1,725,255 research outputs found
Phenotypic Characterization and Expression Analysis of P(9036) Mutants
No full text<div><p>(A) P(9036)-mutant larvae show feeding and growth defects as compared to wild-type (wt) controls. In wild-type, red food fills the gut, whereas it accumulates in the pharynx of P(9036) mutants. Physically, the food can pass the mutant pharynx (see arrow).</p>
<p>(B) P(9036) mutants show a wandering behavior, in which they leave the food source (depicted in a schematic snapshot drawing; dots represent larvae outside the food source, which is shown in red).</p>
<p>(C) Quantification of the P(9036) wandering phenotype shows that from 50 individuals, 23 ± 4 mutants can be found outside the food source, in contrast to only 2 ± 1 for the wild-type control at a given time point (<i>n</i> = 8 time points).</p>
<p>(D) The known <i>klu</i> alleles <i>klu</i>XR19, <i>klu</i>R51C, and P(1741) fail to complement P(9036), and trans-heterozygous larvae display the feeding phenotype.</p>
<p>(E) Microarray analysis of P(9036) revealed several neuropeptide genes as being deregulated in P(9036) mutants compared to wild-type controls (×-fold changes in P(9036) are listed; genes with more than 2-fold change are boxed).</p>
<p>(F–H) Semi-quantitative in situ hybridizations to first instar larval brains verify the upregulation of the neuropeptide gene <i>hug</i> in P(9036) <i>klu</i> mutants in comparison to wild-type controls, and show an upregulation of <i>hug</i> in <i>ppl</i> feeding mutants as well. The expression of <i>hug</i> is in the SOG. Anterior points to the upper left corner; ventral views are shown.</p>
<p>(I–K) Semi-quantitative in situ hybridizations to late second instar larval brains demonstrate a downregulation of <i>hug</i> in wild-type under starvation (PBS) and sugar conditions (20% sucrose), in comparison to normal feeding condition (yeast). Anterior points to the upper left corner; ventral views are shown.</p></div
Hawaii mainichi - XXXV, no. 9036
No full textInk smudged along the right side of the cover page of this issue
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Promoting and providing expert guidance in work-intensive clinical settings
No full text10.1007/s12186-010-9036-3Vocations and Learning32141-15
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