169 research outputs found
Творчість В. Родіонова: проблемний діапазон художнього світогляду (Creativity V. Rodionov: problem diapazon of the artistic swiss)
No full textУ статті акцентується увага на творчості В. Родіонова. Зроблено акцент на проблематиці творів письменника; визначено, що діяльність В. Родіонова характеризується актуальністю та вагомістю проблематики, висвітлення якої прямолінійне, позбавлене завуальовувань і спрямоване на екзистенційний аналіз фактів щоденного буття в усіх його проявах, що реалізується на двох рівнях: загальнолюдському й національному.
(The article focuses on the work of V. Rodionov. The emphasis is placed on the problems of the writer’s works. It is determined that V. Rodionov’s activity is characterized by urgency and weight of problems, the coverage of which is straightforward, deprived of veils, and aimed at an existential analysis of the facts of everyday life in all its manifestations, which is realized on two levels: universal and national. The problem range of the universal is due to the analysis of the values of human life. Research in this direction is not accidental, since the artist seeks to form a peculiar view that will cover such aspects as: the depreciation of life and human relationships, despair and loss of spirituality, the presence of a disharmonious movement of society, the value of artistic paintings, literary works at the present stage of development, the problem of modern interpretation the concept of «love», the importance of the phenomenon of memory as a way to integrate the experience of the past into the present, and hence the ability to compare and contrast, to create a projection into the future, to avoid the occurrence of problem situations in different chronological limits. Acute social and moral issues, highlighted in the literary work of V. Rodionov, are usually distinguished by the author. At the heart of every single piece of poetic or prose nature always lies one actual problem. Violation of the profound problems provoked the emergence of didacticism, the narrative of the most important, verbal-fi gurative thinking, but to moralise and insist on the expediency of his statements. V. Rodionov does not strive, since he has the sole purpose of conveying the acuteness of the problem, the avoidance of which will contribute to the progress of the individual and society as a whole.
The subsystems approach to genome annotation and its use in the Project to Annotate 1000 Genomes
No full textOverbeek R, Begley T, Butler RM, et al. The subsystems approach to genome annotation and its use in the Project to Annotate 1000 Genomes. Nucleic Acids Research. 2005;33(17):5691-5702.The release of the 1000th complete microbial genome will occur in the next two to three years. In anticipation of this milestone, the Fellowship for Interpretation of Genomes (FIG) launched the Project to Annotate 1000 Genomes. The project is built around the principle that the key to improved accuracy in high-throughput annotation technology is to have experts annotate single subsystems over the complete collection of genomes, rather than having an annotation expert attempt to annotate all of the genes in a single genome. Using the subsystems approach, all of the genes implementing the subsystem are analyzed by an expert in that subsystem. An annotation environment was created where populated subsystems are curated and projected to new genomes. A portable notion of a populated subsystem was defined, and tools developed for exchanging and curating these objects. Tools were also developed to resolve conflicts between populated subsystems. The SEED is the first annotation environment that supports this model of annotation. Here, we describe the subsystem approach, and offer the first release of our growing library of populated subsystems. The initial release of data includes 180 177 distinct proteins with 2133 distinct functional roles. This data comes from 173 subsystems and 383 different organisms
Some examples of homogeneous Einstein manifolds
No full textsummary:The author obtains the classification of all invariant Einstein metrics on the following homogeneous spaces: SU(3)/T\sb{\max}, , F\sb 4/ \text {spin} (8), SU(5)/Sp(2) \times T\sp 1. Combining this with the results of other authors, the classification of all invariant Einstein metrics on all compact simply connected homogeneous spaces admitting a homogeneous Riemannian metric of positive sectional curvature is obtained
Structure and parameter identification technique for modeling problems of two-phase filtration in porous media
No full textA simplified method to determine resistance to rapid crack propagation in polyethylene pipes
No full textMongolia and the SCO: Distance Cooperation
No full textАнализируются перспективы сотрудничества Монголии и Шанхайской организации сотрудничества. Рассматриваются основные факторы, оказывающие влияние на интеграцию Монголии в структуры ШОС. Итоговый вывод - низкая степень заинтересованности Улан-Батора в более тесной интеграции в данную организацию, что определяется слабым уровнем вовлеченности Монголии в дела Центральной Азии -незначительными торгово-экономическими связями, отсутствием общности региональных угроз и вызовов, внешними по отношению к региону факторами.The article considers the prospects of Mongolia's cooperation with the Shanghai Cooperation Organization. The author analyzes the main factors influencing Mongolia's integration into the SCO structure. The author draws a conclusion about Ulan-Bator's lack of interest in closer integration with the organization, which is caused by Mongolia's modest involvement in the affairs of Central Asia, the country's insignificant economic and trade ties with the region as a whole, the absence of common regional challenges and threats and factors, external to the regional
TOWARDS UNDERSTANDING THE MECHANISMS OF EPIGENETIC REGULATION: PART 1. AN EVOLUTIONAL INSIGHT INTO PCG-MEDIATED GENE REPRESSION
No full textThe evolutionary conserved PcG proteins maintain stable transcriptional epigenetic repression, established earlier by transiently acting regulator proteins. The exact mechanism of PcG-mediated repression is not identified yet, and here we outline existing models of the repression mechanism. We also shortly summarize the current knowledge about PcG proteins and their role in various processes and present an insight into the evolution of PRC1 and PRC2 complexes.</jats:p
Inflammatory Cell Infiltration of Adrenals in COVID-19
No full textSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was originated in November-December 2019 in Wuhan, China, and has rapidly spread around the world causing severe health and socioeconomical damage to the entire civilization. The key feature of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is upper respiratory tract infection, which may be complicated by bilateral pneumonia. Angiotensin converting enzyme 2 (ACE2) has been identified as a key host factor, required for virus entry into cells. Interestingly, ACE2 is expressed not only in the respiratory system, but also in the other organs and systems including adrenal glands. Here we provide the first description of the pathomorphological changes in adrenal glands in patients with severe COVID-19 characterized by perivascular infiltration of CD3+ and CD8+ T-lymphocytes. Due to the central role of the adrenals in the stress response of the organism, this finding is of potential clinical relevance, because infection with the SARS-CoV-2 virus might critically impair adrenal function under pathophysiological conditions
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