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Assessment of fit accuracy and retentive strength of additively manufactured zirconia crowns luted to Ti-base abutments with different resin cements: An in vitro study
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Purpose This study investigated the influence of cement gap size on the marginal and internal fit, and cement gap size and type on retention of additively manufactured zirconia (AM-Z) crowns on titanium bases (Ti-base). Materials and Methods A total of 135 zirconia crowns were designed with three different cement gap sizes: 20 mu m, 30 mu m, and 40 mu m (n = 45 per group). The crowns were additively manufactured using a lithography-based ceramic 3D printer (Cerafab, Lithoz GmbH, Austria) and a zirconia slurry (LithaCon 3Y 210, Lithoz GmbH, Austria). All crowns, Ti-base (RC Variobase, Straumann, Switzerland), and crown-Ti-base assemblies were scanned, and the marginal and internal gaps were measured using specialized software, following the triple scan protocol. Specimens were further divided into three subgroups based on the resin luting agent used for bonding the crowns to the Ti-bases (n = 15 per subgroup): Group PV21 used Panavia 21 (P21) (Kuraray Noritake Dental Inc., Japan), Group PV5 used Panavia V5 (PV5) (Kuraray Noritake Dental Inc., Japan), and Group MHA used Multilink Hybrid Abutment (Ivoclar Vivadent, Liechtenstein). After cementation, specimens were subjected to thermocycling between 5 degrees C and 55 degrees C. Pull-out forces between the additively manufactured zirconia (AM-Z) crowns and Ti-bases were measured using a universal testing machine. Variance analysis was conducted on root mean square (RMS) values for internal and marginal gaps, as well as pull-out forces (alpha = 0.05). Results The one-way analysis of variance test revealed a statistically significant difference in marginal discrepancy values (p < 0.001). A post-hoc Tukey analysis indicated that the marginal (25.9 m) and internal discrepancy (24.6 mu m) values associated with the 30 mu m cement gap size were higher than those obtained with other cement gap sizes (p < 0.01). No significant differences were found between the 20 m and 40 mu m cement gap sizes (p = 0.113). The 30 mu m cement gap group demonstrated lower discrepancies. Both cement gap size and cement brand significantly influenced the marginal and internal fit, as well as the pull-out resistance of the crowns. The impact of the cement brand, the cement gap size, and their interaction significantly affected the retention between the Ti-bases and crowns (p < 0.01). The use of P21 with a 30 m gap resulted in significantly higher pull-out values than P21 with a 20 mu m gap (p = 0.008) and P21 with a 40 mu m gap (p = 0.004). Retention with a 40 mu m cement gap was not significantly different from that with a 20 mu m cement gap, regardless of the cement brand (p = 0.089). PV5 presented the lowest pull-out values across all cement gap sizes (p = 0.02). Conclusion Cement gap size significantly affected the fit, and cement gap size and type significantly impacted the retention between AM-Z crowns and Ti-bases. Cement space of 30 mu m and PV21 resin luting agent led to improved adaptation and high bonding strength
Gremlin-1 and Wagner Classification: Potential Biomarker for Amputation in Diabetic Foot Patients
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Diabetic foot (DF) is a significant complication with high morbidity and mortality, often resulting from neuropathy and ischemia. In our study, we aimed to evaluate the relationship between serum Gremlin-1 levels and disease severity based on the Wagner classification in DF patients, and to determine its prognostic value in predicting the need for amputation. Eighty-five patients with DF ulcers or considered at high risk for DF were included in the study. The patients' complications were evaluated, and laboratory results were obtained from their records. The Wagner classification was applied, and serum Gremlin-1 levels were analyzed using the ELISA method. It was found that as the Wagner stage of the DF increased, Gremlin-1 levels decreased significantly at the statistical borderline (p = 0.05). In the group of patients who underwent amputation, Gremlin-1 levels decreased significantly (p 7.5%, Gremlin-1 levels increased significantly (p < 0.05). In patients with albuminuria, serum Gremlin-1 levels decreased significantly (p < 0.05). It was determined that Gremlin-1 plays a role through an unknown mechanism in DF patients, and its levels decrease as the Wagner stage increases. Gremlin-1 levels were significantly decreased in the amputation group (p < 0.05). It was shown that Gremlin-1 could be a prognostic marker for predicting amputation
A Low Dose of Edaravone Decreases the Epileptiform Activity in the Absence Epilepsy Model by Reducing Oxidative Stress and Neuroinflammation
No full textAbstract
AimEdaravone is a potent anti-inflammatory and antioxidant agent used in amyotrophic lateral sclerosis treatment. The effect of Edaravone on absence epilepsy was investigated in WAG/Rij (Wistar Albino Glaxo from Rijswijk) rats, a genetic animals model of absence epilepsy.Material and methodTwenty-eight WAG/Rij rats were randomly assigned to four groups: control, and Edaravone-treated groups receiving 1, 10, or 30 mg/kg. A tripolar electrode was inserted into the skull using the stereotaxic device for electrocorticography (ECoG) recording. Then, the animals were allowed to recover. Baseline ECoG recordings were obtained from all groups, and then Edaravone was administered at the indicated doses for 21 days. ECoG records of all groups were retaken on the 22nd day. The brain was dissected and sent for biochemical analysis at the end of the experiment. Total antioxidant status (TAS), total oxidant status (TOS), and tumor necrosis factor-alpha (TNF-alpha) levels in brain tissue were measured using enzyme-linked immunosorbent assay (ELISA).ResultsThe administration of 1 and 10 mg/kg Edaravone decreased the number and duration of spike-wave discharges (SWDs), but 30 mg/kg Edaravone increased the number and duration of SWDs. All Edaravone doses did not change the amplitude. In the biochemical analysis, 1 and 10 mg/kg Edaravone increased TAS level and decreased TOS and TNF-alpha levels compared to control group. 30 mg/kg Edaravone did not affect TAS, TOS, and TNF-alpha levels compared to control group.ConclusionThe present study exhibited that low doses of Edaravone for long-term treatment reduced the incidence of SWDs in WAG/Rij rats by reducing oxidative stress and neuroinflammation. The high doses of Edaravone increased SWDs incidence in the same model
Application of artificial intelligence brain structure-based paradigm to predict the slip condition impact on magnetized thermal Casson viscoplastic fluid model under combined temperature dependent viscosity and thermal conductivity
No full textABSTRACT
One of the main reasons for the popularity of ANNs is their wonderful capability to handle very
complex and nonlinear mathematical problems. It can, therefore, provide a very valuable
computational framework wide in applications, from biotechnology to biological computation
and fluid dynamics. In this article, computational ANN paradigms are utilized in the analysis of
boundary layer flow and heat transfer of magnetized Casson fluid over a nonlinearly stretching
elastic sheet under velocity slip conditions. Casson fluid behavior under the influence of mag
netohydrodynamics with the influence of heat generation, temperature-dependent dynamic vis
cosity, variable thermal conductivity, and viscous dissipation are considered in this study. With
the help of a similarity transformation, the complex partial differential equations governing the
flow and energy take on the form of nonlinear ordinary differential equations. These resulting
nonlinear ordinary differential equations are solved by using the bvp4c solver in MATLAB. The
numerical solutions generated from the bvp4c solver for the problem under consideration are
used to develop the reference dataset for the anticipated radiative Casson fluid LevenbergMarquardt backpropagation neural network (LMT-ABPNN). Finally, developed dataset features
were applied to the artificial intelligence-based LMT-ABPNN procedure to validate the numerical
results for radiative Casson fluid. This LMT-ABPNN is trained, tested, and validated in predicting
the approximate numerical results for RCF under various conditions. The proposed LMT-ABPNN
performance validation is carried out based on mean squared error fitness, error histograms, and
regression analysis. Results obtained for regression metrics, absolute error, MSE and error his
togram plots through the LMT-ABPNN architecture do confirm the superior performance attained
here. From the results, the study raises close concordance with respect to reference data. The lo
Endoscopic butterfly cartilage myringoplasty: our long term results
No full textAbstract
Background: Myringoplasty is one of the treatments used for perforated tympanic membrane. Aim/objective: We aimed to evaluate the long-term anatomical and functional outcomes of patients who underwent endoscopic inlay butterfly cartilage myringoplasty. Material and methods: We retrospectively analyzed 74 patients who had undergone endoscopic butterfly cartilage myringoplasty were followed for at least five years. The evaluation included age, sex, duration of follow-up, perforation location, size, preoperative and postoperative pure tone audiometry thresholds (years 2 and 5), air-bone gap, follow-up complications, and postoperative graft and tympanic membrane status. Results: The study included 74 patients with a mean follow-up duration of 76.7 months (range: 60-125 months). The graft success rates were 89.1% at two years and 82.4% at five years postoperatively. There was a significant improvement in air conduction thresholds when comparing preoperative levels to those at two and five years postoperatively (p = 0.003). The air-bone gap showed a significant reduction from preoperative levels to those observed at two and five years postoperatively (p < 0.0001). Conclusion and significance: Our study demonstrates that endoscopic butterfly cartilage myringoplasty is safe and effective for achieving long-term anatomical and functional success. We recommend extending the follow-up period to five years with additional annual assessments thereafter
Development of Essential Thrombocythemia Following Cessation of Hydroxyurea Therapy in an Elderly Patient with Carotid Arteritis and Recurrent Splenomegaly: A Diagnostic Dilemma
No full textPersistent thrombocytosis and the potential for thrombohaemorrhagic consequences are hallmarks of essential thrombocythemia (ET), a myeloproliferative neoplasm [1]. Thrombotic and/or hemorrhagic episodes may exacerbate ET. Erythromelalgia, transient ischemic attack, myocardial infarction, deep vein thrombosis, or pulmonary embolism constitute a few of the most prevalent symptoms of small and medium artery thrombosis [2]. Patients with mildly symptomatic ET-associated aortic thrombosis may benefit from pharmacologic care alone, according to a few case studies; however, the drugs selected and the justifications for treatment vary widely [3] [4] [5] [6].
Large vessel vasculitis is a chronic inflammatory illness that affects the aorta wall and principal branches. Immune dysregulation is thought to be the cause of vessel wall inflammation. Systemic autoimmune diseases, such as giant cell arteritis, Takayasu arteritis, rheumatoid arthritis, Cogan syndrome, ankylosing spondylitis, and Behçet's disease, can all produce inflammatory large vessel vasculitis [3]. Malignancies are seldom the cause of recurrent large vessel vasculitis. Although the frequency of vasculitides associated with cancer ranges from 2.3% to 8.0%, the majority of vasculitides present as cutaneous [4] [5].
Herein, we present the rare co-occurrence of carotid arteritis and recurrent splenomegaly in a 69-year-old man with ET who had discontinued cytoreductive therapy. An elderly male patient was admitted to the department of radiology for unexplained splenomegaly and essential thrombocytosis. No significant pathology was observed in the bone marrow biopsy, and complaints of significant weight loss and abdominal pain developed recently. Therefore, the patient required additional imaging modalities, such as FDG PET-CT and neck Doppler ultrasound, to further investigate the underlying pathology in a detailed manner. FDG PET-CT revealed mild uptake along the left carotid artery, suspicious for large-vessel vasculitis, with minimally increased uptake in small lymph nodes and marked splenomegaly. Doppler ultrasound confirmed carotid arteritis. The patient was treated with steroids and planned for ruxolitinib, resulting in clinical improvement. This case report highlights the importance of comprehensive vascular assessment in patients with unexplained and persistent symptoms, as well as the inflammatory–thrombotic spectrum in essential thrombocytopenia
PREFACE: SPECIAL ISSUE ON "ANALYSIS AND MODELING OF HEAT AND MASS TRANSFER IN FRACTAL POROUS MEDIA" - PART II
No full textHeat and mass transfer in fractal porous media has attracted globally extensive attention in recent decades.Modeling of such behavior, however, becomes quite challenging due to the complicated structure of themedia. Thus, the special issue collects a series of recent works on analysis and modeling of heat andmass transfer in porous media. The topics include coupled modeling of transient seepage for oil industry,characterization of porous structure of cement for civil engineering, and multi-phase and multi-scaledmodeling porous flow for a more-universal analysis, etc
Investigation of the Immune System Effects of Desloratadine on Lipopolysaccharide-Stimulated Mammalian Macrophage Cells
No full textBackground: Neuroimmune interactions are central to inflammatory and neurological disorders. Desloratadine (DES), a second-generation H(1 )antihistamine, has been suggested to exert immunomodulatory effects, yet its impact on innate immune cells remains unclear. Methods: J774.2 macrophages were treated with DES (1-10 mu g/mL) +/- lipopolysaccharide (LPS, 1 mu g/mL). Cytokine secretion (IL-6, TNF-alpha, IL-12p40, GM-CSF) was measured by ELISA, and cell viability was assessed using Trypan Blue exclusion. Results: DES induced a dose-dependent suppression of TNF-alpha, with significant inhibition at higher concentrations, and reduced IL-12p40 at 10 mu g/mL. IL-6 showed a modest, nonsignificant decrease, whereas GM-CSF was increased, indicating a pro-inflammatory effect on macrophage activation. No cytotoxicity was detected at any dose. Conclusions: DES selectively modulates macrophage responses, strongly inhibiting TNF-alpha and IL-12p40 while enhancing GM-CSF, reflecting a dual anti- and pro-inflammatory profile. These findings support further investigation of DES in neuroinflammatory and immune-mediated conditions
Optıcal Solıtons For The Dıspersıve Concatenatıon Model Wıth Kerr Law Of Self-Phase Modulatıon By Lıe Symmetry
No full textThis study delves into the realm of new optical solitons within the framework of the dispersive concatenation model, specifically focusing on Kerr law self-phase modulation. The research employs Lie Symmetry Analysis to transform the complex governing equations into ordinary differential equations (ODEs). These ODEs are then tackled using two distinct methodologies: the F-expansion method and a novel generalized method. Through these approaches, a broad spectrum of soliton solutions is successfully derived, showcasing the robustness and effectiveness of the proposed techniques. Additionally, the physical interpretations of these solutions are illustrated via 3D profile plots, offering profound insights into the intricate behavior of the solitons
How do facial dermatological diseases affect the quality of life in adult female patients? A prospective study
No full textIt has been reported that dermatological diseases located
on the face that cause cosmetic deterioration have a significant effect on the quality of life (QoL) of female patients. In a
previous study, only 73 female cases were included, and it was
determined that all different dermatological diseases located on
the face (without any differences between them) significantly
affected the QoL of female patients.1
However, the number of
cases in this study was quite insufficient.
In this study, 626 adult female patients, aged 20 to 59 years,
who visited the outpatient dermatology clinic and had facial dermatological diseases were prospectively included; their clinical
and demographic characteristics and Dermatology Life Quality
Index (DLQI) questionnaire results were evaluated. DLQI forms
filled out by 113 healthy individuals without dermatological
diseases were included as the control group. The study was
approved by the Institutional Ethics Committee (2018-03/02).
The study was performed according to the principles of the
Declaration of Helsink