1,721,177 research outputs found
Dai 'servizi pubblici' ai 'servizi di pubblica utilità': evoluzione della morfologia giuridica dell'interesse pubblico e riflessi sulle situazioni soggettive
No full textComunicazione presentata al convegno su "La tutela giurisdizionale nei confronti del potere amministrativo
e “le ragioni” dell’interesse pubblico", svoltosi a Siena il 12 e 13 giugno 2009 quale VIII edizione
delle Giornate di studio sulla giustizia amministrativa dedicate a E. Cannada Bartoli e nell’ambito del
programma INTERLINK su Politica e amministrazione. Pubblicata nei relativi atti in: AUTORI VARI - A. CONTIERI, F. FRANCARIO, M. IMMORDINO, A. ZITO CUR. L'interesse pubblico tra politica e amministrazione. (vol. II, pp. 769-806). ISBN: 978-88-6342-188-0. NAPOLI: Editoriale Scientifica (ITALY)
Analisi sperimentale della circolazione del ciclista
No full textVengono relazioni gli esiti di una campagna sperimentale di rilevamento della condotta di guida dei ciclisti in ambito urbano
AZO/SiO2 ve a-ZITO ince filmlerin saydam ısıtıcı ve ısı yansıtma uygulamalarına yönelik optimizasyonu
No full textIn this study, AZO/SiO2 and amorphous In-Zn-Sn-oxide (a-ZITO) functional coatings were developed with combinatorial approach for transparent heater and heat reflecting applications. AZO/SiO2 and amorphous In-Zn-Sn-oxide (a-ZITO) coatings were obtained via magnetron sputtering. A series of optimization steps were carried out specific to each method and coating type. The samples were produced on 75x50 mm2 glass substrates. Further, optimum post-deposition annealing conditions were identified as 400 °C and Ar+%4 H2 atmosphere to improve electrothermal properties.
750 nm thick and polycrystalline AZO/SiO2 coatings displayed impressive room-temperature electrical conductivity of nearly 3774 S/cm with a sheet resistance of 3.53 Ω/□, carrier concentration of 1.14x1021 cm-3, and Hall mobility of 20.48 cm2/Vs. These films exhibited very high optical transmittance (96%) in the visible range and reflectance (73% at 2.5 µm) in the NIR region. Electrothermal tests demonstrated that the achievable saturation temperature was 161 °C with a power density of 5981 W/m2 in case of applying 12 V. Deicing tests were performed with samples cooled to -40 °C and resulted with complete removal of ice/water only within 180 s.
a-ZITO coatings were deposited using a 3” sputtering target on substrates held at 150 °C. This target was prepared within a particular oxide composition which was determined via combinatorial approach. The films were remained amorphous after the annealing step and demonstrated room-temperature electrical conductivity of 1805 S/cm, sheet resistance of 7.49 Ω/□, carrier concentration of 0.3x1021 cm-3, and Hall mobility of 36.59 cm2/Vs. The transmission in the visible range and reflectance at 2.5 µm were measured as 86% and 35%, respectively. a-ZITO coating was displayed a saturation temperature of 112 °C and a power density of 4635 W/m2 whereas defrosting within 173 s (initial temperature -40 °C) was observed with 12 V input.Bu tez çalışmasında, saydam ısıtıcı ve ısı yansıtıcı uygulamalarına yönelik olarak AZO/SiO2 ve amorf In-Zn-Sn-oksit (a-ZITO) fonksiyonel kaplamalar geliştirilmiştir. Her iki kaplama türü de magnetron sıçratma yöntemi ile üretilmiş, fakat a-ZITO kaplamaların geliştirilmesinde kombinatoryal yöntemden faydalanılmıştır. Nihai fonksiyonel kaplamalara bir dizi optimizasyon sonrası ulaşılmıştır. Örnekler 75x50 mm2 cam altlıklar üzerinde biriktirilmiştir. Ayrıca, elektrotermal özelliklerin iyileştirilmesi için biriktirme sonrası tavlama koşulları 400 °C ve Ar+%4 H2 atmosferi olarak belirlenmiştir.
750 nm kalınlıkta ve polikristalin yapıda üretilen AZO/SiO2 kaplamalar, oda sıcaklığında 3774 S/cm elektriksel iletkenlik, 3,53 Ω/□ düzlemsel direnç, 1,14x1021 cm-3 taşıyıcı konsantrasyonu ve 20,48 cm2/Vs Hall mobilitesi değerlerini sağlarken, görünür bölgede %96 ışık geçirgenliği ve 2,5 µm’de %73 reflektans sergilemiştir. Elektrotermal testler, 12 V uygulama durumunda 5981 W/m2 güç yoğunluğu ile yüzey doyum sıcaklığının 161 °C olduğunu göstermiştir. Buz giderme testleri, -40 °C'ye soğutulmuş numunelerle gerçekleştirilmiş ve tüm buz ve suyun giderilmesi için gereken sürenin 180 saniye olduğunu ortaya koymuştur.
Nihai, a-ZITO kaplama kompozisyonu kombinatoryal biriktirme yöntemi kullanılarak belirlenmiş ve bu kompozisyon dahilinde üretilen hedef malzemeden, 150 °C altlık sıcaklığında kaplamalar oluşturulmuştur. 750 nm kalınlığındaki ZITO kaplamalar, tavlama sonrası da amorf yapıyı korumuştur. Bu kaplamaların, oda sıcaklığı elektriksel iletkenliği 1805 S/cm, düzlemsel direnci 7,49 Ω/□, taşıyıcı konsantrasyonu 0,3x1021 cm-3 ve Hall mobilitesi 36,59 cm2/Vs olarak belirlenirken, görünür bölge ışık geçirgenliği %86 ve 2,5 µm’de reflektans değeri %35 şeklinde ölçülmüştür. 12 V gerilim altında yüzey doyum sıcaklığı 112 °C, güç yoğunluğu 4635 W/m2 ve -40 °C’den başlayacak şekilde buz giderme süresi 173 saniye olarak saptanmıştır.M.S. - Master of ScienceTUBITA
De la Méditerranée au Canada: questions d'eau, de climat et d'environnement
No full textWater issues, Climatic change and Environnement in Canada, with reference on Mediterranean Countries
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
COINVOLGIMENTO DELLA NEURITINA NELLA MIGRAZIONE DEI NEURONI GNRH: EVIDENZE SPERIMENTALI IN VITRO ED IN VIVO
Full text linkIn this thesis we studied Neuritin (also called Nrn or cpg15), a GPI-anchored protein identified among a pool of candidate plasticity-related genes induced by kainate in rat hippocampal dentate gyrus (Nedivi, Hevroni et al. 1993). It has been shown that it is involved in neurites elongation and in promoting synaptic maturation (Putz, Harwell et al. 2005). Neuritin acts in a non-cell autonomous manner to coordinately regulate the growth of apposing dendritic and axonal arbors. Its expression is regulated by neurotrophines, NGF, calcium levels and androgens. Our previous studies demonstrated that NGF up-regulates Nrn expression during PC12 neuron differentiation, and that Nrn enhances the differentiating effects of NGF on PC12 cells favoring the extension of longer neurites (Cappelletti, Galbiati et al. 2007). Interestingly, Nrn expression peaks during neuronal development and, particularly, in the embryonic proliferative zones. During embryogenesis one of the most important aspects is the active neuronal migration in order to reach the final position and obtain the correct development of the nervous system. The migration of neurons and precursor cells involves molecular mechanisms which are often similar to those involved in neurite outgrowth. The generation of the GnRH neuron network, that plays a key role in the regulation of the reproduction system, represent a particular example of neuronal migration. These neurons generates from the olfactory epithelium and move to the hypothalamus where they exerts their regulatory function. For this reason a neuronal immortalized cell line of GnRH neurons, named Gn11 cells, is considered a good model to study neuronal migration (Radovick, Wray et al. 1991; Maggi, Pimpinelli et al. 2000; Cariboni, Maggi et al. 2007). A preliminary microarray analysis performed on Gn11 cells showed neuritin as one of the most abundant genes expressed in this cell line, leading us to hypothesize that it is involved in the neuronal migration process. To demonstrate this hypothesis, we analyzed neuritin mRNA and protein expression levels in different cell lines, characterized by a different migratory behavior. Interestingly, neuritin expression is much higher in migrating than in non-migrating cells. In Boyden microchemotaxis and wound-healing assays, the migratory ability of Gn11 cells is reduced when neuritin expression is silenced, while it is increased by neuritin over-expression. We also demonstrated through a Boyden microchemotaxis assay that the over-expression of Nrn in primary culture of ganglionic eminences (the area generating the migrating interneurons) increases interneuron migration. Furthermore, our hypothesis is strenghtened by results obtained with the selective elettroporation of ganglionic eminences of rat’s E16 brain slices indicating an increased migration of interneurons when neuritin is over-expressed.
Post-translational modifications of alpha-tubulin are known to be associated with microtubule dynamics. ICC and Western blot analyses showed an enrichment of stable microtubules, that likely reflects the diminished migratory capability of the cells, in neuritin silenced cells; moreover, neuritin over-expression, that induces an increase in the migratory ability in the cells, is also able to up-regulates the tyrosinated form of a-tubulin reflecting the presence of more dynamic microtubules.
Altogether these data demonstrate a novel function of neuritin in promoting migration of neuronal cells, both in vitro and in vivo, through the modulation of microtubule stability, and makes neuritin a good candidate as a therapeutic target for different diseases in which cellular migration is involved.
Cappelletti, G., M. Galbiati, et al. (2007). "Neuritin (cpg15) enhances the differentiating effect of NGF on neuronal PC12 cells." J Neurosci Res 85(12): 2702-2713.
Cariboni, A., R. Maggi, et al. (2007). "From nose to fertility: the long migratory journey of gonadotropin-releasing hormone neurons." Trends Neurosci 30(12): 638-644.
Maggi, R., F. Pimpinelli, et al. (2000). "Immortalized luteinizing hormone-releasing hormone neurons show a different migratory activity in vitro." Endocrinology 141(6): 2105-2112.
Nedivi, E., D. Hevroni, et al. (1993). "Numerous candidate plasticity-related genes revealed by differential cDNA cloning." Nature 363(6431): 718-722.
Putz, U., C. Harwell, et al. (2005). "Soluble CPG15 expressed during early development rescues cortical progenitors from apoptosis." Nat Neurosci 8(3): 322-331.
Radovick, S., S. Wray, et al. (1991). "Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice." Proc Natl Acad Sci U S A 88(8): 3402-3406
Definizioni e principi in materia di accesso - Art. 22 l. 241/1990
No full textIl saggio indaga il tema della disciplina dell’accesso ai documenti amministrativi, come modificata dalla L. 11 febbraio 2005, n. 15. La legge, modificando le disposizioni dell’art. 22 L. 241/1990, opera un significativo ampliamento della tutela accordata ai cittadini che, interagendo con la pubblica amministrazione, vedono riconosciuto il loro diritto di accesso. Dopo aver esaminato le definizioni previste nel comma 1, si approfondisce il dibattito relativo alla natura giuridica dell’accesso e le altre disposizioni contenute nei commi seguenti. Emerge un progressivo ampliamento del principio di trasparenza amministrativ
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