. The incidence of pancreatic cancer is increasing, and it continues to be associated with high mortality and morbidity rates. The difficulty of early diagnosis (the lack of specific symptoms and biomarkers at early stages), the aggressiveness of the disease, and its resistance to systemic therapies are the main factors for the poor prognosis of pancreatic cancer. The only curative treatment for pancreatic cancer is surgery, but the vast majority of patients with pancreatic cancer have advanced disease at the time of diagnosis. Pancreatic surgery is among the most challenging surgical procedures, but recent improvements in surgical techniques, careful patient selection, and the availability of minimally invasive techniques (e.g., robotic surgery) have dramatically reduced the morbidity and mortality associated with pancreatic surgery. Patients who are not candidates for surgery may benefit from locoregional and systemic therapy. In some cases (e.g., patients for whom marginal resection is feasible), systemic therapy may be considered a bridge to surgery to allow downstaging of the cancer; in other cases (e.g., metastatic disease), systemic therapy is considered the standard approach with the goal of prolonging patient survival. The complexity of patients with pancreatic cancer requires a personalized and multidisciplinary approach to choose the best treatment for each clinical situation. The aim of this article is to provide a literature review of the available treatments for the different stages of pancreatic cancer
Viollet-le-Duc and the “restoration” of Mont Blanc
No full textThe essay, a synthesis of the Ph.D. thesis of the author, examines the study of Viollet-le-Duc on Mont Blanc, starting from the analysis of his book Le massif du Mont Blanc. The translation of the book, the study of text and illustrations, on which the research is based, was the occasion to verify some key topics on the theoretical and design activity of the French architect: observation as a tool of knowledge and drawing as verification, communication and validation of an idea. In general, the study also investigates the interest of Viollet-le-Duc in natural phenomena, in particular the attraction for mountains, which is documented by many, little-known writings, drawings and surveys. It also opens up new, fruitful reflections on the usefulness of drawing, iconographic restitution, protection and restoration of landscape. Finally, the essay underlines the unity of method in Viollet-le-Duc’s studies. He was convinced that the earth is a great building in which each part has a role. For this reason, he had the same approach both for the study of deformations of the earth’s crust and the analyses of medieval constructive techniques
The cl2/dro1/ccdc80 null mice develop thyroid and ovarian neoplasias
No full textWe have previously reported that the expression of the CL2/CCDC80 gene is downregulated in human papillary thyroid carcinomas, particularly in follicular variants. We have also reported that the restoration of CL2/CCDC80 expression reverted the malignant phenotype of thyroid carcinoma cell lines and that CL2/CCDC80 positively regulated E-cadherin expression, an ability that likely accounts for the role of the CL2/CCDC80 gene in thyroid cancer progression. In order to validate the tumour suppressor role of the CL2/CCDC80 gene in thyroid carcinogenesis we generated cl2/ccdc80 knock-out mice. We found that embryonic fibroblasts from cl2/ccdc80(-/-) mice showed higher proliferation rate and lower susceptibility to apoptosis. Furthermore, cl2/ccdc80(-/-) mice developed thyroid adenomas and ovarian carcinomas. Finally, ret/PTC1 transgenic mice crossed with the cl2/ccdc80 knock-out mice developed more aggressive thyroid carcinomas compared with those observed in the single ret/PTC1 transgenic mice. Together, these results indicate CL2/CCDC80 as a putative tumour suppressor gene in human thyroid carcinogenesis
Making Exercise Part of the Daily Routine
No full textA survey conducted to examine the influence of technology and sedentary activities, time management, and motivation to become more physically active.Spring 2012Accompanied by video fil
Biological function of Cl 2 gene and it’s role in thyroid cancer
No full textHere I report data to support a tumor suppressor role of the Cl 2 gene. Indeed, I detected a drastic reduction, of Cl 2 gene expression in almost all thyroid carcinomas analyzed, with respect to normal thyroid, with the lowest expression levels observed in the follicular variants of papillary carcinomas. Loss of heterozygosity and CpG hypermethylation at the second exon likely accounts for Cl 2 downregulation in thyroid carcinomas. A drastic reduction in Cl 2 expression, with respect to normal counterpart tissues, was also observed in breast, colon and ovarian carcinomas. The restoration of Cl 2 expression in two human thyroid anaplastic carcinoma cell lines leads to the suppression of the malignant phenotype associated with a higher susceptibility to apoptosis.
The development of thyroid adenomas and ovarian carcinomas in Cl knock-out mice validates the tumor suppressor role of Cl 2 gene. Finally, transgenic mice for RET/PTC1 oncogene crossed with the Cl 2 knock-out mice developed much more aggressive thyroid carcinomas compared with those observed in the single mutant RET/PTC 1 mice.
Therefore, these results taken together indicate Cl 2 as a putative tumor suppressor gene in the process of human thyroid carcinogenesis
Under-dilated TIPS Associate With Efficacy and Reduced Encephalopathy in a Prospective, Non-randomized Study of Patients With Cirrhosis
No full textPortosystemic encephalopathy (PSE) is a major complication of trans-jugular intrahepatic porto-systemic shunt (TIPS) placement. Most devices are self-expandable polytetrafluoroethylene-covered stent grafts (PTFE-SGs) that are dilated to their nominal diameter (8 or 10 mm). We investigated whether PTFE-SGs dilated to a smaller caliber (under-dilated TIPS) reduce PSE yet maintain clinical and hemodynamic efficacy. We also studied whether under-dilated TIPS self-expand to nominal diameter over time.
METHODS:
We performed a prospective, non-randomized study of 42 unselected patients with cirrhosis who received under-dilated TIPS (7 and 6 mm) and 53 patients who received PTFE-SGs of 8 mm or more (controls) at referral centers in Italy. After completion of this study, dilation to 6 mm became the standard and 47 patients were included in a validation study. All patients were followed for 6 months; Doppler ultrasonography was performed 2 weeks and 3 months after TIPS placement and every 6 months thereafter. Stability of PTFE-SG diameter was evaluated by computed tomography analysis of 226 patients with cirrhosis whose stent grafts increased to 6, 7, 8, 9, or 10 mm. The primary outcomes were incidence of at least 1 episode of PSE grade 2 or higher during follow up, incidence of recurrent variceal hemorrhage or ascites (based on need for at least 1 large-volume paracentesis by 4 weeks after TIPS placement), incidence of shunt dysfunction requiring TIPS recanalization, and reduction in porto-caval pressure gradient.
RESULTS:
PSE developed in a significantly lower proportion of patients with under-dilated TIPS (46%) than controls (73%) during the first year after the procedure (P=.015), but the proportions of patients with recurrent variceal hemorrhage or ascites did not differ significantly between groups. No TIPS occlusions were observed. These results were confirmed in the validation cohort. In an analysis of self-expansion of stent grafts, during a mean follow-up period of 252 days after placement, none of the PTFE-SGs self-expanded to the nominal diameter in hemodynamically relevant sites (such as portal and hepatic vein vascular walls).
CONCLUSION:
In prospective, non-randomized study of patients with cirrhosis, we found under-dilation of PTFE-SGs during TIPS placement to be feasible, associated with lower rates of PSE, and effectiv
