1,723,127 research outputs found
Simpson, L R, 8931
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/416944Surname: SIMPSON. Given Name(s) or Initials: L R. Military Service Number or Last Known Location: 8931. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 52042.239506
Item: [2016.0049.49205] "Simpson, L R, 8931
Linked collectors and determiners for: The jumping plant-lice of the Neotropical genus Tainarys (Hemiptera: Psylloidea) associated with Anacardiaceae.
No full textNatural history specimen data linked to collectors and determiners held within, "The jumping plant-lice of the Neotropical genus Tainarys (Hemiptera: Psylloidea) associated with Anacardiaceae". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/833a1d16-a79f-45dc-8931-46524d9844b0">https://bionomia.net/dataset/833a1d16-a79f-45dc-8931-46524d9844b0</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/833a1d16-a79f-45dc-8931-46524d9844b0">https://gbif.org/dataset/833a1d16-a79f-45dc-8931-46524d9844b0</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: The jumping plant-lice of the Neotropical genus Tainarys (Hemiptera: Psylloidea) associated with Anacardiaceae.
No full textNatural history specimen data linked to collectors and determiners held within, "The jumping plant-lice of the Neotropical genus Tainarys (Hemiptera: Psylloidea) associated with Anacardiaceae". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/833a1d16-a79f-45dc-8931-46524d9844b0">https://bionomia.net/dataset/833a1d16-a79f-45dc-8931-46524d9844b0</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/833a1d16-a79f-45dc-8931-46524d9844b0">https://gbif.org/dataset/833a1d16-a79f-45dc-8931-46524d9844b0</a>. Formatted as a Frictionless Data package
A Next Generation Synthesis of BACE1 Inhibitor Verubecestat (MK‑8931)
No full textThe development of
a commercial manufacturing route to verubecestat
(MK-8931) is described, highlights of which include the application
of a continuous processing step to outcompete fast proton transfer
in a Mannich-type ketimine addition, a copper-catalyzed amidation
reaction, and an optimized guanidinylation procedure to form the key
iminothiadiazine dioxide core
BACE1 Inhibitor MK-8931 Alters Formation but Not Stability of Dendritic Spines
Full text linkBeta-site amyloid-precursor-protein cleaving enzyme 1 (BACE1) is the rate limiting protease in the production of the amyloid-beta peptide (A beta), which is considered to be the causative agent in the pathogenesis of Alzheimer's Disease (AD). Therefore, the therapeutic potential of pharmacological BACE1 inhibitors is currently tested in clinical trials for AD treatment. To ensure a positive clinical outcome it is crucial to identify and evaluate adverse effects associated with BACE1 inhibition. Preclinical studies show that chronic blockade of BACE1 activity alters synaptic functions and leads to loss of dendritic spines. To assess the mechanism of synapse loss, dendritic spine dynamics of pyramidal layer V cells were monitored by in vivo two-photon microscopy in the somatosensory cortex of mice, treated with the BACE1 inhibitor MK-8931. MK-8931 treatment significantly reduced levels of A beta 40 and density of dendritic spines in the brain. However, the steady decline in dendritic spine density specifically resulted from a diminished formation of new spines and not from a loss of stable spines. Furthermore, the described effects on spine formation were transient and recovered after inhibitor withdrawal. Since MK-8931 inhibition did not completely abolish spine formation, our findings suggest that carefully dosed inhibitors might be therapeutically effective without affecting the structural integrity of excitatory synapses if given at an early disease stage
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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