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Resolución UNRN Nº 712/2011. Modificar la Resolución UNRN Nº 45/2008
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN Nº 712/2011. Modificar la Resolución UNRN Nº 45/2008 en lo relativo a la denominación de la carrera y título, la propuesta curricular y los alcances partiendo de cuatro títulos diferenciados por nivel de enseñanza para el cual sea habilitado junto con los parámetros para su gestión en la modalidad a distancia de acuerdo con lo previsto en la Resolución ME 1717/04fals
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712
No full textTyrosine kinase 2 (TYK2) is a nonreceptor tyrosine kinase
that
belongs to the JAK family also comprising JAK1, JAK2, and JAK3. TYK2
is an attractive target for various autoimmune diseases as it regulates
signal transduction downstream of IL-23 and IL-12 receptors. Selective
TYK2 inhibition offers a differentiated clinical profile compared
to currently approved JAK inhibitors. However, selectivity for TYK2
versus other JAK family members has been difficult to achieve with
small molecules that inhibit the catalytically active kinase domain.
Successful targeting of the TYK2 pseudokinase domain as a strategy
to achieve isoform selectivity was recently exemplified with deucravacitinib.
Described herein is the optimization of selective TYK2 inhibitors
targeting the pseudokinase domain, resulting in the discovery of the
clinical candidate ABBV-712 (21)
Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712
No full textTyrosine kinase 2 (TYK2) is a nonreceptor tyrosine kinase
that
belongs to the JAK family also comprising JAK1, JAK2, and JAK3. TYK2
is an attractive target for various autoimmune diseases as it regulates
signal transduction downstream of IL-23 and IL-12 receptors. Selective
TYK2 inhibition offers a differentiated clinical profile compared
to currently approved JAK inhibitors. However, selectivity for TYK2
versus other JAK family members has been difficult to achieve with
small molecules that inhibit the catalytically active kinase domain.
Successful targeting of the TYK2 pseudokinase domain as a strategy
to achieve isoform selectivity was recently exemplified with deucravacitinib.
Described herein is the optimization of selective TYK2 inhibitors
targeting the pseudokinase domain, resulting in the discovery of the
clinical candidate ABBV-712 (21)
ATA 712 02.07.2020 Extraordinária
No full textATA Nº 712 DA SESSÃO EXTRORDINÁRIA DO CONSELHO DE UNIDADE DO CE
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Biography and History [712]
No full textBiography and History.
This manuscript is now IO Islamic 3016 in the India Office collections.
[metadata: Otto Loth, A Catalogue of the Arabic Manuscripts in the Library of the India Office, (volume 1), no. 712 here with further notations and hyperlinks].
712.
3016. Size 91/2 in. by 6 in.; foll. 250. Fourteen lines in a page.
Another copy of the preceding work.
Well written in Nasta’liḳ, of the end of The twelfth century. The copy from which this was made, was finished on the last of Shawwâl, 856. On fol. 236 is a table of the Uigur alphabet. Some notes are added in the earlier portion
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