19 research outputs found
نسخہ خطی شمائل حسنیہ میں منشی غلام حسن شہید ملتانیؒ کےآثارکا تعارف: INTRODUCTION TO THE WORKS OF MUNSHI GHULAM HASSAN SHAHEED MULTANI IN THE MANUSCRIPT “SHAMIL-E-HASSANIA’’
No full textThe book “Shamil-e-Hassania’’ was authored by Molvi Nzam-u-Din Rang puri (Mercy be Upon Him) in which he has pen downed the glorious presentment, sayings and persona of his beloved spiritual master “Munshi Ghulam Hassan Shaheed Multani (Mercy be Upon Him)” –The book is comprised of four chapters and Rukan Doam end note. In the third chapter, he has briefed about written work of Hazrat Khawaja Munshi Ghulam Hassan Shaheed Multani. He discussed the books with name from page 18 to page 21. The objective of this book was not only to give tribute to his beloved spiritual master, but also to establish a way forward for ultimate truth seekers in this mortal world. This book serves as a beacon for strayed and remedy for ignorance.Different sufi saints of Chisti family until Hazrat Niam ud Din aolia (Mercy be Upon Him ) and finally to Hazrat Khawaja Hafiz Muhammad Jamalullah Chishti Nizami (Mercy be upon him) And Munshi Ghulam Hassan Shaheed Multani. In Shamil-e-Hassania Munshi Ghulam Hassan Shaheed Multani (Mercy be upon him) have been discussed. In the end note, his sescendants and their caliphs have been discussed in detail. At many places in this account, author has supported the secrets of Toheed, and Honors of Sufism in the light of Quran and Hadith, Moreover, the use of mystic poetry has further glorified the comprehensiveness of the book
ملتان میں فلسفے کی روایت
No full textIt is an established fact that Multan is one of the oldest cities of the world, which has a reputation of a living city for the last five thousand years. It has a great tradition of institution and thought which reflects its centers of worship, variety of religions and beliefs, compilation of holy book of "Rig Veda' and philosophical attainments and pursuits of the scholars. Great Muslim philosopher, historians, travelers and Sufies have visited this city, one way or the other. Nasir Khusrau (philosopher and a preacher), Al-Beruni (historian and scholar), Fakhar-ud-din Razi (interpreter and philosopher), Samauddin Multani, Abdullah Multani, Maulana Fateh-ullah and Bahauddin Zakariya Multani have become the major source of philosophical tradition in Multan. Atiq Fikri, Qazi Javed and Shabbir Ahmad Ghauri has traced this tradition and the author of this paper has utilized the sources as well as the cultural heritage of Sufi poets of this area
Hazrat Sheikh Bahaa al-Din Zakaria al-Multani (566 AH-661 AH) and his efforts in benevolence, self-purification, and self-purification
No full textSheikh Zakaria bin Muhammad Al-Multani Al-Arabi Al-Qurayshi was born in Multan in 578 AH and learned from Sheikh Shihab al-Din al-Suhrawardi, author of the book (Awarif al-Ma'arif). This research will present the Sheikh’s efforts in purification, charity, and Sufism, and his life is a lesson in the life of this new Islamic nation for the hearts of the dead. Creates a new passion for life. It is the source of Sufi life and benevolence or self-purification. In light of the strenuous efforts and the clear and invaluable impact of the personality of Sheikh Al-Islam Zakaria, may God have mercy on him, in the Indian subcontinent, a chair was allocated in the Department of Arabic Language at Bahauddin Zakaria University in Multan under the name “Sheikh Bahauddin Zakaria Chair,” and work on it began in October 2007. The main objective of this chair is to promote the scientific, educational and religious services of Hazrat Sheikh Al-Islam Bahauddin Zakaria in Sufism. Islamic Sufism was promoted in the Indian subcontinent according to the Suhrawardi series at his hands
Human Immunodeficiency Virus II: Clinical Presentation, Opportunistic Infections, Treatment, and Prevention
No full textSettlement Experiences in a Small City: Kamloops, British Columbia
No full textWhat is the settlement experience of immigrants coming through family reunion intake class in Kamloops, British Columbia? The importance of undertaking this study lies in the settlement challenges faced by smaller communities outside of the major metropolitan areas of Canada. It is imperative to better understand the settlement experience of family-class immigrants in a smaller city.
British Columbia is a large province and settlement experiences can be very different from one community to another. From 2002 to 2006 there were 4,111 new immigrants to the Thompson Okanagan Development Region (BC Multiculturalism and Immigration Branch, May 2007). All immigrant groups rely on health, education and other social services, and social workers play a key role
in the delivery of direct and essential services. This study will generate discussion and policy recommendations for government, practitioners, policy-makers and other stakeholders around issues such as needs and settlement experiences of immigrants, ethno-specific groups, credentials recognition and other labour market issues, and capacity issues for delivering key services in a smaller community.Peer reviewe
Settlement experiences in a small city: Kamloops, British Columbia
No full textWhat is the settlement experience of immigrants coming through family reunion intake class in Kamloops, British Columbia? The importance of undertaking this study lies in the settlement challenges faced by smaller communities outside of the major metropolitan areas of Canada. It is imperative to better understand the settlement experience of family-class immigrants in a smaller city.
British Columbia is a large province and settlement experiences can be very different from one community to another. From 2002 to 2006 there were 4,111 new immigrants to the Thompson Okanagan Development Region (BC Multiculturalism and Immigration Branch, May 2007). All immigrant groups rely on health, education and other social services, and social workers play a key role
in the delivery of direct and essential services. This study will generate discussion and policy recommendations for government, practitioners, policy-makers and other stakeholders around issues such as needs and settlement experiences of immigrants, ethno-specific groups, credentials recognition and other labour market issues, and capacity issues for delivering key services in a smaller community.Peer reviewe
Pour que la tempête ne s’étende jamais hors du verre d’eau : réflexions sur la protection des convictions religieuses au Canada
No full textÀ la suite de la décision de la Cour suprême du Canada dans l’arrêt Multani c. Commission scolaire Marguerite-Bourgeoys rendue en 2006, le Québec a été le théâtre de ce qu’il est aujourd’hui juste d’appeler la « crise des accommodements raisonnables ». Pour répondre à la situation, le gouvernement québécois a mis sur pied la Commission de consultation sur les pratiques d’accommodement reliées aux différences culturelles, dont le rapport n’accorde que très peu de poids à l’hypothèse voulant que la crise des accommodements ait des racines juridiques. Selon l’auteur, les critères établis par la jurisprudence canadienne pour identifier les convictions religieuses pouvant bénéficier d’une protection particulière en droit ont été élargis au point de ne plus permettre aux tribunaux et aux décideurs publics d’identifier la frontière séparant les convictions religieuses des autres convictions personnelles.L’auteur examine les enjeux liés à la définition du phénomène religieux dans le monde et les critères établis par les instances judiciaires canadiennes pour identifier les formes d’appartenance individuelle pouvant faire l’objet de la protection de la loi.Following the Supreme Court of Canada’s 2006 decision in Multani v. Commission scolaire Marguerite-Bourgeoys, Quebec has been the stage of what can now be called the “reasonable accommodations crisis”. In response to the situation, the Quebec government set up the Consultation Commission on Accommodation Practices Related to Cultural Differences, whose final report gives very little weight to the hypothesis that the accommodations crisis has legal roots. From a legal perspective, the criteria established by Canadian jurisprudence to identify religious beliefs that can benefit from specific legal protection have been broadened to such a point that courts and decisionmakers in civil society can no longer identify the line between religious and personal beliefs.The author develops his argument by examining issues relating to the definition of religion throughout the world and the criteria established by Canadian judicial bodies to identify forms of personal affiliation that can be legally protected
Abstract CT030: STARTRK-NG: A phase 1/1b study of entrectinib in children and adolescents with advanced solid tumors and primary CNS tumors, with or without TRK, ROS1, or ALK fusions
No full textAbstract
Background: The STARTRK-NG (Studies of Tumor Alterations Responsive to Targeting Receptor Kinases - Next Generation) trial is a Phase 1/1b dose-escalation and expansion study of entrectinib in pediatric patients with cancer. Entrectinib is a potent oral, CNS-penetrant, inhibitor of the tyrosine kinases TRKA/B/C (encoded by the genes NTRK1/2/3, respectively), ROS1, and ALK with IC50s < 2 nM (biochemical kinase assay). Three adult studies (Phase 1 ALKA-372-001, Phase 1 STARTRK-1, and Phase 2 STARTRK-2) have enrolled hundreds of patients with advanced or metastatic solid tumors harboring TRKA/B/C, ROS1, or ALK molecular alterations, with or without CNS disease. Previously, we reported 400 mg/m2 daily as the adult body surface area (BSA)-based Recommended Phase 2 Dose (RP2D) (Patel et al, ASCO 2015). An objective response rate of 79% was seen in 24 tyrosine kinase inhibitor-naïve patients with TRK, ROS1, or ALK fusions who were treated at doses consistent with the RP2D (Drilon et al, AACR 2016). Gene fusions have been observed in a variety of adult solid tumor types, including non-small cell lung cancer, salivary gland cancers, soft tissue sarcomas and glioneuronal tumors. These fusions have also been found in cancers that affect the pediatric population, such as infantile fibrosarcoma, juvenile breast cancer, mesoblastic nephroma, intrinsic pontine gliomas, acute leukemias and anaplastic lymphoma. In addition, overexpression of TRKB and activating ALK point mutations have been observed in neuroblastoma. Thus, a pan-TRK, ROS1, and ALK inhibitor, like entrectinib, may potentially have broad therapeutic utility in pediatric patients.
Methods: This is a multicenter, dose escalation study in pediatric patients (aged 2-21 years) with relapsed or refractory extracranial solid tumors (Phase 1), with additional expansion cohorts (Phase 1b) in patients with primary brain tumors harboring TRK, ROS1, or ALK molecular alterations inclusive of gene fusions, neuroblastoma, and other non-neuroblastoma, extracranial solid tumors harboring TRK, ROS1, or ALK gene fusions (NCT02650401). During dose escalation, a 3+3 schema will be used to determine the pediatric RP2D of entrectinib with a starting dose of 250 mg/m2 (approximately 60% of the adult BSA-based RP2D), administered orally once daily in repeated 4-week cycles, with concordant pharmacokinetics and pharmacodynamics studies. Up to four dose levels will be evaluated. Dose modifications, if necessary, will follow a protocol-specific dosing nomogram for each dose level. Once the pediatric RP2D is determined, the Phase 1b expansion cohorts will be opened simultaneously, and prospective molecular profiling will be performed to determine eligibility except for patients with neuroblastoma.
Citation Format: Ami V. Desai, Garrett M. Brodeur, Jennifer Foster, Suzanne Shusterman, Amit J. Sabnis, Magaret Macy, Cynthia Wetmore, Ellen Basu, Zachary Hornby, Vanessa Esquibel, Edna Chow Maneval, Pratik S. Multani, Elizabeth Fox. STARTRK-NG: A phase 1/1b study of entrectinib in children and adolescents with advanced solid tumors and primary CNS tumors, with or without TRK, ROS1, or ALK fusions [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr CT030. doi:10.1158/1538-7445.AM2017-CT030</jats:p
Les rapports entre le droit administratif et les droits et libertés : la révision judiciaire ou le contrôle constitutionnel ?
No full textL’auteur propose de revisiter l’arrêt Roncarelli c. Duplessis pour répondre à la question suivante : dans l’hypothèse où le droit administratif et le droit constitutionnel sont susceptibles de fournir la solution à un litige, celui-ci doit-il être résolu en ayant recours au critère de l’atteinte minimale tiré du test de l’arrêt R. c. Oakes, propre au droit constitutionnel, ou aux règles de la révision judiciaire du droit administratif? Comme elle encourage l’autoreproduction normative, la logique de l’accommodement raisonnable respecte davantage le mouvement initié par l’arrêt Roncarelli.L’auteur s’intéresse d’abord au mouvement de procéduralisation réflexive des dispositifs de gouvernance démocratique amorcé par l’arrêt Roncarelli. L’auteur examine le raisonnement des juges dissidentes Deschamps et Abella dans l’arrêt Multani c. Commission scolaire Marguerite-Bourgeoys, rendu par la Cour suprême du Canada en 2006, précisant que c’est leur approche, celle de l’accommodement raisonnable, qui prévaut depuis. S’appuyant ensuite sur l’analyse de divers auteurs, il suggère que la démarche de l’accommodement raisonnable est plus appropriée puisqu’elle invite les parties à construire la signification et la portée de la norme qui doit les régir, leur permettant ainsi d’identifier des solutions qui encouragent davantage le vivre-ensemble.The author re-examines the decision in Roncarelli v. Duplessis in order to answer the following question: if administrative and constitutional law can both provide the solution to a given case, should the issue be resolved through a constitutional law approach, namely; the minimal impairment test developed in R. v. Oakes, or through the undue hardship criterion taken from the obligation of reasonable accommodation and usually associated with administrative law? Since it encourages normative self-reference, the reasonable accommodation approach more greatly respects the movement initiated by the Roncarelli decision.The author first examines the movement of reflexive proceduralization of the means of democratic governance that emerged from Roncarelli. He analyzes the reasoning underpinning the minority opinion of Justices Deschamps and Abella in the Multani v. Commission scolaire Marguerite-Bourgeoys judgment by the Supreme Court of Canada in 2006, and notes that it is their approach, based on the reasonable accommodation framework, that has been applied since then. Based on the work of various authors, he then suggests that the reasonable accommodation method is more appropriate, as it allows parties to construct and determine the meaning and the scope of the norm that governs them, thus giving them the opportunity to identify solutions that favour living together
