319 research outputs found
Mathematical modeling of endocrine regulation subject to circadian rhythm
No full textThe 2017 Nobel Prize in Physiology or Medicine awarded for discoveries of molecular mechanisms controlling the circadian rhythm has called attention to the challenging area of nonlinear dynamics that deals with synchronization and entrainment of oscillations. Biological circadian clocks keep time in living organisms, orchestrating hormonal cycles and other periodic rhythms. The periodic oscillations of circadian pacemakers are self-sustained; at the same time, they are entrainable by external periodic signals that adjust characteristics of autonomous oscillations. Whereas modeling of biological oscillators is a well-established research topic, mathematical analysis of entrainment, i.e. the nonlinear phenomena imposed by periodic exogenous signals, remains an open problem. Along with sustained periodic rhythms, periodically forced oscillators can exhibit various “irregular” behaviors, such as quasiperiodic or chaotic trajectories. This paper presents an overview of the mathematical models of circadian rhythm with respect to endocrine regulation, as well as biological background. Dynamics of the human endocrine system, comprising numerous glands and hormones operating under neural control, are highly complex. Therefore, only endocrine subsystems (or axes) supporting certain biological functions are usually studied. Low-order dynamical models that capture the essential characteristics and interactions between a few hormones can than be derived. Goodwin's oscillator often serves as such a model and is widely regarded as a prototypical biological oscillator. A comparative analysis of forced dynamics arising in two versions of Goodwin's oscillator is provided in the present paper: the classical continuous oscillator and a more recent impulsive one, capturing e.g. pulsatile secretion of hormones due to neural regulation. The main finding of this study is that, while the continuous oscillator is always forced to a periodic solution by a sufficiently large exogenous signal amplitude, the impulsive one commonly exhibits a quasiperiodic or chaotic behavior due to non-smooth dynamics in entrainment.Team Tamas Keviczk
A.E. Duffey, Anton van Wouw: The smaller works: A far from passive record
No full textAnton van Wouw : the smaller works is, as its title implies, concerned with the generally lesser-known smaller works of Dutch-born sculptor, Anton van Wouw. Using the measure of "half life-size and smaller" as a guideline, author Alexander Duffey provides a comprehensive and well-illustrated overview of the many full-length small sculptures, busts, relief panels and maquettes produced by Van Wouw between 1881 (nine years prior to his arrival in South Africa at the age of 28) and 1940. Naturalistically sculpted and generally cast in bronze, these smaller works are wide-ranging in their subject matter, depicting innocuous, commonplace scenes alongside aspects of Afrikaner history, representations of Boer and British leaders, and so-called "native studies" (p 11)
A far from passive record Anton van Wouw: The smaller works, AE Duffey: book review
No full textAnton van Wouw : the smaller works is, as its title implies, concerned with the generally lesser-known smaller works of Dutch-born sculptor, Anton van Wouw. Using the measure of "half life-size and smaller" as a guideline, author Alexander Duffey provides a comprehensive and well-illustrated overview of the many full-length small sculptures, busts, relief panels and maquettes produced by Van Wouw between 1881 (nine years prior to his arrival in South Africa at the age of 28) and 1940. Naturalistically sculpted and generally cast in bronze, these smaller works are wide-ranging in their subject matter, depicting innocuous, commonplace scenes alongside aspects of Afrikaner history, representations of Boer and British leaders, and so-called "native studies" (p 11)
Hugo von Hofmannsthal and Anton Kippenberg of the Insel-Verlag: a case study of author-publisher relations
No full textHugo von Hofmannsthal, Austrian poet, dramatist, and essayist (1874-1929), published with the Insel-Verlag from its inception in 1901 until his death. This work examines Hofmannsthal's relationship with his publisher Anton Kippenberg (1874-1950). The author was drawn to the Insel-Verlag initially through his association with its founders, Alfred Walter Heymel and Rudolf Alexander Schröder, who published the short-lived periodical Die Insel. Known for its emphasis on aesthetics, the magazine set a tone that became characteristic for the firm. As a poet, Hofmannsthal found the climate beneficial and the audience of the Insel-Verlag receptive to his early lyrical works and certain other writings outside the mainstream of his later production. Under Anton Kippenberg's direction, these works were assured careful attention to detail; typeface, binding, illustrations, and all aspects of the physical book were designed to harmonize with its contents, enabling Hofmannsthal to present his writings in a format which did his creations honor.
Hofmannsthal published four categories of material with the Insel-Verlag: his early lyrical works; republications issued as deluxe editions; reprints of selected texts in the inexpensive but elegantly designed Insel-Bücherei, and other Insel publications such as the Insel-Almanach or Inselschiff; and introductions and essays composed in his role as editor of compilations appearing under the Insel imprint. Hofmannsthal showed a great awareness of the Insel's particular Verlagsprofil in his selection of texts issued under its signet.
Anton Kippenberg brought financial stability, business-like organization, and sound aesthetic judgement to the Insel-Verlag, creating an atmosphere in which Hofmannsthal's works could thrive. Early in his association with the Insel-Verlag, Kippenberg advanced a program which echoed many of Hofmannsthal's concerns and thus further solidified their relationship. Kippenberg proposed to give a book the design and format appropriate to its contents, to serve world literature, to expand the market for these titles without sacrificing quality to economics, and to support a select group of contemporary authors.
Hofmannsthal's association with publisher Anton Kippenberg was a complex and often stormy one. United through shared goals, the two men worked to achieve a relationship mutually beneficial to each, one in which both the reputation of the individual and that of the firm were enhanced by their cooperation
Hugo von Hofmannsthal and Anton Kippenberg of the Insel-Verlag: a case study of author-publisher relations
No full textHugo von Hofmannsthal, Austrian poet, dramatist, and essayist (1874-1929), published with the Insel-Verlag from its inception in 1901 until his death. This work examines Hofmannsthal's relationship with his publisher Anton Kippenberg (1874-1950). The author was drawn to the Insel-Verlag initially through his association with its founders, Alfred Walter Heymel and Rudolf Alexander Schröder, who published the short-lived periodical Die Insel. Known for its emphasis on aesthetics, the magazine set a tone that became characteristic for the firm. As a poet, Hofmannsthal found the climate beneficial and the audience of the Insel-Verlag receptive to his early lyrical works and certain other writings outside the mainstream of his later production. Under Anton Kippenberg's direction, these works were assured careful attention to detail; typeface, binding, illustrations, and all aspects of the physical book were designed to harmonize with its contents, enabling Hofmannsthal to present his writings in a format which did his creations honor. Hofmannsthal published four categories of material with the Insel-Verlag: his early lyrical works; republications issued as deluxe editions; reprints of selected texts in the inexpensive but elegantly designed Insel-Bücherei, and other Insel publications such as the Insel-Almanach or Inselschiff; and introductions and essays composed in his role as editor of compilations appearing under the Insel imprint. Hofmannsthal showed a great awareness of the Insel's particular Verlagsprofil in his selection of texts issued under its signet. Anton Kippenberg brought financial stability, business-like organization, and sound aesthetic judgement to the Insel-Verlag, creating an atmosphere in which Hofmannsthal's works could thrive. Early in his association with the Insel-Verlag, Kippenberg advanced a program which echoed many of Hofmannsthal's concerns and thus further solidified their relationship. Kippenberg proposed to give a book the design and format appropriate to its contents, to serve world literature, to expand the market for these titles without sacrificing quality to economics, and to support a select group of contemporary authors. Hofmannsthal's association with publisher Anton Kippenberg was a complex and often stormy one. United through shared goals, the two men worked to achieve a relationship mutually beneficial to each, one in which both the reputation of the individual and that of the firm were enhanced by their cooperation
Half-Sandwich Alkyl, Amido, and Iodo Samarium(II) Complexes: Non-Conventional Sterically Governed Oxidation of (tBu(4)Carb)(2)Sm
No full textbibtex: ISI:000395753300031 bibtex\location:'POSTFACH 101161, 69451 WEINHEIM, GERMANY',publisher:'WILEY-V C H VERLAG GMBH',type:'Article',affiliation:'Trifonov, AA (Reprint Author), Russian Acad Sci, Inst Organometall Chem, Tropinina 49,GSP 445, Nizhnii Novgorod 630950, Russia. Trifonov, AA (Reprint Author), Russian Acad Sci, Inst Organoelement Cpds, Vavilova str 28, Moscow 119334, Russia. Selikhov, Alexander N.; Mahrova, Tatyana V.; Cherkasov, Anton V.; Fukin, Georgy K.; Trifonov, Alexander A., Russian Acad Sci, Inst Organometall Chem, Tropinina 49,GSP 445, Nizhnii Novgorod 630950, Russia. Maron, Laurent, Univ Toulouse, CNRS, INSA, UPS,UMR 5215, Ave Rangueil 135, F-31077 Toulouse, France. Trifonov, Alexander A., Russian Acad Sci, Inst Organoelement Cpds, Vavilova str 28, Moscow 119334, Russia.','author-email':'[email protected]',da:'2018-12-05','doc-delivery-number':'EN1EM',eissn:'1521-3765','funding-acknowledgement':'Russian Foundation for Basic Research [14-03-00527, 16-33-00041]','funding-text':'The Russian Foundation for Basic Research (Projects 14-03-00527 and 16-33-00041) is acknowledged for the financial support of this work.','journal-iso':'Chem.-Eur. J.','keywords-plus':'HIGHLY REACTIVE ORGANOLANTHANIDES; RAY CRYSTAL-STRUCTURE; INTRAMOLECULAR HYDROPHOSPHINATION/CYCLIZATION; CRYSTALLOGRAPHIC CHARACTERIZATION; POLYMERIZATION CATALYSTS; OLEFIN POLYMERIZATION; YTTERBIUM(II) ALKYLS; LANTHANIDE COMPLEXES; ORGANIC-SYNTHESIS; METAL-COMPLEXES','number-of-cited-references':'75','research-areas':'Chemistry','times-cited':'1','unique-id':'ISI:000395753300031','usage-count-last-180-days':'2','usage-count-since-2013':'10','web-of-science-categories':'Chemistry, Multidisciplinary'\International audienceThe half-sandwich tetra-tert-butylcarbazol-9-yl iodo complex [(tBu(4)Carb)Sm(m-I)(THF)(2)](2) (1) was synthesized by the salt metathesis reaction of tBu(4)CarbK and SmI2(THF)(2) in THF. Complex 1 along with metallic Cu was also isolated from the oxidation reaction of (tBu(4)Carb)(2)Sm by CuI. The formation of stable radical tBu(4)Carb(center dot) was detected in this non-conventional process, indicating preferential oxidation of anion tBu(4)Carb(-) vs. Sm-II. The treatment of 1 with two equivalents of dibenzo-18-crown-6 resulted in heterolytic dissocia-tion of a h 5-bond Sm-tBu(4)Carb and afforded an ionic compound [tBu(4)carb(-)][SmI(crown)(THF)(2)](+) (4). Alkylation of 1 with o-NMe2C6H4CH2K (1: 2 molar ratio) in THF allowed for the synthesis of half-sandwich SmII alkyl complex (tBu(4)Carb) SmCH2(o-NMe2C6H4CH2)(THF)(2) (5) in 55% yield. The amido complex (tBu(4)Carb) SmN(SiMe3)(2)(DME) (6) was obtained by the reaction of 1 with two molar equivalents of NaN(SiMe3)(2) in THF in 89% yield
Half-Sandwich Alkyl, Amido, and Iodo Samarium(II) Complexes: Non-Conventional Sterically Governed Oxidation of (tBu(4)Carb)(2)Sm
No full textbibtex: ISI:000395753300031 bibtex\location:'POSTFACH 101161, 69451 WEINHEIM, GERMANY',publisher:'WILEY-V C H VERLAG GMBH',type:'Article',affiliation:'Trifonov, AA (Reprint Author), Russian Acad Sci, Inst Organometall Chem, Tropinina 49,GSP 445, Nizhnii Novgorod 630950, Russia. Trifonov, AA (Reprint Author), Russian Acad Sci, Inst Organoelement Cpds, Vavilova str 28, Moscow 119334, Russia. Selikhov, Alexander N.; Mahrova, Tatyana V.; Cherkasov, Anton V.; Fukin, Georgy K.; Trifonov, Alexander A., Russian Acad Sci, Inst Organometall Chem, Tropinina 49,GSP 445, Nizhnii Novgorod 630950, Russia. Maron, Laurent, Univ Toulouse, CNRS, INSA, UPS,UMR 5215, Ave Rangueil 135, F-31077 Toulouse, France. Trifonov, Alexander A., Russian Acad Sci, Inst Organoelement Cpds, Vavilova str 28, Moscow 119334, Russia.','author-email':'[email protected]',da:'2018-12-05','doc-delivery-number':'EN1EM',eissn:'1521-3765','funding-acknowledgement':'Russian Foundation for Basic Research [14-03-00527, 16-33-00041]','funding-text':'The Russian Foundation for Basic Research (Projects 14-03-00527 and 16-33-00041) is acknowledged for the financial support of this work.','journal-iso':'Chem.-Eur. J.','keywords-plus':'HIGHLY REACTIVE ORGANOLANTHANIDES; RAY CRYSTAL-STRUCTURE; INTRAMOLECULAR HYDROPHOSPHINATION/CYCLIZATION; CRYSTALLOGRAPHIC CHARACTERIZATION; POLYMERIZATION CATALYSTS; OLEFIN POLYMERIZATION; YTTERBIUM(II) ALKYLS; LANTHANIDE COMPLEXES; ORGANIC-SYNTHESIS; METAL-COMPLEXES','number-of-cited-references':'75','research-areas':'Chemistry','times-cited':'1','unique-id':'ISI:000395753300031','usage-count-last-180-days':'2','usage-count-since-2013':'10','web-of-science-categories':'Chemistry, Multidisciplinary'\International audienceThe half-sandwich tetra-tert-butylcarbazol-9-yl iodo complex [(tBu(4)Carb)Sm(m-I)(THF)(2)](2) (1) was synthesized by the salt metathesis reaction of tBu(4)CarbK and SmI2(THF)(2) in THF. Complex 1 along with metallic Cu was also isolated from the oxidation reaction of (tBu(4)Carb)(2)Sm by CuI. The formation of stable radical tBu(4)Carb(center dot) was detected in this non-conventional process, indicating preferential oxidation of anion tBu(4)Carb(-) vs. Sm-II. The treatment of 1 with two equivalents of dibenzo-18-crown-6 resulted in heterolytic dissocia-tion of a h 5-bond Sm-tBu(4)Carb and afforded an ionic compound [tBu(4)carb(-)][SmI(crown)(THF)(2)](+) (4). Alkylation of 1 with o-NMe2C6H4CH2K (1: 2 molar ratio) in THF allowed for the synthesis of half-sandwich SmII alkyl complex (tBu(4)Carb) SmCH2(o-NMe2C6H4CH2)(THF)(2) (5) in 55% yield. The amido complex (tBu(4)Carb) SmN(SiMe3)(2)(DME) (6) was obtained by the reaction of 1 with two molar equivalents of NaN(SiMe3)(2) in THF in 89% yield
Musikstädte as real and imaginary soundscapes: urban musical images as literary motifs in twentieth-century German modernism
No full textPhDThis study examines German literary images of musical life as part of the wider sound identity of the modern German city at the turn of the twentieth century. Focussing on a forty-year period from 1890 to 1930, synonymous with the emergence of the modern German metropolis as an aesthetic object, the project assesses, compares and contrasts how musical life in the Musikstädte was perceived and portrayed by writers in an increasingly noisy urban environment. How does urban musical life influence and condition city writings? What are the differences and similarities between the writings on various musical cities? Can an urban textual sound identity be derived from these differences and similarities? The approach employed to answer these questions is a new, cross-disciplinary one to urban sound in literature, moving beyond reading the key sounds of the urban soundscape using urban musicology, sensorial anthropology and cultural poetics towards a literary contextualisation of the urban aural experience.
The literary motifs of the symphony, the gramophone and urban noise are put under the spotlight through the analysis of a wide range of modernist works by authors who have a special relationship with music. At the centre of this analysis are the Kaffeehausliteratur authors Hermann Bahr, Alfred Polgar and Peter Altenberg, the then Munich-based author Thomas Mann and the lesser known René Schickele. The analysis of these particular works is framed in the music-geographical context of the Musikstadt and literary underpinnings of this topos, ranging from Ingeborg Bachmann to Hans Mayer and, once again, Thomas Mann. In analysing these texts, the methodological approach devised by Strohm, who identifies the blending of a range of urban sounds as a definition of urban space and identity, is applied. His ideas combine historical literary
analysis, musical history and urban sociology. They are rarely used in the analysis of the auditory environment.Arts and Humanities Research Council
Westfield TrustWestfield Trust Studentship
Arts and Humanities Reseach Council (AHRC
Simulating build to order strategies, capacity estimations and impacts of batching
No full textThesis: M. Eng. in Advanced Manufacturing and Design, Massachusetts Institute of Technology, Department of Mechanical Engineering, 2016.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 96-98).When a startup scales up its enterprise the manufacturing system used to govern the production process should be robust enough to scale up with it. NVBOTS is in a position where it plans to scale up production by an order of magnitude within a few months. NVBOTS's manufacturing systems should therefore be reevaluated to ensure its design will meet requirements. In order to model the production process at NVBOTS a discrete event manufacturing simulation is developed. Both a Push system and a Build to Order (BtO) system are initially considered. The trade-offs that exist in these policies are identified and analyzed. A recommendation is made to adopt a BtO policy and to build in a batch size of one. Based on the feedback from NVBOTS an advanced model is then developed, which incorporates some benefit of batching. The effects of batch size on lead time, inventory level and capacity are investigated. Even when assuming a 30% setup time for assembly steps, the optimal batch size with regards to lead time or inventory levels remains at one. However, it is found that batching has a significant impact on the capacity of the system. The advanced model also introduces a new policy named Sell x Build y (SxBy, e.g. S1B6), which allows NVBOTS to operate in larger batches by minimizing the effect on lead time while keeping inventory roughly constant. With the current labor levels, and using a S1B6 policy, the model estimates a maximum capacity of around 23 printers per month. The expected 99 percentile lead time of this policy is roughly 11 work days. The work described in this thesis covers roughly half of the project on manufacturing systems at NVBOTS. The other half is covered in Yugal Raj Jain's thesis [1]. Jain's thesis focuses on multiple product lines and late-stage differentiation, and analyses CONWIP and CONWIP-BtO policies. In contrast, this thesis focuses on the capacity at the current facility and the policies which NVBOTS should look to adopt in the short term. The policies that this thesis considers includes Push, BtO and SxBy policies.by Alexander Willem Anton van Grootel.M. Eng. in Advanced Manufacturing and Desig
PESI - a taxonomic backbone for Europe
No full textThis is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The attached file is the published version of the article.NHM Repositor
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