1,721,925 research outputs found
Aerosolized BIO-11006, a Novel MARCKS- Related Peptide, Improves Airway Obstruction in a Mouse Model of Mucus Hypersecretion
No full textRationale:
Mucus hypersecretion has been shown to be an important cause of airway obstruction in COPD and asthma, and has been associated with fatal asthma. Previous in-vitro and in-vivo studies have provided direct evidence that the myristoylated alanine-rich C kinase substrate (MARCKS) is a central regulatory molecule linking secretagogue stimulation at the goblet cell surface to mucin granule release. BIO-11006 is a novel, highly soluble, aerosolized peptide that inhibits MARCKS function and results in reduced mucus secretion and improved airway obstruction. BIO-11006 is being tested in Phase 2 clinical studies of COPD.
Objective:
To determine access of BIO-11006 to the intracellular compartment of normal human bronchial epithelial (NHBE) cells, and assess the effectiveness of BIO-11006 inhalation solution in inhibiting airway obstruction caused by mucus hypersecretion as a function of dose and time.
Methods:
Biotin labeled BIO-11006 was incubated with NHBE cells and visualized with fluorescein-labeled streptavidin. Ovalbumin-sensitized and challenged mice with airway inflammation and hyperresponsiveness to methacholine (MCh) were treated with aerosolized BIO-11006 solution prior to MCh challenge, and effects on airway obstruction and mucus secretion were measured.
Results:
A 30-minute aerosol exposure to a 10 mM BIO-11006 solution was maximally effective in inhibiting MChinduced airway obstruction and mucus hypersecretion. There was a long-lasting effect on inhibition of airway obstruction after a single treatment with BIO-11006 (t1/2~4 hrs). The duration of effect on inhibition of mucin secretion was shorter (t1/2~2 hrs).
Conclusion:
The pharmacodynamic properties of aerosolized BIO-11006 Inhalation Solution are suitable for therapeutic use. Inhaled BIO-11006 effectively inhibits mucin secretion and improves airway obstruction
Mg2+ transport in plasma membrane vesicles of renal epithelium of the Mozambique tilapia (Oreochromis mossambicus)
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11006.pdf (Publisher’s version ) (Open Access
Proyecto de Inversión Pública Aplicado al Servicio Educativo en la I.E. Ramón Espinoza Sierra N°11006 – Pj El Porvenir, Chiclayo
Get PDFEl presente trabajo de investigación titulado: Proyecto de inversión pública aplicado al servicio educativo en la I.E. Ramón Espinoza Sierra N°11006 – PJ El Porvenir, Chiclayo, se desarrolló en el centro educativo de gestión pública Ramón Espinoza Sierra N°11006, ubicado en la Av. Arica N°371, provincia y distrito de Chiclayo, departamento de Lambayeque.
Tiene como objetivo general, elaborar un Proyecto de Inversión Pública a nivel de pre – inversión que posibilitaría mejorar el servicio educativo en la I.E. Ramón Espinoza Sierra N°11006 – Chiclayo; las variables de estudio son: Variable Independiente (V1) proyecto de inversión pública y (V2) servicio educativo. Por lo que se adjudicó ser una investigación es de Diseño No Experimental. Se consideró como población de estudio a 40 estudiantes del 4°, 39 estudiantes de 5° grado de secundaria y 24 docentes de la institución. Se utilizó instrumentos de recolección de datos como encuesta y guía de observación. La encuesta fue validada mediante el juicio de expertos y procesada en el software estadístico SPSS para obtener datos confiables; arrojando como resultado que los usuarios están insatisfechos con el servicio educativo en cuanto a infraestructura; por otra parte, se realizó la evaluación de la infraestructura mediante la ficha validada por el PRONIED, los resultados fueron que esta no cumple con los estándares establecidos por el MINEDU para el diseño de locales escolares.
A partir de ello, se elaboró el Proyecto de Inversión Pública basado en la metodología del Sistema Nacional de Programación Multianual y Gestión de Inversiones, denominado: “Mejoramiento del Servicio Educativo de la I.E. Ramón Espinoza Sierra N°11006 del P.J El Porvenir, Distrito de Chiclayo, Provincia de Chiclayo – Departamento de Lambayeque”. El proyecto tiene una inversión de S/. 5, 962,407.04 con un VACS de S/. 6, 121,483.58 con el indicador de eficacia de 5481 personas, brindando un costo eficacia de S/.1116.86 por beneficiario
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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