339 research outputs found
Episodes toward a Fluxarchitecture. The work of George Maciunas, Shadrach Woods and Joachim Pfeufer
No full textFluxus, an artistic movement that emerged in 1960, crossed borders within the arts. Soon it expanded to include sculpture, poetry, performance, photography, and cinema, taking on a multi-disciplinary character that regularly crossed or erased borders within the arts. Its relationship to architecture, however, is more complex. In the 1960s, a few architects sought to resolve contradictions between the principles of Fluxus and the presumptions of their own field, and explored the possibilities of change —flux— in architectural practice. This article will investigate possible connections between Fluxus and the architectural practices. It considers three figures who were both theorists and architects: Georges Maciunas, Shadrach Woods and Joachim Pfeufer. Their practices, considered together, form what in this article I coin “fluxarchitecture”.Fluxus, un movimiento artístico que surgió en 1960, atravesó fronteras dentro de las artes. Pronto se expandió e incluyó escultura, poesía, performance, fotografía y cine, adquiriendo un carácter multidisciplinario que regularmente cruzaba o borraba las fronteras dentro de las artes. Sin embargo, su relación con la arquitectura es más compleja. En la década de 1960, algunos arquitectos buscaron resolver las contradicciones entre los principios de Fluxus y las presunciones de su propio campo, y exploraron las posibilidades de cambio —flux— en la práctica arquitectónica. Este artículo investigará posibles conexiones entre Fluxus y las prácticas arquitectónicas. Presta atención a tres figuras de teóricos y arquitectos: Georges Maciunas, Shadrach Woods y Joachim Pfeufer. Sus prácticas, consideradas en conjunto, forman lo que en este artículo acuño como “fluxarchitecture”
The human extracellular matrix signal molecule hCYR61 expression is associated with conditions of enhanced bone formation and with the proliferative state of osteoblasts.
No full textThe human extracellular matrix signal molecule hCYR61 expression is associated with conditions of enhanced bone formation and with the proliferative state of osteoblasts.
No full textApolipoprotein E gene polymorphisms and thrombosis and restenosis after coronary artery stenting.
No full textExperimental data support a protective function of apolipoprotein E (apoE) against restenosis, the main factor limiting the long-term benefit of percutaneous coronary interventions. We investigated the possibility that the single nucleotide polymorphisms (SNPs) -219G/T, 113G/C, 334T/C, and 472C/T of the gene encoding apoE (APOE) are associated with the incidence of death and myocardial infarction or restenosis after stenting in coronary arteries. In addition, we asked whether the apoE isotype-related epsilon2/epsilon3/epsilon4 polymmorphism, defined by specific allele combinations (haplotypes) of the 334T/C and 472C/T polymorphism, and other APOE haplotypes, derived from all four SNPs investigated, are associated with adverse clinical and angiographic outcomes after stenting. Our study included 1,850 consecutive patients with symptomatic coronary artery disease (CAD) who underwent stent implantation. Follow-up angiography was performed in 1,556 patients (84.1%) at 6 months after the intervention. We found that none of the APOE SNPs is associated with death and myocardial infarction or restenosis after stenting. In addition, we observed no relationship between APOE haplotypes and adverse outcomes. In conclusion, the APOE -219G/T, 113G/C, 334T/C, and 472C/T polymorphisms, either alone or in combination, do not represent genetic markers of the risk of thrombotic and restenotic complications in patients with CAD treated with coronary stenting. Koch, W.J. Mehilli, A. Pfeufer, A. Schomig, and A. Kastrati. Apolipoprotein E gene polymorphisms and thrombosis and restenosis after coronary artery stenting
The expression of the signal molecule cystein rich protein 61 is associated with conditions of enhanced bone formation and remodeling
No full textIdentification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders
No full textElevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in Drosophila melanogaster and Danio rerio identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. In addition, genetic susceptibility to increased heart rate is associated with altered cardiac conduction and reduced risk of sick sinus syndrome, and both heart rate-increasing and heart rate-decreasing variants associate with risk of atrial fibrillation. Our findings provide fresh insights into the mechanisms regulating heart rate and identify new therapeutic targets
L'homo diligens, archétype du visiteur du Poïpoïdrome (Robert Filliou et Joachim Pfeufer) et d'un être empathique
No full textLe sociologue Alain Caillé (2009) constate que l’équilibre entre les logiques de relations structurées par le profit et celles détachées de l’intérêt, telle l’empathie, a aujourd’hui été rompu en faveur de la figure de l’homo œconomicus, une personne égoïste dont le comportement est régi par son intérêt particulier. L’œuvre artistique de Robert Filliou et Joachim Pfeufer, le Poïpoïdrome, centre d’inutilité publique, résonne avec ce positionnement critique contre l’idéologie utilitariste. Conceptualisée dès 1963, cette œuvre fut imaginée comme un espace de rencontre, de participation, de disponibilité et d’indétermination. À partir du Poïpoïdrome comme espace participatif favorisant l’empathie, nous mettrons en éclairage le lien entre Robert Filliou et l’utopiste Charles Fourier, nous poserons l’hypothèse de la figure d’un homo diligens, figure conceptuelle d’une personne guidée par l’amour, comme archétype du visiteur du Poïpoïdrome et d’un être empathique. The sociologist Alain Caillé (2009) notes that the balance between the logic of relationships structured by profit and those detached from interest, such as empathy, has now been broken in favour of the figure of homo œconomicus, a selfish person whose behaviour is governed by his or her particular interest. Robert Filliou and Joachim Pfeufer’s artistic work, the Poïpoïdrome, a centre of public uselessness, resonates with this critical stance against utilitarian ideology. Conceptualised in 1963, the work was imagined as a space for encounters, participation, availability and indeterminacy. Using the Poïpoïdrome as a participatory space that fosters empathy, we will highlight the link between Robert Filliou and the utopian Charles Fourier, and put forward the hypothesis of the figure of homo diligens, a conceptual figure of a person guided by love, as the archetypal visitor to the Poïpoïdrome and an empathetic person
Genetics of the ECG: QT or not QT- A genetic analysis of a complex electrophysiological trait confirms several previously detected associations.
No full textGenetic structure of Europeans: a view from the North-East
No full textUsing principal component (PC) analysis, we studied the genetic constitution of 3,112 individuals from Europe as portrayed by more than 270,000 single nucleotide polymorphisms (SNPs) genotyped with the Illumina Infinium platform. In cohorts where the sample size was >100, one hundred randomly chosen samples were used for analysis to minimize the sample size effect, resulting in a total of 1,564 samples. This analysis revealed that the genetic structure of the European population correlates closely with geography. The first two PCs highlight the genetic diversity corresponding to the northwest to southeast gradient and position the populations according to their approximate geographic origin. The resulting genetic map forms a triangular structure with a) Finland, b) the Baltic region, Poland and Western Russia, and c) Italy as its vertexes, and with d) Central- and Western Europe in its centre. Inter- and intra- population genetic differences were quantified by the inflation factor lambda (lambda) (ranging from 1.00 to 4.21), fixation index (F(st)) (ranging from 0.000 to 0.023), and by the number of markers exhibiting significant allele frequency differences in pair-wise population comparisons. The estimated lambda was used to assess the real diminishing impact to association statistics when two distinct populations are merged directly in an analysis. When the PC analysis was confined to the 1,019 Estonian individuals (0.1\% of the Estonian population), a fine structure emerged that correlated with the geography of individual counties. With at least two cohorts available from several countries, genetic substructures were investigated in Czech, Finnish, German, Estonian and Italian populations. Together with previously published data, our results allow the creation of a comprehensive European genetic map that will greatly facilitate inter-population genetic studies including genome wide association studies (GWAS)
The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts
No full textA SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI and homozygosity for the minor allele was first observed in data from a genome-wide association scan of 86,604 SNPs in 923 related individuals from the Framingham Heart Study offspring cohort. The association was reproduced in four additional cohorts, but was not seen in a fifth cohort. To further assess the general reproducibility of this association, we genotyped rs7566605 in nine large cohorts from eight populations across multiple ethnicities (total n = 16,969). We tested this variant for association with BMI in each sample under a recessive model using family-based, population-based, and case-control designs. We observed a significant (p < 0.05) association in five cohorts but saw no association in three other cohorts. There was variability in the strength of association evidence across examination cycles in longitudinal data from unrelated individuals in the Framingham Heart Study Offspring cohort. A combined analysis revealed significant independent validation of this association in both unrelated (p = 0.046) and family-based (p = 0.004) samples. The estimated risk conferred by this allele is small, and could easily be masked by small sample size, population stratification, or other confounders. These validation studies suggest that the original association is less likely to be spurious, but the failure to observe an association in every data set suggests that the effect of SNP rs7566605 on BMI may be heterogeneous across population samples
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