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Unveiling cutting-edge developments in defective BiOI nanomaterials: Precise manipulation and improved functionalities towards bolstered photocatalysis
No full textDefect engineering represents a paradigm shift in tailoring nanomaterials for enhanced catalytic performance across various applications. This manuscript succinctly highlights the significance of defect engineering in improving the catalytic performance of BiOI nanoparticles for multiple applications, particularly in photocatalysis. The photocatalytic process of BiOI semiconductor is intricately linked to its indirect bandgap and layered crystalline structure. By influencing the structural dynamics of its layered materials, defects contribute significantly to optimizing its catalytic performance. Fundamental insights into manipulating defects, including oxygen and iodine vacancies, bismuth defects, and synergistic dual defects, in BiOI are meticulously discussed. Advanced characterization techniques, spanning spectroscopy to microscopy, are explored for precise defect identification and quantification. The fragile van der Waals forces foster interactions between adjacent iodine atoms in BiOI, contributing to the overall structural stability. Understanding these structural intricacies lays a robust foundation for comprehending and exploring the exceptional physicochemical properties of twodimensional BiOI. The manuscript showcases BiOI potential in energy and environmental sectors, ranging from solar-driven H2 evolution to CO2 reduction and various harmful pollutant degradation. By unravelling the intricate interplay between defects and catalytic activity, this manuscript sets a new benchmark for tailored catalytic solutions. This manuscript offers a comprehensive overview of defect engineering in BiOI and charts a path towards sustainable and efficient photocatalytic systems. It underscores the imperative of meticulous defect control and innovation in addressing the pressing challenges of the energy and environmental landscape
The effect of progressive relaxation exercises and planned training given in cesarean section on pain anxiety and comfort
No full textAraştırma sezaryen sonrası uygulanan progresif gevşeme egzersizleri ve verilen planlı eğitimin ağrı, anksiyete ve konfor üzerine etkisini belirlemek amacı ile randomize kontrollü deneysel tipte yapılmıştır. Veriler 1 Ocak-30 Aralık 2023 tarihleri arasında toplanmıştır. Araştırmanın örneklemini Sivas Numune Hastanesi Kadın Hastalıkları Cerrahi Kliniği'nde yatan ve sezaryen olan 129 kadın (egzersiz grubu=43, eğitim grubu=43, kontrol grubu=43) oluşturmuştur. Sezaryen sonrası egzersiz grubuna alınan kadınlara progresif gevşeme egzersizleri yaptırılmış, eğitim grubundaki kadınlara planlı eğitim verilmiş, kontrol grubundaki kadınlara standart bakım uygulamalar dışında herhangi bir uygulama yapılmamıştır. Veriler Kişisel Bilgi Formu, Visual Analog Skala, Durumluk Kaygı Envanteri, Sürekli Kaygı Envanteri, Doğum Sonu Konfor Ölçeği ve Becerinin/İşlemin Değerlendirilmesi Formu ile toplanmıştır. Gruplar arası karşılaştırmalarda egzersiz, eğitim ve kontrol grubundaki kadınların egzersiz ve eğitim sonrası son testteki Visual Analog Skala, Durumluk Kaygı Envanteri, Sürekli Kaygı Envanteri ve Doğum Sonu Konfor Ölçeği puan ortalamaları arasında istatistiksel olarak anlamlı farklılık saptanmıştır (p˂0,05). Progresif gevşeme egzersizi ve eğitim sonrası, egzersiz ve eğitim grubundaki kadınların ağrı, eğitim grubundaki kadınların anksiyete düzeyleri azalmış, egzersiz ve eğitim grubundaki kadınların da konfor düzeyleri artmıştır.The research was conducted as a randomized controlled experimental type to determine the effects of progressive relaxation exercises and planned training on pain, anxiety and comfort after cesarean section. Data were collected between January 1 and December 30, 2023. The sample of the study consisted of 129 women (exercise group=43, education group=43, control group=43) who were hospitalized in the Gynecology and Surgery Clinic of Sivas Numune Hospital and had a cesarean section. Progressive relaxation exercises were performed on women in the post-cesarean exercise group, planned training was given to women in the education group, and no application was made to women in the control group. Data were collected with Personal Information Form, Visual Analog Scale, State Anxiety Inventory, Trait Anxiety Inventory, Postpartum Comfort Scale and Skill/Procedure Evaluation Form. In the comparisons between the groups, a statistically significant difference was found between the mean scores of the Visual Analog Scale, State Anxiety Inventory, Trait Anxiety Inventory and Postpartum Comfort Scale in the post-test after exercise and training of the women in the exercise, training and control groups (p˂0.05). After progressive relaxation exercise and education, the pain levels of women in the exercise and education group decreased, the anxiety levels of women in the education group decreased, and the comfort levels of women in the exercise and education group increased
New benzimidazole derivatives containing hydrazone group as anticancer agents: Inhibition of carbonic anhydrase IX and molecular docking studies
No full textIn this study, we propose identifying potential novel compounds targeting carbonic anhydrase (CA) IX and anticancer activity. To study the impact of these synthesized compounds on CA IX and anticancer activity, we have developed and synthesized novel benzimidazole-hydrazone derivatives (3a-3j). The target compounds' H-1 NMR (nuclear magnetic resonance), C-13 NMR, and high resolution mass spectrometry spectra were used to confirm their chemical structures. L929 (healthy mouse fibroblast cell line) used as control healthy cell line and MCF-7 (breast cancer), C6 (rat glioblastoma), HT-29 (colon cancer), cells were used in cell culture studies. As a result of cell culture studies, it was determined that the newly synthesized compounds 3d and 3j had cytotoxic effects on colon cancer. Again, it was determined that the compound 3d had a more toxic effect than cisplatin on both breast cancer and glioma cells. According to the CA IX activity results, compounds 3d and 3j were found to have the highest activity. Compounds 3d and 3j are essential for having anti-cancer properties and inhibiting the carbonic anhydrase IX enzyme. Molecular docking of these compounds was carried out in the active site of CA IX. Flow cytometry and immunofluorescence microscope analyses also confirmed that these compounds had cytotoxic effects on cancer cells.Anadolu University Medicinal Plant Drug and Scientific Research and Application Center (AUBIBAM)The authors thank Anadolu University Medicinal Plant Drug and Scientific Research and Application Center (AUBIBAM) for their support and contributions
Pre- and Postoperative Evaluation of the Changes in Anthropometric Parameters on Female Laparoscopic Sleeve Gastrectomy Patients: A Cross-Sectional Follow-Up Study
No full textBackground/Aims: Obesity is a major global health issue, exacerbated by reduced physical activity due to technological advancements. Bariatric surgery is the most effective treatment for significant weight loss. This study examines 2-month postoperative changes in anthropometric parameters, muscle strength, and regional fat reduction in female patients.Materials and Methods: In this observational prospective study, anthropometric measurements were collected from female patients who underwent laparoscopic sleeve gastrectomy between October 2022 and March 2023. Data were recorded preoperatively and at the first and second months postsurgery.Results: A significant reduction in skinfold thickness, indicative of fat mass reduction, was observed, alongside a marked improvement in grip strength within the 8-week postoperative period.Conclusion: This study is notable for being the first to comprehensively evaluate short-term changes in skinfold thickness following bariatric surgery. In addition, it is pioneering in its application of the pinch strength test alongside the hand grip strength test in this context
Smoking, drinking, and food addiction among youth in Sivas, Türkiye
No full textEDB2023047Amaç: Madde bağımlılığı önemli bir sorundur. Dünya genelinde beslenme alışkanlıklarının değişmesi ve hazır gıdalara olan ilginin artması da önemli bir konulardandır. Bu çalışmanın amacı, gençlerde nikotin bağımlılığı düzeyi ve alkol kullanımı ile yeme bağımlılığı arasındaki ilişkiyi araştırmaktır. Ayrıca bu ilişkide dürtüselliğin aracı değişken rolünü değerlendirmek amaçlanmıştır. Gereç ve Yöntem: Çalışma 533 öğrenci ile gerçekleştirilmiştir. Veriler anket formu, Fagerström Nikotin Bağımlılığı Testi (FTND), Alkol Kullanım Bozuklukları Tanıma Testi (AUDIT-C), UPPS Dürtüsel Davranış Ölçeği ve Yale Yeme Bağımlılığı Ölçeği kullanılarak çevrimiçi olarak toplanmıştır. Verileri analiz etmek için korelasyon, MANCOVA ve aracılı regresyon analizi (Hayes, Model 4) kullanılmıştır. Bulgular: Çalışmaya %79 kadın ve %21 erkek katılımcı dahil edilmiştir. Katılımcılar arasında sigara ve alkol tüketimi yaygınlığı sırasıyla %21,2 ve %15,8'dir. Şiddetli düzeyde yeme bağımlılığı prevalansı %5,4 olarak hesaplanmıştır. Bu çalışmanın bulguları, cinsiyetin alkol tüketimi ve nikotin bağımlılığının derecesi üzerinde önemli bir etkisi olduğunu ve bu etkilerin dürtüsel davranış özelliklerine bağlı olarak değiştiğini göstermektedir. Aracı regresyon analizinin sonuçları da nikotin bağımlılığının derecesinin dürtüsel davranışlara bağlı olarak yeme bağımlılığı üzerinde önemli bir etkiye sahip olduğunu, ancak bu etkinin alkol kullanımı için anlamlı olmadığını göstermektedir. Sonuç: Çalışmamızın bulguları, yasal madde kullanımı ve yeme bağımlılığının farklı düzeylerinin gençler arasında yaygın olduğunu göstermektedir. Ayrıca, sonuçlarımız nikotin bağımlılığının derecesi ile dürtüsel davranışlara atfedilebilecek yeme bağımlılığı arasında önemli bir korelasyon olduğunu göstermektedir. Bu konuda daha somut ve güvenilir bilgiler elde etmek için farklı tekniklerin kullanımını da içeren daha fazla araştırma yapılması gerekmektedir.Aim: Substance abuse is a major issue. The change in eating habits worldwide and the increasing interest in convenience foods are also important issues. The aim of this study is to investigate the relationship between the degree of nicotine dependence, alcohol consumption, and food addiction in young people. It also aimed to assess the role of impulsivity as a mediating variable in this relationship. Materials and Methods: The study was conducted with 533 students. Data were collected online using the questionnaire form, Fagerström Test for Nicotine Dependence Test (FTND), Alcohol Use Disorders Identification Test (AUDIT-C), UPPS Impulsive Behaviour Scale, and Yale Food Addiction Scale. Correlation, MANCOVA, and mediated regression analysis (Hayes, Model 4) were used to analyze the data. Results: The study involved 79% female and 21% male participants. The prevalence of smoking and alcohol consumption among the participants was 21.2% and 15.8%, respectively. The prevalence of severe food addiction was estimated at 5.4%. The findings of this study indicate that sex has a significant effect on alcohol consumption and degree of nicotine dependence, with these effects varying depending on impulsive behavior characteristics. The results of the mediated regression analysis also demonstrate that the degree of nicotine dependence has a significant effect on food addiction depending on impulsive behaviors, although this effect is not significant for alcohol use. Conclusion: The findings of our study indicate that legal substance use and food addiction are prevalent among young people. Furthermore, our results demonstrate a significant correlation between the degree of nicotine dependence and food addiction, which can be attributed to impulsive behaviors. Further research, including the use of different techniques, is required in order to obtain more concrete and reliable information on this subject.Sivas Cumhuriyet Universit
Telangiectasia macularis multiplex acquisita: A new entity and literature review
No full textTelangiectasia macularis multiplex acquisita (TMMA) is a very rare entity that has been reported in the Asian population to date. Associations with hepatitis infection and several other systemic diseases have been reported. Its association with hepatitis C infection is a newly designated entity. Here, a 42-year-old Turkish patient with hepatitis C infection who was diagnosed with TMMA is presented, and a literature review is given. Recognition of the characteristic presentation of this rare disease will facilitate the clinician's diagnosis and approach
Effect of Reaction Parameters on the Synthesis of Cyclodextrin-Based Nanostructured Polymers for Drug Delivery
No full textIn this study, cyclodextrin-based nanostructures (CDNSs) were synthesized through the cross-linking of cyclodextrin (CD) with epichlorohydrin (ECH) as a cross-linker. Two types of CDNSs, alpha-CDNS and beta-CDNS, were prepared to systematically investigate the influence of reaction parameters-such as the solubilization time of alpha-CD and beta-CD, the molar ratio of ECH to CD, and NaOH concentration-on the physicochemical properties of the final product. Naproxen (NAP), a poorly water-soluble drug, was selected as a model compound to assess the drug-loading capacity of the synthesized CDNSs. The effect of each reaction parameter on NAP integration into the CDNSs was examined at varying weight ratios. The optimal reaction conditions were determined to be a solubilization time of 6 h, an ECH/CD molar ratio of 8/1, and an NaOH concentration of 33%. Under these conditions, the NAP loading efficiency of alpha-CDNSs was calculated as 67.12%. Comparative analysis revealed that alpha-CDNSs outperformed beta-CDNSs in terms of drug-loading capacity. Additionally, the synthesized CDNSs and NAP-loaded CDNSs were characterized using FTIR, DSC, XRD, SEM, and Zetasizer analyses, while the NAP concentration was determined by HPLC.Sivas Cumhuriyet University Scientific Research Projects (CUBAP); [M-561]This study was financially supported by Sivas Cumhuriyet University Scientific Research Projects (CUBAP) under project number M-561
Comprehensive bibliometric analysis and perspectives on therapies targeting colon cancer stem cells over a 40-year period
No full textThe presence of cancer stem cells (CSCs) is one of the primary causes of recurring therapy resistance because they have two main capacities: self-renewal and avoiding apoptotic pathways. Despite their relevance, no full bibliometric analysis has yet been done in this topic. The goal of this work is to use bibliometric analysis to map the fundamental and emergent areas in therapeutics targeting colon cancer stem cells. To perform bibliometric analysis on colon cancer stem cells (CCSCs) literature, spanning roughly the last 40 years, in order to establish a firm base for future projections by emphasizing the findings of the most notable research. All information pertinent to CCSCs was accessed from Web of Science Core Collection database. In order to identify and analyze the research hotspots and trends related to this topic, Biblioshiny (RStudio) and VOSviewer were utilized to ascertain the countries/regions, institutions, journals, authors, references, and keywords involved. The targeted time span covered 1735 research-, and review articles. The most frequent keywords were colorectal cancer, cancer stem cells, and colon cancer, while the most trending keywords in the last few years were protein stability, spheroid formation, ubiquitination, exosomes, patient-derived organoids, and gut microbiota. Over the past 40 years, there has been a significant advancement in researchers' understanding of colon cancer stem cells. In addition, the cluster map of co-cited literature showed that colon cancer stem cell research has emerged as a research hotspot. It was also anticipated that the main focus of the future efforts appears to involve clinical applications of cell-targeted colon cancer therapy. These results provide researchers with a comprehensive understanding of this field and provide insightful ideas for further research. (c) 2025 The Author(s). Published by Elsevier BV on behalf of The Japanese Society for Regenerative Medicine. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/)
The life and sufi understanding of Ebubekir Kani Efendi
No full textBalta Veysel, Ebubekir Kânî Efendi'nin hayatı, divânı bağlamında tasavvufî görüşleri, Yüksek Lisans Tezi, Sivas 2025 1712 Tokat doğumlu, Tokat Mevlevihanesi mensubu, Osmanlı şair ve münşilerinden ve Osmanlı Devleti divan kâtiplerinden olan Ebubekir Kânî Efendi'nin hayatını ve tasavvuf anlayışını konu edindiğimiz tezimiz üç bölümden oluşmaktadır. Giriş bölümü tezin konusu, kapsamı, yöntemi ve şekli konusunda açıklamalardan meydana gelmiştir. Birinci bölümde ise Ebubekir Kânî Efendi'nin hayatı hakkında bilgiler verildi. İkinci bölümde ise Ebubekir Kânî Efendi'nin Divânı bağlamında tasavvufi görüşleri incelenmiştir. Üçüncü bölümde varlık anlayışı incelenmiştir. On sekizinci yüzyılda yaşayan Ebubekir Kânî Efendi kırk yaşına kadar Tokat Mevlevihane'sinde ruhi ve manevi eğitimini sürdürmüş, Hekimoğlu Ali Paşa üçüncü kez sadrazam olunca Trabzondan İstanbul'a giderken Tokat'a uğramış burada tanıdığı Ebubekir Kânî Efendi'yi şeyhi Abdulahad Dede'den izin alarak 1755 yılında İstanbul'a götürmüştür. Kânî Efendi İstanbul'da Divan-ı Hümayun kaleminde eğitimini tamamlamış, kendisine sivil yüzbaşı rütbesi verilmiştir. Divan Katipliği yapan Ebubekir Kânî Efendi çoğu zaman bürokratik kalıplardan sıkılan ve kişilik olarak kayıtlı olmayı sevmeyen biridir. Bükreş, Eflak ve Rusçuk gibi yerleri gezmiş, buralarda beylere kâtiplik yapmıştır; buralarla ilgili gözlemlerini yazmış, yazıları takipçileri ve sevenleri tarafından ölümünden sonra derlenmiştir. Resmi görevini sürdürürken duygu ve düşüncelerini yazmaktan geri durmayan Kânî Efendi, sözünü esirgemeyen, hoşsohbet bir Osmanlı aydını olarak karşımıza çıkmaktadır. Şiirlerinde varlığın hakikati, kulluk bilincinin önemi, ilahi ve mecazi aşk yanında toplumsal konular ve ahlâkî aksaklıkları ince mecaz ve nüktelerle işlemiştir. Özellikle tasavvufî söylem ve kavramları kullanarak insanın anlam ve önemini vurgulamıştır. Biz bu tezimizde Ebubekir Kânî Efendiyi incelemeye ve divanındaki şiirleri bağlamında ruhi ve tasavvufi yönüne ışık tutmaya çalıştık.Our thesis on Ebubekir Kani Efendi, born in Tokat in 1712, a member of the Tokat Mevlevihanesi, an Ottoman poet and scribe, and one of the Ottoman State Divan secretaries, and his Sufi understanding, consists of three sections. The first section includes explanations about the topic, scope, method, and format of the thesis. The second section provides information about the life of Ebubekir Kani Efendi. The third section examines Ebubekir Kani Efendi's Sufi views within the context of his Divan, analyzed under Sufi concepts. Ebubekir Kani Efendi, who lived in the 18th century, continued his spiritual and moral training at the Tokat Mevlevihanesi until he was forty. When Hekimoğlu Ali Pasha became Grand Vizier for the third time, he passed through Tokat on his way from Trabzon to Istanbul and took Ebubekir Kani Efendi to Istanbul in 1755. In Istanbul, Kani Efendi completed his education at the Divan-ı Hümayun office and was given the rank of civilian captain. As a Divan Secretary, Ebubekir Kani Efendi was often someone who was bored with bureaucratic routines and did not enjoy being registered. He traveled to places like Bucharest, Wallachia, and Ruschuk, worked as a scribe for the local beys, and wrote down his observations about these places. His writings were compiled by his followers and admirers after his death. While fulfilling his official duties, Kani Efendi did not refrain from writing his feelings and thoughts. He appears as an outspoken, affable Ottoman intellectual. In his poems, he explored themes such as the truth of existence, the importance of servitude consciousness, love, divine and metaphorical love, as well as social issues and moral shortcomings, using subtle metaphors and witticisms. He especially emphasized the significance and meaning of human existence by employing Sufi discourse and concepts. In this thesis, we aimed to introduce Ebubekir Kani Efendi and shed light on his spiritual and Sufi aspects within the context of the poems in his Divan
Covalently Bonded 1D Chains and 2D Networks From Si-Doped CL-20: Computational Study
No full textTo discover high-energy-density materials with characteristics superior to current models, it is necessary to study a wide range of potential structures. A promising representative of new derivatives of the class of high-energy compounds is silicon-substituted molecules CL-20, which have a reactivity and kinetic stability close to pure CL-20 but have a higher density and energy release. Low-dimensional covalent SiCL-20 nanostructures based on silicon analogue of the classical CL-20 high-energy molecule are considered in this work. Covalent nanostructures may have advantages over molecular crystals due to their special properties, such as higher packing density and kinetic stability. It has been established that silicon-substituted CL-20 molecules can connect through CH2 molecular bridges into covalent structures. Geometrical parameters, energy characteristics, electronic properties, and quantum chemical reactivity descriptors for several representatives of 1D and 2D systems based on Si5CL-20 have been calculated using density functional theory. The skeleton of each silicon fragment of the CL-20 system undergoes small changes when combined into covalent chains and networks. Still, the systems retain their consistency, and the effective diameter of the silicon frameworks in the nanostructure takes average values from 4.300 to 4.462 & Aring;. The binding energy of nanostructures increases with the number of silicon CL-20 fragments in the system. The binding energies for a single silicon molecule CL-20 and a double chain SiCL-20 consisting of 12 fragments are 3.846 and 4.077 eV/atom, respectively. Thus, the silicon nanostructures become more thermodynamically stable with increasing the size and dimension of the compound. The study of electronic characteristics made it possible to establish that the value of the HOMO-LUMO gap decreases with an increasing number of fragments in the system, and the considered SiCL-20 covalent molecules can be classified as wide-gap semiconductors, like their classical CL-20 analogues. For example, the values of the HOMO-LUMO gaps for silicon derivatives of CL-20 with dimensions 1 x 1, 6 x 1, 6 x 2, and 4 x 3L are 5.601, 4.378, 4.004, and 3.882 eV respectively. Despite their highly stressed skeleton, they are stable enough to be considered for energy applications and are promising candidates for building blocks of high-energy materials and fuels.Ministry of Science and Higher Education of the Russian Federation [FSWU-2024-0014]; Ministry of Science and Higher Education of the Russian FederationThe work was supported by the Ministry of Science and Higher Education of the Russian Federation, project FSWU-2024-0014