159,489 research outputs found
Intramuscular tranexamic acid: a real-world application of pharmacokinetics
Full text linkFor many anaesthetists around the world, the mere mention of the word ‘pharmacokinetics’ is sufficient to make their eyes glaze over and their attention wander. Pharmacokinetics is seen as an art that is as obscure and esoteric as the art of divination (prediction) practiced by the likes of Professor Sybille Trelawny 1 but that has varying and mostly limited relevance to clinical practice. Although this hyperbole may have elements of truth, it is a fact that pharmacokinetic data are the essential foundation upon which rational drug dosing guidelines are developed for all drugs
Raddoppiamento sintattico and glottalization phenomena in Italian
Full text linkThis paper is a preliminary phonetic exploration of aspects of the well-known Italian sandhi phenomenon of Raddoppiamento sintattico (henceforth RS), which involves the gemination of word-initial consonants under certain conditions, eg dei [k]ani ‘some dogs’ but tre [kk]ani ‘three dogs’. It is often assumed that RS C-gemination is regular, but there is increasing evidence that it competes with other phenomena such as vowel lengthening. This paper first discusses results of our auditory study of RS contexts, which show that RS is far less frequent in spontaneous speech than is theoretically predicted. This paper then looks specifically at glottal stop insertion and creak in RS contexts, based on the results of an initial small-scale acoustic investigation. The first has controversially been reported as occurring in RS environments where it serves to block RS (Absalom & Hajek, 1997). In addition, glottal stops have also been claimed to provide a coda to short word-final stressed vowels outside of RS environments (Vayra, 1994). We discuss our unexpected finding that glottalization characterizes phrase boundaries in our spontaneous speech data, and the implications that this evidence may have for the phonetic and phonological description of Italian and for our understanding of RS
Exchanging values: a comparison of Flaubert's concept of irony in Madame Bovary and Faulkner's reading of commodity culture in Absalom, Absalom!
Full text linkFlaubert attacked what he called "avachissement universel," the spread of bourgeois stupidity to all aspects of French culture. Faulkner also coined a term that indicated his concern with cultural changes, "snopesism." The differences between these two concepts, bovarism and snopesism, manifest a dramatic shift in the representation of society effected by the rise of commodity culture. Focusing on classical topoi as particularly dense cultural signifiers, I look at the developing presentations of culture in Absalom, Absalom! and Madame Bovary. As stable referents of bourgeois culture, classical topoi strongly identify a set of cultural values for Flaubert that he can then ironize. Faulkner, by contrast, demonstrates the destabilization of cultural referents with the "rise of the redneck" signaled by snopesism. However, while Flaubertian irony relies on the bourgeois betise he criticizes, Faulkner's critique of snopesism develops the tensions between utopian fantasies of fulfillment and irretrievable los
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Thomas Sutpen’s personality analyzed through the characters of Faulkner’s novel Absalom, Absalom!
Full text linkEn el presente trabajo pretendemos estudiar la caracterización mediante el estudio y la
comparación de la personalidad de Thomas Sutpen, el protagonista de Absalom, Absalom!,
descrita a través de los testimonios de los personajes de la novela. Para ello, hemos utilizado el
NEO PI-R, un inventario de la personalidad diseñado por Costa y McCrae que organiza la
información en cinco dominios de la personalidad. La primera versión de Sutpen pertenece a
Rosa Coldfield y destaca su dominio no Afable de la personalidad. La segunda versión
estudiada se encuentra en el capítulo VII de la novela y corresponde al General Compson,
quien destaca de Sutpen el dominio de la Responsabilidad. Después realizamos el mismo
estudio de la personalidad a los personajes que le describían para ver cómo influía su
personalidad en la narración. Por último, pusimos en práctica el modelo de la Covarianza
Causal de Kelley, que trata de presentar el motivo de los personajes para el comportamiento de Sutpen.Departamento de Filología InglesaGrado en Estudios Inglese
Absalom: Balancing assembly lines with assignment restrictions
No full textAssembly line balancing problems (ALBPs) arise whenever an assembly line is configured, redesigned or adjusted. An ALBP consists of distributing the total workload for manufacturing products among the work stations along the line. On the one hand, research has focussed on developing effective and fast solution methods for exactly solving the simple assembly line balancing problem (SALBP). On the other hand, a number of real-world extensions of SALBP have been introduced but solved with straight-forward and simple heuristics in many cases. Therefore, there is a lack of procedures for exactly solving such generalized ALBP. In this paper, we show how to extend the well-known solution procedure Salome [Scholl, A., Klein, R., 1997. Salome: A bidirectional branch-and-bound procedure for assembly line balancing. Informs J. Comput. 9 319-334], which is able to solve even large SALBP instances in a very effective manner, to a problem extension with different types of assignment restrictions (called ARALBP). The extended procedure, referred to as Absalom, employs a favorable branching scheme, an arsenal of bounding rules and a variety of logical tests using ideas from constraint programming. Computational experiments show that Absalom is a very promising exact solution approach although the additional assignment restrictions complicate the problem considerably and necessitate a relaxation of some components of Salome.Assembly line balancing Assignment restrictions Combinatorial optimization Branch-and-bound
Absalom: Balancing assembly lines with assignment restrictions
No full textAssembly line balancing problems (ALBPs) arise whenever an assembly line is configured, redesigned or adjusted. An ALBP consists of distributing the total workload for manufacturing products among the work stations along the line. On the one hand, research has focussed on developing effective and fast solution methods for exactly solving the simple assembly line balancing problem (SALBP). On the other hand, a number of real-world extensions of SALBP have been introduced but solved with straight-forward and simple heuristics in many cases. Therefore, there is a lack of procedures for exactly solving such generalized ALBP.In this paper, we show how to extend the well-known solution procedure Salome [Scholl, A., Klein, R., 1997. Salome: A bidirectional branch-and-bound procedure for assembly line balancing. Informs J. Comput. 9 319-334], which is able to solve even large SALBP instances in a very effective manner, to a problem extension with different types of assignment restrictions (called ARALBP). The extended procedure, referred to as Absalom, employs a favorable branching scheme, an arsenal of bounding rules and a variety of logical tests using ideas from constraint programming.Computational experiments show that Absalom is a very promising exact solution approach although the additional assignment restrictions complicate the problem considerably and necessitate a relaxation of some components of Salome.Assembly line balancing, Assignment restrictions, Combinatorial optimization, Branch-and-bound
A 2 h periodic variation in the low-mass X-ray binary Ser X-1
No full textSpectroscopy of the low-mass X-ray binary Ser X-1 using the Gran Telescopio Canarias have revealed a ?2 h periodic variability that is present in the three strongest emission lines. We tentatively interpret this variability as due to orbital motion, making it the first indication of the orbital period of Ser X-1. Together with the fact that the emission lines are remarkably narrow, but still resolved, we show that a main-sequence K dwarf together with a canonical 1.4 M? neutron star gives a good description of the system. In this scenario, the most likely place for the emission lines to arise is the accretion disc, instead of a localized region in the binary (such as the irradiated surface or the stream-impact point), and their narrowness is due instead to the low inclination (?10°) of Ser X-1
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
Full text linkBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
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