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Investigação fitoquímica das partes aéreas de Passiflora alata Curtis
Get PDFDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2011O gênero Passiflora (Passifloraceae) possui cerca de 630 espécies, constituindo o maior gênero da família, ocorrendo principalmente nas Américas. As espécies desse gênero são amplamente utilizadas na medicina tradicional, sendo relatados usos como ansiolíticos, antiespasmódico, antiinflamatório e sedativo. Especificamente P. alata, espécie central do presente trabalho, apresenta como principais metabólitos secundários relatados para as folhas flavonóides e saponinas, entre as atividades descritas as que possuem mais publicações são as sobre o SNC. No entanto, assim como para outras espécies, não existe um consenso sobre quais compostos ou classes de compostos são responsáveis por determinada atividade. Nas folhas de P. alata foi identificado por CLAE isoorientina, orientina, isovitexina e vitexina-2"-O-ramnosideo sendo esse último o composto majoritário das folhas. As partes aéreas também foram avaliadas por CCD e CLAE, apresentando perfil distinto sendo o pericarpo, das partes avaliadas, o mais rico em variedade de compostos flavonoídicos, mas em concentrações inferiores. Pode-se observar também que o flavonóide majoritário das folhas (vitexina-2"-O-ramnosideo) não é o composto majoritário detectado nas outras partes investigadas. Foi mensurado o teor de compostos fenólicos nas diferentes partes aéreas de P. alata, e as sementes apresentaram o maior teor desses compostos (3,93 g EAG /100 g de extrato) tornando-a promissora para análises químicas e biológicas futuras. A vitexina-2"-O-ramnosideo, flavonóide majoritário das folhas de P. alata, foi isolado do pericarpo de P. alata, fato ainda não descrito na literatura para essa parte da espécie. Das folhas de P. alata foi isolado uma saponina. A influência de diferentes métodos de extração das folhas e secagem dos extratos de P. alata demonstram que os métodos de extração e secagem mais eficientes para se obter um extrato com maior teor de vitexina-2"- O-ramnosideo são respectivamente infusão e liofilização.The genus Passiflora (Passifloraceae) has about 630 species, making it the largest genus in the family, occurring mainly in the Americas. The species of this genus are widely used in traditional medicine, with uses being reported as anxiolytic, antispasmodic, anti-inflammatory and sedative. Specifically for P. alata, the central specie of this work, the main secondary metabolites reported for leaves are flavonoids and saponins, among the activities described in the literarture activities are on the CNS. However, as for other species, there is no consensus about which compounds or classes of compounds are responsible for certain activities. In leaves of P. alata was identified by HPLC isoorientina, orientin, isovitexin and hitexin-2"-O-rhamnoside the latter being the major compound leaves. The aerial parts were evaluated by TLC and HPLC, and showed a distinct profile. The pericarp, the parties evaluated the richest in variety of flavonoid compounds, but in lower concentrations. What can also be observed is the major flavonoid from leaves (vitexin-2"-Orhamnoside) is the major compound detected in other parts investigated. The concentration of phenolic compounds was measured in the different aerial parts of P. alata, the seeds showed the highest content of these compounds (3.93 g EAG / 100 g of extract), making it promising for future chemical and biological analyses. The vitexin-2"-O-rhamnoside, major flavonoid from leaves of P. alata, was isolated from the pericarp of P. alata, which was not described in the literature for this part of the species. From the leaves of P. alata was isolated a saponin. The influence of different methods extraction and drying of leaves extracts of P. alata showed which the methods of extraction and drying more efficient to obtain an extract with a higher content of vitexin-2"-O-rhamnoside are respectively infusion and lyophilization
BBMRI-ERIC-Associated Expert Centres/Trusted Partners V2.0
No full text“BBMRI-ERIC associated Expert Centres trusted partners” are building the bridge between academic and applied research in a public-private partnership model; by integrating pre- competitive research and development endeavours by providing not only access to biological samples and medical data but access also to the broad spectrum of medical and scientific expertise related to the samples, data, and their analysis.
BBMRI-ERIC Expert Centres are closely linked to the Vision and Mission strategy of BBMRI-ERIC.
This document describes the BBMRI-ERIC Expert Centre public-private-partnership model, the application criteria, the assessment and vote process
Adopted by Assembly of Members 27 October 2015
Time Capsule Letter - Eric Caldwell, West Mecklenburg High School
No full textLetter to the Class of 2013, written by West Mecklenburg High School Senior Eric Caldwell. This letter was added to the time capsule buried in honor of Central Piedmont's 25th anniversary in 1988 and was reopened in 2013 during the 50th anniversary celebrations
Exterior view of Eric H Pratten Residence, [Pymble, New South Wales, 1] [picture] /
No full textTitle from acquisitions documentation.; Part of: Eric Milton Nicholls collection.; Designed by Walter Burley Griffin in partnership with Eric Milton Nicholls.-- Beyond Architecture. Sydney, Powerhouse Museum, 1998. p. 84.; Inscriptions: "Photo by Phil Ward, 296 Pitt St. Sydney"--Stamped on verso.; "Chap 8 237"-- Pencil inscription on verso.; Condition: Good.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn3603884a-s225; Also available as a glass negative: Exterior view of Eric Pratten house, Pymble, New South Wales [1], 1934, PIC/9929/2748 LOC Cold Store PIC NICH.; Purchased from Marie and Glynn Nicholls, 2006.; Vernon inventory, Pt. IV/3 No 3o
Eric Tregenza
No full text"S399081 Eric Tregenza 43rd Btn. Dec 1941 - April 1943".S399081 Eric Tregenza 43rd Battalion. December 1941 - April 1943
Eric Pearson
No full text"Eric Pearson 138963 12 A.R.D. R.A.A.F. 1942-1945".Eric Pearson. 138963. 12 Airframe Repair Depot, Royal Australian Air Force 1942-1945
Eric McDonald
No full text"NX106242 Eric McDonald 133 H. A/A Battery Mobile. [F]enton Field."NX106242 Eric McDonald. 133 Heavy Anti Aircraft Battery Mobile. [F]enton Field
Eric Kneebone
No full text"Eric. Kneebone No. 118026. RAA.F. No. 1.R.S.U. Katherine. N.T. 1942 - 43."Eric Kneebone Number 118026. Royal Australian Air Force. Number 1 Repair and Salvage Unit, Katherine, Northern Territory 1942 - 43
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