1,724,987 research outputs found
Image_1_Lactobacillus paracasei CNCM I-5220-derived postbiotic protects from the leaky-gut.TIF
No full textThe maintenance of intestinal barrier function is essential for preventing different pathologies, such as the leaky gut syndrome (LGS), which is characterized by the passage of harmful agents, like bacteria, toxins, and viruses, into the bloodstream. Intestinal barrier integrity is controlled by several players, including the gut microbiota. Various molecules, called postbiotics, are released during the natural metabolic activity of the microbiota. Postbiotics can regulate host–microbe interactions, epithelial homeostasis, and have overall benefits for our health. In this work, we used in vitro and in vivo systems to demonstrate the role of Lactobacillus paracasei CNCM I-5220-derived postbiotic (LP-PBF) in preserving intestinal barrier integrity. We demonstrated in vitro that LP-PBF restored the morphology of tight junctions (TJs) that were altered upon Salmonella typhimurium exposure. In vivo, LP-PBF protected the gut vascular barrier and blocked S. typhimurium dissemination into the bloodstream. Interestingly, we found that LP-PBF interacts not only with the host cells, but also directly with S. typhimurium blocking its biofilm formation, partially due to the presence of biosurfactants. This study highlights that LP-PBF is beneficial in maintaining gut homeostasis due to the synergistic effect of its different components. These results suggest that LP-PBF could be utilized in managing several pathologies displaying an impaired intestinal barrier function.</p
Image_4_Lactobacillus paracasei CNCM I-5220-derived postbiotic protects from the leaky-gut.TIF
No full textThe maintenance of intestinal barrier function is essential for preventing different pathologies, such as the leaky gut syndrome (LGS), which is characterized by the passage of harmful agents, like bacteria, toxins, and viruses, into the bloodstream. Intestinal barrier integrity is controlled by several players, including the gut microbiota. Various molecules, called postbiotics, are released during the natural metabolic activity of the microbiota. Postbiotics can regulate host–microbe interactions, epithelial homeostasis, and have overall benefits for our health. In this work, we used in vitro and in vivo systems to demonstrate the role of Lactobacillus paracasei CNCM I-5220-derived postbiotic (LP-PBF) in preserving intestinal barrier integrity. We demonstrated in vitro that LP-PBF restored the morphology of tight junctions (TJs) that were altered upon Salmonella typhimurium exposure. In vivo, LP-PBF protected the gut vascular barrier and blocked S. typhimurium dissemination into the bloodstream. Interestingly, we found that LP-PBF interacts not only with the host cells, but also directly with S. typhimurium blocking its biofilm formation, partially due to the presence of biosurfactants. This study highlights that LP-PBF is beneficial in maintaining gut homeostasis due to the synergistic effect of its different components. These results suggest that LP-PBF could be utilized in managing several pathologies displaying an impaired intestinal barrier function.</p
Image_3_Lactobacillus paracasei CNCM I-5220-derived postbiotic protects from the leaky-gut.TIF
No full textThe maintenance of intestinal barrier function is essential for preventing different pathologies, such as the leaky gut syndrome (LGS), which is characterized by the passage of harmful agents, like bacteria, toxins, and viruses, into the bloodstream. Intestinal barrier integrity is controlled by several players, including the gut microbiota. Various molecules, called postbiotics, are released during the natural metabolic activity of the microbiota. Postbiotics can regulate host–microbe interactions, epithelial homeostasis, and have overall benefits for our health. In this work, we used in vitro and in vivo systems to demonstrate the role of Lactobacillus paracasei CNCM I-5220-derived postbiotic (LP-PBF) in preserving intestinal barrier integrity. We demonstrated in vitro that LP-PBF restored the morphology of tight junctions (TJs) that were altered upon Salmonella typhimurium exposure. In vivo, LP-PBF protected the gut vascular barrier and blocked S. typhimurium dissemination into the bloodstream. Interestingly, we found that LP-PBF interacts not only with the host cells, but also directly with S. typhimurium blocking its biofilm formation, partially due to the presence of biosurfactants. This study highlights that LP-PBF is beneficial in maintaining gut homeostasis due to the synergistic effect of its different components. These results suggest that LP-PBF could be utilized in managing several pathologies displaying an impaired intestinal barrier function.</p
Image_2_Lactobacillus paracasei CNCM I-5220-derived postbiotic protects from the leaky-gut.TIF
No full textThe maintenance of intestinal barrier function is essential for preventing different pathologies, such as the leaky gut syndrome (LGS), which is characterized by the passage of harmful agents, like bacteria, toxins, and viruses, into the bloodstream. Intestinal barrier integrity is controlled by several players, including the gut microbiota. Various molecules, called postbiotics, are released during the natural metabolic activity of the microbiota. Postbiotics can regulate host–microbe interactions, epithelial homeostasis, and have overall benefits for our health. In this work, we used in vitro and in vivo systems to demonstrate the role of Lactobacillus paracasei CNCM I-5220-derived postbiotic (LP-PBF) in preserving intestinal barrier integrity. We demonstrated in vitro that LP-PBF restored the morphology of tight junctions (TJs) that were altered upon Salmonella typhimurium exposure. In vivo, LP-PBF protected the gut vascular barrier and blocked S. typhimurium dissemination into the bloodstream. Interestingly, we found that LP-PBF interacts not only with the host cells, but also directly with S. typhimurium blocking its biofilm formation, partially due to the presence of biosurfactants. This study highlights that LP-PBF is beneficial in maintaining gut homeostasis due to the synergistic effect of its different components. These results suggest that LP-PBF could be utilized in managing several pathologies displaying an impaired intestinal barrier function.</p
Straatsburg en de Raad van State; een eerste impressie
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5220.pdf (Publisher’s version ) (Open Access
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Data from: Modelling impacts of habitat loss and fragmentation on mammal species
No full textIn my thesis ‘Modelling impacts of habitat loss and fragmentation on mammal species’, my aim was to quantify species-specific impacts on land-use change across a large number of mammal species. To achieve this aim, I wanted to (1) obtain and validate species-specific data relevant for quantifying these impacts across a large number of mammal species and (2) quantify ecologically meaningful indicators of habitat loss and fragmentation. Chapters 2-4 of my thesis focus on the first subgoal, chapters 5-6 focus on the second subgoal. In this repository, data accompanying chapters 4 and 5 were published.
In chapter 4: ‘Global environmental drivers of home range size in terrestrial and marine mammal species’, the relationship between home range size (HRS) and environmental variables was quantified, accounting for species traits and their interactions with environmental variables for terrestrial and marine mammals. A novel, comprehensive dataset of 2,800 HRS estimates from 586 terrestrial and 27 marine mammal was used. The results indicated that HRS of terrestrial mammals was strongly related to both species traits (body mass, diet, and locomotion type) and environmental conditions (human disturbance, productivity, seasonality). HRS of marine mammals was only related to environmental conditions (mean sea surface temperature and standard deviation of sea surface temperature). In this repository the following data were published that were used to perform the analyses:
• Home_range_data: Excelsheet with the subset of home range sizes from the HomeRange database (Broekman et al., 2023) included in the analysis with associated data on the values of species traits and environmental variables.
• Data_sources: List of references for the home range data included in this study.
• Chapter4_AppendixS2: Results of model selection for terrestrial and marine mammals.
In chapter 5: ‘Impacts of existing and planned roads on terrestrial mammal habitat in New Guinea’, the Equivalent Connected Area (ECA) was estimated of habitat for 139 terrestrial mammal species with >90% of their habitat area in New Guinea. The ECA was calculated in three different situations: (1) no roads (baseline situation), (2) existing roads (current situation), and (3) existing and planned roads (future situation). Habitat fragmentation effects of roads were then quantified for each species by comparing the ECA in situations 2 and 3 to the ECA in situation 1. On average across the species, the ECA in the current situation equals 89% (SD = 12%) of the baseline ECA values (i.e., a situation without roads) and the lowest remaining ECA was found for Shawmayer’s coccymys (Coccymys shawmayeri, 53%). The average remaining ECA decreases to 71% (SD = 20%) of the baseline ECA values in the future situation. Further, the future remaining ECA drops to below 50% of the baseline for 28 species and the lowest remaining ECA was found for the montane soft-furred paramelomys (Paramelomys mollis, 36%). In this repository the following data were published that were used to perform the analyses:
• Roads_new_Guinea: shapefile with the existing and planned roads in New Guinea. These road data were either obtained from the Global Roads Inventory Project (GRIP) database (Meijer et al., 2018) or digitized from the maps published by Alamgir et al. (2019) and Sloan et al. (2019). Attribute data for each road includes an unique road identity number, road type, road surface, road width, and whether the road is an existing road or planned road.
• Refined_range_[species_name]: species-specific raster files (.tif) in WGS84 projection at ~100m resolution indicating whether a grid cell is part of the refined species range (= 1).
• Trait_data_and_results: Excelsheet with species-specific trait data, road crossing probabilities, and ECA values.
• Chapter5_AppendixS1: see Trait_data_and_results
References
Alamgir M., Sloan S., Campbell M.J., Engert J., Kiele R., Porolak G., Mutton T., Brenier A., Ibisch P.L., Laurance W.F. (2019) Infrastructure expansion challenges sustainable development in Papua New Guinea. Plos One, 14, 20.
Broekman M.J.E., Hoeks S., Freriks R., Langendoen M.M., Runge K.M., Savenco E., ter Harmsel R., Huijbregts M.A., Tucker
M.A. (2023) HomeRange: A global database of mammalian home ranges. Global Ecology and Biogeography, 32, 198-205.
Meijer J.R., Huijbregts M.A.J., Schotten K., Schipper A.M. (2018) Global patterns of current and future road infrastructure. Environmental Research Letters, 13, 10.
Sloan S., Campbell M.J., Alamgir M., Engert J., Ishida F.Y., Senn N., Huther J., Laurance W.F. (2019) Hidden challenges for conservation and development along the Trans-Papuan economic corridor. Environmental Science & Policy, 92, 98-106
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