Sivas Cumhuriyet Üniversitesi Kurumsal Akademik Arşivi - Sivas Cumhuriyet University Open Access System
Not a member yet
34175 research outputs found
Sort by
Synthesis of sustainable heterocyclic aryl sulfonamide derivatives: computational studies, molecular docking, and antibacterial assessment
No full textThe treatment of infectious diseases is impacted by the emergence of multidrug-resistant microbiological infections. Due to the long-term usage of antibacterial clinical drugs, microbes develop resistance to clinical drugs. To take advantage of the potential of these families of chemicals, several derivatives of thiophene containing p-toluene sulfonamide (TPS) were prepared using an eco-friendly method with high yields. These synthetic derivatives had a wide range of structural diversity to demonstrate a structure-activity link. In multi-component reaction (MCR), the versatile reactants (1 mmol) react for up to 6-8 h at pH 7.2 +/- 0.2 and temperature 70 +/- 1 degrees C. The reaction involved the reusable organic catalyst l-Proline (1 mol%), and the mechanisms through a Knoevenagel condensation pathway, which has the advantage of effectively producing the described thiophene derivatives (TD). Then, further TD reacts with p-toluene sulfonamide (Tosyl-Cl) at 0 degrees C within 10-12 h to provide the final product TPS. The present investigation provides an inexpensive and eco-friendly method of TPS derivatives. A perusal of the tables indicates that TPS derivatives exhibited promising activity against S. typhimurium as compared to E. coli and S. aureus. The compounds having good activity contained electron-withdrawing as well as electron-donating substituent groups on the benzaldehyde benzene ring of the amino part of the amide.Graphical abstract Green sustainable development of multi component heterocyclic aryl sulfonamide reactionJazan University [RG24-M033]; Deanship of Graduate Studies and Scientific Research, Jazan University, Saudi ArabiaThe authors gratefully acknowledge the funding of the Deanship of Graduate Studies and Scientific Research, Jazan University, Saudi Arabia, through project number: (RG24-M033)
Sivas Gök Medrese de Yer Alan Hayat Ağacı Bezemesinin Ezoterizm Kavramı Açısından İncelenmesi
No full textThis study has been prepared to evaluate the tree of life symbol, which has a wide place in Turkish and World culture, within the framework of the concept of esotericism in general, as well as to examine the tree of life symbol in Sivas Gök Madrasah, one of the important architectural structures of the Seljuks, in terms of esoteric indicators. In the study, the concept of esotericism and the tree of life symbol were briefly touched upon, and the tree of life symbol in Sivas Gök Madrasah was tried to be examined in terms of esoteric indicators. The conceptual framework of the research was based on descriptive tools through scanning, and the opportunities of qualitative research were used to determine the situation in the literature in the light of the findings obtained. In the article prepared by making use of publications, these and other studies on the subject, the subject is limited to the concept of esotericism, the tree of life symbol and the evaluation of the tree of life symbol in Sivas Gök Madrasa in terms of the concept of esotericism. In this context, the tree of life symbol, which also has a place in esotericism, has been tried to be examined through esoteric indicators. The main purpose of this study is to contribute to the understanding of the esoteric meaning of the tree of life symbol in Sivas Gök Madrasa, as well as the symbolic meanings of the tree of life symbol, which has an important place in the Anatolian geography we are in.Hazırlanan bu çalışma genel olarak ezoterizm kavramı çerçevesinde Türk ve Dünya kültüründe geniş yere sahip olan hayat ağacı sembolünün değerlendirilmesinin yanı sıra, Selçukluların önemli mimari yapılarından Sivas Gök Medrese de bulunan hayat ağacı sembolünün ezoterik göstergeler açıcından incelenmesine yönelik olarak oluşturulmuştur. Çalışma da, ezoterizm kavramı ve hayat ağacı sembolüne kısaca değinilerek, Sivas Gök Medrese de bulunan hayat ağacı sembolü, ezoterik göstergeler açısından irdelenmeye çalışılmıştır. Araştırmanın kavramsal çerçevesi betimsel araçlardan tarama yolu ile temellendirilmiş, elde edilen bulgular ışığında literatürdeki durumu tespit etmek amacı ile nitel araştırmanın imkânlarından faydalanılmıştır. Konu ile ilgili tez, yayın ve diğer çalışmalardan yararlanılarak hazırlanmış olan makale de konu, ezoterizm kavramı, hayat ağacı sembolü ve Sivas Gök Medrese de bulunan hayat ağacı sembolünün ezoterizm kavramı açısından değerlendirilmesi ile sınırlandırılmıştır. Bu bağlamda ezoterizm içerisinde de yeri olan hayat ağacı sembolü, ezoterik göstergeler üzerinden irdelenmeye çalışılmıştır. Hazırlanan bu çalışmanın temel amacı, içinde bulunduğumuz Anadolu coğrafyasın da önemli bir yere sahip olan hayat ağacı sembolünün simgesel anlamlarının irdelenmesinin yanı sıra, Sivas Gök Medrese de bulunan hayat ağacı sembolünün de ezoterik göstergeler üzerinden anlaşılmasına katkı sağlayabilmektir
The Effect of Technology Supported Guided Inquiry Environmental Education on Preservice Science Teachers' Attitudes Towards Sustainable Environment, Environmental Education Self-Efficacy and Digital Literacy
No full textThis study examines the effect of technology supported guided inquiry environmental education (TsGIEE) on preservice science teachers' attitudes towards sustainable environment (AtSE), environmental education self-efficacy (EESE) and digital literacy (DL). Embedded design from mixed research method was preferred in the study. 33 (20 female-13 male) fourth grade preservice science teachers participated in the study. A significant difference was found between the pre-test and post-test scores obtained from the overall scale of EESE. In addition, a significant difference was found between the scores obtained from the content knowledge (CK) and instructional strategies (IS) sub-dimensions of the EESE in favor of the post-test. Moreover, a significant difference in favor of the post-test was found between the scores obtained from the overall AtES scale and the use of environmental resources (UER) sub-dimension. There was no significant difference between the scores obtained from the general and sub-dimensions of the digital literacy (DL) scale. When the qualitative data were analyzed, the participants produced metaphors in the category of raising environmental awareness the most regarding TsGIEE. In addition, the participants emphasized that the applications contained informative and useful information and that they gained competence in teaching environmental issues thanks to these applications. Within the framework of the findings obtained, it is recommended to organize technology-supported guided inquiry learning environments in environmental education
Investigating the relationship between impulsive behaviors and Turkish pedestrians' attitudes based on sociodemographic factors
No full textPedestrian attitude is an important issue in road safety. In order to understand pedestrian attitudes, it is necessary to study their sociodemographic and psychological characteristics. With respect to this, the aim of the study was to examine age and sex differences in impulsive behavior and the role of impulsive behavior on pedestrian attitudes in T & uuml;rkiye. A total of 347 Turkish pedestrians (145 male, 202 female) completed the Pedestrian Attitude Questionnaire (PAQ), the Urgency Premeditation Perseverance Sensation Seeking (UPPS) Impulsive Behavior Scale, and a Questionnaire Form. First, the psychometric structure of the PAQ was found to support the original structure, addressing attitudes towards other road users and attitudes towards traffic rules. With increasing age, negative attitudes towards traffic rules decreased. Female pedestrians also showed more negative attitudes towards other road users. The results of hierarchical regression analyses indicate that impulsive behavior is significantly associated with pedestrian attitudes depending on sociodemographic factors. The findings suggest that pedestrians' impulsive behavior may influence their attitudes in traffic, but this influence varies by age and sex. The outcomes have important implications for intervention studies and road safety.Scientific and Technological Research Council of Tuerkiye (TUEBIdot;TAK)Open access funding provided by the Scientific and Technological Research Council of Tuerkiye (TUEB & Idot;TAK). No funding was received for conducting this stud
Inverse Nodal Problem for Sturm- Liouville Boundary Value Problem
No full textInverse nodal problems has been studied for Sturm-Liouville equations with point δ coaction. First, the eigenvalues of the problem are obtained. Then, the solution of the inverse problem is given by obtaining potential function and the parameters in the boundary conditions with the help of a dense set of nodal points. Lastly, the uniqueness theorem is proven and a constructive procedure for solutions is provided.[No abstract available
Lutetian-Bartonian (Middle Eocene) micropalaeontology, biostratigraphy and palaeoecology of the Mengen Coal Basin, Northwest Turkiye (Turkey)
No full textThis study focuses on the upper Lutetian-lower Bartonian Tokmaklar Formation in the Mengen Basin of Northwest Turkiye (Turkey), examining various aspects such as biostratigraphy, palaeoecology, and isotope data (S18O and S13C), providing insights into the geological history and environmental conditions during this interval. Moreover, the study incorporates coal petrography on four samples to explore a potential correlation between the coalification process and the preservation of palynomorphs. The formation is informally divided into two distinct categories: a coal-bearing sequence positioned at the base of the formation and a coal-free sequence above it. However due to dense vegetation and soil cover in the area, the availability of suitable outcrops for measured sections and obtaining samples is severely limited. Therefore, we relied on drilling data from Turkish Coal Enterprises (TCE) for the purpose of coal exploration, as well as two partial sections (Ender and C,orak) from underground mining. Microapalaeontological evidences involving benthic foraminiferans, ostracods, and palynomorphs, along with isotope data (S18O and S13C), suggest that the Tokmaklar Formation was deposited as a result of a local transgressive process during the late Lutetian-early Bartonian. Furthermore, palynological data, particularly the existence of mangroves such as Nypa, lepidocaryoid palm and Acrostichum aureum, coupled with quantitative palaeoclimate analysis, the negative S18O values, and the lower S13C values indicate a warm, probably tropical climate under high rainfall. (c) 2024 Elsevier B.V. and Nanjing Institute of Geology and Palaeontology, CAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.Scientific Research Projects of Kutahya Dumlupinar University (BAP) [2015-79]This study was supported by a research grant from the Scientific Research Projects of Kutahya Dumlupinar University (BAP Grant Code 2015-79). The authors thank the Cukurova University, Central Laboratory Management and Dr. Deniz Kadir Takc & imath; for taking Scanning Electron Microscope photographs. We thank Ahmet Yigitalp who helped us for the field study. The authors would like to thank Prof. Dr. Dimiter Ivanov and an anonymous referee for helpful comments and suggestions
Relationship between Oxidized Low-Density Lipoprotein Treatment and Hepatocellular Carcinoma Associated Transcript 1 Expression
No full textLong non-coding RNAs (lncRNAs) have multiple biological functions in the vascular system including in endothelial cells (ECs). Hepatocellular carcinoma associated transcript 1 (HULC) is a lncRNA and highly up-regulated in liver cancer. Oxidized low-density lipoprotein (ox-LDL) is a remarkable risk factor for various disease. We investigated and compared HULC expression in human umbilical vein endothelial cells (HUVECs) treated with two different concentration of ox-LDL. We used quantitative polymerase chain reaction (qPCR) method to detect HULC expression level in HUVECs. HULC expression was found to be statistic significantly up-regulated in HUVECs treated with higher concentration of ox-LDL (PLong non-coding RNAs (lncRNAs) have multiple biological functions in the vascular system including in endothelial cells (ECs). Hepatocellular carcinoma associated transcript 1 (HULC) is a lncRNA and highly up-regulated in liver cancer. Oxidized low-density lipoprotein (ox-LDL) is a remarkable risk factor for various disease. We investigated and compared HULC expression in human umbilical vein endothelial cells (HUVECs) treated with two different concentration of ox-LDL. We used quantitative polymerase chain reaction (qPCR) method to detect HULC expression level in HUVECs. HULC expression was found to be statistic significantly up-regulated in HUVECs treated with higher concentration of ox-LDL (
Predictors for Publication of Specialty Theses in the Field of Infectious Diseases and Clinical Microbiology
No full textObjective: Specialty theses in the field of infectious diseases and clinical microbiology (IDCM) play an important role in shaping medical knowledge, yet their publication in scientific journals remains a critical concern. We reviewed the theses of the IDCM specialty program, analyzed the publication rates in scientific journals, and made some recommendations for the future. Materials and Methods: We analyzed the registered IDCM theses in the electronic database of the Council of Higher Education (YÖK, Ankara) between 1984 and 2021. Specialty theses from other medical fields, PhD and master theses, were excluded from the study. Results: Out of 1265 theses, 1061 were included after exclusion criteria were applied. The study revealed that 647 (61%) of residents were female. Of 1061 authors, 117 (11%) received financial support during the preparation of the thesis. The most common thesis topics were viral hepatitis, healthcare-associated infections, antibiotic susceptibility, zoonotic diseases, febrile neutropenia, and sepsis. The predominant type of study design was observational (88%). Notably, 27 (3%) were randomized controlled trials. The overall rate of publication in a peer-reviewed journal was 25%. Nonetheless, 117 (11%) theses were published in the journals indexed in the Science Citation Index (SCI) or the Science Citation Index-Expanded (SCI-E). The median time from the presentation of theses to publication was four years. Conclusion: The publication rate of specialty theses in scientific journals in the field of IDCM was found to be low. Publication of the thesis as a scientific manuscript should be a part of the residency program and the completion process of the thesis. All the residents or young specialists should be encouraged to submit their theses for publication. © 2025, DOC Design and Informatics Co. Ltd.. All rights reserved
6 Şubat 2023 Kahramanmaraş Pazarcık (Mw: 7,7) depremi ışığında Doğu Anadolu Fay Zonu Erkenek Segmentinin Kinematik Analizi / The Kinematics of Active Crustal Deformation in the Erkenek Segment of the Eastern Anatolian Fault Zone Using Comprehensive Surface Rupture Analysis from the February 6, 2023 Earthquake (Mw 7.7)
No full textTÜBİTAK 1002C Doğal Afetler Odaklı Saha Çalışması Acil Destek Programı ve TÜBİTAK 121Y410The Eastern Anatolian Fault Zone (EAFZ) is a significant neotectonic feature in Anatolia, characterized as an active intra-continental left-lateral strike-slip fault. The EAFZ comprises two distinct parts: the southern branch, referred to as the main branch, and the northern branch. This study examines the surface rupture near Çelikhan (Adıyaman) on the Erkenek Segment, which developed during the February 6, 2023 Pazarcık earthquake (Mw 7.7), occurring along the southern branch of the EAFZ. The primary emphasis of this study centers on preliminary findings derived from thorough geological investigations conducted on the surface fault rupture. Additionally, novel insights into seismic activity associated with the Erkenek Segment were revealed for the first time through meticulous field studies. In the studies, the maximum left-lateral displacement measured in the Çelikhan section of the surface fracture was 3.25 meters, accompanied by a vertical slip of 50 centimeters. The magnitude of left-lateral displacement decreased and attenuated moving northeastward from Çelikhan. Based on kinematic analysis of slip data obtained from fault planes along the Erkenek segment, the deformation aligned with the segment's geometry and occurred within a strike-slip tectonic regime influenced by compressional stress predominantly oriented in NE-SW and NNW-SSE directions.Anadolu’nun Neotektonik dönemi yapılarından biri olan Doğu Anadolu Fay Zonu (DAFZ) kıta içi deformasyonu sağlayan sol yanal doğrultu atımlı aktif bir fay zonudur. DAFZ; kuzey kol ve ana kol olarak da adlandırılan güney kol olmak üzere iki bölümden oluşmaktadır. Bu çalışmanın konusunu DAFZ’nin güney kolu üzerinde meydana gelen 6 Şubat 2023 Pazarcık depreminde (Mw: 7,7), Erkenek Segmenti üzerinde gelişen yüzey kırığının Çelikhan (Adıyaman) yakınlarındaki bölümü üzerinde gerçekleştirilen detaylı jeolojik, paleosismolojik ve haritalama çalışmalarının ön bulguları oluşturmaktadır. Yapılan çalışmalarda yüzey kırığı Çelikhan kesiminde 50 cm düşey atımın eşlik ettiği maksimum sol yanal yer değiştirme miktarı 3,25 m olarak ölçülmüştür. Çelikhan’ın kuzeydoğusuna doğru gidildikçe sol yanal yer değiştirme miktarının azaldığı ve sönümlendiği görülmüştür. Erkenek segmenti boyunca fay düzlemlerinden ölçülen kayma verilerinin kinematik analizi sonucunda, segmentin geometrisi ile uyumlu deformasyonun yaklaşık KD-GB ve KKB-GGD doğrultulu sıkışma gerilmesiyle ilişkili doğrultu atımlı tektonik rejim altında geliştiği saptanmıştır.TÜBİTA
The significance of taurine for patients with Crimean-Congo hemorrhagic fever and COVID-19 diseases: a cross-sectional study
No full textObjectives: In this study, we aimed to evaluate the change in taurine levels in two diseases [Crimean-Congo hemorrhagic fever (CCHF) and novel coronavirus disease (COVID-19)], which have a significant impact on public health as they frequently cause mortality and morbidity. Methods: This observational, cross-sectional study was conducted between September 15, 2023, and November 30, 2023, at the Emergency Department, Sivas Cumhuriyet University Faculty of Medicine. There were three groups in our study. These groups were 35 COVID-19 patients with confirmed diagnosis, 35 CCHF patients, and a control group consisting of 35 healthy volunteers who were similar to these patient groups in terms of age and gender. Plasma amino acid levels of taurine, beta-alanine, arginine, carnosine, cystine, histidine, lysine, and methionine were measured and compared in these three groups. Results: In the pairwise comparison of the groups, the increase in taurine plasma levels in CCHF (p<0.001) and COVID-19 (p=0.002) patients compared to the control group was statistically significant, whereas the difference between CCHF and COVID-19 patient groups was not significant (p=0.303). Multinomial logistic regression analysis revealed that taurine, beta-alanine, arginine, and lysine levels were significant predictors in differentiating patients with CCHF and COVID-19 from healthy individuals. Conclusions: We concluded that it may be important to determine taurine levels during the treatment and observation processes of these two diseases, which seriously affect public health. This study will contribute to a better understanding of the pathogenesis of the CCHF and COVID-19 diseases