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[Duluth, Missabe & Northern Ry., Engine Drawing Card, Sketch No. 7777]
No full textThis engine drawing card was created for Duluth, Missabe & Northern Railway, Class 10-52 F. Section J-10 F. Sketch 7777. Copy Spec. Ry. Co's spec. 1/5/27., spec C-9696 (SK. Mod.)
Zum Endothelinsystem im Morris-Hepatom-7777-Behandlung mit Endothelinrezptorantagonisten in vitro und in vivo
Get PDFDas Peptid Endothelin-1 (ET-1) hat neben seiner vasokonstriktorischen Wirkung auch wachstumsinduzierende Eigenschaften. Um seine Bedeutung für Tumorwachstum zu untersuchen wurde das ET-System des experimentellen Lebertumors Morris-Hepatom (MH)-7777 in vitro und in vivo zunächst charakterisiert. Erstmals wurde dann versucht, Tumorwachstum auch in vivo durch Behandlung mit einem ET-Rezeptorantagonisten zu inhibieren. METHODEN: Im Kulturüberstand von MH-7777-Zellen wurde die Menge des synthetisierten irET-1 gemessen. Über Proliferationsassays erfolgte die Untersuchung des Zellwachstums bei Inkubation mit ET-1 sowie den ET-Rezeptorantagonisten BQ 123, LU 135252 und LU 302872. Zur Charakterisierung des ET-Systems im MH-7777 in vivo wurden ir(Big-)ET-1-Plasma- und Gewebekonzentrationen bestimmt. Die Messung der ET-Rezeptordichte und der Rezeptoraffinität erfolgte in Scatchard-Rezeptor-Bindungsstudien. Die Hälfte einer Gruppe von 44 hepatomtagenden Buffaloratten wurde über 28 Tage mit dem kombinierten ETA/B-Rezeptorantagonisten LU 302872 behandelt (orale Applikation). DIE ERGEBNISSE zeigen eine endogene irET-1-Produktion der MH-7777-Zellen. Exogene ET-1-Stimulation der Zellen bewirkt eine signifikante Proliferationssteigerung. Die Proliferationshemmung durch die beiden ETA-Rezeptorantagonisten ist schwächer ausgeprägt als die in zwei verschiedenen Proliferationsassays bestätigte Hemmung (pThe peptide endothelin-1 (ET-1) has growth-promoting properties besides its vasopressor characteristic. In order to gain information about its importance for tumor growth the ET system of the experimental liver tumor Morris hepatoma (MH)-7777 was characterized in vitro and in vivo. For the first time it was then tried to inhibit tumor growth in vivo by treatment with an ET receptor antagonist. METHODS: The endogenously produced immunoreactive (ir) ET-1 was quantified in the supernatant of MH-7777 cells. Cell growth at incubation with different concentrations of ET-1 and the ET receptor antagonists BQ 123, LU 135252 and LU 302872 was evaluated performing cell proliferation assays. In order to characterize the ET system in MH-7777 in vivo ir(big-)ET-1 concentrations were determined in plasma and tissue. ET receptor density and affinity in hepatoma was determined performing Scatchard receptor binding assays. Half of 44 hepatoma-bearing Buffalo rats received the combined ETA/B receptor antagonist LU 302872 for 28 days orally. THE RESULTS show an endogenous irET-1 production by MH-7777 cells. Exogenous ET-1 stimulation causes a significant increase in cell proliferation. Growth inhibitory action of ETA-receptor antagonists is not as strong as the inhibition (
Penerjemahan bahasa sunda kitab al- ma'ṡūrāt hasan al-banna (sebuah pertanggungjawaban akademik berbasis semantik)
No full textPenulisan ini bertujuan mendeskripsikan penerjemahan kitab al-Ma?ṡūrāt karya Hasan al-Banna, di mana penulis menerjemahkannya sendiri dari bahasa Arab ke dalam bahasa daerah (Sunda), dalam hal ini penulis menerapkan metode penerjemahan semantik dalam penerjemahannya. Permasalahan yang diteliti yaitu bagaimana penerapan metode semantik penerjemahan al-Ma?ṡūrāt ke dalam bahasa Sunda berdasarkan dengan analisis semantik Metode yang digunakan dalam penulisan ini adalah metode penulisan kualitatif, dengan pendekatan deskriptif yang berlandaskan pada penulisan terhadap teks al-Ma?ṡūrāt karya Hasan al-Banna serta terjemahannya sebagai objek penulisan. Teknik analisis data dalam penulisan ini, yaitu dengan menerjemahkan kitab al-Ma?ṡūrāt ke dalam bahasa Sunda, kemudian menerapkan metode penerjemahan semantik dalam penerjemahannya. Dalam penulisan ini, penulis menggunakan teori semantik atau?ilm al-dilalah yang dikemukakan oleh Ahmad Mukhtar, yakni ilmu yang membahas tentang makna, dan teori penerjemahan semantik yang dikemukakan oleh Peter Newmark, yakni Semantic translation take more account of the aesthetic value. Hasil terjemahan menunjukkan bahwa metode penerjemahan semantik untuk menerjemahkan kitab al-Ma?ṡūrāt adalah sesuai, karena kitab tersebut berisikan kumpulan ayat Al-Qur?an dan hadis, serta bacaan doa-doa dengan memperhaatikan unsur estetika teks sumbe
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Estrogen Binding Protein Activity in Morris Hepatoma 7777 Compared With Normal Rat Liver
Get PDFEstrogen binding protein activities were determined in the cytosol from adult male Buffalo rat liver and Morris hepatoma 7777. Estrogen receptors were prepared using the protamine sulfate precipitation technique of Chamness. The ability of various unlabeled steroids competing with [3H]estradiol was examined to establish the binding specificity. Estradiol binding in Morris hepatoma 7777 cytosol was greatly decreased compared with that present in hepatic cytosol prepared from normal rat liver. The receptor concentration expressed as femtomoles per milligram of cytoplasmic protein was 31.1 ± 2.9 SD for normal rat liver and 0.41 ± 0.88 SD for the hepatoma. Gel filtration chromatography revealed the presence of an estrogen binder in hepatoma cytosol which was not present in either normal liver or in the protamine sulfate precipitates of hepatoma cytosol. The molecular weight, binding specificity, and precipitation of this protein by specific antiserum suggests that it is α-fetoprotein. © 1984, American Gastroenterological Association. All rights reserved
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Estrogen binding protein activity in Morris hepatoma 7777 compared with normal rat liver.
No full textEstrogen binding protein activities were determined in the cytosol from adult male Buffalo rat liver and Morris hepatoma 7777. Estrogen receptors were prepared using the protamine sulfate precipitation technique of Chamness. The ability of various unlabeled steroids competing with [3H]estradiol was examined to establish the binding specificity. Estradiol binding in Morris hepatoma 7777 cytosol was greatly decreased compared with that present in hepatic cytosol prepared from normal rat liver. The receptor concentration expressed as femtomoles per milligram of cytoplasmic protein was 31.1 +/- 2.9 SD for normal rat liver and 0.41 +/- 0.88 SD for the hepatoma. Gel filtration chromatography revealed the presence of an estrogen binder in hepatoma cytosol which was not present in either normal liver or in the protamine sulfate precipitates of hepatoma cytosol. The molecular weight, binding specificity, and precipitation of this protein by specific antiserum suggests that it is alpha-fetoprotein
Effects of Ionizing Radiations on the Activity of Valyl-tRNA Synthetase Isolated from Rat Liver and Morris Hepatoma 7777.
No full textThe effects of ionizing radiations on valyl-tRNA synthetase (L-valine tRNA ligase (AMP), E.C.6.1.1.9.), 100-fold purified from rat liver and Morris hepatoma 7777, are reported. The results showed that: 1) the enzymatic activity is strongly inhibited by radiations; 2) the enzymatic inactivation is much more marked in dilute than in concentrated solutions; 3) the inactivation of enzyme is linked to oxidation of sulphydryl groups indispensable to the catalytic activity of the enzyme; 4) no substantial difference in relation to inactivation by radiation was observed, between rat liver and Morris hepatoma 7777 enzymes.</jats:p
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