8 research outputs found
The role of uzbek novators in political and economical change and the critical view of Fitrat`s in her “Debate” book
No full textThis article indicates the main features of literature in human beings life and enlights the history of Turkistan in XXcentury. The main issues of collapsing of three empires in Turkistan and the sorrowful days of Bukhara are explained by author in this material. Additionally, today`s some global problems are debated and reasoned in pieces of Fitrat`s book
Modern library and reading in multimedia environment
No full textThe article identifies the library's ability to stimulate reader activity in the context of the multimedia culture development. It also considers main changes in the library activities as an organizer of reading in multimedia culture including the increase of emphasis on readers, their subjectivity, interaction dialogue forms development, multimedia projects implementation, online services and digital resources introduction, education of readers on literate media behavior and text activity in the Internet. The author states that in the context of multimedia, library can become an active participant in overcoming information chaos, streamlining information flows, enhancing reading and also contribute to the development of inter-reader communication. The article concludes that it is necessary to prepare library specialists, tutors, ready to organize communication about books and reading in a real and virtual environment, network navigation, analysis of Internet resources, recognition of misinformation, and teaching readers various techniques of textual activity
Methodological Aspects of Studying the Reading of Modern Youth
No full textРукопись поступила в редакцию 31 июля 2018 г.В статье речь идет о методологических аспектах изучения чтения российской молодежи: обоснована необходимость формирования исследовательских подходов, связанных с трансформациями в книжном процессе, появлением новых дифференцирующих оснований взаимодействия с названной категорией читателей, необходимостью выявления стимулирующего или, напротив, угнетающего воздействия различных коммуникационных каналов. Представлены адекватные для нынешнего этапа развития цифровых технологий теоретические подходы исследования «Чтение российской молодежи в век цифровых технологий: стимулы и практики». Охарактеризованы базовые понятия исследования, показаны различия и эмпирические индикаторы практик чтения, практик читательской деятельности; рассмотрена значимая для современной молодежи система стимулов чтения на институциональном и неинституциональном уровнях. Сделаны выводы о необходимости разработки методов и приемов выявления практик чтения на основе произошедших в книжном процессе трансформаций, особенностей коммуникативного поведения и познавательной деятельности поколения зет, выявления действенных для него стимулов чтения и переосмысления деятельности институтов инфраструктуры чтения на основе субъект-субъектного взаимодействия с молодежью в реальном и сетевом пространствах.The article deals with the methodological aspects of studying reading to Russian youth: the necessity of adapting research approaches due to follwoing factors: transformations in the publishing industry; emergence of the new ways to ineract with varying categories of readers; necessity to identify stimulating or, conversely, depressing effects of various communication channels. The author describes theoretical approaches in the project “Reading of Russian youth in the age of digital technologies: incentives and practices”, which are more adequate for the current digital technologies. The basic concepts of the research are characterized, the differences and empirical indicators of reading practices are shown. The reading incentive system for non-institutional levels, which is signifi cant for today's youth, is considered. The author concludes that there is a need to develop methods and techniques for identifying reading practices based on the transformations that have occurred in the publishing industry, the characteristics of the communicative behavior and cognitive activity of the Z generation, identifying effective reading incentives and rethinking the activities of reading infrastructure institutions on the basis of subject-subject interaction with young people in real life and network spaces
Various approaches for reduction of heavy metal pollution of topsoil
No full textThe paper considers various approaches to reduce heavy metal (HM) pollution of agricultural and non-agricultural soils. The main measures to reduce HM activity in agricultural soils include liming, application of mineral and organic fertilizers, artificial and natural sorbents. On lands not used for agricultural purposes, the main types of HM reduction are soil washing and replacement of contaminated soil with imported soil. © 2019 Author(s)
Role of Aβ-RAGE interaction in oxidative stress and cPLA2 activation in astrocytes and cerebral endothelial cells
No full textBlood–brain barrier (BBB) dysfunctions have been implicated in the progression of Alzheimer's disease. Cerebral endothelial cells (CECs) and astrocytes are the main cell components of the BBB. Although amyloid-β oligomers (Aβ42) have been reported to mediate oxidative damage to the CECs and astrocytes and trigger the downstream mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway, the cell surface binding site for Aβ42 and exact sequence of these events have yet to be elucidated. In this study, the receptor for advanced glycation endproducts (RAGE) was postulated to function as a signal transducing cell surface receptor for Aβ42 to induce reactive oxygen species (ROS) generation from NADPH oxidase and trigger downstream pathways for the phosphorylation of extracellular signal-regulated kinases (ERK1/2) and cytosolic phospholipase A2 (cPLA2). We found that Aβ42 competed with the anti-RAGE antibody (AbRAGE) to bind to RAGE on the surfaces of CECs and primary astrocytes. In addition, AbRAGE abrogate Aβ42-induced ROS production and the colocalization between the cytosolic (p47-phox) and membrane (gp91-phox) subunits of NADPH oxidase in both cell types. AbRAGE as well as NADPH oxidase inhibitor and ROS scavenger suppressed Aβ42-induced ERK1/2 and cPLA2 phosphorylation in CECs. At the same time, only AbRAGE, but neither NADPH oxidase inhibitor nor ROS scavenger, inhibited the ERK1/2 pathway and cPLA2 phosphorylation in primary astrocytes. Therefore, this study demonstrates that NADPH oxidase complex assembly and ROS production are not required for Aβ42 binding to RAGE at astrocytic surface leading to sequential phosphorylation of ERK1/2 and cPLA2, and suggests the presence of two different RAGE-dependent downstream pathways in the CECs and astrocytes
Agriculture of the Republic of Uzbekistan after the peak of the pandemic
No full textWhen studying the topic, the author analyzes the implementation of reforms and their impact on the development of the agricultural sector of the Republic of Uzbekistan. Special attention is paid to the pandemic crisis that has affected all spheres of the economy and the life of the population. The importance of the actions taken by the state in relation to the improvement of the agricultural sector, not only through the production of agricultural raw materials, but also in other ways, is revealed. One of these ways is the production of products that can compete on the world market, the production of semi-finished products, and others. Methods of analysis, synthesis, grouping, observation, and deduction were used in the study of the material. Using these methods, the authors were able to come to a better conclusion, and make suitable conclusions and suggestions. In conclusion, the ways to improve the efficiency of agricultural production, through the introduction of resource-saving technologies, innovative technologies, and especially the removal of state attention to the agricultural sector, are revealed. The article also focuses on the state of agriculture during and after the pandemic, and compares it with other countries of the world. The authors made proposals that are most suitable for the development of agriculture, ensuring food security and independence of the population
L'utilisation des plateformes pédagogiques pour développer des compétences de communication orale en FLE au Kazakhstan : aspects didactiques et pédagogiques
No full textInternational audienceThe article is devoted to the problem of implementing an individual approach in teaching languages on interactive educational platforms. The criteria for analyzing interactive educational platforms from the point of view of individualization are proposed. The article also discusses the problems of creating pedagogical platforms for teachers of the French language; such a pedagogical platform is considered by the author as an innovative didactic tool. This fulfills all the functions of didactic tools and can be used for distance learning of French language for a group of students; describing the available pedagogical platforms, the author concludes that the proposed options do not meet the needs of language teachers. The research hypothesizes that learning on an interactive educational platform in the context of an individual approach can increase the level of knowledge of students. The article describes the developed educational platform Ca va école for learning French. The paper also presents the results of a pedagogical experiment to evaluate the effectiveness of the developed methodology
