2,840 research outputs found
RIC-HSCT for MF/SS
No full textAdvanced-stage mycosis fungoides and Sezary syndrome (MF/SS) have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT), particularly using a reduced-intensity conditioning (RIC) regimen, is a promising treatment for advanced-stage MF/SS. We performed RIC-HSCT in nine patients with advanced MF/SS. With a median follow-up period of 954days after HSCT, the estimated 3-year overall survival was 85.7% (95% confidence interval, 33.4-97.9%) with no non-relapse mortality. Five patients relapsed after RIC-HSCT; however, in four patients whose relapse was detected only from the skin, persistent complete response was achieved in one patient, and the disease was manageable in other three patients by the tapering of immunosuppressants and donor lymphocyte infusion, suggesting that graft-versus-lymphoma effect and "down-staging" effect from advanced stage to early stage by HSCT improve the prognosis of advanced-stage MF/SS. These results suggest that RIC-HSCT is an effective treatment for advanced MF/SS
Preparation of mono-sized epoxy/MF microcapsulesin the appearance of polyvinyl alcohol as co-emulsifier
No full textFor epoxy microcapsules embedded in concrete as mechanic-triggered self-healing adhesive, globular shape with uniform size is the basic requirement to ensure the solid shell broken and the liquid core released at a designed stress. In this paper, monodispersed melamine\u96formaldehyde (MF) resin-walled epoxy E-51 microcapsules were successfully fabricated in an in situ polycondensation process, in which a certain amount of polyvinyl alcohol (PVA) solution was added as coemulsifier to control the microcapsules\u92 shape and size. Detail investigation shows, with the cooperation of PVA, the microcapsule morphologies and size distribution were ease to be adjusted by the parameters such as emulsifying agents, agitation rate, pH value and acidification time
ACT Family Violence Intervention Program review
No full textThis paper reports on a review of the Australian Capital Territory’s Family Violence Intervention Program, which provides an interagency response to family violence matters.
The scope of the review was to analyse the program’s activities and outcomes using 2007–08 data provided by participating agencies, supported by in-depth interviews with key stakeholders including victims whose matters had been finalised in court. After the completion of this report, additional data from 2008–09 and 2009–10 was made available by some Family Violence Intervention Program (FVIP) participating agencies. Although not within the scope of this evaluation, these data pointed to some preliminary improvements in the FVIP
NF membrane fouling by aluminum and iron coagulant residuals after coagulation-MF pretreatment
No full textThe effects of coagulant residuals on fouling of a nanofiltration (NF) membrane were investigated. Experiments were carried out with a laboratory-scale microfiltration (MF)-NF setup and a pilot MF-NF plant. In the laboratory-scale experiments, NF feed water was pretreated with poly-aluminum chloride (PACl) or alum followed by MF. NF membrane permeability declined when the feed water contained residual aluminum at 18 μg/L or more, but not when it was lower than 9 μg/L. When pretreated with ferric chloride, no substantial decline of NF membrane permeability was observed: residual iron did not affect the permeability. When SiO2 was added to the water before the pretreatment with PACl, the NF membrane permeability declined at about double the speed. Thermodynamic calculations and elemental analysis of foulants recovered from the membranes indicated that the majority of inorganic foulants were compounds composed of aluminum, silicate, and possibly potassium. In the pilot plant, NF feed was pretreated by PACl. Transmembrane pressure for NF doubled over 4.5 months of operation. Although the aluminum concentration in the NF feed was not high (30 μg/L), analysis of membrane foulants revealed excessive accumulation of aluminum and silicate, also suggesting that aluminum residuals caused the membrane fouling by alumino-silicates or aluminum hydroxide
Anti-Wolbachia surface protein antibodies are present in the urine of dogs naturally infected with Dirofilaria immitis with circulating microfilariae but not in dogs with occult infections
No full textHeartworm infection (Dirofilaria immitis) can cause kidney damage due to the presence of circulating microfilariae (mf) that contribute to the production and deposit of immune complexes. It has been shown that mf are a major source of Wolbachia antigen during active infection. Here the authors compared urine samples from 19 naturally infected dogs with (mf+) and 12 without (mf-) microfilariae for the presence of proteinuria and anti-Wolbachia Surface Protein (-WSP) IgG in ELISA. Kidneys from 6 mf+ and 3 mf- dogs were also examined by anti-WSP immuno-histochemistry. All infected dogs showed proteinuria, but mf+ dogs had significantly higher values compared to mf-dogs. Mf+ dogs had optical density values for anti-WSP IgG consistently higher than established cut-off values and were significantly higher than values for mf- dogs. Kidneys from mf+ dogs showed Wolbachia+ mf in glomerular capillaries. Results strongly suggest that Wolbachia associated with circulating mf may contribute to immune-mediated kidney disease in dogs with heartworm infection
Compartir datos de investigación en cardiología
No full textEl artículo expone las ventajas que aporta el compartir datos en la investigación en el área de cardiologíaAleixandre Benavent, R.; Ferrer Sapena, A.; Alonso Arroyo, A.; Peset Mancebo, MF. (2013). Compartir datos de investigación en cardiología. Revista Española de Cardiología. 66(12):1007-1008. https://doi.org/10.1016/j.recesp.2013.08.005S10071008661
Overcoming health systems barriers to successful malaria treatment.
No full textThe success of malaria control programmes is recognised to be handicapped by the capacity of the health system to deliver interventions such as first-line treatment at optimal coverage and quality. Traditional approaches to strengthening the health system such as staff training have had a less sustained impact than hoped. However, novel strategies including the use of mobile phones to ease stockouts, task-shifting to community health workers, and inclusion of the informal sector appear more promising. As global health funding slows, it is critical to better understand how to deliver a proven intervention most effectively through the existing system
Correction Factor on Dynamic Force in a Marsh Funnel Test for Tunneling
No full textThis paper presents an improvement on a previous model for predicting the Marsh funnel (MF) test that is used in slurry shield tunneling for evaluating the rheological properties of bentonite slurries. The improvement focuses on the prediction of the dynamic part for fluids with small MF times. The velocity profile of the Herschel-Bulkley fluid in a laminar pipe flow condition is first investigated and a correction factor is introduced in the improved model. Comparisons of results from experiments and calculations with the previous model confirm the improved performance over the existing model. The rheological parameters obtained from the improved model show good resemblance to those obtained from a laboratory viscometer. The work also provides a reference to similar applications such as fluid transportation through pipelines where dynamic pressure dominates and therefore should be correctly predicted considering its velocity profile in a laminar condition.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Offshore and Dredging Engineerin
Epidemiology and the Burden of malaria in Mozambique, The
No full text[eng] Malaria occurs mostly in the tropical regions of the world. Sub-Saharan Africa is the area most affected. The occurrence of a very efficient mosquito vectors Anopheles gambiae complex and Anopheles funestus group sustain high transmission of the Plasmodium falciparum, the most predominant and deadly malaria parasite species. Local weather conditions are appropriate and often transmission occurs throughout the year. Limited resources and socio-economic instability constitute the major factors impeding efficient malaria control activities. The worldwide malaria eradication programme carried out during the 1950's focused mainly on insecticide residual spraying with DDT, anti-malarial drug treatment, and surveillance. Regional eradication of the disease was achieved, nevertheless, in many endemic regions of sub-Saharan Africa excluded from the eradication campaign, the disease is still afflicting their inhabitants. The malaria disease burden estimation in tropical Africa relies on mortality and morbidity data collected by the health system information. Conservative estimates of the burden of disease claim for more than 300 million clinical episodes and 1 - 3 million deaths every year and young children harbour the largest and most important portion of this bulk. Currently, the situation is deteriorating, increasing malaria-related morbidity and mortality have been reported. The rapid development and widespread of parasites strains resistant to almost all anti-malarial drugs, and vector resistance are the major contributing factors. In addition, global climate change is affecting the health of human populations, including changes in the transmission and seasonality of vector-borne diseases. The range of factors affecting transmission and distribution of vector-borne diseases, particularly malaria, include those related to temperature, humidity and precipitation. In Mozambique, malaria is endemic throughout the country, due to a multitude of factors such as climatic/environmental (favourable temperatures and rain patterns, abundant breeding sites) and socio-economical (poverty related improper housing/shelter, unaffordable preventive means). Transmission is perennial, with peaks during and after rainy seasons. The intensities of transmission may vary depending on the amount of rain and air temperature. However, at present there is a lack of good quality and updated information on the endemicity levels in the country. The country-wide malaria survey carried out between 2002 and 2003 aimed to determine the prevalence and intensity of Plasmodium infections, the prevalence and the severity of anaemia in children under 10 years of age and in pregnant women across different ecological settings, in order to characterize the malaria transmission intensities and to estimate the disease burden in Mozambique. The last comprehensive malaria survey in the country was carried out in 1952. For that reason, this survey was an unique opportunity to perform a sound methodological assessment of the current epidemiological malaria situation in the country. Based on altitude and on geographical region differences samples were collected from stratified areas distinguished as coastal, plateau and highland strata, in the northern, centre-northern, central and southern regions. For sampling at community level, in each of those stratified areas, a modified cluster sampling method with 30 clusters, used by WHO for evaluation of coverage of the Expanded Programme of Immunization was adopted. The study consisted of house-to-house survey, in 24 districts randomly selected. A total of 12,002 subjects including children less than ten years of age and pregnant women were enrolled. The malariometric survey consisted of finger pricking and blood collection to prepare thick and thin film for malaria parasite species identification, and respective density and determination of haemoglobin concentration. Measurement of axillary temperature and in those with fever a rapid enzyme test for malaria diagnosis was performed. The entomologic survey consisted of pyrethrum spray knock down mosquito collections. In total 6,557 female anopheline mosquitoes caught in 1,440 dwellings, were analysed for sporozoite infection using PCR techniques and the entomological inoculation rates were determined for each strata across regions.[spa] La malaria se encuentra preferentemente en las regiones tropicales del mundo, siendo África sub-sahariana el área con más afectación. La gran eficiencia de los mosquitos vectores Anopheles gambiae complex y Anopheles funestus favorece una gran transmisión del Plasmodium falciparum, el parásito más predominante y más maligno de las especies causante de malaria. Las condiciones ambientales locales son apropiadas y a menudo la transmisión se da a lo largo todo el año. Los recursos limitados y la inestabilidad socio-económica constituyen los principales factores que impiden la total eficacia de las estrategias de control de la malaria. El programa de erradicación mundial de la malaria se se llevó a cabo durante los años 50 focalizándose básicamente en la fumigación con DDT, el tratamiento con fármacos anti-maláricos y la vigilancia. La erradicación regional de la enfermedad se conseguió en muchas regiones endémicas del África sub-sahariana, no obstante en zonas excluidas de la campaña de erradicación, la enfermedad continua afectando a sus habitantes. La estimación de la carga de enfermedad por malaria en el África tropical se obtiene de los datos de mortalidad y morbilidad recogidos por el sistema de informació de la salud. Los datos conservadores estiman que la carga de esta enfermedad causa más de 300 millones de episodios clínicos y entre 1 - 3 millones de muertes cada año, siendo los niños los más afectados. En la actualidad, la situación se esta deteriorando, observándose un incremento de la morbilidad y mortalidad por malaria. El rápido desarrollo, la propagación de cepas del parásito resistentes ante todos los fármacos anti-maláricos y la presencia de vectores resistentes son los factores que más han contribuido a este incremento. A demás, el cambio climático global está afectando la salud de las poblaciones, incluyendo cambios en la transmision y estacionalidad de las enfermedades mediadas por vectores. Los factores que afectan la transmisión y la distribución de este tipo de enfermedades, particularmente la malaria, incluyen los relacionados con la temperatura, la humedad y las precipitaciones. En Mozambique, la malaria es una enfermedad endémica en todo el país, debido a la multitud de factores, como los climáticos/medioambientales (temperaturas favorables y patrones de precipitación, abundantes espacios para la reproducción) y socio-económicos (pobreza relacionada con vivienda inadecuada, medios preventivos inasequibles). La transmisión es perenne, con picos durante y después de la estación de lluvias. Las intensidades de transmisión pueden variar dependiento de la cantidad de precipitación y la temperatura en el ambiente. Sin embargo, actualmente, hay una falta de información actualizada y de calidad sobre los niveles de endemicidad del país. El estudio llevado acabo por todo el país entre los años 2002 y 2003 tenía como objetivo determinar la prevalencia y la intensidad de las infecciones por Plasmodium, la prevalencia y la severidad de la malaria en niños menores de 10 años de edad y en mujeres embarazadas a través de diferentes nichos ecológicos, para poder caracterizar la intensidad de transmisión por malaria y estimar la carga de esta enfermedad en Mozambique. El último estudio exahustivo de estas características en el país fue realizado en 1952. Por esta razón, este estudio era una oportunidad única para realizar un asesoramiento metodológico profundo de la situación epidemiológica actual de la malaria el país. Las muestras fueron recogidas basándose en la altitud y diferencias geográfica de cada región. Las areas estratificadas se clasificaron en: estrato costero, plateau y de montaña, y según la región en: norte, centro-norte, central y sur. Para el muestreo a nivel de comunidad, en cada una de esas áreas estratificadas, se utilizó un método por muestreo modificado por grupos con 30 grupos, ya usado por la OMS para la evalución de la cobertura del Programa Ampliado de Vacunación. El estudio consisitió en visitar casa por casa en 24 distritos seleccionados aleatóriamente. Se incluyeron un total de 12,002 individuos, tanto niños menores de 10 años de edad como mujeres embarazadas. El estudio malariométrico consistió en recoger sangre por punción en el dedo para preparar una lámina delgada y otra gruesa para la identificación de la especie del parásito de la malaria y una estimación de la densidad, y para la determinación de la concentración de hemoglobina. Se tomó la tempreatura axilar y en presencia de fiebre se realizaba un test enzimático rápido para el diagnóstico de malaria. El estudio entomológico consistió en la recogida de mosquitos rociados con piretrum. En total 6,557 mosquitos anófeles hembra de 1,440 viviendas fueron analizados para infeción de esporozoito usando técnicas de PCR, y la tasa de inoculación entomológica fue determinada para cada estrato a través de las diferentes regiones
Thermal analysis of a miniature magnetic fluid seal installed in an implantable rotary pump
No full textThe capacity of a magnetic fluid (MF) seal is decreased by increased MF temperature. A cooling system for MF is limited in a miniature MF seal installed in an implantable rotary pump. MF temperature in an MF seal installed in an implantable rotary pump was studied. The temperature of MF in a rotary pump was measured in vitro. Also, steady-state thermal analyses were conducted for an implantable rotary pump model. The results showed that (1) the decrease in magnetization of an MF due to increased temperature is negligible when the heat transfer coefficient of the seal housing is greater than 500 W/(m2·K) and (2) the increased temperature is mainly due to heat flux from the motor, and the magnitude of temperature increase due to viscous friction in the MF is low. In conclusion, an MF seal can be used in an implantable rotary pump from the standpoint of heat characteristics
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