1,722,218 research outputs found
Foreign Capital, Inflation, Sterilization, Crowding-Out and
Get PDFThis paper discusses some puzzles in the contemporary macroeconomic scene in India, from the perspective of public finance and economic development. These include a fiscal deficit higher than it was during the 1991 crisis, but without a large current account deficit or rise in inflation or interest rates, a rising inflow of external capital, accompanied by the RBI’s sterilizing these inflows and accumulating large reserves, even in the face of low inflation. We offer a critique of some previous analyses, and some models that are suggestive of how real and monetary factors might be integrated in providing a firmer grounding for the policy debates current in India.foreign capital, sterilization, absorption, crowding out, inflation, growth
Expression of calcium-activated chloride channels TMEM16A and TMEM16B in adult mouse vomeronasal epithelium and during embryonic development of the olfactory epithelium
Get PDFOlfaction enables animals to be familiar with the surrounding environmental changes. Exchange of odor molecules between animals is a way to communicate with each other and is necessary for various physiological processes, like reproduction, food preferences, prey detection, etc. The olfactory epithelium is always in contact with the inhaled air that is accompanied by odor molecules. Olfactory sensory neurons are the primary neurons of the olfactory epithelium. These neurons follow the “one receptor one neuron” rule, i.e. each individual olfactory sensory neuron expresses only one type of olfactory receptor out of ~1300 types in mouse. These neurons are specialized to convert chemical interaction, between odor molecules and olfactory receptor, into electrical signals by specific transduction mechanisms, which occur in the cilia of these neurons. The ciliary membrane contains cyclic nucleotide-gated channels and calcium-activated chloride channels. It is well documented that calcium-activated chloride channels are used to enhance signal to noise ratio in olfactory sensory neurons but we do not know about their involvement in the development of olfactory epithelium. TMEM16A and TMEM16B, the members of transmembrane proteins 16 (TMEM16) family, are responsible for the calcium-activated chloride current in various cells. In present work, I studied expression of TMEM16A and TMEM16B proteins during embryonic development of mouse and tried to find their role in olfactory epithelium development.
I found expression of TMEM16A and TMEM16B in the developing olfactory epithelium at different embryonic ages. At embryonic day 12.5 (E12.5), TMEM16A immunoreactivity was present at the apical surface of the entire olfactory epithelium, but from E16.5 became restricted to a region near the transition zone with the respiratory epithelium. Olfactory sensory neurons are devoid of TMEM16A but this channel is expressed in the apical organelle free region and microvilli of supporting cells. Nasal septal glands and lateral nasal glands also express TMEM16A at the luminal surface of glands. In contrast, TMEM16B immunoreactivity was observed at E14.5 at the apical surface of the olfactory epithelium. Its expression was observed only in mature olfactory sensory neurons. With the maturation of olfactory sensory neurons and elongation of cilia TMEM16B expression is increased along with ACIII, CNGA2 and acetylated-tubulin. Interestingly, olfactory sensory neurons express only TMEM16B, but I found expression of TMEM16A as well as of TMEM16B in microvilli of vomeronasal sensory neurons. These findings indicate different physiological roles for TMEM16A and TMEM16B in the developing as well as in the postnatal olfactory and vomeronasal epithelia. Taking into account the previous evidences, I hypothesized that the presence of TMEM16A at the apical part and in microvilli of the supporting cells as well as in nasal glands is involved (1) in the regulation of the chloride ionic composition of the mucus covering the apical surface of the olfactory epithelium and/or (2) in proliferation and development during embryonic development. By comparing immunohistochemistry experiments on TMEM16A-/- and TMEM16A+/+ littermate mice I excluded the hypothesis that TMEM16A is involved in proliferation or development of the olfactory epithelium. So, either TMEM16A does not play a central role in the development of the olfactory epithelium or its genetic ablation does not affect olfactory development. Supporting cells, Bowman’s and nasal glands morphology remained unchanged in TMEM16A-/- mice, but at present we do not know whether the mucus composition is same as in TMEM16A+/+ littermate mice. Localization of TMEM16B to the cilia of mature olfactory sensory neurons and in microvilli of vomeronasal sensory neurons is consistent with a role in sensory signal transduction mechanism.
In conclusion, the present work explored the dynamic expression pattern of TMEM16A and TMEM16B. It might be possible that different physiological roles of these proteins depend on the intracellular and extracellular factors expressed in the corresponding cells
Developmental expression of the calcium-activated chloride channels TMEM16A and TMEM16B in the mouse olfactory epithelium
No full textCalcium-activated chloride channels are involved in several physiological processes including olfactory perception. TMEM16A and TMEM16B, members of the transmembrane protein 16 family (TMEM16), are responsible for calcium-activated chloride currents in several cells. Both are present in the olfactory epithelium of adult mice, but little is known about their expression during embryonic development. Using immunohistochemistry we studied their expression in the mouse olfactory epithelium at various stages of prenatal development from embryonic day (E) 12.5 to E18.5 as well as in postnatal mice. At E12.5, TMEM16A immunoreactivity was present at the apical surface of the entire olfactory epithelium, but from E16.5 became restricted to a region near the transition zone with the respiratory epithelium, where localized at the apical part of supporting cells and in their microvilli. In contrast, TMEM16B immunoreactivity was present at E14.5 at the apical surface of the entire olfactory epithelium, increased in subsequent days, and localized to the cilia of mature olfactory sensory neurons. These data suggest different functional roles for TMEM16A and TMEM16B in the developing as well as in the postnatal olfactory epithelium. The presence of TMEM16A at the apical part and in microvilli of supporting cells is consistent with a role in the regulation of the chloride ionic composition of the mucus covering the apical surface of the olfactory epithelium, whereas the localization of TMEM16B to the cilia of mature olfactory sensory neurons is consistent with a role in olfactory signal transduction
PIL893387 Supplemental Material - Supplemental material for Phase, microstructure, and wear behavior of Al<sub>2</sub>O<sub>3</sub>-reinforced Fe–Si alloy-based metal matrix nanocomposites
No full textSupplemental material, PIL893387 Supplemental Material for Phase, microstructure, and wear behavior of Al2O3-reinforced Fe–Si alloy-based metal matrix nanocomposites by Akash Saxena, Neera Singh, Bhupendra Singh, Devendra Kumar, Kishor Kumar Sadasivuni and Pallav Gupta in Proceedings of the Institution of Mechanical Engineers, Part L: Journal of Materials: Design and Applications</p
Social media travel influencers’ attributes and tourists’ travel intention: the role of source credibility / Mohammad Faisal and Devendra Kumar Dhusia
Get PDFSocial media influencer marketing is redefining the marketing strategies and has become a powerful tool therein. Social media travel influencers are common people who have social media channels or pages through which they shape their followers’ perceptions. This research study attempts to analyse the credibility traits of social media travel influencers and the travel intent of tourists in Delhi and the National Capital Region. A structured questionnaire was designed and shared online to collect data. A total of 166 responses were received and only 100 are valid. This study utilised quota sampling for the selection of the sample, and data is analysed with the help of SmartPLS3 for measurement and structural model evaluation. The results disclose that expertise, intimate self-disclosures (ISDs), and trustworthiness have a significant effect on influencers’ credibility, while credibility and intimate self-disclosures (ISDs) have a significant direct effect on tourists’ travel intention. Moreover, trustworthiness also showed a significant indirect effect on tourists’ travel intention. These findings establish the importance of credibility traits and the mediating role of credibility between the traits and tourists’ travel intention. Marketers should consider the influencer’s expertise and credibility to select a travel influencer whose content is perceived as intimate and credible
Enclosure Design for 3D Printing
No full textIn the recent past many industries have widely started adopting 3D Printing for prototyping and manufacturing of low volume customized parts. This paper will look at additive manufacturing or 3D printing and how electronic enclosures can be developed using this technology. It will define the meaning of this term and what is so significant about it. It will delve a bit into its advantages, compared to conventional methods of manufacturing and its types. Then finally we will discuss the steps involved in design of these enclosures and some guidelines while designing them for 3D printing. Harshna Gupta | Gaurav Chaudhary | Krishna Mohan Singh | Devendra Kumar | Ashish Malik "Enclosure Design for 3D Printing" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-4 , June 2018, URL: https://www.ijtsrd.com/papers/ijtsrd13023.pd
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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