1,724,804 research outputs found

    [Eastman Kodak Co., Engine Drawing Card, Sketch No. 8121]

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    This engine drawing card was created for Eastman Kodak Company, Class 6-54 D. Section K-6 D. Sketch 8121. Copy Spec. 30D3

    8117 Fällanden. 8118 Pfaffhausen. 8121 Benglen

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    Im Original-PDF fehlt die Abbildung 2 auf S. 3 (Umschlag eines Briefes aus New Glarus). Die Seite wurde daher gescannt und ist als separate Datei beigelegt.Einleitung ; DIE POST - 8118 Pfaffhausen ; DIE POST - 8121 Benglen ; DIE POST - 8117 Fällanden ; Von der Wagnerwerkstatt zum Postbüro ; Ära Gachnang ; Die erste Postablage ; Postboten als Langstreckenläufer ; Züribott ; Weibel ; Anhang (Chronologie ; Stempelverzeichnis

    Phase 1 Study Evaluating the Pharmacokinetics, Dose Proportionality, Bioavailability, and Tolerability of Subcutaneous Levothyroxine Sodium (XP‐8121)

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    ABSTRACT Levothyroxine sodium has been the cornerstone of hypothyroidism management worldwide, with daily oral administration (PO) recognized as standard of care. Oral administration of levothyroxine, however, poses challenges due to variability in pharmacokinetics (PK), influenced by factors such as gastrointestinal absorption, food/drug interactions, and patient adherence. XP‐8121 (levothyroxine for subcutaneous administration) is a ready‐to‐use, subcutaneous (SC) injection formulation of levothyroxine in Phase 3 development. This Phase 1, single‐center, 2‐part study aimed to characterize the PK and dose proportionality of XP‐8121 SC compared to 600 μg oral Ievothyroxine in healthy adults. Additionally, the study evaluated the safety and tolerability of XP‐8121 and incorporated population pharmacokinetic (PPK) modeling to support future development. Part 1 was a randomized, open‐label, crossover, fixed‐sequence study (n = 30). Dose linearity was evaluated by escalating XP‐8121 SC doses up to 1200 μg. Part 2 was an open‐label, single‐period study (n = 30) evaluating PK characteristics of a single dose of XP‐8121 SC (1500 μg), potential clinical exposure range, and dose proportionality. After oral levothyroxine administration, baseline‐adjusted levothyroxine concentration increased rapidly in plasma (Tmax median: 3.1 h); absorption for all XP‐8121 SC doses was slower compared to 600 μg oral levothyroxine, and levels remained elevated for 4–5 days before decreasing. Dose proportionality was confirmed, and safety results were similar between all groups. PPK analysis results suggested that weekly doses of XP‐8121 SC at four times the daily oral levothyroxine dose provide similar exposure at steady state (AUCss). Overall, these data for XP‐8121 provide adequate predictive performance to inform future phase 2 studies

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    ĐÍNH CHÍNH: HOẠT ĐỘNG KINH DOANH DỊCH VỤ DU LỊCH CỦA CÁC HỘ DÂN VÙNG ĐẦM PHÁ LĂNG CÔ, THỪA THIÊN HUẾ

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    CORRECTION: Tourism service business activities of households in Lang Co Lagoon, Thua Thien Hue province Authors: Cao Thi Thuyet*, Truong Van Tuyen, Ho Le Phi Khanh, Nguyen Ngoc Truyen, Tran Thi Anh Nguyet   ID: 7203 | DOI: https://doi.org/10.26459/hueunijard.v132i3D.7203 Citation: Thuyet, C. T., Van Tuyen, T., Khanh, H. L. P., Truyen, N. N., & Nguyet, T. T. A. (2023). HOẠT ĐỘNG KINH DOANH DỊCH VỤ DU LỊCH CỦA CÁC HỘ DÂN VÙNG ĐẦM PHÁ LĂNG CÔ, THỪA THIÊN HUẾ. Hue University Journal of Science: Agriculture and Rural Development, 132(3D), 81-94.   CORRECTION NOTICE: The Journal hereby corrects/amends the information in "Abstract"; "section 3.1 starting on page 84"; "section 4.6 starting on page 91" of the article with ID 7203 published online in Issue 132(3D) of 2023 as follows: ID: 8121 | DOI: https://doi.org/10.26459/hueunijard.v134i3D.8121 View correction statement: CORRECTIONĐÍNH CHÍNH: HOẠT ĐỘNG KINH DOANH DỊCH VỤ DU LỊCH CỦA CÁC HỘ DÂN VÙNG ĐẦM PHÁ LĂNG CÔ, THỪA THIÊN HUẾ Tác giả: Cao Thị Thuyết*, Trương Văn Tuyển, Hồ Lê Phi Khanh, Nguyễn Ngọc Truyền, Trần Thị Ánh Nguyệt ID: 7203 | DOI: https://doi.org/10.26459/hueunijard.v132i3D.7203 Citation: Thuyet, C. T., Van Tuyen, T., Khanh, H. L. P., Truyen, N. N., & Nguyet, T. T. A. (2023). HOẠT ĐỘNG KINH DOANH DỊCH VỤ DU LỊCH CỦA CÁC HỘ DÂN VÙNG ĐẦM PHÁ LĂNG CÔ, THỪA THIÊN HUẾ. Hue University Journal of Science: Agriculture and Rural Development, 132(3D), 81-94.   THÔNG TIN ĐÍNH CHÍNH: Trong số 132(3D) năm 2023, bài báo với ID 7203 được xuất bản trực tuyến, nay Tạp chí xin đính chính/hiệu chỉnh lại thông tin tại "Tóm tắt"; "mục 3.1 từ trang 84"; “mục 4.6 từ trang 91” như sau: ID: 8121 | DOI: https://doi.org/10.26459/hueunijard.v134i3D.8121 Xem đính chính: ĐÍNH CHÍN

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Dynamical universality classes of simple growth and lattice gas models

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    Large scale, dynamical simulations have been performed for the two dimensional octahedron model, describing the Kardar–Parisi–Zhang (KPZ) for nonlinear, or the Edwards–Wilkinson class for linear surface growth. The autocorrelation functions of the heights and the dimer lattice gas variables are determined with high precision. Parallel random-sequential (RS) and two-sub-lattice stochastic dynamics (SCA) have been compared. The latter causes a constant correlation in the long time limit, but after subtracting it one can find the same height functions as in case of RS. On the other hand the ordered update alters the dynamics of the lattice gas variables, by increasing (decreasing) the memory effects for nonlinear (linear) models with respect to RS. Additionally, we support the KPZ ansatz and the Kallabis–Krug conjecture in ##IMG## [http://ej.iop.org/images/1751-8121/51/3/035003/aaa97f3ieqn001.gif] {2+12+1} dimensions and provide a precise growth exponent value ##IMG## [http://ej.iop.org/images/1751-8121/51/3/035003/aaa97f3ieqn002.gif] {β=0.2414(2)\beta={0.2414}(2)} . We show the emergence of finite size corrections, which occur long before the steady state roughness is reached

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods
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