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Synthesis, antimicrobial and antibiofilm activities of silver(I) complexes with N-alkylbenzimidazole derivatives and their protein interaction modelling study
No full textThis study investigates the antimicrobial and antibiofilm potential of three silver(I) complexes derived from Nalkylbenzimidazole derivatives: bis[(Z)-1-styryl-benzimidazole]silver(I) nitrate (4), bis[(E)-1-styryl-benzimidazole]silver(I) nitrate (5), and bis(1-cinnamyl-benzimidazole)silver(I) nitrate (6). Detailed synthesis and characterization of these complexes are followed by assessments of their efficacy against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans. Among the tested compounds, complex 6 exhibited the highest antimicrobial activity, with a minimal inhibitory concentration of 6 mu mol/L against P. aeruginosa, and significant antibiofilm activity, achieving 67.72 % inhibition at a concentration of 3 mu mol/L. These interesting findings led us to conduct a molecular docking study to understand the mechanisms of action by investigating the interactions between the silver(I) complexes and some key protein targets involved in bacterial and fungal biofilm formation, including (p)ppGpp synthetase/hydrolases, FtsZ proteins, and pyruvate kinases. This comprehensive approach, combining experimental and computational analyses derived from N-alkylbenzimidazole derivatives, particularly complex 6, which exhibits remarkable efficacy against various pathogens, reveals promising therapeutic applications of these silver(I) complexes and advances our understanding of their potential mode of action against biofilm-associated infections
The effect of planned education for cervical cancer on women's health beliefs and health seeking behaviors
No full textAraştırma serviks kanserine yönelik verilen planlı eğitimin kadınların sağlık inançları ve sağlık arama davranışları üzerine etkisinin incelenmesi amacı ile deneysel türde yapılmıştır. Örneklemi 1 Mart-30 Ekim 2024 tarihleri arasında Şarkışla Halk Eğitim Merkezi'nde araştırmaya alınma kriterlerini sağlayan 100 kadın oluşturmuştur. Kadınlar deney gurubu (n=50) ve kontrol grubu (n=50) olarak iki gruba ayrılmıştır. Deney grubuna planlı eğitim verilmiş, kontrol grubuna eğitim verilmemiştir. Veriler Kişisel Bilgi Formu, Rahim Ağzı Kanseri ve Pap Smear Testi İçin Sağlık İnanç Modeli Ölçeği, Sağlık Arama Davranışı Ölçeği ve Değerlendirme Formu ile toplanmıştır. Planlı eğitim sonrası eğitim verilen deney grubunun kontrol grubuna göre ve eğitim sonrası deney grubunun kendi içinde Pap smear engeller puan ortalamasında anlamlı düzeyde azalma olduğu bulunmuştur (p<0,05). Planlı eğitim sonrası eğitim verilen deney grubunun Rahim Ağzı Kanseri Sağlık Motivasyonu puan ortalamasının anlamlı düzeyde arttığı ve Geleneksel Sağlık Arama davranışı puan ortalamasının anlamlı düzeyde azaldığı belirlenmiştir (p<0,05). Eğitim sonrası deney grubundaki kadınların %32'si serviks kanser tarama testi yaptırmış, kontrol grubundaki kadınların ise sadece %8'i serviks tarama testi yaptırmıştır. Kadınların Pap smear engellerinde ve geleneksel sağlık arama davranışında azalma olurken, rahim ağzı kanseri sağlık motivasyonları artmıştır.The research was conducted in an experimental manner with the aim of examining the effect of planned education for cervical cancer on women's health beliefs and health seeking behaviors. The sample consisted of 100 women who met the inclusion criteria at Şarkışla Public Education Center between 1 March and 30 October 2024. Women were divided into two groups: experimental group (n=50) and control group (n=50). Planned training was given to the experimental group, and no training was given to the control group. Data were collected with the Personal Information Form, Health Belief Model Scale for Cervical Cancer and Pap Smear Test, Health Seeking Behavior Scale and Evaluation Form. It was found that there was a significant decrease in the average Pap smear obstacles score of the experimental group, which was given training after planned training, compared to the control group and within the experimental group after the training (p<0,05). It was determined that the Cervical Cancer Health Motivation mean score of the experimental group, which was given training after the planned training, increased significantly and the Traditional Health Seeking behavior mean score decreased significantly (p<0,05). After the training, 32% of the women in the experimental group had a cervical cancer screening test, while only 8% of the women in the control group had a cervical screening test. While there was a decrease in women's Pap smear barriers and traditional health-seeking behavior, their cervical cancer health motivation increased
APPLICATION OF PULSED LIGHT IN LIQUID FOODS
No full textPulsed light offers rapid inactivation of a wide range of microorganisms in foods. This technology involves short pulses of high-energy electromagnetic radiation in the spectral range from UV to infrared delivered by inert-gas lamps. This chapter focuses on the application of pulsed light in various liquid foods. After a brief overview of pulsed light technology, the equipment specifically designed for the treatment of liquid foods and critical processing parameters are discussed. Then, research conducted on the effects of pulsed light on the microbial loads and quality parameters of liquid foods is summarized. Finally, remarks on the potential commercial application of pulsed light in liquid foods are made. © 2025 by Apple Academic Press, Inc
Impact of Environmental Conditions on Renewable Energy Prediction: An Investigation Through Tree-Based Community Learning
No full textThe real-time prediction of energy production is essential for effective energy management and planning. Forecasts are essential in various areas, including the efficient utilization of energy resources, the provision of energy flexibility services, decision-making amidst uncertainty, the balancing of supply and demand, and the optimization of online energy systems. This study examines the use of tree-based ensemble learning models for renewable energy production prediction, focusing on environmental factors such as temperature, pressure, and humidity. The study's primary contribution lies in demonstrating the effectiveness of the bagged trees model in reducing overfitting and achieving higher accuracy compared to other models, while maintaining computational efficiency. The results indicate that less sophisticated models are inadequate for accurately representing complex datasets. The results evaluate the effectiveness of machine learning methods in delivering valuable insights for energy sectors managing environmental conditions and predicting renewable energy sourcesEuropean Union's Horizon Europe research and innovation program; [101172877]This work was supported in part by the European Union's Horizon Europe research and innovation program under grant number: 101172877
Leptin/Melanocortin Pathway in Cholelithiasis Patients: A Diagnostic Perspective
No full textBackground: Cholelithiasis is the most prevalent inflammatory condition of the gallbladder. The regulation of biological processes, including energy homeostasis, and control of body weight are key mechanisms that the leptin and melanocortin pathways play a role in Cholelithiasis is the most prevalent inflammatory condition of the gallbladder. There are various risk factors for the development of gallstone disease, especially weight gain, and obesity is just one of them. This risk factor can be minimized by maintaining appetite and energy balance. Here, leptin and melanocortin pathways are the key mechanisms in maintaining appetite and energy homeostasis. Objectives: The aim of this study was to investigate the relationship between the levels of LEP, LEPR, TrkB, BDNF, POMC, and MC4R proteins in patients with Cholelithiasis. This study aims to determine the relationship between LEP, LEPR, TrkB, BDNF, POMC, and MC4R protein levels, which play a role in maintaining appetite and energy homeostasis, and cholelithiasis. Methods This study examined 44 patients diagnosed with Cholelithiasis and 44 healthy control subjects who had not previously been diagnosed with any form of Cholelithiasis. The levels of leptin (LEP), Leptin Binds To Leptin Receptors (LEPR), Tropomyosin Receptor Kinase B (TrkB), Brain-Derived Neurotrophic Factor (BDNF), Pro-OpioMelanoCortin (POMC), and Melanocortin-4 Receptors (MC4R) molecules were analyzed using the Enzyme-Linked Immunosorbent Assay (ELISA) method. The results were analyzed using the SPSS Software (Version 22.0) program and GraphPad Prism 8.0.1 software. Results: The study found a statistically significant decrease (p < 0.05) in MC4R, TrkB, BDNF, and POMC protein levels in Cholelithiasis patients compared to the control group. There was no statistically significant difference in LEP and LEPR concentration values between the two groups (p = 0.247, p = 0.674). Conclusion: The proteins MC4R, TrkB, BDNF, and POMC, which are involved in the leptin and melanocortin pathways may play a significant role in Cholelithiasis disease. However, more detailed research on the relevant proteins is needed. Nevertheless, this research will guide new studies
Semiological analysis of the animated film Pinocchio within the framework of root values
No full textToplumların şekillenmesinde medyanın oldukça önemli bir rol kazandığı görülmektedir. Özellikle çocuklar ve gençler üzerindeki etkisinden yola çıkılarak bu gücün eğitimde kullanılmasına yönelik çalışmalar yapılmaktadır. Dünyada medyanın eğitici gücünün çocuk eğitiminde öneminin artmasıyla birlikte çocuklar yönelik olarak yapılan çizgi filmlerin incelenmesi önem taşımaktadır. Çünkü çocuklar birçok değeri ilk olarak çizgi filmler aracılığıyla edinmektedir. Yapılan bu çalışmada değerler eğitimi kapsamında 2023 Pinokyo animasyon filminin on kök değere (sevgi, saygı, sorumluluk, sabır, yardımseverlik, vatanseverlik, dostluk, dürüstlük, özdenetim ve adalet) göre incelenmesi amaçlanmaktadır. Pinokyo filminin yönetmenleri Guillermo del Toro – Mark Gustafson olup filmin toplam süresi 114 dakikadır. Araştırma nitel yöntemleri içinde yer alan doküman analizi kullanılarak yapılmıştır. Verilerin analizinde içerik analizi ve göstergebilim çözümlemesi yapılmıştır. İnceleme sonucunda Pinokyo çizgi filminde toplamda f=124 kök değere ilişkin olumlu-olumsuz veri elde edilmiştir. Pinokyo filmi içerisinde en fazla yer alan kök değerin f=27 “dürüstlük” ve f=27 “sevgi” değerlerinin olduğu görülmektedir. En az yer alan kök değerin ise f=2 “sabır” değeri olduğu inceleme sonucunda elde edilmiştir.It is seen that the media has gained a very important role in shaping societies. Studies are being conducted to use this power in education, especially based on its effect on children and young people. With the increasing importance of the educational power of the media in child education in the world, it is important to examine cartoons made for children. Because children first acquire many values through cartoons. In this study, it is aimed to examine the 2023 Pinocchio animation film according to ten root values (love, respect, responsibility, patience, helpfulness, patriotism, friendship, honesty, self-control and justice) within the scope of values education. The directors of the Pinocchio film are Guillermo del Toro – Mark Gustafson and the total duration of the film is 114 minutes. The research was conducted using document analysis, which is included in qualitative methods. Content analysis and semiotic analysis were performed in the analysis of the data. As a result of the examination, positive and negative data regarding a total of f=124 root values were obtained in the Pinocchio cartoon. It is seen that the most common root values in the Pinocchio film are f=27 “honesty” and f=27 “love”. As a result of the examination, it was obtained that the least common root value was f=2 “patience” value
Mediator role of cognitive distortions in the relationship between posttraumatic stress disorder symptoms and peritraumatic stress levels
No full textBackground: There are many studies showing the relationships between posttraumatic stress disorder (PTSD), peritraumatic stress, and cognitive distortions. However, there is a very limited number of studies focusing on the relationship between PTSD and cognitive distortions in children and adolescents. This study aimed to investigate the relationship between PTSD symptoms and peritraumatic stress levels in adolescents who experienced the 6 February Turkey earthquakes and the mediator role of cognitive distortions in this relationship. Methods: The study sample consisted of 261 adolescents with a mean age of 15.51 +/- 1.07. The Child Posttraumatic Stress Disorder Reaction Index (CPTSD-RI), the Peritraumatic Distress Inventory (PDI), and the Cognitive Distortion Scale (CDS) were administered to the participants. Results: It was determined that there was a positive relationship between the peritraumatic stress levels and PTSD symptoms of the participants, and their peritraumatic stress levels significantly and positively predicted their PTSD symptoms and cognitive distortions. According to the results of the regression analyses, the self-perception, self-blame, helplessness, hopelessness, and perceiving life as dangerous dimensions of cognitive distortions and total CDS scores of the participants had partial mediator roles in the relationship between their peritraumatic stress levels and PTSD symptoms. Limitations: Participants' PTSD symptoms were assessed using self-report scales. Pre-traumatic factors were not questioned. Conclusion: Our results showed that the peritraumatic stress levels of adolescents who survived the 6 February Turkey earthquakes predicted their PTSD symptom levels, and their cognitive distortions played a mediator role in the relationship between their peritraumatic stress levels and PTSD symptoms. Implications and contribution: In psychological and psychiatric assessments of adolescents living in earthquake zones, peritraumatic stress levels should be kept in mind as a significant factor that can pose a risk in terms of PTSD. Furthermore, it is believed that cognitive distortions that can be causally related to PTSD should be taken into account in the treatment of PTSD
Evaluation of Knowledge Levels and Awareness of Dentists Working in Sivas Province about Ergonomics
No full textAmaç: Diş hekimleri ergonomik olarak risk altındaki meslek çalışanları arasındadır. Ergonomik kurallara uygun olmayan çalışmalar sonucunda oluşan mesleki hasarların en büyük sınıfını kas ve iskelet sistemi hastalıkları oluşturmaktadır ve bu hastalıkların diş hekimlerinde prevalansı oldukça yüksektir. Uygun çalışma duruşu, hasarların önlenmesinde başlangıç noktasıdır. Bu konuda diş hekimlerinin kişisel farkındalığı oluştuğu takdirde meslek uzun yıllar sağlıklı bir şekilde sürdürülebilmektedir. Gereç ve Yöntemler: Bu yapılandırılmış anket çalışmasının amacı; Sivas ili merkezinde çalışan 103 diş hekiminde ergonomi bilincini ve ergonomik koşullara uyulmadığında oluşabilecek mesleki hastalıklara ilişkin bilgi düzeylerini belirlemek ve farkındalık oluşturmaktır. Anket formu demografik bilgiler, farkındalık bölümü, risk faktörleri bölümü ve İskandinav kas-iskelet sistemi anketi (İKİSA) bölümünden oluşmaktadır. Verilerin istatistiksel analizinde IBM SPSS 23® programı kullanılmıştır. Bulgular: Diş hekimlerinin %96,1’i mesleki ergonomi hakkında bilgisi olduğunu, % 94,2’si doğru çalışma pozisyonunu bildiğini belirtmiştir. Ancak %68,9’u uzun süre aynı pozisyonda çalıştığını ve %52,4’ü hastalar arasındaki zamanlarında esneme veya nefes egzersizi yapmadıklarını bildirmiştir. İKİSA sonuçları, cinsiyete ve görev yapılan yere göre istatistiksel olarak anlamlı farklı bulunmuştur (p0,05). Sonuç: Çalışmamız Sivas ilinde görev yapan diş hekimlerinin ergonomik çalışma koşulları ve mesleki kas ve iskelet sistemi hastalıklarına karşı farkındalıklarının yetersiz olduğunu ortaya koymuştur.Aim: Dentists are among the occupational workers at ergonomic risk. Musculoskeletal system diseases constitute the largest class of occupational injuries that occur when ergonomic rules are not followed and the prevalence is high in dentists. Appropriate working posture is the starting point in the prevention of damages. If dentists are aware of this issue, the profession can be continued in a healthy way for many years. Materials and Methods: The aim of this structured questionnaire study was to determine the awareness of ergonomics in 103 dentists working in the centre of Sivas province and to determine their level of knowledge about occupational diseases that may occur when ergonomic conditions are not complied with and to raise awareness. The questionnaire consists of demographic information, awareness, risk factors and Nordic musculoskeletal questionnaire (NMQ). IBM SPSS 23® programme was used for statistical analysis. Results: 96.1% of dentists stated that they knew occupational ergonomics and 94.2% knew the correct working position. However, 68.9% reported that they worked in the same position for a long time and 52.4% reported that they did not do stretching or breathing exercises. NMQ results were found to be statistically significantly different according to gender and place of work (
Comparison of nutritional screening tools in pediatric oncology patients receiving chemotherapy treatment
No full text46th Congress of the European-Society-for-Clinical-Nutrition-and-Metabolism (ESPEN) -- SEP 07-10, 2024 -- Milan, ITALYBackground: Malnutrition in pediatric oncology patients is a complex and multifactorial process, and the most appropriate screening tool to determine the risk of malnutrition is not clear. The study aimed to compare the Screening Tool for Risk on Nutritional Status and Growth (StrongKids), Pediatric Yorkhill Malnutrition Score (PYMS), Screening Tool for the Assessment of Malnutrition in Pediatrics (STAMP), which are commonly used in the general pediatric population, with the Nutrition Screening Tool for Childhood Cancer (SCAN), which was specifically validated for pediatric cancer, in determining the risk of malnutrition. Methods: This cross-sectional study included 92 children aged 2-18 years who were admitted to the hematology- oncology unit and were receiving chemotherapy. The prevalence of nutritional risk was determined using the SCAN, StrongKids, PYMS, STAMP, and anthropometric assessments were performed. Sensitivity and specificity values, and the degree of agreement between screening tools were calculated. Result: The SCAN identified nutritional risk in 69.6 % of the children. According to StrongKids, PYMS and STAMP, the high nutritional risk in children was 43.5 %, 56.5 % and 64.1 %, respectively. The sensitivity of STAMP (81.2 %) was higher than that of StrongKids (60.9 %) and PYMS (79.7 %). The specificity of StrongKids, PYMS and STAMP was 96.4 %, 96.4 %, and 75.0 %, respectively. There was substantial agreement between SCAN and PYMS. Conclusion: PYMS has the best specificity and sensitivity in identifying patients at risk of malnutrition as determined by SCAN. Implications for practice: In addition to anthropometric measurements, population-specific or highly sensitive nutritional screening tools should be used to determine the risk of malnutrition. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.European Soc Clin Nutr & Meta
Brucellosis Seroprevalence and Diagnostic Challenges: A Comprehensive Review from 2017-2021
No full textObjective:This study aimed to evaluate the performance of the Rose Bengal test (RB), serum agglutination test (SAT), and Coombs test (CT) in samples suspected of brucellosis, analyze the seasonal distribution, examine the relationship with Crimean-Congo hemorrhagic fever (CCHF), which is frequently observed in our region, and determine the seroprevalence of brucellosis in the area. Materials and Methods: A retrospective analysis was conducted on 12,279 brucellosis- suspected samples submitted from various clinics between 2017 and 2021. RB, SAT, and CT tests were performed, and results were analyzed concerning seasonal and yearly distributions as well as factors such as age and gender differences. Results: Among the 12,279 RB tests conducted, 281 (2.3%) were positive, and 11,998 (97.7%) were negative. Of the positive results, 96 samples were positive for both RB and SAT, while 185 were RB positive but SAT negative. CT provided positive results in 101 out of 185 cases with discordant RB and SAT results. The seroprevalence rate was 1.5%, with higher rates observed among males and during the spring and summer seasons. A notable increase in seropositivity was observed during the pandemic. Conclusion: This study highlights the annual and seasonal distribution of brucellosis and differences across age and gender groups.The Coombs test played a crucial role in resolving cases with discordant RB and SAT results. A rise in brucellosis cases during the pandemic was noted, with significant co-infections involving CCHF