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Experiences of Family Caregivers Engaging in Dysphagia Care for Elderly People with Swallowing Disorders
Get PDF新潟大学Niigata University博士（保健学）新大院博(保)第62
客家村落の集落変遷における空間構成と生活行動の持続性に関する研究 : 水道普及による天井周辺における水利用の変容
Get PDF新潟大学Niigata University博士（工学）新大院博(工)第582
異なるインプラント・アバットメント結合様式におけるスクリューの繰り返しの締結と取り外しが除去トルクと形態に与える影響
Get PDF新潟大学Niigata University博士（歯学）新大院博(歯)第581
糖代謝とmTORC1との相互作用が、ALDH高活性の患者由来子宮体癌スフェロイド細胞の増殖に関与する
Get PDF新潟大学Niigata University博士（医学）Cancer stem cells are associated with aggressive phenotypes of malignant tumors. A prominent feature of uterine endometrial cancer is the activation of the PI3K–Akt–mTOR pathway. In this study, we present variations in sensitivities to a PI3K–Akt–mTORC1 inhibitor among in vitro endometrial cancer stem cell-enriched spheroid cells from clinical specimens. The in vitro sensitivity was consistent with the effects observed in in vivo spheroid-derived xenograft tumor models. Our findings revealed a complementary suppressive effect on endometrial cancer spheroid cell growth with the combined use of aldehyde dehydrogenase (ALDH) and PI3K–Akt inhibitors. In the PI3K–Akt–mTORC1 signaling cascade, the influence of ALDH on mTORC1 was partially channeled through retinoic acid-induced lactate dehydrogenase A (LDHA) activation. LDHA inhibition was found to reduce endometrial cancer cell growth, aligning with the effects of mTORC1 inhibition. Building upon our previous findings highlighting ALDH-driven glycolysis through GLUT1 in uterine endometrial cancer spheroid cells, curbing mTORC1 enhanced glucose transport via GLUT1 activation. Notably, elevated LDHA expression correlated with adverse clinical survival and escalated tumor grade, especially in advanced stages. Collectively, our findings emphasize the pivotal role of ALDH–LDHA–mTORC1 cascade in the proliferation of endometrial cancer. Targeting the interaction between mTORC1 and ALDH-influenced glycolysis holds promise for developing novel strategies to combat this aggressive cancer.Ueda, H., Ishiguro, T., Mori, Y. et al. Glycolysis-mTORC1 crosstalk drives proliferation of patient-derived endometrial cancer spheroid cells with ALDH activity. Cell Death Discov. 10, 435 (2024). https://doi.org/10.1038/s41420-024-02204-y新大院博(医)第1231
スティーヴンス・ジョンソン症候群/中毒性表皮壊死症の新たな治療戦略 : Fas-Fasリガンド相互作用を介した細胞死シグナル経路活性化の阻害による治療効果の検証
Get PDF新潟大学Niigata University博士（医学）Yuki Saito, Roberta Lotti, Haruna Kimura, Akito Hasegawa, Brydon Bennett, Antonino Amato, Carlo Pincelli, Riichiro Abe,
Advancements in Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis Treatment: Utilizing Fas–FasL Inhibition to Target Cell Death Signaling Pathways for Practical Human Application,
Journal of Investigative Dermatology,
Volume 145, Issue 4,
2025,
Pages 962-965.e4,
ISSN 0022-202X,
https://doi.org/10.1016/j.jid.2024.08.028.
(https://www.sciencedirect.com/science/article/pii/S0022202X24021067)新大院博(医)第1234
クローン病患者におけるサルコペニアおよびサルコペニア肥満の臨床的特徴
Get PDF新潟大学Niigata University博士（医学）"Objective Crohn's disease (CD) is a chronic inflammatory bowel disease that is associated with malnutrition. Sarcopenia is a malnutrition condition characterized by skeletal muscle loss that impairs the physical function. We investigated the clinical characteristics of patients with CD with sarcopenia and sarcopenic obesity (sarcopenic-o).
Methods The body composition of patients with CD was evaluated using a bioelectrical impedance analysis. The clinical characteristics of patients with sarcopenia and sarcopenic-o were analyzed, and a predictive model for sarcopenia was developed.
Patients Patients with CD recruited from 2019 to 2021 were included.
Results Among the 104 patients, 35 (33.7%) and 10 (9.6%) had sarcopenia and sarcopenic-o, respectively. In the sarcopenia group, the skeletal muscle index (SMI) and body mass index (BMI) were lower than those in the control group (SMI, 6.3 kg/m2 vs. 7.7 kg/m2, p<0.01; BMI, 18.8 kg/m2 vs. 22.6 kg/m2, p<0.01), whereas the Crohn's disease activity index (CDAI) was higher than in the control group (114.2 vs. 42.0, p<0.01). The predictive models of sarcopenia using the BMI and CDAI revealed high performance with areas under the receiver operating characteristic curve (AUC) of 0.87 and 0.72, respectively, and high specificity (0.94) and sensitivity (0.71), respectively. Sarcopenic-o patients could not be screened using the BMI (25 kg/m2), and the SMI and body fat percentage were negatively correlated in patients with sarcopenia (p<0.01).
Conclusion Sarcopenia and sarcopenic-o are relatively common conditions among patients with CD. Sarcopenia can be predicted using the clinical parameters of BMI and CDAI. Sarcopenic-o can be a severe form of sarcopenia."Takumi Naruse, Hiroki Sato, Kazuya Takahashi, Chihiro Sato, Yuichi Kojima, Yuzo Kawata, Kentaro Tominaga, Ken-ichi Mizuno, Shuji Terai, Association between Clinical Characteristics and Sarcopenia or Sarcopenic Obesity in Crohn's Disease, Internal Medicine, 2025, 64 巻, 10 号, p. 1451-1458, 公開日 2025/05/15, [早期公開] 公開日 2024/10/18, Online ISSN 1349-7235, Print ISSN 0918-2918, https://doi.org/10.2169/internalmedicine.4420-24, https://www.jstage.jst.go.jp/article/internalmedicine/64/10/64_4420-24/_article/-char/ja新大院博(医)第1235
進行性の脊髄円錐病変は血管内大細胞型B細胞リンパ腫を示唆する
Get PDF新潟大学Niigata University博士（医学）Background and purpose: Spinal cord lesions are observed in 40% of all central nervous system lesions in intravascular large B-cell lymphoma (IVLBCL). However, because IVLBCL is a very rare disease, its clinical features are not well defined, which may delay appropriate diagnosis and treatment, whilst the acute to subacute course of brain lesions in patients with IVLBCL is well established. Therefore, this study aimed to clarify the clinical features of spinal cord lesions in patients with IVLBCL.
Methods: The medical records of patients with IVLBCL admitted to our hospital between 2010 and 2020 were searched. The inclusion criteria were preceding neurological symptoms without non-neurological symptoms and pathologically confirmed IVLBCL in various organs. Clinical features of spinal cord involvement in patients with IVLBCL were assessed and distinguished from those of brain involvement.
Results: Sixteen consecutive patients with IVLBCL were divided into two groups: six patients with spinal involvement (spinal cord type) and 10 patients with brain involvement (brain type). In the spinal cord type, four patients had chronic progression and two had subacute progression. Acute progression (0% vs. 80.0%) and sudden onset (0% vs. 50.0%) occurred significantly less frequently in the spinal cord than in the brain. All spinal cord lesions involved the conus medullaris.
Conclusions: Spinal cord involvement in IVLBCL has a predominantly chronic progressive course that is exclusive to brain involvement. Conus medullaris lesions are suggestive of IVLBCL and are useful for early and accurate diagnosis and treatment.Kitahara S, Kanazawa M, Natsumeda M, et al. Progressive conus medullaris lesions are suggestive of intravascular large B-cell lymphoma. Eur J Neurol. 2023; 30: 3236-3243. doi:10.1111/ene.15941This is the peer reviewed version of the following article:Kitahara S, Kanazawa M, Natsumeda M, et al. Progressive conus medullaris lesions are suggestive of intravascular large B-cell lymphoma. Eur J Neurol. 2023; 30: 3236-3243. doi:10.1111/ene.15941, which has been published in final form at https://doi.org/10.1111/ene.15941. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.新大院博(医)第1242
直腸癌の側方領域における壁外非連続性癌進展病巣の臨床的意義
Get PDF新潟大学Niigata University博士（医学）Background
Although previous studies have demonstrated that tumor deposits (TDs) are associated with worse prognosis in colon cancer, their clinical significance in rectal cancer has not been fully elucidated, especially in the lateral pelvic lymph node (LPLN) area. This study aimed to clarify the clinical significance of TDs, focusing on the number of metastatic foci, including lymph node metastases (LNMs) and TDs, in the LPLN area.
Methods
This retrospective study involved 226 consecutive patients with cStage II/III low rectal cancer who underwent LPLN dissection. Metastatic foci, including LNM and TD, in the LPLN area were defined as lateral pelvic metastases (LP-M) and were evaluated according to LP-M status: presence (absence vs. presence), histopathological classification (LNM vs. TD), and number (one to three vs. four or more). We evaluated the relapse-free survival of each model and compared them using the Akaike information criterion (AIC) and Harrell’s concordance index (c-index).
Results
Forty-nine of 226 patients (22%) had LP-M, and 15 patients (7%) had TDs. The median number of LP-M per patient was one (range, 1–9). The best risk stratification power was observed for number (AIC, 758; c-index, 0.668) compared with presence (AIC, 759; c-index, 0.665) and histopathological classification (AIC, 761; c-index, 0.664). The number of LP-M was an independent prognostic factor for both relapse-free and overall survival, and was significantly associated with cumulative local recurrence.
Conclusion
The number of metastatic foci, including LNMs and TDs, in the LPLN area is useful for risk stratification of patients with low rectal cancer.Yamai, D., Shimada, Y., Nakano, M. et al. Clinical significance of metastatic tumor deposit foci in rectal cancer in the lateral pelvic lymph node area. Int J Clin Oncol 28, 1388–1397 (2023). https://doi.org/10.1007/s10147-023-02391-1新大院博(医)第1248