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West, A M, Ons-5172
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/424981Surname: WEST. Given Name(s) or Initials: A M. Military Service Number or Last Known Location: ONS-5172. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 25920.250825
Item: [2016.0049.57242] "West, A M, Ons-5172
Stereo view of the MK-5172 complexes.
No full text<p>(A) MK-5172 bound to the wild-type protease with the substrate envelope in blue. Intra- and inter-molecular hydrogen bond interactions are marked as red and grey dashed lines. MK-5172 is shown bound to the drug-resistant variants (B) R155K, (C) D168A and (D) A156T with the transparent coordinates representing the wild-type structure to better highlight the molecular changes of each mutation. In all cases, catalytic residues are depicted in yellow, the P2 subsite in pink, and the drug molecules in orange.</p
Noise Assessment Method for High-Speed Railway Applications in Sweden
No full textISSN 0284-5172, 201
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
MK-5172 : a second-generation protease inhibitor for the treatment of hepatitis C virus infection.
No full textApproximately 170 million people worldwide are chronic carriers of the hepatitis C virus (HCV). Twenty-five percent of them develop liver cirrhosis and hepatocellular carcinoma during their life. Successful antiviral treatment dramatically reduces the risk of disease progression. HCV infection is treated with pegylated interferon and ribavirin; the addition of a protease inhibitor (boceprevir or telaprevir) can also be considered for patients with genotype 1.This review summarizes the data about the pharmacokinetics, pharmacodynamics, efficacy and safety of MK-5172 , a second-generation inhibitor of HCV NS3/4A protease.The pharmacokinetic profile allows for once-a-day administration. Combined with pegylated interferon and ribavirin, MK-5172 results in a high rate of HCV eradication (in about 90\% of cases) and a better outcome than boceprevir-based triple therapy. Also in interferon-free combinations, MK-5172-associated eradication rates are very high (89 - 100\%). MK-5172 has a higher barrier to resistance than first-generation protease inhibitors and is active against most variants associated with resistance to first-generation protease inhibitors. Tolerability and safety profile are good. Although data are limited, MK-5172 appears to overcome most of the drawbacks of the first-generation protease inhibitors and is thus a very promising agent to be used in combination with other antivirals to eradicate HCV infection
Hoja Geológica 5172-III
Get PDFFil: Panza, J.L.A. Servicio Geológico Minero Argentino; Argentina.Fil: Malumián, N. Servicio Geológico Minero Argentino; Argentina.Fil: Parisi, C. Servicio Geológico Minero Argentino; Argentina.El presente informe describe la geología del área cubierta por la Hoja 5172-Ill Yacimiento Río Turbio l :250.000 que comprende la fisiografía, geología histórica y la evolución del paisaje, las unidades del Cretácico superior y Cenozoico, la geología estructural y económica, con una lista comprensiva de antecedentes.
La Hoja 5172-III está situada en el extremo sudoccidental de la provincia de Santa Cruz. El principal núcleo poblacional es la ciudad de Río Turbio que con 12.000 habitantes es uno de las mayores de la provincia. La mayor actividad económica y minera es la continua explotación del yacimiento de carbón homónimo, el más importante del país.
Forma parte del ambiente geológico de la cuenca Austral o Magallánica. La columna litológica, exclusivamente sedimentaria, es una de las pocas secuencias marinas casi completa y expuesta del Cretácico superior y Paleogeno en la República Argentina. Las rocas aflorantes más antiguas son las pelitas y areniscas marinas de la Formación Cerro Toro (Campaniano inferior) que son seguidas por las areniscas marinas de la Formación Cerro Cazador (Campaniano superior).
En leve discordancia se apoya la Formación Monte Chico, nueva formación (Maastrichtiano) seguida en aparente concordancia por la Formación Cerro Dorotea (Paleoceno), ambas conformadas por psamitas y psefitas marinas.
En discordancia continúa la Formación Río Turbio (areniscas y pelitas marinas litorales del Eoceno medio a Eoceno superior bajo con mantos de carbón en explotación) que ha sido subdividida bioestratigráficamente mediante microfósiles. Es cubierta en manifiesta discordancia por los conglomerados fluviales ele la Formación Río Guillermo (Eoceno superior) y, más arriba, por las pelitas y psamitas continentales de la Fomrnción Río Leona (Eoceno cuspidal a Oligoceno inferior).
Continúan las areniscas marinas someras de la Formación Centinela (Mioceno inferior) que son sucedidas en leve discordancia por sedimentitas y piroclastitas continentales de la Formación Santa Cruz (Mioceno inferior cuspidal-Medio basal), las que están asociadas a los depósitos pscfíticos del Primer Nivel de Agradación Pectemontano correspondiente a la Formación Cordillera Chica (Mioceno superior). Al Pleistoceno y Holoceno se asignan depósitos glaciarios, fluviales, eólicos y ele remoción en masa.
En el Pleistoceno predominó la acción glacial como modeladora del paisaje, el cual está en la actualidad sometido a la acción fluvial; localmente son importantes las formas y efectos producidos por acción eólica y remoción en masa.
La comarca que comprende la Hoja se caracteriza por una estructura de plegamiento, destacándose un gran homoclinal de rumbo nortesur y buzamiento hacia el este.
Se brindan las descripciones o ilustraciones de los microfósiles más importantes bioestratigráficamente
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172
No full textRecent advances in direct-acting antivirals against Hepatitis C Virus (HCV) have led to the development of potent inhibitors, including MK-5172, that target the viral NS3/4A protease with relatively low susceptibility to resistance. MK-5172 has a P2-P4 macrocycle and a unique binding mode among current protease inhibitors where the P2 quinoxaline packs against the catalytic residues H57 and D81. However, the effect of macrocyclization on this binding mode is not clear, as is the relation between macrocyclization, thermodynamic stabilization, and susceptibility to the resistance mutation A156T. We have determined high-resolution crystal structures of linear and P1-P3 macrocyclic analogs of MK-5172 bound to WT and A156T protease and compared these structures, their molecular dynamics and experimental binding thermodynamics to the parent compound. We find that the "unique" binding mode of MK-5172 is conserved even when the P2-P4 macrocycle is removed or replaced with a P1-P3 macrocycle. While beneficial to decreasing the entropic penalty associated with binding, the constraint exerted by the P2-P4 macrocycle prevents efficient rearrangement to accommodate the A156T mutation, a deficit alleviated in the linear and P1-P3 analogs. Design of macrocyclic inhibitors against NS3/4A needs to achieve the best balance between exerting optimal conformational constraint for enhancing potency, fitting within the substrate envelope and allowing adaptability to be robust against resistance mutations
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