600 research outputs found
Sabino Springett, el creador
No full textLa obra de Sabino Springett constituye un imaginario indeludible en la plástica contemporánea peruana; todos poseemos en la memoria fragmentos de su obra y algunos también del propio Sabino... Al margen de su verdadero nombre o datos míticos y no necesariamente ciertos acerca de su origen como artista, estamos ante una realidad contundente y material que trasciende cualquier anécdota, leyenda e incluso a la muerte misma: su obra. Ésta constituye una poética muy interesante sin duda, un valioso patrimonio artístico, y además una enseñanza de la cual podemos extraer su entrega sincera a todo lo que afrontó en la vida: la pintura por supuesto y al Perú mismo
Assessing user experiences within interaction: experience as a qualitative state and experience as a causal event
No full textBreakfast on a Dragon’s Tail: and Other Book Bites by M. Springett
No full textSpringett, Martin. Breakfast on a Dragon’s Tail: and Other Book Bites. Markham, ON: Fitzhenry and Whiteside, 2011. Print. This unusual volume by award-winning illustrator/author Martin Springett takes the “choose your own ending” idea to a whole new level by not providing an ending at all. In fact the whole book is made up of thirteen beginnings of stories, each accompanied by a full-page illustration, which might have served as a book cover. The book is designed to promote creative activities. Springett tells children that each story “should have a beginning, a middle and an end” and that he has provided the beginning. He encourages children to finish the stories in any way they like, through creative endeavors ranging from poetry to a “chalk drawing on the sidewalk”. Children are also encouraged to post their stories to publisher Fitzhenry and Whiteside’s website, where “teachers and parents will also find useful information and classroom activities”. Springett’s art-work depicts the fantastic in each story. The first image, accompanying Breakfast on a Dragon’s Tail, is bordered by patterns that recall a medieval illuminated manuscript. In the same vein, the letter “O” which begins the story is embellished with a dragon curled around it. The others are more cartoon-like. Springett’s writing is very good . His story beginnings are engaging. In the Twelve Dancing Crocodiles the reader finds out that a magician and twelve dancing princesses have disappeared. Are they the twelve dancing crocodiles? They are if you want them to be. In The Nattering Tree, people sit under a tree and listen as the tree talks to itself. There are also lots of good one-line jokes in the story beginnings. In the Dithering Ducks of Deptford, one of the ducks says, “Never listen to a gnome! They are born naughty!” Another story, which has nothing to do with computers, is called Chip and Pin. In Dracula and Son, Springett irreverently refers to the characters as “Papa Drac” and “Drac Junior”. It would have been entertaining to read Springett’s versions of the endings. In fact, some children may be put off by the fact that they have to think up their own endings and entertain themselves. Because of that, this book will probably work best in a structured environment, where children have a reason to stay on track and complete the stories. Overall this book is an interesting concept, that is probably best suited to the classroom environment, so it is recommended with that reservation.Recommendation: 3 stars out of 4 Reviewer: Sandy Campbell Sandy is a Health Sciences Librarian at the University of Alberta, who has written hundreds of book reviews across many disciplines. Sandy thinks that sharing books with children is one of the greatest gifts anyone can give
Differences in post‐mortem findings after stillbirth in women with and without diabetes
No full textAims: The reason for the fivefold increased risk of stillbirth in women with diabetes is not known. Further understanding of the underlying mechanisms may facilitate identification of pregnancies at increased risk. We have compared post-mortem reports in matched pairs of stillbirths in women with and without diabetes. Methods: Post-mortem reports were provided by the Centre for Maternal and Child Enquiries. Stillbirths as a result of lethal congenital and genetic abnormalities were excluded. Whole body, placenta and organ weights and histo-pathological findings in cases and controls were compared and also related to published reference values. Results: We analysed post-mortem reports on 23 matched pairs of stillbirths from 2009 to 2010. Mean placental weight in women with diabetes was 75 g less than in control subjects (95% CI -143 to -7 g; P = 0.032). In maternal diabetes, the thymus was often small and showed a 'starry sky' pattern on histology in 11 of 20 cases compared with four of 22 controls (P = 0.03). This histological finding was associated with a particularly low mean placental weight z-score -2.1 (1.1) standard deviations below a reference population corrected for gestational age. Conclusions: In over half of the stillbirths occurring in women with diabetes, there was a 'starry sky' appearance in the fetal thymus on histology, this being associated with a small placenta. These findings are consistent with a critical subacute metabolic disturbance being a prominent cause of the increased risk of stillbirth in pregnancies complicated by maternal diabetes.</p
Identification of a family of cAMP-binding guanine nucleotide exchange factors by Gregory M. Springett.
No full textThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.Vita.Includes bibliographical references (leaves 137-139).Ph.D
PPO.28 Birth prevalence and one year survival of congenital diaphragmatic hernia, England and Wales, 2002-2011
No full textBACKGROUND: Congenital diaphragmatic hernia (CDH) is the failure of the diaphragm to develop and fuse properly during fetal development, allowing the abdominal organs to push up into the chest cavity. Newborn infants with CDH often have severe respiratory distress which can be life-threatening unless treated appropriately. The aim of this study was to determine the birth prevalence, characteristics, antenatal diagnosis, pregnancy outcome and survival of cases with CDH.METHODS: Six regional congenital anomaly registers (covering 36% of births in England and Wales) from 2002-2011 contributed 743 cases to this study.RESULTS: The overall birth prevalence of CDH was 3.4 (95% CI: 3.1-3.6) per 10,000 births; there was no significant change in the birth prevalence over the ten years. Sixty-one percent were isolated, 27% were associated with another structural anomaly (multiple) and 12% had a chromosomal anomaly (36% Edwards, 9% Patau syndrome). Sixty-six percent of isolated, 80% of multiple and 83% of chromosomal CDH cases were antenatally diagnosed. The majority of cases with isolated and multiple CDH were live born (84% and 62% respectively), whereas 58% of CDH pregnancies associated with a chromosomal anomaly ended in a termination (58%). The 1-year survival of live born babies was higher in isolated CDH (75%) compared to multiple (64%) and chromosomal CDH cases (57%).CONCLUSIONS: The prevalence of CDH remained constant over the past 10 years. Sixty-one percent of CDH cases were isolated, of whom 66% were antenatally diagnosed. One-year survival in isolated cases was only 75%
Comparison of foot pain and foot care among rheumatoid arthritis patients taking and not taking anti-TNF? therapy: an epidemiological study
No full textEpidemiological studies report foot pain affects more than 90% of people with rheumatoid arthritis (RA). Most data about foot involvement in RA were collected prior to the availability of novel treatments such as biologics. The objective of this study is to compare the prevalence of foot symptoms, frequency of foot examination, and access to foot care services among RA patients currently treated with anti-TNF? to those not receiving biologics. This study is a cross-sectional epidemiological study: a 28-item self-administered questionnaire was posted to 1,040 people with RA throughout the UK. Overall, 585 (55%) useable replies were received, and 120 (20.5%) respondents were currently taking anti-TNF? medication. Prevalence of current foot pain was 99% among the biologics group compared with 76% not treated with biologics. Stiffness, swelling, and numbness in the feet were all significantly more common in the anti-TNF? group (P < 0.05). Most respondents (90%) taking biologics discussed their foot pain with their rheumatologist, but only 70% were receiving podiatry (compared to 78% not taking anti-TNF?). Subjects reported that their feet were examined significantly less frequently (P < 0.001) than their hands. Foot complaints are common in this group, and allied health professions could enhance rheumatological care by undertaking foot assessment
Venous-arteriolar reflex in human gastrocnemius studied by NIRS.
No full textHeat-up tilting manoeuvre from 0 to 60 degrees induces oxygenated and deoxygenated haemoglobin concentration changes in the human gastrocnemius. These changes, measured by NIRS, can only be partially explained by the blood volume displacement due to the gravitational force. In the present study it is demonstrated, by a dye dilution technique (indocyanine green), that a reduction in blood flow (venous-arteriolar and/or spinal reflex) is responsible of the limited oxyhaemoglobin concentration increase observed when going from 0 (2.54 +/- 0.48 blood flow in arbitrary units, a.u.) to 60 (1.46 +/- 0.55 a.u.) degrees. The proposed technique is potentially applicable to the detection of specific pathological aspects of microcirculation, such as arterial occlusion in the leg, diabetes mellitus, and congestive heart failure, where the venous-arteriolar reflex may be affected
Thermodynamic efficiency, reversibility, and degree of coupling in energy conservation by the mitochondrial respiratory chain
No full textThe protonmotive mitochondrial respiratory chain, comprising complexes I, III and IV, transduces free energy of the electron transfer reactions to an electrochemical proton gradient across the inner mitochondrial membrane. This gradient is used to drive synthesis of ATP and ion and metabolite transport. The efficiency of energy conversion is of interest from a physiological point of view, since the energy transduction mechanisms differ fundamentally between the three complexes. Here, we have chosen actively phosphorylating mitochondria as the focus of analysis. For all three complexes we find that the thermodynamic efficiency is about 80-90% and that the degree of coupling between the redox and proton translocation reactions is very high during active ATP synthesis. However, when net ATP synthesis stops at a high ATP/ADP(Pi)(.)ratio, and mitochondria reach "State 4" with an elevated proton gradient, the degree of coupling drops substantially. The mechanistic cause and the physiological implications of this effect are discussed. Wikstrom and Springett analyze the thermodynamic efficiency of redox reactions and proton translocation by the complexes of mitochondrial respiratory chain. They report that the thermodynamic efficiency is about 80-90% and that the degree of coupling between the redox and proton translocation reactions is very high during active ATP synthesis, but decreases when ATP synthesis stops.Peer reviewe
Participatory practice community-based action for transformative change
No full textParticipatory Practice explores the core ideas of participatory practice and how theory and practice can be integrated to achieve transformative change. The ideas in the book are founded on two premises: firstly, that transformative practice begins in the everyday stories that people tell about their lives and that practical theory generated from these narratives is the best way to inform both policy and practice. Secondly, that participatory practice is a tool for examining this knowledge in that it allows practitioners to examine the way they view the world and to situate their local practice within bigger social issues. The book is expected to be of interest to both academics and community-based practitioners. Professor Springett commented: “Writing the book was a transformative experience in itself because we had to cross the divide between our different professions. The idea to write it came from our joint concern for the appropriation of the language of participation by many politicians and agencies without a real examination of what true participation actually consists of.
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