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LIPIcs, Volume 246, DISC 2022, Complete Volume
No full textLIPIcs, Volume 246, DISC 2022, Complete Volum
Bulletin No. 246 - Hybrid Corn Adaptation Trials in Wyoming, 1940
No full textBulletin No. 246 - Hybrid Corn Adaptation Trials in Wyoming, 194
An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus challenge
No full textST-246 is a low-molecular-weight compound (molecular weight=376), that is potent (concentration that inhibited virus replication by 50%=0.010 micro M), selective (concentration of compound that inhibited cell viability by 50%=>40 micro M), and active against multiple orthopoxviruses, including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), and variola viruses. Cowpox virus variants selected in cell culture for resistance to ST-246 were found to have a single amino acid change in the V061 gene. Reengineering this change back into the wild-type cowpox virus genome conferred resistance to ST-246, suggesting that V061 is the target of ST-246 antiviral activity. The cowpox virus V061 gene is homologous to vaccinia virus F13L, which encodes a major envelope protein (p37) required for production of extracellular virus. In cell culture, ST-246 inhibited plaque formation and virus-induced cytopathic effects. In single-cycle growth assays, ST-246 reduced extracellular virus formation by 10 fold relative to untreated controls, while having little effect on the production of intracellular virus. In vivo oral administration of ST-246 protected BALB/c mice from lethal infection, following intranasal inoculation with 10x 50% lethal dose (LD50) of vaccinia virus strain IHD-J. ST-246-treated mice that survived infection acquired protective immunity and were resistant to subsequent challenge with a lethal dose (10x LD50) of vaccinia virus. Orally administered ST-246 also protected A/NCr mice from lethal infection, following intranasal inoculation with 40 000x LD50 of ectromelia virus. Infectious virus titers at day 8 postinfection in liver, spleen, and lung from ST-246-treated animals were below the limits of detection (<10 PFU/ml). In contrast, mean virus titers in liver, spleen, and lung tissues from placebo-treated mice were 6.2x107, 5.2x107, and 1.8x105 PFU/ml, respectively. Finally, oral administration of ST-246 inhibited vaccinia virus-induced tail lesions in Naval Medical Research Institute mice inoculated via the tail vein. Taken together, these results validate F13L as an antiviral target and demonstrate that an inhibitor of extracellular virus formation can protect mice from orthopoxvirus-induced disease..Source type: Electronic(1
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Resolución UNRN Nº 246/2009. Declara contratación directa fracasada
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN Nº 246/2009. Declara contratación directa fracasadafals
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
The Theory of “Grund” in the Philosophy of Böhme and Schelling : Protestant Mysticism in Germany(2)
Full text linkIn the previous chapters of our paper we considered the significance of the German Protestant Mysticism of Valentin Weigel and Johann Arundt. They protested against the scholasticism and formalism of the Lutheran Church, just as Luther himself had once thundered against Rome. At the beginning of the seventeenth century ,German mysticism again finds its voice in a cobbler, Jacob Böhme. Böhme attempts to explain the fact of evil and sin in the world as a necessary phase in the process of divine self-expression. Everywhere in reality he finds oppositions and contradictions. Since all things come from God, he must be the primal ground of all oppositions; he is an undifferentiated, fathomless ground, the primal objectless will. So Böhme calls this ground “Ungrund”. And he attempts to trace the evolution of this groundless will, combining Christian theological ideas such as the Trinity, angels, the fall of Lucifer, the fall of man, the plan of salvation, which were derived mainly from the magical nature mysticism of Paracelsus. Nevertheless, he plainly belongs in the direct line of German spiritual reformers whom we have been studying. He was deeply influenced by Luther, especially in the insight of the transforming element of personal faith in religion and in the acceptance of the teaching of mystical ground. The readers of Schelling’s Philosophical Inquiry into the Essence of Human Freedom in 1809 were surprised and enraptured by a wealth of new and previously unheard of expressions which are drawn directly from Böhme, or are fashioned on the model of his symbolic language. He comes close to the ideas of Böhme on freedom and “Ungrund”. In the above-mentioned context, this paper seeks to elucidate the following points: (1) Böhme’s mystical experience and his work, Aurora (2) “Ungrund” and “Grund” (3) “Grund” in his book, Way to Christ (4) Schelling’s theory of “Grund”departmental bulletin pape
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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