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Development of Potent Type V MAPK Inhibitors: Design, Synthesis, and Biological Evaluation of Benzothiazole Derivatives Targeting p38α MAPK in Breast Cancer Cells
No full textType V MAPK inhibitors are distinguished by their capacity to target both the ATP binding site and a specific allosteric site on the enzyme. The present work utilized in silico analysis with Maestro 13.8.135 (Schrodinger) software in conjunction with experimental investigations to enhance the antiproliferative efficacy and forecast the likely mechanism of action of benzothiazole derivatives. Approximately 28 compounds were developed, produced, and assessed for their antiproliferative properties against two breast cancer cell lines: ER+ (MCF7) and ER- (MDA-MB-231), in addition to one normal mouse fibroblast cell line (L929). Their antiproliferative activities were evaluated via the MTT test, with doxorubicin and cisplatin serving as reference drugs for comparison. Consequently, the compounds with the greatest activity against the MCF7 cell line were chosen, and their inhibitory effects on the p38 alpha MAPK enzyme were examined. The molecular docking studies of compounds 15 and 19 demonstrated significant binding affinities for p38 alpha MAPK. Molecular dynamics simulations conducted over 100 ns revealed that compounds 15 and 19 exhibit stability inside both the ATP-binding domain and the lipid domain of p38 alpha MAPK. The research focused on creating effective Type V MAPK inhibitors demonstrate that compounds 15 and 19 possess considerable ability to inhibit p38 alpha MAPK, hence establishing them as promising anticancer agents.BAP Projects of Mersin University [2020-1-TP3-4028]This study was supported by 2020-1-TP3-4028 BAP Projects of Mersin University
News Language and Gender Equality: Women Representation in News
No full textKadınlar dünya genelinde haberlerde erkeklere oranla genellikle daha az yer almaktadır. Bu durum, toplumsal cinsiyet eşitliği açısında önemli bir sorun teşkil etmektedir. Küresel Medya İzleme Projesi'nin (GMMP) 2020 raporu, haber kaynaklarının ve konularının yalnızca % 24'ünü kadınların oluşturduğunu ortaya koymaktadır. Bu istatistik, medyada kadınların görünürlüğünün ne kadar sınırlı olduğunu açıkça göstermektedir. Dahası, kadınlar haberlerde yer aldıklarında bile, kullanılan dil ve haberlerin ele alınış biçimi sıklıkla sorunlu olabilmektedir. Kadınlarla ilgili haberlerde sansasyonel ifadeler, dikkat çekici başlıklar ve cinsiyet önyargılarını pekiştirici söylemler kullanılmakta, bu da toplumsal cinsiyet eşitsizliğinin yeniden üretilmesine olumsuz katkıda bulunmaktadır. Medyanın toplumsal normları oluşturmadaki rolü dikkate alındığında, bu sorun daha da önem kazanmaktadır. Özellikle haber medyası, yalnızca bilgi sağlamakla kalmaz, aynı zamanda toplumsal değerlerin yeniden inşasında da güçlü bir aktör olarak işlev görür. Kadınların haberlere nasıl yansıtıldığı, onların toplumsal rollerini, haklarını ve kamusal alandaki algılarını derinden şekillendirme gücüne sahiptir. Bu nedenle, kadınların medya temsillerindeki sorunların tespit edilmesi ve çözüm önerilerinin geliştirilmesi, toplumsal cinsiyet eşitliği açısından kritik bir öneme sahiptir. Bu çalışmada, GMMP raporunda yer alan ve Cinsiyet Farklılığı İzleyici (Gender Gap Tracker) aracı ile sunulan veriler ve bulgular incelenmiştir. Çalışmanın ana hedefi, kadınların medyadaki temsiline dair durumu analiz etmeyi ve bu bağlamda mevcut bulguları ortaya koymaktır. Çalışma kapsamında Türk medyasından da 37 haberin cinsiyet temsil analizi yapılmış ve bu analiz Türk medyasından örnek bir kesit olarak sunulmuştur. Sadece bir haber haricinde analiz edilen tüm haberlerde erkek temsilinin baskın olduğu görülmüştür.Women are generally less visible in the news than men around the world. This is a significant problem for gender equality. The Global Media Monitoring Project's (GMMP) 2020 report found that women make up only 24% of news sources and topics. This statistic clearly shows the limited visibility of women in the media. Moreover, even when women are in the news, the language used and the way the news is presented can often be problematic. News about women tends to use sensational language, attention-grabbing headlines, and discourses that reinforce gender bias, which contribute negatively to the reproduction of gender inequality. This issue becomes even more important when considering the role of the media in creating social norms. The news media, in particular, not only provide information, but also function as powerful actors in the reconstruction of social values. How women are reflected in the news has the power to profoundly shape their social roles, rights, and perceptions in the public sphere. Identifying problems in the media's portrayal of women and developing solutions is therefore crucial for gender equality. This study examines the data and findings contained in the GMMP report and presented through the Gender Gap Tracker tool. The main objective of the study is to analyse the situation regarding the representation of women in the media and to present current findings in this context. Within the framework of the study, the gender representation of 37 news items from the Turkish media was analysed and presented as a sample of the Turkish media. It was found that male representation was dominant in all but one of the news items analysed
Mobile app communication to prevent ER visits post-circumcision: a prospective observational study
No full textPurpose To assess the impact of a mobile phone application facilitating real-time visual and verbal communication on reducing emergency-room admissions following circumcision. Methods This prospective observational study included circumcision surgeries performed by one surgeon at our clinic between April and June 2024, after obtaining parental consent. Parents were divided into two groups: one received a mobile app phone number, while the other did not. The mobile app group was based on parents' communication needs, such as distance or socioeconomic factors. Follow-up appointments were scheduled for one week and one month; the mobile app group had follow-ups via the app, while the non-communicating group followed up in person. WhatsApp was used due to its cost-effectiveness and accessibility. Data on emergency visits, communications, and complications were recorded prospectively and analyzed retrospectively using SPSS with t tests and Mann-Whitney U tests (p < 0.05). Results A total of 200 patients were enrolled, with 162 meeting the inclusion criteria. The study was divided into two groups: 'Communicating group' (Group 1, 75 patients) had access to the mobile app, while 'Non-communicating group' (Group 2, 87 patients) received routine post-operative instructions. No significant differences in age or weight were found. The most common complications included wound infection, non-healing wounds, swelling, bleeding, and micturition issues. Emergency visits were significantly higher in Group 2 (12.64%) compared to Group 1 (1.33%) (p = 0.01). Conclusion The use of a mobile app for post-surgical communication may significantly reduce emergency-room visits following circumcision
Anadolu Masalları ile Grimm Masallarının Büyü Motifi Açısından Karşılaştırılması
No full textThis study was prepared based on the fairy tales of two nations (Anatolian fairy tales and Grimm Fairy Tales), which have religious and cultural differences, in order to reveal similarities and variables between cultures. The study was created specifically for the elements of magic, both because it has a universal quality and because it is a set of actions encountered in daily life. One thousand thirty tales from the Anatolian field and two hundred and eleven tales from the Grimm Fairy Tales were analysed. The elements determined on the tales include magic, enchanted, and bound events/persons in the spell/enchantment bracket. Spells were evaluated under the main headings of transformation spell, imitation spell, healing spell and word spell according to the action performed. As a result of the examination of the tales obtained through literature review, it was determined that transformation, imitation and word spells have many commonalities in both cultures. Although the healing spell is included in the Anatolian fairy tales at the point of eliminating childlessness, it is understood that this motif is not included in Grimm Fairy Tales in relation to magic. The data obtained, apart from some differences, are important in terms of revealing the universal nature of the fairy tale once again.Bu çalışma, kültürler arası benzerlikleri ve değişkenleri ortaya koymak maksadıyla, dini ve kültürel farklılıklara sahip olan iki milletin masalları (Anadolu masalları ve Grimm Masalları) temel alınarak hazırlanmıştır. Yapılan inceleme gerek evrensel nitelik taşıması gerekse günlük hayatta da karşılaşılan eylemler bütünü olması sebebiyle büyü unsurları özelinde oluşturulmuştur. Anadolu sahasından bin otuz, Grimm Masallarından iki yüz on bir masal incelenmiştir. Masallar üzerinde tespit edilen unsurlar büyü/büyülü parantezinde sihirli, efsunlu, bağlanmış olayları/kişileri de içine almaktadır. Büyüler gerçekleşen eyleme göre dönüşüm büyüsü, taklit büyüsü, şifa büyüsü ve söz büyüsü ana başlıklarında değerlendirilmiştir. Literatür taraması yoluyla elde edilen masalların incelenmesi neticesinde dönüşüm, taklit ve söz büyüsünün her iki kültürde de pek çok ortaklık barındırdığı tespit edilmiştir. Şifa büyüsünün ise çocuksuzluğu giderme noktasında Anadolu sahası masallarında yer almasına karşın Grimm Masallarında bu motifin, büyü ile ilişkili olarak yer almadığı anlaşılmıştır. Elde edilen veriler, bazı farklılıklar ayrı tutulduğunda, masalın evrensel niteliğini bir kere daha ortaya koyması açısından önemlidir
Feasibility of emulsion-filled pea protein-collagen-carrageenan hydrogel for 3D printing
No full text[No abstract available]Lietuvos Mokslo Taryba, LMTLMTLT, (S-A-UEI-23-1, 22-12-2023
Morphological and morphometric traits of Turkiye's Aseel chicken
No full textThis research studies the morphology and morphometry traits of Aseel chickens raised in various regions of Turkiye. We used Turkish Aseel genotypes to assess the live weight and physical features of 60 female and 58 male subjects of varying ages. We measured brood length, breadth, head and beak width, neck and body length, chest width, depth, and circumference, thigh diameter, length, and depth, and leg length. Males' average live weight, chest circumference, thigh length, and comb length, which affect game efficacy, are 3.23 kg, 37.88 cm, 20.69 cm, and 40.20 mm, respectively. Although there was a statistically significant difference between the gender groups for all evaluated characteristics, there was only a statistically significant difference between the age groups for head width and chest circumference, shank depth, diameter, and length, and live weight (P<0.05). The data showed differences among different areas, particularly about the measurements of the comb, prompting researchers to propose a hypothesis suggesting a potential correlation between these changes and regional temperature disparities. We evaluated Turkish Aseels for feather, comb, eye color, markings, and comb type. Medium-weight breeds with hair, earlobes, beards, and spurs Weight and characteristics determine the Turkish Aseel breed. Comb structures were shorter, and their live weight was lower than that of other game roosters or Aseel kinds. Based on their morphology, domestic Aseel males may have a distinct genotype and subtype. Evaluating morphometric characteristics is an important aspect of the research. However, conducting additional comparative research is crucial. Genotyping studies with larger numbers are necessary for greater accuracy.Ankara University Scientific Research Projects Coordination Unit [18B0239004]This research has been supported within the content of the project no 18B0239004 by Ankara University Scientific Research Projects Coordination Unit
On the geometry of Lorentzian Sasakian manifolds
No full textBu tezde Lorentzian Sasakian manifoldlarını, bu manifoldların eğrilik tensörlerini ve pseudoparalel altmanifoldlarını araştırdık. Bu tez beş bölümden oluşmaktadır. Birinci bölümde tezde ele alınan problemin önemini, güncelliğini ve konu ile ilgili yapılmış olan çalışmalar hakkında literatür taramasını ve ayrıca tezdeki problem için gerekli olan bazı önemli tanım ve teoremleri verdik. İkinci bölümde hemen hemen parakontak metrik manifoldlar ve bu manifoldların özel bir sınıfı olan Lorentzian Sasakian manifoldları ele aldık. Tezin üçüncü,dördüncü ve beşinci bölümleri orijinal olan kısımlarıdır. Üçüncü bölümde Lorentzian Sasakian manifoldların Riemann, Ricci, concircular ve projektif eğrilik tensörleri yardımıyla bazı eğrilik koşulları altında karakterizasyonlarını belirledik. Dördüncü bölümde Lorentzian Sasakian manifoldların invaryant pseudoparalel altmanifoldlarını çeşitlerine göre sınıflandırdık. Lorentzian Sasakian manifoldun pseudoparalel, 2 pseudoparalel, Ricci genelleştirilmiş pseudoparalel ve Ricci genelleştirilmiş 2-pseudoparalel altmanifoldlarını detaylı bir şekilde araştırdık. Beşinci bölümde özel bir eğrilik tensörü olan 0-eğrilik tensörüne göre Lorentzian Sasakian manifoldların invaryant altmanifoldlarının karakterizasyonu elde ettik.In this thesis, we studied Lorentzian Sasakian manifolds, the curvature tensors of these manifolds, and pseudoparallel submanifolds. This thesis consists of five chapters. In the first chapter, we presented the significance and relevance of the problem addressed in the thesis, conducted a literature review on studies related to the topic, and provided some essential definitions and theorems required for the problem in the thesis. In the second chapter, we discussed nearly paracontact metric manifolds and a special class of these manifolds, namely Lorentzian Sasakian manifolds. The third, fourth, and fifth chapters of the thesis contain the original contributions. In the third chapter, we determined the characterizations of Lorentzian Sasakian manifolds under certain curvature conditions using the Riemann, Ricci, concircular, and projective curvature tensors. In the fourth chapter, we classified the invariant pseudoparallel submanifolds of Lorentzian Sasakian manifolds according to their types. We thoroughly investigated the pseudoparallel, 2-pseudoparallel, Ricci generalized pseudoparallel, and Ricci generalized 2- pseudoparallel submanifolds of Lorentzian Sasakian manifolds. In the fifth chapter, we obtained the characterization of the invariant submanifolds of Lorentzian Sasakian manifolds with respect to a special curvature tensor, the 0-curvature tensor
Screening of Novel 1,2,4-triazine Clubbed 1,2,3-triazole Derivatives as Α-glucosidase Inhibitors: In Silico Study
No full textIntroduction: A new set of 1,2,4-triazine combined 1, 2, 3-triazole hybrids were designed computationally for predicting anti-diabetic potential. All the derivatives taken for study exhibited excellent anti-diabetic potential with significant IC50 values. Methods: The present research includes the development of pharmacophore models, 3D QSAR, virtual screening, molecular docking, and evaluation of models based on certain criteria. The DHRRR_1 showed the best pharmacophore model with a survival score of 5.9937. The 3D QSAR analysis developed a model with the values of R2 = 0.9714 and Q2 = 0.7202. The binding pose and affinity of the most potent compound, 10c, in the active site of α-glucosidase was investigated using in-silico molecular docking analysis. Results: It was observed that compound 10c demonstrated promising binding affinity with a score of -8.078 kcal/mol and exhibited binding interaction with the essential amino acids ASN301 and LEU227. There were five compounds (1-5) that showed significant binding affinity towards the target comprising active amino acids (ASH202, ASP333 and VAL335). The molecular dynamic study showed the stability of ligand-protein binding interactions. Conclusion: The results of the present investigation can accelerate the optimization and reformation of the latest anti-diabetic agents that target the α-glucosidase. © 2025 Bentham Science Publishers.King Saud University, KSU, (RSPD2024R852)King Saud University, KS
Determination by Immunohistochemistry of Acute Phase Proteins in Naturally Infected Sheep with Listeriosis
No full textListeriosis is an infectious and fatal disease affecting domestic mammals, poultry, and humans worldwide. The effectiveness of local tissue expression of acute phase proteins in listeriosis in domestic mammals is not yet clear. The aim of this study is to evaluate the local expression of acute phase proteins in 26 brainstem tissue samples according to the distribution and severity of inflammation due to natural Listeriosis disease in sheep. The study material consisted of 26 brainstem paraffin blocks, including 20 from listeriosis-infected cases and 6 from healthy controls. Sections obtained from the paraffin blocks were subjected to histopathological and immunohistochemical analyses. Histopathological examination revealed normal histological structures in the brainstems of the control group. In contrast, brainstem sections from listeriosis cases exhibited histopathological findings such as micro abscesses composed of neutrophil granulocytes and microglial cells, gliosis, meningitis, congestion, perivascular cuffs, neuronal degeneration, and neuronophagia. Based on the distribution and severity of inflammation, listeriosis cases were categorized into three groups: 5 mild cases (Group I), 8 moderate cases (Group II), and 7 severe cases (Group III). Immunohistochemical analysis demonstrated significantly increased expression levels of C-reactive protein (CRP), Haptoglobin (Hp), and Serum Amyloid A (SAA) in listeriosis groups compared to the control group, with the highest statistical scores observed in Group II and Group III (p<0.001). The findings of this study suggest that acute-phase proteins may play crucial roles in the pathophysiological processes of naturally infected listeriosis and could express locally. Particularly, the increased expression of these proteins with the progression of inflammation may provide valuable insights into disease severity and the infection process
FİNANSAL PERFORMANSIN ÇOK KRİTERLİ KARAR VERME TEKNİKLERİYLE ANALİZ EDİLMESİ: BIST TAŞ VE TOPRAĞA DAYALI SEKTÖRÜNDE BİR UYGULAMA
No full textThis study aims to measure the financial performance of firms in the Stone and Earth-Related Subsector of the BIST 100 Manufacturing Industry using their financial indicators for the year 2023. Within the scope of this objective, the MCDM (Multi-Criteria Decision-Making) method was utilized. Unlike previous studies in this field, the present research employed the ENTROPY and MOORA methods. A review of the literature revealed that only a limited number of studies have been conducted from this perspective. In the implementation phase, the weights of objective criteria were determined using the ENTROPY technique, and these criteria were subsequently ranked through the MOORA method's Weighting Ratio, Reference Point, Full Multiplicative Form, and MULTIMOORA techniques. The findings of the study revealed that the criteria weights determined by the ENTROPY method were effective in measuring financial performance. Furthermore, the MOORA method was found to serve as a guiding tool in identifying firms with high financial performance. Based on the results of the analysis, the firms with the highest financial performance were identified as BOBET, NUHCM, and LMKDC, respectively. Conversely, the firms with the lowest financial performance were determined to be KUTPO, USAK, and QUAGR, all sharing equal scores. Additionally, it was observed that not all MOORA techniques yielded identical results, although their outcomes were found to be very close to each other.Bu çalışmada BİST 100 İmalat Sanayi Taş ve Toprağa Bağlı Alt Sektöründe yer alan firmaların 2023 yılına ait finansal göstergeleri ile finansal performansının ölçülmesi hedeflenmiştir. Belirlenen hedef kapsamında ÇKKV yöntemi kullanılmıştır. Daha önce bu kapsamda yapılan çalışmalardan farklı olarak yapılan bu çalışmada ENTROPİ ve MOORA yöntemleri kullanılmıştır. Literatür incelendiğinde bu bakış açısıyla yapılan çok fazla araştırmaya rastlanılmamıştır. Uygulamada objektif kriterlerin ağırlıkları ENTROPİ tekniği ile belirlenmiş ve sonrasında bu kriterler; MOORA yönteminin Önem Katsayısı, Referans Noktası, Tam Çarpım ve MULTİMOORA teknikleri ile sıralanmıştır. Çalışmanın sonucunda ise ENTROPİ yöntemi ile belirlenen kriterler ağırlıklarının finansal performansları ölçme de işlevsel olduğu ve bununla birlikte MOORA yönteminin finansal performansları yüksek olan firmaların belirlenmesinde yol gösterici olduğu tespit edilmiştir. Çalışmada yapılan analizlerin sonuçlarına göre, finansal performansları en yüksek olan firmalar sırasıyla; BOBET, NUHCM ve LMKDC olarak saptanmıştır. Finansal performansları en kötü olan firmalar ise eşit değerlere sahip olan; KUTPO, USAK ve QUAGR olarak tespit edilmiştir. Ayrıca MOORA yönteminde uygulanan tekniklerin hepsinde aynı sonuç alınamadığı da görülmüştür. Ancak ilgili tekniklerin birbirlerine çok yakın sonuçlar verdiği de tespit edilmiştir