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Abstract 2764: Mechanisms of genomic-microenvironmental interactions in uveal melanoma
No full textAbstract Uveal melanoma (UM) is the most common primary eye cancer and has a high rate of metastasis with liver tropism. UM can be stratified according to metastatic risk into low risk Class 1 and high risk Class 2 tumor. Biallelic mutational inactivation of the tumor suppressor BAP1 is the quintessential molecular feature of Class 2 UM, but the mechanism by which loss of BAP1 leads to metastasis is poorly understood. We recently showed using single-cell RNA sequencing that the tumor microenvironment of primary and metastatic Class 2 UM is characterized by large numbers of inhibitory T cells and macrophages. Taken together, these findings led us to hypothesize that loss of BAP1 triggers changes in tumor-immune cell interactions that lead to an immunosuppressive microenvironment. To test this hypothesis, we performed RNA-seq and proteomic mass spectrometry in uveal melanocytes and UM cells engineered to lack BAP1 expression. These experiments identified a small cassette of immune modulatory genes that are up-regulated at the mRNA and protein levels following BAP1 loss. These proteins are known to drive monocytes towards type 2 macrophage polarization, which secrete cytokines that can inhibit T cell activation. Our findings suggest that altered interaction between UM cells and monocytes may be key to the emergence of metastatic competence in UM, and we are exploring this possibility with function experiments that may open the door to targeted therapy to subvert this process. Citation Format: Christopher J. Kaler, James J. Dollar, Stefan Kurtenbach, Jeffim N. Kuznetsov, Michael A. Durante, J. William Harbour. Mechanisms of genomic-microenvironmental interactions in uveal melanoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 2764
[IO Islamic 2764] ديوان حافظ
No full textDîwân-i-Ḥâfiż.
This manuscript is now IO Islamic 1248 in the India Office collections.
[metadata: Hermann Ethé, Catalogue of Persian Manuscripts in the Library of the India Office, 2 vols. (Oxford: India Office, 1903): volume 1, number 2764 here with notations and hyperlinks].
1248
The same.
This copy contains only:
Ghazals, in alphabetical order, on fol.1b, beginning as usual.
A few ḳiṭ’as, on fol. 160a.
One mathnawî ( الا اى آهوى = Brockhaus, No. 685), on fol. 162b.
A few rubâ’îs, on fol. 163a.
Dated the 2nd of Muḥarram, A.H. 1084 (A.D. 1673, April 19), by ׳Abd-alnabî Ḳâdirî ibn Shaikh Ḥusain, a friend of the Imâm Miyânjân Muḥammad ibn Shaikh Mîrânjî. Bibliotheca Leydeniana.
No. 2764, ff. 164, 2 coll., each ll. 15; Nasta’lîḳ; illuminated frontispiece; size, 91/8 in. by 51/2 in
O BIOPODER NA CONTEMPORANEIDADE E A ALTERNATIVA BUDISTA
No full texthttps://seer.ufrgs.br/debatesdoner/article/view/2764/163
Basic and clinical characteristics of 2764 participants by cognitive status.
No full textBasic and clinical characteristics of 2764 participants by cognitive status.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The radioactive Substances (Testing Instruments) Exemption (Scotland)Order 1962
No full textERAF: A6.SI.1962.2764(S.124 )STATUTORY INSTRUMENTS 1962 No. 2764 (S. 124) ATOMIC ENERGY AND RADIOACTIVE SUBSTANCES The Radioactive Substances (Testing instruments) Exemption (Scotland) Order 196
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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