1,725,380 research outputs found
Hawaii Senate Bill 3182
No full textSenate Bill 3182 ("The purpose of Senate Bill No. 3182 is to appropriate an undetermined sum out of the general revenues for fiscal year 1988-89 for the development of geothermal resources, a cable system, and a comprehensive permit system
Hawaii Senate Bill 3182
No full textSenate Bill 3182 ("The purpose of Senate Bill No. 3182 is to appropriate an undetermined sum out of the general revenues for fiscal year 1988-89 for the development of geothermal resources, a cable system, and a comprehensive permit system
Santa Fe (ATSF) 3182
No full textA photograph postcard (& Negative) showing Santa Fe 3182, 2-8-2, southbound through Big Canyon, near Arbuckle, OK, 73 cars
Block Card 3182 Radford Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 3182 Radford Avenue (Toledo, Ohio) | Dwelling | Replat of Vanderbilt Terrace (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Ham, Mordecai Fowler, 1877-1961 (SC 3182)
Get PDFFinding aid and scan (Click on Additional Files below) for Manuscript Small Collection 3182. Typescript of funeral service for Reverend Mordecai F. Ham, held in Louisville, Kentucky. Includes lengthy remarks by Reverend Billy Graham, who assisted in the service. Also includes Ham’s obituary from the Louisville Courier-Journal
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Blood-Derived Extracellular Vesicle-Associated miR-3182 Detects Non-Small Cell Lung Cancer Patients
No full textWith five-year survival rates as low as 3%, lung cancer is the most common cause of cancer-related mortality worldwide. The severity of the disease at presentation is accredited to the lack of early detection capacities, resulting in the reliance on low-throughput diagnostic measures, such as tissue biopsy and imaging. Interest in the development and use of liquid biopsies has risen, due to non-invasive sample collection, and the depth of information it can provide on a disease. Small extracellular vesicles (sEVs) as viable liquid biopsies are of particular interest due to their potential as cancer biomarkers. To validate the use of sEVs as cancer biomarkers, we characterised cancer sEVs using miRNA sequencing analysis. We found that miRNA-3182 was highly enriched in sEVs derived from the blood of patients with invasive breast carcinoma and NSCLC. The enrichment of sEV miR-3182 was confirmed in oncogenic, transformed lung cells in comparison to isogenic, untransformed lung cells. Most importantly, miR-3182 can successfully distinguish early-stage NSCLC patients from those with benign lung conditions. Therefore, miR-3182 provides potential to be used for the detection of NSCLC in blood samples, which could result in earlier therapy and thus improved outcomes and survival for patients
The long noncoding RNA linc00858 promotes progress of lung cancer through miR-3182/MMP2 axis
No full textIn previous studies, numerous dysregulated lncRNAs were identified using RNA-sequencing. Lung cancer is the most common malignant tumour worldwide and the second leading cause in cancer. The aim of this study is to investigate the function and mechanism of lincRNA00858 in the lung cancer. RT-PCR was used to detect the expression of lincRNA00858. Proliferation, invasion, and epithelial-mesenchymal transition (EMT) were examined by CCK8, transwell assay and western blot to evaluate the function of linc00858. Dual-luciferase reporter assay was used to identified the potential target of linc00858. Over-expression of linc00858 significantly promoted cell proliferation, invasion. We also found that linc00858 facilitated the EMT process. Dual-luciferase reporter assay revealed that linc00858 can bind with miR-3182 directly. Linc00858 can negatively regulate the expression of miR-3182. Further experiments demonstrated that MMP2 was the direct target of miR-3182. Rescue experiments revealed that linc00858 functioned through miR-3182/MMP2 axis. Taken together, we verified the role of an unknown linc00858 in lung cancer and provided its mechanism. Mechanistically, linc00858 acted as a competitive endogenous RNA to sponged miR-3182 and regulate MMP2 in lung cancer. Our study provided new clues for understanding the mechanism of lung cancer
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