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Afgan Öğrencilerin Algıladıkları Sosyal Dışlanma, Ayrımcılık ve Irkçılığın Türk Kamu Diplomasisine Etkileri: Sivas Cumhuriyet Üniversitesi ve Süleyman Demirel Üniversitesi Örnekleri
No full textThis study analyzes the threats faced by Türkiye's public diplomacy activities through international students based on the perception of discrimination and racism. The findings of the study revealed that, in the perception of Afghan students, prejudice, social exclusion, discrimination, xenophobia, and even racist behaviors are common in Turkish society. The study followed a qualitative research method, conducting in-depth interviews with a total of 15 students from Sivas Cumhuriyet University and Süleyman Demirel University, and the data were analyzed with Maxqda 2020 software.Bu çalışma, Afgan öğrenciler özelinde Türkiye’nin uluslararası öğrenciler üzerinden inşa ettiği kamu diplomasisi faaliyetlerinin karşı karşıya olduğu tehditleri ayrımcılık ve ırkçılık algısı temelinde ele almıştır. Çalışmanın bulguları, Afgan öğrencilerin algısında, Türk toplumunda kendilerine yönelik önyargı, sosyal dışlama, ayrımcılık, zenofobi ve hatta ırkçı davranışların yaygın şekilde görüldüğünü ortaya koymuştur. Çalışmada nitel araştırma yöntemi takip edilmiştir. Sivas Cumhuriyet Üniversitesi ve Süleyman Demirel Üniversitesi’nden toplamda 15 öğrenciyle derinlemesine mülakat gerçekleştirilmiş ve veriler Maxqda 2020 programıyla analiz edilmiştir
UNLOCKING THE POTENTIAL: MEDIATING EFFECT OF CUSTOMER ENGAGEMENT AND ONLINE SHOPPING MOTIVATION ON MMO PLAYERS' WILLINGNESS TO PAY MORE
No full textBu çalışma, MMO oyuncularının bağımlılık düzeylerinin ödeme isteklilikleri üzerindeki etkisini araştırmayı amaçlamaktadır. Bu etki, çevrimiçi alışveriş motivasyonu ve müşteri bağlılığı değişkenlerinin aracılığı ile incelenmektedir. Çevresel faktörlerin ödeme istekliliği üzerindeki etkisi, bağımlılık seviyesi sabit kalsa bile, çevrimiçi alışveriş motivasyonu ve müşteri bağlılığı ile araştırılmıştır. Online oyun katılımcılarının tutum ve algılarına ilişkin veriler çevrimiçi anket aracılığıyla toplanmıştır. Çalışmaya dahil edilen katılımcı sayısı 772 kişi olarak belirlenmiştir. Bu örneklem büyüklüğüne göre çalışmanın gücü %96,5 olarak hesaplanmıştır. Katılımcıların demografik özellikleri açıklandıktan sonra analizler YEM ile gerçekleştirilmiştir. Sonuçlar, ödeme istekliliğinin çevrimiçi oyun bağımlılığı seviyesinden etkilendiğini doğrulamaktadır. Online alışveriş motivasyonları arasında erken benimseme, uyarım arayışı ve müşteri bağlılığı değişkenleri hem ayrı ayrı hem de birlikte tüketicilerin ödeme istekliliğini artırmaktadır. Bu makale, MMO oyuncularının satın alma ve ödeme davranışlarını inceleyerek, giderek artan sayıda çevrimiçi oyuncunun davranışları hakkında net bir görüş sunmaktadır.This study aims to investigate the effect of MMO players' addiction levels on their willingness to pay. It examines this effect by mediating online shopping motivation and customer engagement variables. The impact of environmental factors on willingness to pay, even when the level of dependency remains fixed, has been investigated with online shopping motivation and customer engagement. We collected data on the attitudes and perceptions of online game participants through a questionnaire. Data suitable for the study were obtained from 772 people. According to this sample size, the power of the study was calculated as 96.5%. After the participants' demographics were explained, the analyses were performed with SEM. The results confirm that willingness to pay is affected by the level of online game addiction. Among online shopping motivations, early adoption, stimulation-seeking, and customer engagement variables, both separately and together, increase consumers' willingness to pay. This paper provides a clear view on behaviour of an increasing number of online gamers by examining the purchasing and payment behaviour of MMO players
First clinical practice experiences of nursing students in intensive care unit: A qualitative study
No full textBackground Nursing students' practice experiences in the intensive care unit will greatly influence their acquisition of professional skills and the development of their future nursing roles. Aim This study aimed to determine nursing students' first clinical practice experiences in the intensive care unit. Study Design The type of research is qualitative research. The study data were collected from 14 students who were doing clinical practice in the anaesthesia intensive care unit of a university hospital. Face-to-face individual interviews were conducted with each student. A semi-structured interview guide was used in the interviews. Data were analysed with MAXQDA Analytics Pro 2020. This study adhered to the COREQ checklist for reporting. Results Four main themes were reached: 'First Emotions in the Intensive Care Unit', 'Experiences Related to the Perception of Profession', 'Experiences Related to Patient Care' and 'Experiences Related to Personal Development'. It was determined that the most prominent feelings in these clinical practice experiences of the students were fear in patient care, satisfaction and professional image in professional acquisition, and making life more meaningful in their perspective on life. Conclusions Students evaluated the intensive care clinical practice as beneficial in terms of professional and personal development. It is recommended that an orientation program be organized for students before intensive care clinical practice. Relevance to Clinical PracticeQualified critical care nurses of the future are a product of a qualified nursing clinical education today
ONN donor half-salen ligands and their dioxomolybdenum(VI) complexes: Synthesis, crystal structure, experimental-theoretical characterizations and molecular docking studies
No full textThe half-salen ligand (L1) synthesized from 3,4-diaminobenzophenone with 2-hydroxy-1-naphthaldehyde and the new half-salen ligand (L2) synthesized from 4-(diethylamino)salicylaldehyde were used in the preparation of dioxomolybdenum(VI) complexes (C1 and C2). The characterization of the synthesized compounds was carried out by elemental analysis, IR, 1H NMR, UV-Vis and conductivity measurements. The molecular structure of the C2 complex was elucidated by X-ray crystallography. Spectroscopic data show that the half-salen ligands behave as dibasic tridentate ligands and coordinate via phenolic oxygen, azomethine nitrogen and primary amine nitrogen. Both the primary amine group and the hydroxyl group bonded to the molybdenyl center by losing one proton. The complexes, [MoO 2 (L1-L2)(Solv)], are nonelectrolyte and octahedral in structure. The sixth coordination is completed by a solvent molecule (C1: water and C2: ethanol). In addition, the chemical reactivities of the ligands and complexes were analyzed and compared with each other via reactivity descriptors and electronic structure principles of Conceptual Density Functional Theory (CDFT). The interactions with EGFR Kinase domain complexed with tak-285 (PDB ID: 3POZ of L1, L2, C1 and C2 were checked via Molecular Docking analysis. In the light of the relations found between CDFT descriptors and docking scores, it was noted that the most reactive chemical system C1 which has with lowest chemical and highest electrophilicity index interacts more powerful with selected protein
A geospatial approach to understanding sinkhole formation in Akgöl Wetland, Türkiye
No full textThe over-extraction of groundwater for agricultural purposes in the Konya Closed Basin (KCB) has led to land subsidence and new cover collapse sinkholes (CCS) in regions like the Akg & ouml;l Wetland (AW), where such occurrences were previously absent. InSAR data from 2014 to 2023 indicate that the average annual subsidence in AW varies between 15 mm/year and 30 mm/year. Alarmingly, in specific locations, the cumulative subsidence has reached 230 mm over nine years. The significant subsidence observed in the southern region of the study area aligns with a fault line between limestone and alluvial deposits. Furthermore, several bedrock collapse sinkholes (BCS) are seen in the limestone south of the lake. The orientations and alignments of the long axes of these dolines are pointed towards the region where recent CCS has developed. This may suggest the existence of an ancient bedrock collapse structure beneath the alluvium. During intense rainfall, the former lake region experiences transient flooding, with surface water draining southward, converging at the fault line and concealed BCS beneath the alluvium. This flow has induced CCS formation due to the concentration of groundwater flow within the intersection zone. The results of this study emphasise that it is necessary to develop integrated hazard mitigation plans, considering hydrology, lithology, structural geology, remote sensing, and geomorphology to address issues such as the KCB and other global problems.Turkish Academy of Sciences [TUBA-GEBIP-2023]We want to thank the reviewers for their valuable contributions to the study. Besides, Muhammed Zeynel OEztuerk thanks the Turkish Academy of Sciences for their support within the Outstanding Young Scientist Award Program (TUBA-GEBIP-2023)
Synthesis and anti-cancer properties of Pd(II) and Pt(II) coordination compounds of heterocyclic Schiff base ligands
No full textIn this study, three heterocyclic Schiff base ligands (LH) were synthesized through the reaction of 2-aminomethyl thiophene, 2-aminomethyl pyridine, and 2-aminomethyl piperidine amines with 2-hydroxybenzaldehyde. Subsequently, their corresponding metal complexes with platinum(II) and palladium(II) salts were prepared. The ligands act monoanionic, coordinating to the metal center through the O atom of the phenol and N atom of the imine, forming a neutral bis-chelating square-planar complex [ML2]. The ligands and their related Pd(II) and Pt (II) complexes were characterized using FT-IR, 1H NMR, 13C NMR, and mass spectrometry. Additionally, the structure of the C1 complex was elucidated through single-crystal X-ray analysis. When the biological activities of the synthesized compounds were examined, it was found that compound C1 was more efficient than cisplatin in killing breast cancer cells with an IC50 dose (31.80 +/- 4.05 mu M) as a result of MTT studies. The results obtained in flow cytometry studies coincide with these data. In the antioxidant studies obtained using the FRAP method, it was determined that the synthesized compounds did not have any antioxidant power.Karabuk University [KBUBAP-22-YL-135]The authors are grateful to Karabuk University for grant KBUBAP-22-YL-135. The authors also acknowledge the Scientific and Technological Research Application and Research Center, Sinop University, Turkey, using the Bruker D8 QUEST diffractometer
Design, 3D-QSAR, molecular docking, MD simulations, ADME/Tox properties and DFT study of benzimidazole derivatives as promising α-glucosidase inhibitors
No full textAcarbose and miglitol are two distinct alpha-glucosidase inhibitors that are frequently used to manage diabetes mellitus. Unfortunately, the clinical usage of these medications comes with a number of undesirable side effects. Therefore, development of safer and potent alpha-glucosidase inhibitor became more necessary. For this reason, a set of 20 benzimidazole-based oxadiazole molecules was addressed using the three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) approach. Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) using steric (S), electrostatic (E) and hydrogen bond donor (D) models showed good statistical outcomes as Q2 (0.600 and 0.616 respectively) and R2 (0.958 and 0.928 respectively). The developed models were then validated for their external ability; the R2test values were 0.85 and 0.627, respectively. The CoMFA and CoMSIA/SED contour maps helped identify key regions influencing alpha-glucosidase inhibitory activity, leading to the design of four new benzimidazole-based oxadiazole inhibitors with strong predicted activity. The new recommended compounds confirmed promising consequences in the preliminary in silico ADME/Tox prediction. Molecular docking results showed good interactions of compounds M1 and M2 in the active site of the alpha-glucosidase receptor, and their stability was studied using molecular dynamics simulations throughout 200 ns. The reactivity and stability of compounds M1 and M2 were assessed using the DFT approach, suggesting that these compounds have strong inhibitory potential and may serve as effective anti-diabetic agents, warranting further experimental investigation
Synthesis of novel thiazole derivatives containing 3-methylthiophene carbaldehyde as potent anti ?-glucosidase agents: In vitro evaluation, molecular docking, dynamics, MM-GBSA, and DFT studies
No full textThiazole derivatives bearing thiophene carbaldehyde have been successfully prepared by refluxing 3-methylthiophene carbaldehyde with thiosemicarbazide in absolute ethanol followed by treating the obtained product with different phenacyl bromide to get thiazole products in better yields. These derivatives were confirmed using H-1-, C-13 NMR, and EI-MS spectrometry techniques and finally subjected for their alpha-glucosidase inhibitory potential. Two compounds in the series including 2 g (IC50 = 9.00 +/- 0.57 mu M) and 2b (IC50 = 13.50 +/- 0.20 mu M) were found as the most potent alpha-glucosidase inhibitors better than the standard acarbose. Furthermore, the remaining five compounds attributed significantly to less activity. The studied molecules were calculated on the 6-31++g(d,p) basis set at B3LYP, HF, M062X levels with the help of the Gaussian package program, and their chemical activities were compared. Following that, the molecules' interactions with different alpha-glucosidase proteins (PDB IDs: 1R47 and 1UAS) were investigated, and their activities were contrasted. The binding free energy of the molecule with the best docking score is computed using MM/GBSA techniques. The comparative molecular dynamics simulations of the 2g-1UAS and 2g-1R47 complexes highlight the intricate balance of forces that govern biomolecular interactions. The findings suggest that while the 2g-1UAS complex forms more stable interactions, as indicated by lower RMSD values, the 2g-1R47 complex maintains its structural integrity through strong hydrogen bonds. Overall, the equilibrium conformations achieved by both complexes suggest they are well-suited for their roles in physiological environments
Experimental, density functional theory, molecular docking and ADMET analyses on the role of different plant extracts of Aronia melanocarpa (Michx) Elliot species on acetylcholinesterase enzyme activity
No full textIn the present study, different extracts obtained in different solvents from the fruits collected from the Aronia melanocarpa (Michx.) were prepared. The inhibition performances of these extracts on the inhibition of the acetylcholinesterase enzyme were checked via both theoretical and experimental analyses. Although all extracts used in experimental studies showed high inhibitory activity, it was observed that the extract obtained in methanol had higher inhibitory activity than the others. According to the enzyme activity results presented in the light of Ellman method, IC50 values were found between 0.0311-0.0857 mg/mL. Conceptual Density Functional Theory (CDFT) and Molecular Docking calculations were performed to identify the component or components of the extract with high inhibitory activity. Conceptual Density Functional Theoretical based data commented through popular electronic structure principles such as Maximum Hardness and Minimum Electrophilicity Principles showed that the most reactive one among studied dominant components of the extract is Malvin molecule. The interactions between studied molecules and AChE and mechanisms of these interactions were illuminated via Molecular Docking analyses and ADMET studies. As a result, it was shown that the most reactive molecule Malvin (with lowest hardness and the highest electrophilicity) interacts more powerful with AChE compared to other molecules. Within the framework of the theoretical analyses made, it was proposed that in the design and introduction of new AChE inhibitors, structures with low hardness and high electrophilicity values should be preferred
Uluslararası ekonomi finans ve işletme kongresi : özet ve tam metin bildiriler kitabı : EFİ 2025
No full textDünyada bilgi toplumuna doğru bir dönüşümün yaşandığı bu süreçte bilginin üretilmesi, bilginin yayılması ve bilginin
kullanılması önemli bir konu haline gelmektedir. Kongrelerin diğer akademik yayınlarlardan önemli bir farkı olduğu
söylenebilir. Kongrelerde, meslektaşlarımızla bir araya gelip yüz yüze etkileşimde bulunma şansı bilimin temelindeki
paylaşım ve etkileşim esaslarına doğrudan katkı yapmaktadır. EFİ-2025 Kongresi; ekonomi, finans ve işletme alanlarında
çalışmalar yapan akademisyenleri bir araya getirerek ilgili alanlardaki güncel gelişmeleri tartışmak, gelecekteki akademik iş
birliklerini sağlamak ve bir araştırma ağı oluşturmak için akademisyenleri ve lisansüstü öğrencileri bir araya getirmeyi
amaçlamaktadır. Bu yıl üçüncüsü düzenlenen EFİ Kongresi, 50. yılını kutlayan Fırat Üniversitesi ev sahipliğinde ve Sivas
Cumhuriyet Üniversitesi işbirliğiyle, 15-16-17 Mayıs 2025 tarihlerinde Elazığ’da düzenlenmiştir.
Türkiye'nin çeşitli üniversitelerinden akademisyenler ve lisansüstü öğrencilerin katılım sağladığı kongremizde, 62’si yüz
yüze, 49’u çevrimiçi olmak üzere toplam 111 bildiri sunulmuştur. EFİ-2025 Kongresi’nin gerçekleştirilmesinde bizleri her
açıdan destekleyen Fırat Üniversitesi Rektörü Sayın Prof. Dr. Fahrettin GÖKTAŞ ve Sivas Cumhuriyet Üniversitesi Rektörü
Sayın Prof. Dr. Ahmet ŞENGÖNÜL hocalarımız başta olmak üzere, emeği geçen tüm düzenleme kurulu üyelerine sonsuz
teşekkürlerimizi sunarız. Diğer yandan kongrenin düzenlenmesine verdikleri destekle yanımızda olan Elazığ Valiliği, Elazığ
Belediyesi, Elazığ Barosu ve Ekol Lojistik'e teşekkür ederiz