1,721,044 research outputs found
Human anti-mouse IgM and IgG responses in ovarian cancer patients after radioimmunotherapy with 90Y-muHMFG1.
No full textContains fulltext :
69952.pdf (Publisher’s version ) (Open Access)BACKGROUND: Human anti-mouse antibody (HAMA)-IgM and IgG in ovarian cancer patients treated with intraperitoneal (i.p.) 90Y-muHMFG1 as consolidating therapy were analyzed for a relationship with outcome of disease. PATIENTS AND METHODS: Serial serum samples from 208 ovarian cancer patients participating in a phase III trial of i.p. 90Y-muHMFG1 and 25 controls were analyzed for HAMA-IgM and HAMA-IgG. Results were correlated with time to, and location of, disease recurrence. RESULTS: Patients receiving i.p. 90Y-muHMFG1 developed a rapid HAMA-IgM peak (week 4 to 8), followed by a HAMA-IgG peak 2-4 weeks later. HAMA levels in the control group remained unchanged. Early maximum HAMA-IgG peaks were associated with early relapse [hazard ratio (HR), 0.975; 95% confidence interval (CI) 0.956 to 0.995; p=0.012]. Patients with a HAMA-IgG maximum before or at 8 weeks were at significantly higher risk for disease recurrence (HR, 1.6; 95% CI 1.1 to 25;p=0.021) as compared to patients with a HAMA-IgG maximum after 8 weeks. CONCLUSION: Besides time point of maximum HAMA-IgG, no evident relation could be found between HAMA-IgM or HAMA-IgG development and time to relapse or location of recurrence
Mechanical and dynamic properties of TRM with different fibers
No full textTo perform the structural analysis of masonry walls reinforced with composite materials based in textile fiber reinforced mortars (TRM) it is necessary to know the mechanical characteristics of TRM materials. This work presents the experimental campaign developed on mortar plates reinforced with of glass and carbon fiber meshes. Several 4x4x16 mm mortar specimens has been tested under compression and bending forces to obtain the maximum capacity in tension and in compression. The technique has been validated with the simultaneous application of the ultrasound technique to evaluate evolution with the maturation, both of the modulus of elasticity and the Poisson's coefficient. Finally, TRM plates of 400x100x10 mm have been manufactured. These plates have been tested using an Erudite MkIV electronic resonant frequency test system to determine the transverse resonant frequency and, through them, the dynamic modulus of elasticity and the damping factor of the TRM material. This analysis has been carried out at different ages. Finally, the stress-strain curves have been evaluated after 56 days. A combination of different reinforcements with fiberglass and carbon has been tested. With these results, it has been possible to evaluate the maximum capacity in tension and in compression of this material as well the modulus of elasticity and damping factor. These values are necessary to define any type of reinforcement in masonry walls.El presente trabajo de investigación ha sido posible gracias a la financiación recibida del Ministerio de Economía y Competitividad, a través del proyecto BIA2015-69952-R
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Evaluación experimental mediante análisis digital de imágenes del comportamiento de muros de mampostería frente a cargas cíclicas en su plano
No full textEl presente artículo se centra en el comportamiento estructural de muros de mampostería con hueco de ventana sometidos a cargas cíclicas en su plano. Para ello, se realizó una campaña experimental a escala real donde se fabricaron muros de 3 x 2 metros con un hueco central, siguiendo para ello las recomendaciones de las normas españolas para diseño sísmico. Con el objetivo de mejorar la resistencia y ductilidad, un muro se ha reforzado a dos caras mediante el sistema Textile Reinforced Mortar (en adelante TRM). El comportamiento de los muros ha sido analizado en términos de resistencia, ductilidad, comportamiento cíclico, degradación de rigidez y capacidad de disipación de energía. Todos los ensayos fueron monitorizados empleando sensores LVDT, así como la técnica de correlación de imagen. Los resultados muestran que el TRM aumenta la resistencia mecánica, el desplazamiento último, disipa más cantidad de energía y controla la propagación de la fisuración.El presente trabajo de investigación ha sido posible gracias a la financiación recibida del Ministerio de Economía y Competitividad, a través del proyecto BIA2015-69952-R
Comparativa numérico experimental de elementos de mampostería a compresión diagonal
No full textLas estructuras de fábrica de mampostería son un sistema estructural tradicional con una elevada vulnerabilidad sísmica debida a su reducida resistencia a tracción. Con el fin de mejorar el comportamiento sísmico de muros de mampostería pueden emplearse diversas técnicas, como por ejemplo la aplicación de refuerzos externos. Una alternativa actual serían los morteros reforzados con fibra (FRCM, Fiber Reinforced Cement Matrix), que se componen normalmente de una malla bidireccional (de fibra de vidrio, carbono o basalto) y una matriz cementicia. El empleo de los FRCM en las estructuras de mampostería incrementa su resistencia y mejora su ductilidad. El objetivo de este trabajo es comprobar la eficiencia de esta técnica de refuerzo (FRCM) como mejora de la resistencia a corte producida por los esfuerzos de corte asociadas con las acciones sísmicas. Para ello se presentan los resultados experimentales medidos en ensayos de compresión diagonal en muros reforzados a una o dos caras y con diferentes tipos de malla de refuerzo (vidrio y carbono). Se ha observado un incremento de resistencia y ductilidad, para todos los casos de refuerzo ensayados. Además se han definido modelos numéricos que sean capaces de reproducir los resultados experimentales registrados, con el fin de evaluar la mejora del refuerzo, tanto a nivel de carga como a nivel de ductilidad.El presente trabajo de investigación ha sido posible gracias a la financiación recibida del Ministerio de Economía y Competitividad, a través del proyecto BIA2015-69952-R
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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