1,724,351 research outputs found
Pharmacokinetics and tolerability of DA-8031, a novel selective serotonin reuptake inhibitor for premature ejaculation in healthy male subjects
No full textDongseong Shin,1 SeungHwan Lee,2 Sojeong Yi,2 Seo Hyun Yoon,2 Joo-Youn Cho,2 Mi Young Bahng,3 In-Jin Jang,2 Kyung-Sang Yu2 1Clinical Trials Center, Gachon University Gil Medical Center, Incheon, 2Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 3Department of Product Development, Dong-A ST, Seoul, Korea Objective: DA-8031 is a selective serotonin reuptake inhibitor under development for the treatment of premature ejaculation. This is the first-in-human study aimed at evaluating the pharmacokinetics and tolerability of DA-8031 and its metabolites (M1, M2, M4, and M5) in the plasma and urine after administration of a single oral dose in healthy male subjects.Methods: A dose block-randomized, double-blind, placebo-controlled, single ascending dose study was conducted. Subjects received either placebo or a single dose of DA-8031 at 5, 10, 20, 40, 60, 80, or 120 mg. DA-8031 and its four metabolites were analyzed in the plasma and urine for pharmacokinetic evaluation. The effect of genetic polymorphisms of cytochrome-P450 (CYP) enzymes on the pharmacokinetics of DA-8031 was evaluated.Results: After a single dose, plasma DA-8031 reached the maximum concentration at a median of 2–3 h and was eliminated with terminal elimination half-life of 17.9–28.7 h. The mean renal clearance was 3.7–5.6 L/h. Dose-proportional pharmacokinetics was observed over the dose range of 20–80 mg. Among the metabolites, M4 had the greatest plasma concentration, followed by M5 and M1. Subjects with CYP2D6 intermediate metabolizer had significantly greater dose-normalized Cmax and AUC0–t of DA-8031 as well as smaller metabolic ratios than those subjects with CYP2D6 extensive metabolizer. The most common adverse events were nausea, dizziness, and headache, and no serious adverse events were reported.Conclusion: In conclusion, the systemic exposure of DA-8031 was increased proportionally to the dose within 20–80 mg. Genetic polymorphisms of CYP2D6 had an effect on the systemic exposure of DA-8031. DA-8031 was well tolerated after single doses of 80 mg or less. Keywords: DA-8031, pharmacokinetics, selective serotonin reuptake inhibitor, premature ejaculation, first-in-huma
COUNTER DIGITAL SYSTEM USING MICRO CONTROLLER (MCS) -8031
No full textMicrocontroller-8031 is a minimum system that can combine the input and output adigital signal that can be used for the control of an application tool, primarily locatedin industrial. By using an 8031 microcontroller-system device can be controlledsimultaneously / together as well as reliable, because the microcontroller-8031 has aprivilege in terms of hardware.With its features, the microcontroller-8031 can be very useful for the development oftechnology, especially in digital control systems are very efficient and effective.Microcontroller system is a control center of the overall work system.Microcontroller for digital circuits are used as a store counter or control commandsfrom the calculations that will be shown at 7-segment display.Among the advantages to use microcontroller-8031 in this series is due to thepresence of all devices are required, so no longer need a computer and interface, sono longer need a computer and an interface so that the circuit becomes moreeconomical and efficient. whereas in data processing within the systemmicrocontroller, 8031 assembly language is used
COUNTER DIGITAL SYSTEM USING MICRO CONTROLLER (MCS) -8031
No full textMicrocontroller-8031 is a minimum system that can combine the input and output adigital signal that can be used for the control of an application tool, primarily locatedin industrial. By using an 8031 microcontroller-system device can be controlledsimultaneously / together as well as reliable, because the microcontroller-8031 has aprivilege in terms of hardware.With its features, the microcontroller-8031 can be very useful for the development oftechnology, especially in digital control systems are very efficient and effective.Microcontroller system is a control center of the overall work system.Microcontroller for digital circuits are used as a store counter or control commandsfrom the calculations that will be shown at 7-segment display.Among the advantages to use microcontroller-8031 in this series is due to thepresence of all devices are required, so no longer need a computer and interface, sono longer need a computer and an interface so that the circuit becomes moreeconomical and efficient. whereas in data processing within the systemmicrocontroller, 8031 assembly language is used
由多个8031组成的锥体结构计算机
No full text本文介绍了一种新型的并行计算机结构。这种结构是由21个8031单片机组成的.它特别适合于图像处理和模式识别.文中描述了该结构的原理,分析了它的特点,并举出几种算法的例子
РЕАЛИЗАЦИЯ ОТЛАДОЧНОГО КОМПЛЕКСА ДЛЯ СТЕНДА EV8031 НА ОСНОВЕ ОДНОКРИСТАЛЬНОГО МИКРОПРОЦЕССОРА INTEL 8031
Get PDFВ данной статье предлагается способ пошаговой отладки программ для процессора Intel 8031 на стенде EV8031, дается алгоритм реализации программного интерфейса для IBM-совместимого компьютера, который позволяет производить удаленный мониторинг регистров процессора Intel 8031 в режиме пошаговой отладки. In the given article the way of step-by-step debugging of programs for the processor Intel 8031 at stand EV8031 has been offered, the algorithm of implementation of the program interface for the IBM-compatible computer which allows to make remote monitoring of registers of the processor Intel 8031 in a mode of step-by-step debugging is given
Simulasi otomatisasi dengan mikrontoler 8031 untuk peralatan analisa aktivasi neutron cepat
Get PDFTelah dibuat suatu sistem simulasi otomatisasi
peralatan analisa aktivasi neutron cepat dengan
menggunakan komputer PC AT/486.
Komponen sistem terdiri dua bagian, yaitu perangkat
keras yang berupa rangkaian kontroler dan perangkat lunak. Rangkaian kontroler terdiri dari mikrokontroler 8031 yang merupakan CPU dari rangkaian, eprom 2732 yang merupakan tempat penyimpan program dari sistem, IC 1488 yang berfungsi untuk mengirim data ke komputer, IC 1489 berfungsi menerima data dari komputer, IC 741s373 berfungsi untuk membedakan data dan alamat pada port 0 mikrokontroler 8031 dan IC 741s00 yang mempunyai empat buah gerbang NAND. Perangkat lunak terdapat pada komputer dan kontroler. Program pada komputer ditulis dengan Turbo Pascal 7.0. Sedangkan pada kontroler ditulis dengan bahasa assembler inter. 8031.
Hasil percobaan menuniukan bahwa peralatan yang diotomatisasi ini bekeria dengan baik dan mempunyai keseksamaan 99,88% pada pengukuran parameter waktu. A system to control automatically fast neutron
activation analysis simulation equipment uses PC AT/466 computer has been constructed.
This system contains two component, hardware which a controller circuit and software. Controller circuit contains mikrocontroller 8031 as CPU of the system, eprom 2732 as the program system to save on, 1488 as the data transmiter to computer, 1489 as the data reciver from computer, 741s373 that uses to controll betwen address and data at port 0 mikrocontroller 8031 and 741s00 that has four NAND gate. Software is the program that used in computer and controller. In computer uses Turbo Pascal 7.0 and in controller uses assembler Intel 8031.
The experiment result show that the automatized system works well and provide measuring preccision 99,88% of the time parameter
[Great Northern Railway Company, Engine Drawing Card, Sketch No. 8031]
No full textThis engine drawing card was created for Great Northern Railway Company, Class 16-50 2/4 E. Section N-16 2/4 E. Sketch 8031. Copy Spec. [field left blank]
Alat Ukur Temperatur 5 Kanal Menggunakan Mikrokontroler 8031
No full textThis paper describes the designing of five channels instrument for temperature measurement. This instrument also has differential mode facility so the temperature difference between two points can be determined. This instrument was designed by using 8031 microcontroller for the temperature measurement processes. Generally%2C this instrument consists of two main parts. The first part is 8031microcontroller minimum system and the second one is sensor and transmitter circuit. This instrument uses LM35 temperature sensor and transmitter circuit is used to transmit the signal so the remote temperature measurement can be achieved. Experiment was done and the measurement data was recorded. The maximum error of temperature measurement that can be achieved is 1%B0C. The experiment was also done by using 30 meters transmitter cable and it show good result too. Abstract in Bahasa Indonesia : Pada makalah ini dijelaskan tentang perencanaan dan pembuatan alat ukur temperatur dengan fasilitas lima kanal. Alat ukur ini juga dilengkapi dengan fasilitas diferensial mode sehingga dapat mengetahui perbedaan suhu di dua tempat. Mikrokontroler 8031 digunakan sebagai alat bantu yang mengatur semua proses pengukuran temperatur. Secara umum%2C sistem ini terdiri atas dua bagian utama yaitu minimum sistem 8031 itu sendiri dan rangkaian sensor beserta rangkaian transmiternya. Sensor temperatur yang digunakan adalah LM35. Pada sistem ini dilengkapi rangkaian transmiter agar dapa digunakan untuk pengukuran temperatur jarak jauh. Pengujian sistem telah dilakukan dengan melakukan perekaman data pengukuran. Hasil pengujian menunjukkan bahwa kesalahan pengukuran temperatur yang paling besar adalah 1%B0C. Selain itu pengujian juga dilakukan dengan menggunakan kabel transmitter yang panjangnya 30 meter dan menghasilkan pengukuran yang sama.%0D%0A%0D%0A Temperature+Sensor%2C+Transmitter%2C+8031+Microcontrolle
Perencanaan dan pembuatan alat komunikasi emergency antara rumah dan pos keamanan dengan menggunakan mikrokontroller 8031
No full textKejahatan di kota-kota besar dewasa ini semakin meningkat, terutatoa pada kompleks perurnahan elite. Umumnya pada kompleks perumahan tersefout masyarakatnya bersifat individual yang sangat tinggi. Sehingga apabila terjadi bal'iaya p>ada sal all satu rumah, toaka tetangga di sekitarnya tidak Hiau ikut membantu. Oleh karena itu dibutuhkan suatu system keaiaanan yang cepat dan handal. Pada t-ugas akhir ini direncanakan dan dibuat alat komunikasi emergency antara rumah dan pos kearaanan dengan meriggunakan mikrokontrol ler 8031. Pemilik ruroah mengeset kode riomor rtimah, Kode telepon pos kearaanan dan kode emergency. Kode-kode tersebut akan didisplaykan pada seven segraeri untuk melil'iat pengesetan sudah benar atau tidak. Setelah terjadi suatu emergency maka pemilik rumah menekan tombol secret key kemudian peripheral interface menghubungi 8031 yang berfungsi mengendalikan seluruh kerja dari system. Mikrokontroller 8031 melakukan hubungan ke jaringan telepon melalui IC MT 8880 yang diltubungkan melalui jalur telepon pos kearoanan. Sehingga pada pos keamanan akan dikirim sinyal tone. Kemudian IC MT 8880 memberi tahu Mikrokontroller 8031. Mikrokontroller 8031 akan mensimulasikan seolah-olah telepon off hook. Dengan sistem off hook maka dari rumah akan mengirimkan sinyal emergency. Setelah sinyal emergency diterima maka pada seven segmen akan didisplaykan kode noraor rumah, kode emergency serta metftbunyikan busser, sehirigga bagian keamanan mudah melakukan pelacakan. Hasil pengujian alat dapat bekerja sesuai dengan yang diharapkan dan dapat beroperasi dengan baik
Alat Ukur Temperatur 5 Kanal Menggunakan Mikrokontroler 8031
No full textThis paper describes the designing of five channels instrument for temperature measurement. This instrument also has differential mode facility so the temperature difference between two points can be determined. This instrument was designed by using 8031 microcontroller for the temperature measurement processes. Generally%2C this instrument consists of two main parts. The first part is 8031microcontroller minimum system and the second one is sensor and transmitter circuit. This instrument uses LM35 temperature sensor and transmitter circuit is used to transmit the signal so the remote temperature measurement can be achieved. Experiment was done and the measurement data was recorded. The maximum error of temperature measurement that can be achieved is 1%B0C. The experiment was also done by using 30 meters transmitter cable and it show good result too. Abstract in Bahasa Indonesia : Pada makalah ini dijelaskan tentang perencanaan dan pembuatan alat ukur temperatur dengan fasilitas lima kanal. Alat ukur ini juga dilengkapi dengan fasilitas diferensial mode sehingga dapat mengetahui perbedaan suhu di dua tempat. Mikrokontroler 8031 digunakan sebagai alat bantu yang mengatur semua proses pengukuran temperatur. Secara umum%2C sistem ini terdiri atas dua bagian utama yaitu minimum sistem 8031 itu sendiri dan rangkaian sensor beserta rangkaian transmiternya. Sensor temperatur yang digunakan adalah LM35. Pada sistem ini dilengkapi rangkaian transmiter agar dapa digunakan untuk pengukuran temperatur jarak jauh. Pengujian sistem telah dilakukan dengan melakukan perekaman data pengukuran. Hasil pengujian menunjukkan bahwa kesalahan pengukuran temperatur yang paling besar adalah 1%B0C. Selain itu pengujian juga dilakukan dengan menggunakan kabel transmitter yang panjangnya 30 meter dan menghasilkan pengukuran yang sama.%0D%0A%0D%0A Temperature+Sensor%2C+Transmitter%2C+8031+Microcontrolle
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