1,802,744 research outputs found
The Invincible (1758) site: an integrated geophysical assessment
No full textChirp sub-bottom profiler and repeat sidescan sonar imaging of the Invincible wreck site (1758) in the Solent (U.K.), interpretation, and implications for management of the site
Livres nouveaux qui se trouvent à Paris chez Desaint & Saillant, 1758.
No full text[Catalogue de libraire. Paris. Desaint, Jean. 1758][Catalogue de libraire. Paris. Saillant, Charles. 1758]Avec mode text
Priority of Carl Linnaeus as the author of the oldest species of Cladocera (Crustacea: Branchiopoda): Daphnia pulex (Linnaeus, 1758) and Polyphemus pediculus (Linnaeus, 1758)
No full textCopyright © 2020 Magnolia Press. In taxonomy, it is important to maintain chronological order in taxon naming and understanding. Here, I confirm that according to the rules of Zoological Nomenclature, Carl Linnaeus must be regarded as the author of two common cladoceran taxa, Daphnia pulex (Linnaeus, 1758) and Polyphemus pediculus (Linnaeus, 1758). Both were established in the 10th Edition of "Systema Naturae", the starting point of Zoological Nomenclature. The history of these taxa is described
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Design of dual ligands using excessive pharmacophore query alignment : from 7th German Conference on Chemoinformatics: 25 CIC-Workshop Goslar, Germany, 6 - 8 November 2011
No full textDual- or multi-target ligands have gained increased attention in the past years due to several advantages, including more simple pharmacokinetic and phamarcodynamic properties compared to a combined application of several drugs. Furthermore multi-target ligands often possess improved efficacy. We present a new approach for the discovery of dual-target ligands using aligned pharmacophore models combined with a shape-based scoring. Starting with two sets of known active compounds for each target, a number of different pharmacophore models is generated and subjected to pairwise graph-based alignment using the Kabsch-Algorithm. Since a compound may be able to bind to different targets in different conformations, the algorithm aligns pairs of pharmacophore models sharing the same features which are not necessarily at the exactly same spatial distance. Using the aligned models, a pharmacophore search on a multi-conformation-database is performed to find compounds matching both models. The potentially “dual” ligands are scored by a shape-based comparison with the known active molecules using ShaEP.
Using this approach, we performed a prospective fragment-based virtual screening for dual 5-LO/sEH inhibitors. Both enzymes play an important role in the arachidonic acid cascade and are involved in inflammatory processes, pain, cardiovascular diseases and allergic reactions. Beside several new selective inhibitors we were able to find a compound inhibiting both enzymes in low micromolar concentrations. The results indicate that the idea of aligned pharmacophore models can be successfully employed for the discovery of dual-target ligands
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Bucefalose no cultivo de mexilhões: relação do parasita com os hospedeiros iniciais
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Programa de Pós-Graduação em Aquicultura, Florianópolis, 2013.O Trematoda Digenea Bucephalus margaritae (Ozaki & Ishibashi, 1934) é o causador da bucefalose em mexilhão Perna perna (Linnaeus, 1758). Com o objetivo de contribuir para o entendimento do complexo ciclo de vida desse parasita, que utiliza dois hospedeiros intermediários, avaliou-se a relação de infestação de mexilhões cultivados e peixes. As coletas foram realizadas no cultivo experimental de moluscos marinhos da UFSC, na praia da Ponta do Sambaqui, Florianópolis/SC. Cada corda de mexilhão foi coletada com auxílio de rede, que a envolveu, para que não houvesse a fuga dos peixes junto aos moluscos. Foi quantificado o número de mexilhões e peixes com bucefalose, utilizando-se técnicas macro e microscópicas. Foram coletadas 122 cordas e analisados macroscopicamente 1220 mexilhões, dos quais 32,4% estavam parasitados. Mexilhões com mais de 9 meses de cultivo e acima de 90 mm apresentaram maior prevalência do parasita. Foram obtidos 234 peixes associados às cordas de mexilhão, pertencentes a 4 famílias (Blenniidae, Gobiidae, Monacanthidae e Gobiesocidae) e identificadas 5 espécies. Hypleurochilus fissicornis e Gobiosoma hemigymnum foram os mais abundantes. Omobranchus punctatus e Stephanolepsis hispidus ocorreram em duas amostragens e Gobiesox stromosus em uma. Em 74,7% dos blenídeos e gobídeos havia metacercárias encistadas nas brânquias. Houve relação entre a prevalência de mexilhões e peixes infestados pelo bucefalídeo. Os elevados índices de bucefalose indicam que Hypleurochilus fissicornis e Gobiosoma hemigymnum são os principais hospedeiros intermediários deste trematódeo após abandonar o molusco The Trematoda Digenea Bucephalus margaritae (Ozaki & Ishibashi, 1934) is the main causer of "orange disease" in mussel Perna perna (Linnaeus, 1758). With the aim of contributing to the knowlodge of the complex life cycle of this parasite, which uses two intermediate hosts, the relationship of infestation in cultived mussels and fishes was evaluated. Samples were collected in a experimental mussel culture station of southern Brazil. Mussels rope were collected manually with the aid of a fishing net to prevent the escape of fishes along the molluscs. The number of mussels and fishes with B. margaritae was quantified, using macroscopic and histological techniques. 122 mussels rope were collected and 1220 mussels were analyzed macroscopically, of which 32.4% were parasitized. Mussels over 9 months of cultivation and above 90 mm had a higher prevalence of the parasite. It colleted a total of 234 fish associated with mussels culture, representing 5 species and 4 families (Blenniidae, Gobiidae, Monacanthidae and Gobiesocidae). Hypleurochilus fissicornis and Gobiosoma hemigymnum were the most abundant. Omobranchus punctatus and Stephanolepsis hispidus occurred in two samples and Gobiesox stromosus in a single sample. In 74.7% of blenniids and gobiids had metacercariae encysted in the gills. The high levels of Bucephalus margarite show that Hypleurochilus fissicornis and Gobiosoma hemigymnum are the main intermediate hosts of this trematode after leaving the mollusc
Período de permanência de cordas do mexilhão Perna perna (L., 1758) em cultivo
No full textTCC (graduação em Engenharia de Aquicultura) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, 2009O presente trabalho foi realizado no Cultivo Experimental do Laboratório de Moluscos Marinhos (LMM) da UFSC, localizado na Praia do Sambaqui em Florianópolis/ Santa Catarina - Brasil e teve Tem como objetivo verificar o melhor período de permanência de cordas do mexilhão Perna perna em cultivo, de forma a maximizar a produção e aumentar a sustentabilidade , e rentabilidade dos cultivos comerciais. Foram estudados 10 lotes de 100 cordas de mexilhão cada, que foram cultivados no LMM de 2003 a 2008. As perdas que não são devidas a predadores e parasitas podem ocorrer por despencamento, por roubo ou por motivos desconhecidos. Através de análise dos dados coletados observa-se que, para evitar perdas por despencamento, não se deve deixar os mexilhões no mar por um período superior a 180 dias. A estação do ano em que ocorrem as maiores perdas, foi no outono com 4,01% de despencamento, seguido pelo inverno com 3,35% de despencamento, primavera com 1,62% de despencamento, e verão com 2,61% de despencamento. Desta forma, sugere-se que ocorra uma intensificação no manejo, logo após o verão. A porcentagem de perda por roubo ou por motivo desconhecido foi de 19,5%, para o período estudado
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