9 research outputs found
Theoretical EPR study of 6-Mercaptopurine
No full text32nd International Physics Congress of Turkish-Physical-Society (TPS) -- SEP 06-09, 2016 -- Bodrum, TURKEY6-Mercaptopurine is important antineoplastics agent and it is used for immuno suppressive and anti inflammatory. Experimental EPR parameters of 6-Mercaptopurine molecules powder were studied in the literature. The aim of this study EPR parameters of 6 Mercaptopurine molecules were calculated with theoretical calculations and define the possible radicals of 6 Mercaptopurine molecules. Firstly the X-ray structure of 6-Mercaptopurine molecules were found in the literature (1). EPR parameters and possible radicals of 6 Mercaptopurine molecules were calculated from this X-ray structure. Possible radicals of gamma-irradiated 6-Mercaptopurine molecules were constituted. EPR parameters of possible radicals were calculated with 1331XP/6-31.1++ G (d,p) basis set in MT methods for 6 Mercaptopurine molecules.Turkish Phys So
"Orhan Pamuk's novels and their ""afterlife"" in English and German translations"
No full textIn this dissertation, I focus on the Turkish Nobel Prize laureate Orhan Pamuk’s novels and on their English and German translations by Güneli Gün, Maureen Freely, and Ingrid Iren. I argue that literary translation is a creative act, the study and critique of which needs to be anchored within a specific historical, geographical, and temporal horizon.
I studied the reception of Pamuk’s novels in translation and discovered that book reviewers write about translations as if they were transparent copies of the original works. Literary translation in a largely monolingual public sphere is thus overlooked. I provide a theoretical model for the study and critique of translations as autonomous texts beyond the evaluative notion of “fidelity” to originals. I devise a theoretical framework based on my close textual analyses of the translations. I situate translations within their respective context, read them in relation to particular historical circumstances that gave rise to them, and in relation to secondary material written by translators, ranging from creative writing, other translations, prefaces, introductions, afterwords, glossaries, and interviews. This approach elucidates each translator’s project, position, and intention.
The introduction provides literature review and lays out the theoretical framework. Chapter 1 consists of two parts. In part 1, I examine the reception of Orhan Pamuk in Turkey and abroad as revealed in reviews, articles, interviews, and book length manuscripts. In part 2, I read Pamuk’s Kara Kitap (The Black Book), paying close attention to particular images, intertextual and metatextual aspects, and shifts in narrative voice. I choose elements of the novel that are self-referential and language-, context-, and culture-specific. Translation of these elements reveals the translators’ literary and stylistic idiosyncrasies and how each translator recontextualized the text in unique ways. In chapter 2, I focus on the translator Güneli Gün and identify her unique style as a writer. I argue that Gün’s primary purpose as a translator was to bridge Turkish and American literatures and cultures and to introduce Pamuk to the Anglo-American readership in the era before he reached international fame. In chapter 3, I focus on Maureen Freely, who is widely known as Pamuk’s definitive English translator since the Nobel Prize. I analyze her translations, novels, and journalistic writings in order to determine her idiosyncratic style and position as the author of the new translation. I argue that Freely translated the novel in ways that bolster Pamuk’s later image as “the writer of the city of Istanbul.” In chapter 4, I focus on Ingrid Iren, Pamuk’s German translator and read her translation, Das schwarze Buch, in relation to the long history and legacy of translation into German, a context completely different from the previous ones. I argue that Iren performed a significant bridging role between the two languages and cultures through her active recreation of the Turkish narrative into German. The German text is heavily shaped by the translator. In the conclusion, I point to possible avenues for further research.
This study fills in an important gap in the scholarship on Orhan Pamuk by illuminating the role of his translators in the formation of his image as a world author.Item withdrawn by Mark Zulauf ([email protected]) on 2012-04-20T00:20:25Z
Item was in collections:
University of Illinois Theses & Dissertations (ID: 1)
No. of bitstreams: 2
Turkkan_Sevinc.docx: 426429 bytes, checksum: f2e63db75768c5672418482929ad401e (MD5)
Turkkan_Sevinc.pdf: 1575132 bytes, checksum: bdf97935741b00855135a8856154b137 (MD5)Made available in DSpace on 2012-06-27T21:30:32Z (GMT). No. of bitstreams: 3
Turkkan_Sevinc.pdf: 1575132 bytes, checksum: bdf97935741b00855135a8856154b137 (MD5)
license.txt: 4066 bytes, checksum: 6c5d320d10cfef44705d58fcacb96218 (MD5)
Turkkan_Sevinc.docx: 426429 bytes, checksum: f2e63db75768c5672418482929ad401e (MD5)Restriction data tranferred 2014-07-01T11:34:09-05:00
Original Data
Group with Access Administrator
Release Date: 2016-06-28 09:25:15 UTC
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system. Author requested 2nd 2 year closed access embargo. Approved by Graduate College 5-28-2014 sshreeveItem marked as restricted to the 'Administrator' Group (id=1) by William Ingram ([email protected]) on 2012-06-27T21:32:44Z
Item is restricted until 2014-06-27T21:32:23ZItem marked as restricted to the 'Administrator' Group (id=1) by Sarah Shreeves ([email protected]) on 2014-05-28T14:25:16Z
Item is restricted until 2016-06-28T14:25:15ZLimited Restriction Lifted for Item 32315 on 2016-09-22T20:59:18Z
Role of aggressivity on reactivity and craving before and after cue exposure in recently detoxified alcoholics: Results from an experimental study
No full textThe role of aggressivity and cue exposure in induction of craving were investigated in a clinical setting. Thirty abstinent alcoholic patients were divided into a low and a high aggressive group based on scores on the physical aggression subscale of the Buss-Durkee Hostility Inventory and exposed to alcohol cues. Craving was measured by means of the Alcohol Craving Questionnaire (ACQ) and Visual Analogue Scales (VAS). Important findings are: (1) main effects of aggressivity on `emotionality', `purposefulness' and `expectancy' of ACQ were very significant; (2) on `drinking intention' and `craving for alcohol' of VAS, aggressivity and cue exposure showed a significant interaction; (3) the main effect of cue exposure on heart rate also reached a significance level of 0.007. The results were discussed in the context of the Classical, Operant Conditioning Theory, the Cognitive Craving Theory of Tiffany, Gilbert's STAR Model, and the Self-Medication Hypothesis Copyright (C) 2001 S. Karger AG, Basel
Relation between insulin resistance and serum concentrations of IL-6 and TNF-α in overweight or obese women with early stage breast cancer
No full textA systematic review of evidence on malignant spinal metastases : natural history and technologies for identifying patients at high risk of vertebral fracture and spinal cord compression
No full textBackground: Spinal metastases can lead to significant morbidity and reduction in quality of life due to spinal cord compression (SCC). Between 5% and 20% of patients with spinal metastases develop metastatic spinal cord compression during the course of their disease. An early study estimated average survival for patients with SCC to be between 3 and 7 months, with a 36% probability of survival to 12 months. An understanding of the natural history and early diagnosis of spinal metastases and prediction of collapse of the metastatic vertebrae are important.
Objective: To undertake a systematic review to examine the natural history of metastatic spinal lesions and to identify patients at high risk of vertebral fracture and SCC.
Data sources: The search strategy covered the concepts of metastasis, the spine and adults. Searches were undertaken from inception to June 2011 in 13 electronic databases [MEDLINE; MEDLINE In-Process & Other Non-Indexed Citations; EMBASE; Cochrane Database of Systematic Reviews; Cochrane Central Register of Controlled Trials (CENTRAL); Database of Abstracts of Reviews of Effects (DARE), NHS Economic Evaluation Database (NHS EED), HTA databases (NHS Centre for Reviews and Dissemination); Science Citation Index and Conference Proceedings (Web of Science); UK Clinical Research Network (UKCRN) Portfolio Database; Current Controlled Trials; ClinicalTrials.gov].
Review methods: Titles and abstracts of retrieved studies were assessed by two reviewers independently. Disagreement was resolved by consensus agreement. Full data were extracted independently by one reviewer. All included studies were reviewed by a second researcher with disagreements resolved by discussion. A quality assessment instrument was used to assess bias in six domains: study population, attrition, prognostic factor measurement, outcome measurement, confounding measurement and account, and analysis. Data were tabulated and discussed in a narrative review. Each tumour type was looked at separately.
Results: In all, 2425 potentially relevant articles were identified, of which 31 met the inclusion criteria. No study examined natural history alone. Seventeen studies reported retrospective data, 10 were prospective studies, and three were other study designs. There was one systematic review. There were no randomised controlled trials (RCTs). Approximately 5782 participants were included. Sample sizes ranged from 41 to 859. The age of participants ranged between 7 and 92 years. Types of cancers reported on were lung alone (n= 3), prostate alone (n= 6), breast alone (n= 7), mixed cancers (n= 13) and unclear (n= 1). A total of 93 prognostic factors were identified as potentially significant in predicting risk of SCC or collapse. Overall findings indicated that the more spinal metastases present and the longer a patient was at risk, the greater the reported likelihood of development of SCC and collapse. There was an increased risk of developing SCC if a cancer had already spread to the bones. In the prostate cancer studies, tumour grade, metastatic load and time on hormone therapy were associated with increased risk of SCC. In one study, risk of SCC before death was 24%, and 2.37 times greater with a Gleason score 7 than with a score of < 7 (p= 0.003). Other research found that patients with six or more bone lesions were at greater risk of SCC than those with fewer than six lesions [odds ratio (OR) 2.9, 95% confidence interval (CI) 1.012 to 8.35, p= 0.047]. For breast cancer patients who received a computerised tomography (CT) scan for suspected SCC, multiple logistic regression in one study identified four independent variables predictive of a positive test: bone metastases 2 years (OR 3.0 95% CI 1.2 to 7.6; p= 0.02); metastatic disease at initial diagnosis (OR 3.4, 95% CI 1.0 to 11.4; p= 0.05); objective weakness (OR 3.8, 95% CI 1.5 to 9.5; p= 0.005); and vertebral compression fracture on spine radiograph (OR 2.6, 95% CI 1.0 to 6.5; p= 0.05). A further study on mixed cancers, among patients who received surgery for SCC, reported that vertebral body compression fractures were associated with presurgery chemotherapy (OR 2.283, 95% CI 1.064 to 4.898; p= 0.03), cancer type [primary breast cancer (OR 4.179, 95% CI 1.457 to 11.983; p= 0.008)], thoracic involvement (OR 3.505, 95% CI 1.343 to 9.143; p= 0.01) and anterior cord compression (OR 3.213, 95% CI 1.416 to 7.293; p= 0.005).
Limitations: Many of the included studies provided limited information about patient populations and selection criteria and they varied in methodological quality, rigour and transparency. Several studies identified type of cancer (e.g. breast, lung or prostate cancer) as a significant factor in predicting SCC, but it remains difficult to determine the risk differential partly because of residual bias. Consideration of quantitative results from the studies does not easily allow generation of a coherent numerical summary, studies were heterogeneous especially with regard to population, results were not consistent between studies, and study results almost universally lacked corroboration from other independent studies.
Conclusion: No studies were found which examined natural history. Overall burden of metastatic disease, confirmed metastatic bone involvement and immediate symptomatology suggestive of spinal column involvement are already well known as factors for metastatic SCC, vertebral collapse or progression of vertebral collapse. Although we identified a large number of additional possible prognostic factors, those which currently offer the most potential are unclear. Current clinical consensus favours magnetic resonance imaging and CT imaging modalities for the investigation of SCC and vertebral fracture. Future research should concentrate on: (1) prospective randomised designs to establish clinical and quality-of-life outcomes and cost-effectiveness of identification and treatment of patients at high risk of vertebral collapse and SCC; (2) Service Delivery and Organisation research on magnetic resonance imaging (MRI) scans and scanning (in tandem with research studies on use of MRI to monitor progression) in order to understand best methods for maximising use of MRI scanners; and (3) investigation of prognostic algorithms to calculate probability of a specified event using high-quality prospective studies, involving defined populations, randomly selected and clearly identified samples, and with blinding of investigators
Translation to modern Turkish of collection named Gıda-ı Ruh and analysis of it
No full textSosyal Bilimler Enstitüsü, Müzik Ana Bilim DalıGüfte mecmuaları, Geleneksel Türk Müziği Tarihi açısından önemli yazılı kaynaklardır. XIX. Yüzyıla kadar meşk yönteminin uygulandığı müzik eğitiminde güfte mecmuaları önemli yer tutmaktadır. Günümüze kadar meşk yoluyla gelen birçok Türk Müziği bestesi vardır. Bunların bir açıdan doğrulanabilmesi, yani bestelendikleri düşünülen zamanın tarihi bilgileriyle uyum içinde olduğunun gösterilmesi, nota yoluyla olmasa da bazı kayıtlarla desteklenmesi, güfte mecmualarını incelemekle mümkündür. Bu çalışmada, 1316 (Hicri) yılında yazılmış Ali Galib TÜRKKAN'a ait Gıda-ı Ruh isimli güfte mecmuası incelenmiştir. Cumhuriyet Üniversitesi Sosyal Bilimler Enstitüsü'nde yüksek lisans tezi olarak hazırlanan " Gıda-ı Ruh İsimli Güfte Mecmuasının Günümüz Türkçesine Çevirisi ve İncelenmesi" isimli bu çalışma girişi takip eden üç bölümden oluşmuştur. Tez içerisinde güfte mecmualarının önemimden bahsedilmiş, mecmuanın şekli, içeriği ve yazarı hakkında kısa bilgi verilmiştir. Mecmuanın çeviri yazımı ve orijinali eklenmiştir. Mecmua içerisindeki eserler TRT repertuarı ile karşılaştırılıp önemli olduğu düşünülen bilgiler dipnotlar ile belirtilmiştir. Tezin sonuç kısmında, yapılan çalışmadan çıkarılan sonuçlar yorumlanmıştır. Anahtar sözcükler: Türk Müziği, Meşk, Güfte Mecmuası, Gıda-ı RuhLyrics collections are important written sources in terms of Traditional Turkish music history. Up to 17th century, lyrics collections are important in music education in which the meşk(exercise) method is practicing. Up to the present, there are many Turkish music compositions coming through meşk. Verifying of them in one aspect; that is, showing they are in harmony with historical information and the time believed to be composed of them, being supported them by some records despite not with notes are possible with examining the of lyrics collections. In this study, lyrics collection named Gıda-ı Ruh(Nutrient for the Soul) written by Ali Galib TURKKAN in 1316 (Hijri) is examined. This study named "Translation to Modern Turkish of Collection named Gıda-ı Ruh and analysis of it" consists of three sections that follow introduction and is prepared a master thesis in the Institute of Social Sciences of Cumhuriyet University. The importance of lyrics collection is mentioned in the thesis; the shape and also the content of collection and brief information about the author are given. The original form and transcription of the collection are attached. Works within the collection are compared with TRT repertoire and then the information thought to be important is indicated by footnote. In the result part of the thesis, the conclusions drawn from the study are interpreted. Key words: Turkish Music, Meşk(exercise), Lyrics Collections, Gıda-ı Ruh(Nutrient for the Soul
The relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract: UTILISE study
No full textBackground: Congenital anomalies of the kidney and urinary tract (CAKUT) are defined as structural malformations of the kidney and/or urinary tract. Heat shock proteins (HSPs) are expressed in the kidney in response to cellular changes, such as thermal, hemodynamic, osmotic, inflammatory, and mechanical stresses. This study aimed to assess uHSP70 levels during acute urinary tract infections (UTI) and non-infection periods in patients with CAKUT, and to evaluate whether uHSP70 is elevated in CAKUT subtypes. Methods: Among patients with CAKUT, 89 patients with UTI (CAKUT-A), 111 without UTI (CAKUT-B), and 74 healthy children were included in the study. uHSP70 levels were measured using enzyme-linked immunosorbent assay (ELISA). Results: uHSP70 level was significantly higher in the CAKUT-A group than in the CAKUT-B and healthy control groups (p 0.05). Conclusion: Urine HSP70 can also be used to predict UTI in patients with CAKUT. Moreover, uHSP70 levels were higher in children with CAKUT during the non-infectious period than in healthy controls. This suggests that children with CAKUT are at risk of chronic non-infectious damage. Copyright © 2024 Aksu, Afonso, Akil, Alpay, Atmis, Aydog, Bakkaloglu, Bayazıt, Bayram, Bilge, Bulut, Cetinkaya, Comak, Demir, Dincel, Donmez, Durmus, Dursun, Dusunsel, Duzova, Ertan, Gedikbasi, Goknar, Guven, Hacihamdioglu, Jankauskiene, Kalyoncu, Kavukcu, Kenan, Kucuk, Kural, Litwin, Montini, Morello, Obrycki, Omer, Misirli Ozdemir, Ozkayin, Paripovic, Pehlivanoglu, Saygili, Schaefer, Schaefer, Sonmez, Tabel, Tas, Tasdemir, Teixeira, Tekcan, Topaloglu, Tulpar, Turkkan, Uysal, Uysalol, Vitkevic, Yavuz, Yel, Yildirim, Yildirim, Yildiz, Yuksel, Yurtseven and Yilmaz.Istanbul Üniversitesi: 29652; Istanbul Üniversitesi; European Society for Paediatric Oncology, SIOPE: 5.2018; European Society for Paediatric Oncology, SIOPEWe gratefully acknowledge that UTILISE was supported by Scientific Research Projects Coordination Unit of Istanbul University, by the European Society for Pediatric Nephrology (ESPN), by the Society for Children’s Kidney Health, and by Istanbul Faculty of Medicine Foundation. We are also very thankful to children participating in this study, our dedicated chemist Orhan Tepeli and diligent students of Istanbul University Istanbul Faculty of Medicine Zeynep Sakur, Sevgi Ipar, Isıl Gul for their great help and assistance.The author(s) declare financial support was received for the research, authorship, and/or publication of this article. UTILISE Study was supported by Scientific Research Projects Coordination Unit of Istanbul University (29652), by the European Society for Pediatric Nephrology (ESPN) (ESPN #5.2018), by the Society for Children’s Kidney Health (1.2018), and by Istanbul Faculty of Medicine Foundation. Acknowledgment
Prognostic factors and outcomes of adjuvant and first-line metastatic treatments in melanoma a Turkish oncology group study
No full textManagement of melanoma has changed significantly with the discovery of targeted therapies and immune checkpoint inhibitors (ICI). Our aim in the study is to determine which treatment alternatives, specifically dabrafenib plus trametinib and ICIs, are effective in adjuvant therapy and which treatment is effective as first-line metastatic therapy. This retrospective, multicenter study included 120 patients diagnosed with stage IIIB-IIID melanoma receiving both adjuvant and first-line metastatic treatment between 2007 and 2023. Data on clinicopathologic characteristics, treatment regimens and outcomes were collected. Objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS) and overall survival (OS) were analyzed. Patients treated with dabrafenib plus trametinib as adjuvant therapy had the longest relapse-free survival (RFS) (median: 8.3 months), followed by those treated with interferon (4.1 months) and nivolumab (1.9 months) (p = 0.002). Metastatically, the highest ORR was observed in patients treated with dabrafenib plus trametinib (54.5%), followed by ICI (52.0%) and chemotherapy (33.3%). Similarly, DCR was superior for dabrafenib plus trametinib (86.3%) compared to ICI (70.8%) and chemotherapy (66.6%). Median PFS was 9.7 months (95% CI 7.2-12.2 months) in the whole group. This was 14.3 months (95% CI 9.6-19.0 months) with ICI, 10.3 months (95% CI 4.2-16.4 months) with BRAF/MEK inhibitors and 6.3 months (95% CI 4.7-7.9 months) with chemotherapy, which was statistically significant (p 6 months, ORR are all independent factors for OS prognosis. In our study, dabrafenib plus trametinib combination was more effective in adjuvant treatment of melanoma, while immunotherapy was more effective in metastatic first-line treatment
