794 research outputs found
Widespread imiquimod-induced psoriasis like eruption: case report and analysis of mast cell infiltration.
No full textPsoriasis is an inflammatory skin disease that affects over 60 million adults and children worldwide.1 Many genetically innovative and easy-to-use models have been generated to study psoriasiform skin inflammation in mice. Topical application of imiquimod, the agent with immune response modifying activity, is widely used for psoriasis research. A Previous study demonstrated that mast cells (MCs) increase in imiquimod-induced psoriasis in mice.2 Topical application of imiquimod is used to treat actinic keratosis and condyloma acuminatum. Several cases of psoriasis-like eruptions caused by topical imiquimod have been reported. These eruptions are distinct from psoriasis. Moreover, psoriasis-like eruptions observed in areas other than the topical imiquimod site.3 Herein, we report a case of psoriasis like eruptions after topical imiquimod treatment. In previous studies, upregulation in the number and activation of MCs has been found in imiquimod-induced psoriasis in mice. 2 Mast cell infiltration has been found in patients with psoriasis.2 However, mast cell infiltration and the number of MCs in imiquimod-induced psoriasis in humans is unclear. We investigated the number of MCs in our case for a better understanding the mechanism of imiquimod-induced psoriasis like eruption.Tatsuya Katsumi, Ryota Hayashi, Shingo Takei, Manon Okamura, Yuka Tsutsui, Osamu Ansai, Akito Hasegawa, Yu Matsui, Tatsuya Takenouchi, Riichiro Abe, Widespread imiquimod-induced psoriasis-like eruption: case report and analysis of mast cell infiltration, Clinical and Experimental Dermatology, Volume 50, Issue 6, June 2025, Pages 1221–1224, https://doi.org/10.1093/ced/llae527This is a pre-copyedited, author-produced version of an article accepted for publication in Clinical and Experimental Dermatology following peer review.
The version of record, Tatsuya Katsumi, Ryota Hayashi, Shingo Takei, Manon Okamura, Yuka Tsutsui, Osamu Ansai, Akito Hasegawa, Yu Matsui, Tatsuya Takenouchi, Riichiro Abe, “Widespread imiquimod-induced psoriasis-like eruption: case report and analysis of mast cell infiltration,” Clinical and Experimental Dermatology, Volume 50, Issue 6, June 2025, Pages 1221–1224, is available online at: https://doi.org/10.1093/ced/llae527
Chymase-positive mast cells in small sized adenocarcinoma of the lung
No full textMast cells accumulate in angiogenesis-dependent situations of lung adenocarcinoma. Human mast cells are divided into two major subsets: MCT (mast cells with immunoreactivity for tryptase but not chymase) and MCTC (reactive for tryptase and chymase). Chymase is an important mediator of tissue remodeling, but research into chymase-containing mast cell subpopulations has been hampered by the lack of reagents suitable for use with formalin-fixed tissue. We stained chymase using CC1 antibody in 66 cases of small sized lung adenocarcinoma as well as CD34 and tryptase. There were significant positive correlations of microvessel counts with MCT-type and MCTC-type mast cell counts in lung adenocarcinomas. When analyzed according to Noguchi''s classification, MCT-type and MCTC-type mast cells were significantly increased in Noguchi type-C tumors [localized bronchioloalveolar carcinoma (LBAC) with active fibroblastic proliferation] compared with in Noguchi type-A (LBAC) plus type-B tumors (LBAC with alveolar collapse). Members in the high-count group of MCTC-type but not MCT-type mast cells showed a significantly worse outcome than those in the low-count group in LBACs. Counting chymase-positive (MCTC-type) mast cells in tumor stroma may be a good prognosis predictor for LBACs, especially Noguchi type-C tumors
Evaluation of Post-license Advanced Driver Training in Italy
No full textAbstractPost-license advanced driver training addresses different categories of road users such as: novice drivers, professional drivers, company employers and recidivists. These training courses can be carried out on-track or on the road. On-track courses allow participants to gain knowledge on driving physics and experience limits in a safe road environment. On-road courses are more focused on hazard perception and situation awareness.Although extensive research has been done in this field, knowledge of the effects of these courses on road accident risk remains unclear. Previous evaluation of on-track courses did not always show a positive effect on crash rate. For example, post-license training focused on mastery of driving skills can lead to an increase of accident risk, especially on young males.However, research identified several factors that may enhance the effectiveness of driving training. In Europe a new framework for driver education and training has been proposed based on a safe driver hierarchical model (the GADGET model) and the development of a strategy for continuous learning.According to this framework, an evaluation study of on-track post-license advanced driver training has been undertaken in Italy with the main goal of assessing the safety effects of these courses and identifying training aspects to be improved. Besides crash rate, the study aims at assessing also driver behavior, knowledge of risks, self-evaluation and training quality.This paper presents the results of the possible effects of advanced driver training on driving behavior, considering in particular the number and type of violations. For each driver, data on age, gender and driving violations history were extracted from the platform and the national violations database.Three cases were addressed through a before-after analysis with control group. Case 1 considers all drivers who attended an ADT course. Case 2 aimed at understanding the effects of the courses on a specific target group: the traffic violators. Case 3 is similar to Case 2, however the control group was selected in a way that drivers characteristics and the violation rate was similar to the violation rate of the treatment group in the before period.The significance of the differences highlighted was assessed through appropriate statistical tests (i.e. paired t-test and the Wilcoxon signed-rank test).The study showed in general a higher propensity to commit traffic violations after attending an ADT course. These results are in contrast to what expected and show the necessity to diversify the training classes according to the different needs of participants
A methodology to assess pedestrian crossing safety
No full textPurpose: The safety level of a pedestrian crossing is affected by infrastructure characteristics and vehicular and pedestrian traffic level. This paper presents a methodology that allows assessing the safety level of a pedestrian crossing, regulated or not by traffic light, in an urban area according to the features of the crossing. Methods: A hierarchical structure representing factors influencing crossing safety has been developed and the relative contributions of each factor were calculated using AHP method. A composite index for crossing safety and specific indexes for main aspects included in the assessment have been developed. Results: Main assessment aspects are: Spatial and Temporal Design, Day-time and Night-time Visibility and Accessibility. Night-time Visibility resulted to have the higher weight (about 41%). Conclusion: Developed indexes allow ranking of pedestrian crossings and assigning intervention priorities, highlighting the aspects which are to be enhanced. The methodology has been used for the evaluation of 215 pedestrian crossings in 17 European cities for the Pedestrian Crossing Assessment Project co-financed by FIA Foundation. © 2010 The Author(s)
Introduction for Fisheries and Aquatic Biology
No full textChapter I. Aquatic Environment. Ken FURUYA and Ichiro YASUDA : chapter_1.pdfChapter II. Biology and Ecology of Aqua-Shere. Toyoji KANEKO, Katsumi TSUKAMOTO, Atsushi TSUDA, Yuzuru SUZUKI and Katsufumi SATOH : chapter_2.pdfChapter III. Aquatic Resource and Production. Ichiro AOKI, Kazuo OGAWA, Taku YAMAKAWA and Tomoyoshi YOSHINAGA : chapter_3.pdfChapter IV. Chemistry of Aquatic Organism and Their Utilization. Hiroki ABE, Shugo WATABE, Yoshihiro OCHIAI, Shigeru OKADA, Naoko YOSHIKAWA, Yoshiharu KINOSHITA, Gen KANEKO and Shigeki MATSUNAGA : chapter_4.pdfChapter V. Relation between Aqua-Shere and Human Life. Hisashi KUROKURA, Hirohide MATSUSHIMA, Shingo KUROHAGI, Haruko YAMASHITA, Akinori HINO, Kazumasa IKUTA, Satoquo SEINO, Masahiko ARIJI, Ken FURUYA, Junichiro OKAMOTO and Nobuyuki YAGI : chapter_5.pdfPart of "Introduction for Fisheries and Aquatic Biology
Strategies to enhance long-term competitiveness in the telecommunications industry : lessons for NTT
No full textThesis: S.M. in Engineering and Management, Massachusetts Institute of Technology, Engineering Systems Division, 2014.Cataloged from PDF version of thesis.Includes bibliographical references (pages 73-75).In the telecommunications industry, the market is highly global as well as competitive in this era of Internet and data communications. Telecommunications carriers compete with not only other telecommunications carriers providing broadband access and mobile communication but also network application and service providers, which are significant threats for telecommunications carriers. It is difficult for telecommunications carriers to control the market for two significant reasons. Firstly, due to the maturity of technology as well as customers, network services have become commoditized. Secondly, telecommunications network services are vulnerable to over-the-top services based on the Internet. This study aims to investigate how large telecommunications carriers can continue to be competitive in such an environment. This paper focuses on three kinds of strategic options that enable large high-tech companies to continue to make profits; internal R&D, growth and diversification, and M&A. In the second chapter the author focuses on IBM and Cisco, which are good examples of how large companies have evolved over time, combining these three strategies. Then, the use of the three strategies by major telecommunications carriers is investigated. Finally, in the fourth chapter, the author analyzes the future competitiveness of the NTT Group, the major telecommunications carrier in Japan, using these strategies within the next decade.by Shingo Kawai.S.M. in Engineering and Managemen
Study of Active Cyber Defense for Industrial Control Systems 〜 Achieving Resilience in Security Operation Center 〜
No full text名古屋工業大学博士(工学)Doctor of Engineering主査：橋本 芳宏doctoral thesi
Big Five Content Representation of the Japanese Version of the Ten-Item Personality Inventory
No full textThe Ten-Item Personality Inventory (TIPI) is a widely used, very brief measure of the Big Five personality dimensions (Gosling, Rentfrow, & Swann, 2003). Recently, Oshio, Abe and Cutrone (2012) developed and validated a Japanese version of the TIPI. The present study focuses on evaluating the content validity of the TIPI-J with respect to the thirty facets of the Japanese version of the Revised NEO Personality Inventory (NEO-PI-R-J). 163 Japanese undergraduates (67 males and 96 females) completed the TIPI-J and the NEO-PI-R-J. The convergent correlations between the TIPI-J and the Big Five dimensions of the NEO-PI-R-J were as follows: r = 0.65 (Extraversion), r = 0.49 (Agreeableness), r = 0.63 (Conscientiousness), r = 0.70 (Neuroticism), and r = 0.46 (Openness). Twenty-eight of thirty facets of the NEO-PI-R-J correlated positively with equivalent scales of the TIPI-J. A joint factor analysis of the five scales of the TIPI-J with the thirty facets of the NEO-PI-R-J showed clear indicators for the five known superordinate dimensions of personality in both scales. Results indicated that the TIPI-J provides an adequate representation of the Big Five dimensions of personality and correlates sufficiently well with the larger scale NEO-PI-R-J
An Effective Case of Cronkhite-Canada Syndrome Treated by Corticosteroid and Antiplasmin Therapy
No full text浜野恭一教授退任記念論文
Papillary adenocarcinoma in a seminal vesicle cyst associated with contralateral renal agenesis: a case report
No full text30歳男。肛門部痛, 排尿後疼痛, 血尿を主訴に受診し, 急性前立腺炎を疑い入院となった。CTにて右腎無形成と骨盤内に嚢胞性病変を認め左精管からの茶褐色液の流出と造影剤の嚢胞内への流入が見られ左精嚢嚢胞と診断した。内容液の細胞診はclass 1で定期的に精嚢嚢胞穿刺を行い, 内容液を吸引していたが12年後には症状出現期間が極めて短くなり毎月, 穿刺を繰り返すようになり内容液の細胞診はclass IIIで精嚢嚢胞壁の不整が目立つようになった。2ヵ月後にTRUS下精嚢生検と精嚢嚢胞穿刺を行い細胞診classIVで乳頭状腺癌と診断し手術目的で入院となり患者の性機能と膀胱温存希望により精嚢摘出術を施行した。精嚢と膀胱頸部での癒着が強く, 左精嚢摘出後, 周囲組織への浸潤がないことを確認し, 右精嚢も摘除したが嚢胞内面に多発性腫瘍が乳頭状に発育しており組織学的には乳頭状腺癌で一部低分化腺癌がみられ, CA125(+)であった。3ヵ月後膀胱後面に嚢胞状病変が出現し, 精嚢癌の再発と診断し, 腫瘍摘除, 膀胱全摘術, 回腸導管造設術を施行し, 放射線治療を行うも骨盤腔内腫瘍増大と肝転移のために死亡した。We report a case of papillary adenocarcinoma inside a seminal vesicle cyst associated with contralateral renal agenesis in a 30-year-old man. Coexistence of a seminal vesicle cyst and tumors is rare. Surgical excision was performed but he died due to liver metastases one year later
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