392 research outputs found
Role of HSPB8 in the Proteostasis Network: From Protein Synthesis to Protein Degradation and Beyond
No full textProper protein folding is crucial for protein stability and function; when folding fails, due to stress or genetic mutations, proteins may become toxic. Cells
have evolved a complex protein quality control (PQC) system to protect against the toxicity exerted by aberrantly folded proteins, that may aggregate accumulating in various cellular compartments perturbing essential cellular activities, ultimately leading to cell and neuron death. The PQC comprises molecular chaperones, degradative systems (proteasome and autophagy) and components of the unfolded protein response. Prevention of protein aggregation, clearance of misfolded substrates and attenuation of translation, which decreases the amount of misfolding clients to levels manageable by the molecular chaperones, are all key steps for the maintenance of proteostasis and cell survival. In parallel, alterations of proteostasis may also (indirectly) influence RNA homeostasis; in fact, RNA-containing aggregates, known as stress granules, accumulate in cells with impaired PQC and
autophagy colocalizing with proteinaceous aggregates in several neurodegenerative diseases. Among the different molecular chaperones, here we will focus on the small heat shock protein HSPB8, which is expressed in neurons in basal conditions and upregulated in response to misfolded protein accumulation. HSPB8 exerts protective functions in several models of protein conformation neurodegenerative diseases. The putative sites of action of HSPB8 that confer HSPB8 pro-survival and anti-aggregation functions are discussed, as well as its potential role at the crossroad between proteostasis and ribostasis
Single task-level, 2SD-based cutoffs for the Italian version of the Edinburgh Cognitive and Behavioral ALS screen (ECAS)
No full textThe present study aimed at deriving, by means of a traditional “2 standard deviation-based” (2SD) approach, single task-level cutoffs for the Italian version of the Edinburgh Cognitive and Behavioral ALS Screen (ECAS). Cutoffs were derived–as M-2*SD–from the sample of healthy participants (HPs) included within 2016 Poletti et al.’s normative study–N = 248; 104 males; age: 57.8 ± 10.6; education: 14.1 ± 4.6–separately for the four, original demographic classes: 1) education <14 years and age ≤60 years; 2) education <14 years and age >60 years; 3) education ≥14 years and age ≤60 years; 4) education ≥14 years and age >60 years. The prevalence of deficits on each task was then estimated within a cohort of N = 377 amyotrophic lateral sclerosis (ALS) patients without dementia. The distribution of abnormal performance prevalences was overall consistent with the cognitive phenotype of ALS. In conclusion, the single task-level cutoffs herewith provided for the Italian version of the ECAS, which complement those already available within Poletti et al.’s normative framework, will help better profile Italian ALS patients’ cognitive phenotype within both clinical and research settings
It won't happen to me! Psychosocial factors influencing risk perception for respiratory infectious diseases: A scoping review
No full textUnderstanding the determinants of risk perception for COVID-19 might help to promote self-preventive behaviours. This scoping review aimed to map the extent, variety and characteristics of the evidence on the possible determinants of risk perception for COVID-like diseases. PubMed, Scopus and Web of Science were searched for original, peer-reviewed English-written articles published up to March 2020 and investigating risk perception determinants for respiratory infectious diseases in adults. Titles and abstracts were screened, and full texts were analysed by the first author; when unsure, eligibility was discussed with the last author. Data were collected according to an extraction sheet developed by the first and last authors. The cross-sectional evidence covers a variety of diseases, countries and timings of testing. Mostly, questionnaires recorded socio-demographics, media exposure, trust in institutions, disease proximity and knowledge; psychological variables, including personality traits, distress and self-efficacy, were less investigated. A miscellaneous operationalization of risk perception emerged, including the likelihood of getting sick, perceived dangerousness, concerns or a combination of them. A comprehensive understanding of the substantial amount of evidence may be challenging due to methodological heterogeneity. Referring to uniform theoretical frameworks is recommended; also, longitudinal research may be implemented to probe causal relationships
Syria Poletti, una inmigrante con mirada de viajera
No full textSyria Poletti is an Italian immigrant who arrived in Argentina in 1938, when she was 21 years old. After learning Spanish, she wrote her entire literary production in that new language. Due to this uniqueness, the author did not hesitate to conceive herself as an Argentine writer. In her first novel, Gente conmigo (1962), Poletti fic- tionalized elements of her biography and constructed a particular discourse where, in addition to recovering her experience as an immigrant, she also incorporated her gaze as a “European traveler”, judging by the inclusion of interpretive images about Argentina and the nature of its inhabitants. Based on this hypothesis, the objectives of this work will be: to trace the three perspectives from which the author produces–as an Italian immigrant, as a “European traveler” and as an Argentine writer–; analyze the trip based on a reconfiguration of her identity and, finally, identify the strategies she deploys to deliver her interpretation of ArgentinaSyria Poletti es una inmigrante italiana que arribó a la Argentina en 1938, cuando contaba con 21 años de edad. Tras aprender el español, escribió toda su pro- ducción literaria en esa nueva lengua. Debido a esta singularidad, la autora no dudó en concebirse como una escritora argentina. En su primera novela, Gente conmi- go (1962), Poletti ficcionalizó elementos de su biografía y construyó un discurso particular donde, además de recuperar su experiencia como inmigrante, incorporó también su mirada como “viajera europea”, a juzgar por la inclusión de imágenes interpretativas sobre la Argentina y el carácter de sus habitantes. En función de esta hipótesis, los objetivos del presente trabajo serán: rastrear las tres perspectivas desde las que produce literariamente la autora –como inmigrante italiana, como “viajera europea” y como escritora argentina–; analizar el viaje en función de una reconfiguración de su identidad y, por último, identificar las estrategias desplega- das para ofrecer su interpretación de la Argentina
Written on Skin, opera in tre parti di George Benjamin
No full textGeorge Benjamin
Written on Skin, opera in tre parti, su libretto di Martin Crimp, da un'anonima leggenda Occitana del XIII secolo, Le Coeur Mangé
Prima rappresentazione: Aix-en-Provence, Grand Théâtre de Provence, 7 luglio 2012
Personaggi: The Protector (Bar), Agnès, sua moglie (S), Angelo 1 e The Boy (Ct), Angelo 2 e Marie (Ms), Angelo 3 e John (T
anomyzed eco-climatic data
No full textDataset posted on authored by 2023-08-7 authored by Angelo Solimini, Chiara Virgillito, Mattia Manica, Piero Poletti, Giorgio Guzzetta, Giovanni Marini, Roberto Rosà, Federico Filipponi, Paola Scognamiglio, Francesco Vairo, Beniamino Caputo</p
Syria Poletti and peronism in Histonium
No full textEntre junio de 1945 y julio de 1949, Syria Poletti publicó en Histonium, una revista ítalo-argentina fundada en 1939 por Carlos Della Penna, un conjunto cuantitativamente significativo de textos de diversa índole. El paso de la escritora por esta publicación es relevante no sólo porque forma parte de la etapa inicial de su carrera, etapa en la que adquiere experiencia incursionando en diferentes roles y géneros discursivos, sino porque es un período de posicionamiento y reposicionamiento de la autora en el campo intelectual y político argentino. El objetivo del presente trabajo es visibilizar algunos dilemas que Syria Poletti pareciera haber tenido que enfrentar durante su actuación como columnista, cronista y entrevistadora, en un medio hemerográfico que, entre 1947 y 1948, se encolumnó políticamente con el oficialismo.Between June 1945 and July 1949, Syria Poletti published in Histonium, an Italian-Argentine magazine founded in 1939 by Carlos Della Penna, a quantitatively significant set of texts of various kinds. The writer's passage through this publication is relevant not only because it is part of the initial stage of her career, a stage in which she gains experience venturing into different roles and discursive genres, but also because it is a period of positioning and repositioning of the author in the Argentine intellectual and political fields. The objective of this work is to make visible some dilemmas that Syria Poletti seems to have had to face during her work as a columnist, chronicler and interviewer, in a journalistic medium that, between 1947 and 1948, was politically aligned with the ruling party.Fil: Buret, María Florencia. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina
Syria Poletti and peronism in Histonium
No full textEntre junio de 1945 y julio de 1949, Syria Poletti publicó en Histonium, una revista ítalo-argentina fundada en 1939 por Carlos Della Penna, un conjunto cuantitativamente significativo de textos de diversa índole. El paso de la escritora por esta publicación es relevante no sólo porque forma parte de la etapa inicial de su carrera, etapa en la que adquiere experiencia incursionando en diferentes roles y géneros discursivos, sino porque es un período de posicionamiento y reposicionamiento de la autora en el campo intelectual y político argentino. El objetivo del presente trabajo es visibilizar algunos dilemas que Syria Poletti pareciera haber tenido que enfrentar durante su actuación como columnista, cronista y entrevistadora, en un medio hemerográfico que, entre 1947 y 1948, se encolumnó políticamente con el oficialismo.Between June 1945 and July 1949, Syria Poletti published in Histonium, an Italian-Argentine magazine founded in 1939 by Carlos Della Penna, a quantitatively significant set of texts of various kinds. The writer's passage through this publication is relevant not only because it is part of the initial stage of her career, a stage in which she gains experience venturing into different roles and discursive genres, but also because it is a period of positioning and repositioning of the author in the Argentine intellectual and political fields. The objective of this work is to make visible some dilemmas that Syria Poletti seems to have had to face during her work as a columnist, chronicler and interviewer, in a journalistic medium that, between 1947 and 1948, was politically aligned with the ruling party.Fil: Buret, María Florencia. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina
Post-translational modifications and expanded polyglutamine toxicity in neurons
No full textPolyglutamine diseases are a family of nine neurodegenerative disorders caused by expansion in different genes of a CAG triplet repeat stretch, which encodes an elongated polyglutamine tract. This polyglutamine tract is thought to confer a toxic gain of function to the bearing proteins, which leads to late onset and progressive loss of neurons in specific regions of the central nervous system. The mechanisms underlying specificity for neuronal vulnerability remain enigmatic. One explanation is that the polyglutamine tract is not the only determinant of neurodegeneration and that protein context and post-translational events may also be crucial for pathogenesis. Here, we review how post-translational modifications of the polyglutamine proteins contribute to modulate neurotoxicity
Syria Poletti and peronism in Histonium
No full textEntre junio de 1945 y julio de 1949, Syria Poletti publicó en Histonium, una revista ítalo-argentina fundada en 1939 por Carlos Della Penna, un conjunto cuantitativamente significativo de textos de diversa índole. El paso de la escritora por esta publicación es relevante no sólo porque forma parte de la etapa inicial de su carrera, etapa en la que adquiere experiencia incursionando en diferentes roles y géneros discursivos, sino porque es un período de posicionamiento y reposicionamiento de la autora en el campo intelectual y político argentino. El objetivo del presente trabajo es visibilizar algunos dilemas que Syria Poletti pareciera haber tenido que enfrentar durante su actuación como columnista, cronista y entrevistadora, en un medio hemerográfico que, entre 1947 y 1948, se encolumnó políticamente con el oficialismo.Between June 1945 and July 1949, Syria Poletti published in Histonium, an Italian-Argentine magazine founded in 1939 by Carlos Della Penna, a quantitatively significant set of texts of various kinds. The writer's passage through this publication is relevant not only because it is part of the initial stage of her career, a stage in which she gains experience venturing into different roles and discursive genres, but also because it is a period of positioning and repositioning of the author in the Argentine intellectual and political fields. The objective of this work is to make visible some dilemmas that Syria Poletti seems to have had to face during her work as a columnist, chronicler and interviewer, in a journalistic medium that, between 1947 and 1948, was politically aligned with the ruling party.Fil: Buret, María Florencia. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina
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