1,726,647 research outputs found
Abstract 3279: Circulating inflammatory biomarker C-reactive protein and radiotherapy-related pain in breast cancer patients
No full textAbstract
Background: Breast cancer is the most frequently diagnosed cancer and the second leading cause of cancer death in American women. Post-surgery adjuvant radiotherapy (RT) significantly improves clinical outcomes. However, many patients develop treatment-related pain that negatively impacts quality of life.
Methods: We evaluated an inflammatory biomarker, C-reactive protein (CRP) in RT-associated pain in a prospective study of 366 breast cancer patients (64% Hispanic whites, 20% African Americans, 16% non-Hispanic whites) undergoing RT. In each patient, we measured pre- and post-RT plasma CRP levels using a highly-sensitive ELISA kit. Pain score was assessed at pre- and post-RT as the mean of four pain severity items (i.e., pain at its worst, least, average, and now) from the Brief Pain Inventory. Pain scores of 4-10 were considered clinically-relevant pain. Association between pain and CRP levels was evaluated using logistic regression models after adjusting for potential confounders.
Results: Overall, 16% patients at pre-RT and 31% patients at post-RT had pain. In multivariable analyses, RT-related pain score change >4 was significantly associated with CRP change >1 mg/L (OR=3.24, 95%CI=1.33, 7.88), age <50 (OR=3.27, 95%CI=1.20, 8.92), and 3+ comorbidity conditions (OR=5.91, 95%CI=1.33, 26.82).
Conclusion: This is the first study to suggest that increased inflammatory biomarker, CRP level was associated with RT-related pain. Impact: Future larger studies are warranted to validate our findings and facilitate the discovery and development of anti-inflammatory agents to protect patients from RT-related pain and improve quality of life in breast cancer patients undergoing RT.
Citation Format: Eunkyung Lee, Omar L. Nelson, Carolina Puyana, Cristiane Takita, Jean L. Wright, Wei Zhao, Isildinha M. Reis, Rick Lin, Jennifer J. Hu. Circulating inflammatory biomarker C-reactive protein and radiotherapy-related pain in breast cancer patients [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3279. doi:10.1158/1538-7445.AM2017-3279</jats:p
3279. Etienne Marcel
No full text3279. Etienne Marcel. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). IV. Les Valois, 1328-1461. Paris : A. Picard et fils, 1904. pp. 54-55
3279. Etienne Marcel
No full text3279. Etienne Marcel. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). IV. Les Valois, 1328-1461. Paris : A. Picard et fils, 1904. pp. 54-55
Block Card 3279 Detroit Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: American four and a half square | Dwelling | 3279 Detroit Avenue (Toledo, Ohio) | Old West End Area (Toledo, Ohio) | Cushing Place Addition (Toledo, Ohio
Foxp3-6054/−3279 haplotype frequency in PE and Control groups.
No full text<p>Foxp3-6054/−3279 haplotype frequency in PE and Control groups.</p
Despacho n. 3279 de 5 de dezembro de 2013
No full textConversão de licença-prêmio em pecúnia. Processo STJ n. 12373/2012. Despacho n. 3279
Methodist Church of Island, Kentucky (SC 3279)
Full text linkFinding aid only for Manuscripts Small Collection 3279. Contracts, 13 December 1904 and 14 March 1949, with specifications for construction of a church building at Island, Kentucky. Includes photocopy of an undated photograph of the building
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Cultureel conservatisme en economische progressiviteit onder arbeiders : Lipsets thesen getoetst in zes landen
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3279.pdf (Publisher’s version ) (Open Access
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