678 research outputs found
Ude Garami desde inmovilización
No full textVídeo demostrativo de la técnica de Judo en suelo Ude Garami, Entangled Arm Lock o Bloqueo por enroscamiento del brazo desde la posición de inmovilización
Ude Garami desde Tori Boca Arriba
No full textVídeo demostrativo de la ejecución de la técnica de Judo Ude Garami, Entangled Arm Lock o Bloqueo por Enroscamiento del Brazo desde Tori posición boca arriba y Uke sobre él
Thermoregulation: from basic neuroscience to clinical neurology. 1
No full textThe importance of problems associated with thermoregulation has been increasing. During recent decades, several major heatwaves have hit various regions of the planet, resulting in thousands of deaths due to heatstroke, and scientists have established that the threat to human life due to excessive heat associated with human activities is now unavoidable.
During the same time period, mild hypothermia has been discovered as a life-saving treatment for several conditions, most notably those accompanied by brain hypoxia. Simultaneously, many things have changed in our understanding of the physiology and neuroscience of body temperature regulation. It has been established that brown adipose tissue is a thermoregulatory effector in humans – not only during the perinatal period (as thought previously), but also in adulthood. Several transient receptor potential channels have been discovered, many of which possess high sensitivity to temperature and may represent the molecular basis of thermoreception. Enormous progress has been achieved in the identification and characterization of the neural pathways of physiologic thermoeffectors, at least in rodents, and studies in humans have been initiated. A new, consensus concept has been firmly established: it is now believed that body temperature is regulated not by a unified system with a central integrator, comparator, and coordinator but by a federation of independent thermoeffector loops, which coordinate their activities via their common regulated variable – body temperature.
To update neurologists, neuroscientists, trainees, and others on the current knowledge about thermoregulation, we have drawn on the experience and expertise of established leaders in the fields of thermoregulation and neurologic diseases and, collectively, prepared the two parts of this volume of the Handbook of Clinical Neurology. Part 1 (28 chapters) describes the elements of the thermoregulation system (receptors, effectors, and pathways) and explains how the system works and interacts with other homeostatic systems. Part 2 (26 chapters) deals with the clinical significance of body temperature, common conditions in which deep or peripheral body temperatures are changed, and thermoregulatory alterations present in several neurologic diseases, as well as with therapeutic hypo- and hyperthermia and antipyretic therapy.
While working on this project, all authors have made an effort to follow the current consensusmodel of thermoregulation and to avoid referring to the outdated unified control system with its nonexistent complex circuits. The authors also avoided using engineering terms such as the reference signal (set point) or coordinator, as they are now more misleading than informative. We hope our effort will help neurologists to focus their search for the anatomic and physiologic substrates of thermoregulatory symptoms of neurologic diseases on the existing active and passive elements of the thermoregulation system.
As the associate volume editors and the volume editor, we sincerely thank all the contributors to this volume for the indispensable roles they have played in bringing this endeavor to fruition.We believe that readers will find this volume to be a valuable contribution to the existing literature on thermoregulation.We hope that the volume will serve not only as a reference source for academic and practicing neurologists, but also as an educational resource for trainees in neurology and neuroscience, as well as for internists, intensivists, anesthesiologists, toxicologists, and all physicians and scientists interested in learning about thermoregulation. May our readers glean much from the collective knowledge and expertise shared with them on these pages.
Andras Garami
Luca Imeri
Christopher J. Madden
Alexandre A. Steiner
Andrej A. Romanovsk
Establishing an Internet Based Paediatric Cancer Registration and Communication System for the Hungarian Paediatric Oncology Network
No full textCancer registration has developed in Europe over the last 50 years, and in the last decade intensive joint activities between the European Cancer Registries, in response to the need of pan-European harmonization of registration practices, have taken place. The Hungarian Paediatric Cancer Registry has been functioning as the database of the Hungarian Paediatric Oncology Network since 1971, aiming to follow the incidence and the treatment efficacy of malignant diseases.The goals of this globally unique open source information system are the following: 1) to raise the quality of the registration system to the European level by developing an Internet-based registration and communication system, modernizing the database, establishing automatic statistical analyses and adding an Internet website, 2) to support clinical epidemiological studies that we conduct with international collaborators on detailed analyses of the characteristics of patients and their diseases, evaluation of new diagnostic and therapeutic methods, prevention programs, and long-term quality of life and side effects.The benefits of the development of the Internet-based registration and communication system are as follows: a) introduction of an Internet-based case reporting system, b) modernization of the registry database according to international recommendations, c) automatic statistical summaries, encrypted mail systems, document repository, d) application of data security and privacy standards, e) establishment of a website and compilation of educational materials.The overall objective of this scientific project is to contribute towards the improvement of cancer prevention and cancer care for the benefit of the public in general and of cancer patients in particular
Felsőoktatási továbbtanulás kistérségi összefüggései
No full textAzt tudjuk, hogy a közoktatási eredményességet befolyásolja az iskolák térségi elhelyezkedése (lásd Garami Erika kutatásait, például: Garami, 2003, 2009, 2013 vagy Kocsis, 2010). Ebben az írásban azt a (kutatási) kérdést vizsgáljuk, hogy a felsőoktatási továbbtanulás hogyan függ össze a továbbtanulásra jelentkezők kistérségi lakóhelyével. Hipotézisünk szerint, mint ahogy a közoktatási eredmények, úgy a felsőoktatási továbbtanulás is együttmozog a kistérségek fejlettségével, a továbbtanulási törekvés és a tényleges továbbtanulás annál nagyobb arányú, minél fejlettebb egy kistérsé
Cerebral microembolism during transradial coronary angiography: comparison between single and double catheter strategy
No full textA Penny Market által forgalmazott mogyorókrém termékfejlesztése az UTZ Certified program tükrében
No full textFactors underlying cognitive decline in old age and Alzheimer's disease: the role of the hippocampus.
No full textThere are many factors that strongly influence the aetiology, development, and progression of cognitive decline in old age, mild cognitive impairment (MCI), and Alzheimer’s disease (AD). These factors include not only different personality traits and moods but also lifestyle patterns (e.g. exercise and diet) and awareness levels that lead to cognitive decline in old age. In this review, we discuss how personality traits, mood states, and lifestyle impact brain and behaviour in older adults. Specifically, our review shows that these lifestyle and personality factors affect several brain regions, including the hippocampus, a region key for memory that is affected by cognitive decline in old age as well as AD. Accordingly, appropriate recommendations are presented in this review to assist individuals in decreasing chances of MCI, dementia, AD, and associated symptoms
News: Adam Kay: Stories From A Former Medic
No full textThis past Monday, the Robert Smith Lecture Theatre in Saint James’s Hospital filled up —except for the front row, presumably a universal law for any given lecture theatre — for a lunchtime talk with Adam Kay. The former senior registrar in obstetrics and gynaecology, and author of the bestseller This Is Going to Hurt, spoke about his book based on the diaries he kept throughout his years working in the NHS.
Trinity College’s BioSoc hosted the now-TV writer/comedian and awarded him an honorary patronage of the society on the same day as his sold out gig at the National Concert Hall in Dublin. The audience of about 200 was made up largely of medical students, but a good few junior doctors were attending as well — bleeps going off at regular intervals provided a subtle but apropos background for the talk.
The event began by awarding the medal to Kay, followed by a reading of a passage from the book (one of two genital-degloving anecdotes the audience was treated to in the short space of an hour) and a conversation with Rían Hayes, president of BioSoc, who made sure to crush any smidgen of doubt as to whether he had “done his research” for the event. In fairness to him, this did show, and resulted in a nicely flowing and informative conversation. The last part involved the audience in a Q&A session with the comedian.
Kay’s delivery of anecdotes and sarcastic remarks were honoured with a good chuckle each time without fail. In response to a question about whether he had additional funny stories that didn’t make the final cut — he answered with degloving story number two which elicited the same cringe-eliciting response as the first. He went further to compare his work on the book to that of a sound mixer, trying to find the right balance between funny, serious, absurd and tragic, and he made sure his audience got a taste of all sides during his talk. For every story about hungover students ending up face-first in a patient’s abdomen, he also gave glimpses into a life where six out of seven missed Christmases was the norm. An amusing recount of a meeting with British Politician Jeremy Hunt (who more than likely agreed to the meeting to stop the constant stream of Kay’s book addressed to him flooding his office) displayed how the issue of burnout is ever-increasing in the medical profession.
My very first thought after finishing the book (in a single afternoon, which is testament to how entertaining the writing is) was that I should buy this for friends and family, as it conveys the nature of my future occupation more accurately (and probably in an infinitely more entertaining manner) than any of my recounts of personal experiences. Kay confirmed that this was no accident.
“I wanted it to be the books that doctors could say: This is what it’s like!” he said, proving not only that he had very clear intentions with publishing his story, but that the execution was spot-on. Another message that was obviously important to the author, and one that his story very much underlines, is the necessity of healthcare professionals taking good care of themselves and each other. He stressed how vital it is to be armed with some personal way of coping in such a challenging line of work.
One audience member intending to work in the UK inquired about whether things have improved since he left his job in the NHS. Kay gave a sobering reminder of further cuts to the health care budget after 2010 and did no sugarcoating in pointing out how the ultimate solution would be “loads of more money.” He said that objectively, individuals, or even doctors as a group, could do very little to change things in that regard.
On a more positive note, Kay also pressed the importance of making a decision on a career path with “both eyes wide open”, musing on how this crucial choice in his case may have been influenced during medical school by a well-respected registrar. Kay compared different specialties to being like sine waves, some — such as O&G — with extreme highs and lows, and others with somewhat flatter waveforms (insert obvious jab at dermatology), something he strongly advised to take into account when choosing a career.
When the conversation turned to his life as a comedian and TV-writer, Kay didn’t shy away from getting very real about how different the satisfaction that his current job and that being a doctor provided, describing the former as being a lot less tangible and several degrees removed from the impact it was making. This was one of the few times during the talk when some sense of remorse seeped through his words. The same could be felt when he was talking about the end of his days as a doctor, and how hard he found it to open up about what he was going through at the time. As a member of the audience put it afterwards: “Despite how funny he was, you could still sense the sadness he felt around the events that ended his career.”
While many of the answers were based largely on the book, with a good few almost direct quotes from diary entries, Kay’s deadpan delivery kept even those who could see the punchline coming very much entertained. The audience also heard several unwritten stories, for instance painting the hilarious picture of the comedian performing (after a kindly warm-up from Ellie Goulding) a foul-mouthed parody song about the London Underground at Prince Harry’s birthday in St James’s Palace.
Just as reading his book, this talk with Adam Kay was thoroughly entertaining, if somewhat bittersweet. It’s no surprise whatsoever that he seemed to have struck a chord with the crowd in the lecture theatre of a university hospital: his honesty, down to earth personality, and sarcastic humour gave his very important messages about doctors’ well being, or the state of health care a rare degree of authenticity. Apart from heartfelt giggles about the absurdity of what medicine can be at times, Kay’s story and current work also encourage to take the time to make well thought out decisions in pursuing this demanding career. Given the flying start of his new career, and the amount of people he reached one way or another in the last few years, I do believe there is genuine hope for maybe a couple less “guns and badges” handed in before their time down the line – and quite possibly a surge in secret diary-keeping among junior doctors.
Photographs Courtesy Joe Deega
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