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βTrCP-mediated proteolysis of NF-kB1 p105 requires phosphorylation of p105 serines 927 and 932
No full textThis work was supported by the U.K. Medical Research Council, the Arthritis Research Campaign (project grant L0536 to V.L.), and the AINP consortium, EC—5th framework.NF-κB1 p105 functions both as a precursor of NF-κB1 p50 and as a cytoplasmic inhibitor of NF-κB. Following the stimulation of cells with tumor necrosis factor alpha (TNF-α), the IκB kinase (IKK) complex rapidly phosphorylates NF-κB1 p105 on serine 927 in the PEST region. This phosphorylation is essential for TNF-α to trigger p105 degradation, which releases the associated Rel/NF-κB subunits to translocate into the nucleus and regulate target gene transcription. Serine 927 resides in a conserved motif (Asp-Ser927-Gly-Val-Glu-Thr-Ser932) homologous to the IKK target sequence in IκBα. In this study, TNF-α-induced p105 proteolysis was revealed to additionally require the phosphorylation of serine 932. Experiments with IKK1−/− and IKK2−/− double knockout embryonic fibroblasts demonstrate that the IKK complex is essential for TNF-α to stimulate phosphorylation on p105 serines 927 and 932. Furthermore, purified IKK1 and IKK2 can each phosphorylate a glutathione S-transferase-p105758-967 fusion protein on both regulatory serines in vitro. IKK-mediated p105 phosphorylation generates a binding site for βTrCP, the receptor subunit of an SCF-type ubiquitin E3 ligase, and depletion of βTrCP by RNA interference blocks TNF-α-induced p105 ubiquitination and proteolysis. Phosphopeptide competition experiments indicate that βTrCP binds p105 more effectively when both serines 927 and 932 are phosphorylated. Interestingly, however, βTrCP affinity for the IKK-phosphorylated sequence on p105 is substantially lower than that on IκBα. Thus, it appears that reduced p105 recruitment of βTrCP and subsequent ubiquitination may contribute to delayed p105 proteolysis after TNF-α stimulation relative to that for IκBα.Peer reviewe
Grammar [927]
No full textGrammar.
This manuscript is now IO Islamic 1558 in the India Office collections.
[metadata: Otto Loth, A Catalogue of the Arabic Manuscripts in the Library of the India Office, (volume 1), no. 927 here with further notations and hyperlinks].
927.
1558. Uniform with the preceding no.; foll. 223. The second part of the same work, continuing the preceding MS., with which it formed originally one volume.
Dated 4th Sha’bân, 1211, در مقام كنپ فتح كده (Camp Fatḥgaṛh?)
Prefixed is a list of contents.
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PERGESERAN BENTUK DAN MAKNA DALAM TERJEMAHAN ANIME DETECTIVE CONAN EPISODE 927 DAN 928
Get PDFAbstractThe translation is done so the reader can be understood what the first author want to tell the messages. Atranslation can be considered good when the messages of the first author can be understood without anychange or reduction contain meaning. In the process of translating, there will be some addition, and thetranslation cannot be exactly the same as the source language. In that way, there will be a grammatical shiftand shift meaning of the translation. The purpose of this study is to examine how the grammatical shiftfrom Japanese to Indonesian occurred in the translation in the anime Detective Conan episodes 927 and928 as well as how the shift in meaning from Japanese to Indonesian occurred in the translation in the animeDetective Conan episode 927 and 928. This study uses descriptive qualitative research which containsdescriptive data from conversations that come from sources in the form of the anime Detective Conanepisodes 927 and 928. The results are found in the form shift as much as 52 data on shifting levels. In thecategory shift, there are 65 data for structure shifts, there are 9 data for class shifts, 5 data for unit shifts,and 19 data for intra-system shifts. In the shift in meaning in order to a cultural point of view as many as11 data, while the shift in meaning from specific to generic and vice versa there is 1 data.Keywords: translation shift, grammatical shift, shift meaning, anime???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????927 ??928 ??????????????????????????????????????????????????????????????????????????????????????????????????????927 ?? 928 ????????????????????????????????????????????????????? 52 ????????????????????????????????????? 65 ???????????? 9 ????????????? 5 ?????????????? 19 ?????????????????????????? 11 ??????????????????????????? 1 ?????????????????????????????????
Taylor, Stephen (FA 927)
Get PDFFinding aid only for Folklife Archives Collection 927. Paper titled: “A Collection of Gravestone Art in Western Kentucky.” Includes introduction of gravestone art and designs in western Kentucky
EC61-927 Spotlight on Milk
Get PDFExtension Circular 61-927: This circular is about milk and included are many recipes involving milk
El Tlacuache Núm. 927 (2020). 927 Año 19 (2020) abril. El Tlacuache
No full text- Los usos y costumbres de los pueblos indígenas de Morelos, patrimonios en eterna disputa por Luis Migul Morayta Mendoza
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