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Ortodontik tedavide kullanılan farklı ortodontik mum materyalleri ile bal mumunun sitotoksik etkilerinin in vitro değerlendirilmesi
No full textÖZET
Sabit ortodontik tedavi sırasında braketler ve teller ağız mukozasında travma ve ülserasyona neden olabilir. Bu gibi durumlarda, travmayı ve mukozal ülserasyonları önlemek için hastalara koruyucu ortodontik mumlar verilir. Ancak, bu mumların potansiyel sitotoksik etkileri araştırılmamıştır. Bu çalışmada, piyasada bulunan farklı ortodontik koruyucu mumların ve bal mumunun sitotoksik etkileri değerlendirilmiştir. Üç farklı ortodontik mum markasının [Ios (Texas, ABD), Ormco (California, ABD), Bilkim (İzmir, Türkiye) ve bu markalara alternatif olabilecek doğal malzemeler olan sarı ve beyaz balmumunun sitotoksisitesi insan gingival fibroblast hücre hattı üzerinde 3-(4.5- dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) yöntemi kullanarak değerlendirilmiştir. Veriler varyans analizi (ANOVA) ve Tukey testi kullanarak analiz edilmiştir. MTT yöntemiyle elde edilen hücre proliferasyon yüzdeleri analiz edildiğinde, Ios (p0.05). Bu çalışmanın sonuçları, Ios ve Ormco marka ticari mumlarının şiddetli sitotoksisite gösterdiğini, Bilkim marka ticari mum ve beyaz bal mumunun hafif sitotoksitite gösterdiğini ve sarı bal mumunun sitotoksitite göstermediğini ortaya çıkarmıştır
Effectiveness of negative pressure wound therapy as a fixator in split thickness skin graft applied diabetic patients: evaluation of 25 cases
Get PDFEffectiveness of negative pressure wound therapy as a fixator in split thickness skin graft applied diabetic patients: evaluation of 25 cases
Objective: Microangiopathies expose diabetic patients to lower extremity wounds at certain stages of their lives. Split-thickness skin grafting (STSG) has an important place in the surgical treatment of such wounds. The aim of the present study is to evaluate the effects of negative pressure wound therapy (NPWT) on STSG survival.
Methods: A total of 25 diabetic patients (M = 20, F = 5) with acute or chronic lower extremity open wounds were included in the study. All patients underwent wound debridement under regional anesthesia. STSG was applied after wound debridement. NPWT was applied to STSG to increase graft survival.
Results: The hospitalization times of the patients ranged from 1 to 2 weeks. The mean follow-up period of the patients was 6 months. All wounds healed on the 14th postoperative day. There was no recurrence in the 6-month follow-up period.
Conclusion: We objectively demonstrated the positive effects of NPWT application on STSG and graft survival.
Keywords: Negative pressure wound therapy, Skin grafts, Diabetic patient
Evaluation of the most cited articles on strabismus from a new perspective using bibliometric analysis
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Objectives: Strabismus is one of the important areas of interest for ophthalmologists, because it can result in perma-nent vision loss and reduced binocular function. In this bibliometric study, we aimed to contribute to scientists in their research in the field of strabismus by performing multidimensional citation analysis and visualization of the 100 most cited articles regarding strabismus.
Methods: We used the term "strabismus" to search the Thomson Reuters' Web of Science database between 1975 and 2021 years. The top 100 cited articles were analysed by topic, first author, study type, level of evidence, period since publication, journal name, journal impact factor and H-index, total citation number (TCN), average citation per year (ACpY) and also correlation analyses were performed. The SPSS® 23.0 software package was used for all statistical analysis. VOSViewer software was used for visualization and analyses of country, organization, and keyword data of the top 100 cited articles.
Results: A total of 6,582 strabismus-related publications were retrieved, and the 100 most-cited were identified. The median values for journal impact factor, H-index, period since publication, TCN, and ACpY were 4.68±2.65 (4,10),160.29±75.53 (186), 22.17±8.92 (21), 77.98±55.88 (63), and 3.90±2.94 (2,84), respectively. Most of the articles were published between 1990 and 2010 years. The majority of articles were about treatment (n=30), epidemiology (n=21), quality of life and psychosocial aspects (n=14), and strabismus types and clinical features (n=12). The journal with the most articles published, "Ophthalmology," had 25 articles. Interestingly, the correlation analysis demonstrated no association
between TCN and IF.Conclusion: Most of the highly cited papers in the topic of strabismus are on strabismus treatment, particularly botuli-
num toxin treatment. Strabismus articles published in general ophthalmology journals received higher citations.
Keywords: Bibliometric, citation, impact factor, strabismus, VOSviewe
In silico analysis to predict the carcinogenicity and mutagenicity of a group of triazole
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Background and Aims: Fungicides, particularly triazoles, are of global concern for pesticide contamination because of their widespread use. This study focuses on estimating the carcinogenicity and mutagenicity of 15 commonly used triazole fungicides. Methods: In silico prediction tools such as ProTox-II, Toxtree, Lazar, and VEGA were used to predict mutagenicity and carcinogenicity. Results: All compounds were predicted to be "non-mutagenic" by ProTox-II, Toxtree, and Lazar. However, the CONSENSUS of VEGA identified epoxiconazole and prothioconazole as "mutagenic." Regarding carcinogenicity predictions, ProTox-II indicated non-carcinogenicity for all compounds, whereas Toxtree and VEGA (ISS) raised structural alerts for 10 compounds. In addition, Lazar predicted carcinogenicity for tebuconazole, paclobutrazol, and penconazole. It is worth noting that the results exhibit variable reliability, emphasising the need for further investigation and validation. Conclusion: In silico tools proved valuable for predicting the toxicity of triazole fungicides, emphasising the need for additional data. Although the study categorises compounds as non-mutagenic, some exhibit structural alerts for potential carcinogenicity. This strategic approach contributes to pesticide risk assessment by highlighting the role of computational models in advancing our understanding of the health impacts associated with pesticide exposure
The novel double-decker lanthanide metal phthalocyanines substituted with 1-[3,5-bis (trifluoromethyl)phenyl] propoxyl: Synthesis, characterization, electrochemistry, spectroelectrochemistry, and electrochromism
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Novel 1-[3,5-bis(trifluoromethyl)phenyl]propoxyl substituted double-decker phthalocyanine (Pc) complexes
GdPc2 (2), LuPc2 (3) and NdPc2 (4) were synthesized by the reaction of 1-[3,5-bis(trifluoromethyl)phenyl]propoxy phthalonitrile with convenient rare earth metal acetates in n-amyl alcohol under the 1,8-diazabicyclo
[5.4.0]undec‑7-ene catalysis at 300 ◦C. The new precursor for the syntheses of complexes was obtained from 1-
[3,5-bis(trifluoromethyl)phenyl]propanol and 4-nitrophthalonitrile in acetonitrile at reflux temperature in the
presence of potassium carbonate as catalyst. All the complexes were characterized using UV–Vis, fluorescence,
FT-IR, and MALDI-TOF mass spectroscopies. Moreover, FT-IR, 1
H-NMR, and 1
H-1
H COSY NMR methods were
used to characterize the starting compound 1. The sandwich structure of the complexes was also confirmed by
their electrochemical and spectroelectrochemical measurements. The characteristic first reduction process of the
radical Pc ring was observed at 0.03 V for GdPc2 (2), 0.24 V for LuPc2 (3), and 0.19 V for NdPc2 (4). In
accordance with their double-decker structure, the complexes showed ring-based electron transfer processes with
distinct spectral and color changes in the electrolyte medium. With highly reversible redox processes and net
spectral changes, the LuPc2 (3) displayed a better electrochromic response than the others. The electrochromic
film measurements suggested that the LuPc2 (3) is a promising candidate for electrochromic devices
Evaluation of the impact of workplace bullying on professionaljob satisfaction among nurses: A case study of a university hospital
No full textBu çalışma, hemşirelerde iş yeri zorbalığının mesleki iş tatmini üzerine etkisinin değerlendirilmesi amacıyla yapılan tanımlayıcı-kesitsel nitelikte bir araştırmadır. Çalışmamız İstanbul'da bulunan bir vakıf üniversitesi hastanesinde görev alan hemşireler ile yapıldı. Örneklemi, Nisan-Mayıs 2024 tarihleri arasında görev yapan 350 hemşire oluşturdu. Çalışma verileri, Tanıtıcı Bilgi Formu, İş Yeri Zorbalığı Ölçeği, İş Tatmini Ölçeği kullanılarak toplandı. Hemşirelerin yaş ortalaması 29.26±4.93 'dır. Hemşirelerin büyük çoğunluğu kadın (%62.9), bekar (%59.4) ve lisans mezunudur (%67.7). Örneklemin %25.7'i ameliyathanede görev yapmakta olup, %48.3'ü 1-5 yıl çalışma deneyimine sahiptir. Hemşirelerin çoğu mesleklerinden memnun olduğunu (%67.4) ve büyük çoğunluğu kurumdan ayrılmayı düşünmediğini (%73.4) ifade etmiştir. İş Yeri Zorbalığı Ölçeği'nin puan ortalaması 31.451±6.435 (Min=22; Maks=66) ve İş Tatmini Ölçeği puan ortalaması 18.586±2.738 (Min=10; Maks=25) olarak saptanmıştır. İş yeri zorbalığı toplam puanı ve iş tatmini toplam puanı arasında negatif yönde, zayıf düzeyde korelasyon (r= -0.238) bulunmaktadır. Çalışmada ayrıca, iş yeri zorbalığı ile iş tatmini arasındaki neden sonuç ilişkisini saptamak üzere yapılan regresyon analizi anlamlı sonuç vermiştir (F=20.952; p=0.000<0.05). İş tatmini düzeyindeki toplam değişim %5.4 oranında iş yeri zorbalığı tarafından açıklanmaktadır (R2=0.054). İş yeri zorbalığı iş tatmini düzeyini azaltmaktadır (β=-0.238). Özellikle ameliyathane hemşireleri, staff olarak görev yapanlar, vardiyalı çalışanlar, fazla mesai yapanlar ve kurumdan ayrılma düşüncesinde olanlarda işyeri zorbalık puanlarının daha yüksek olduğu (p<0,05) ve paralel biçimde bu gruplarda iş tatmini puanlarının anlamlı olarak düşük olduğu (p<0,05) bulundu Sonuç olarak, çalışmanın yapıldığı hastanede çalışan hemşirelerin işyeri zorbalığına maruz kalma düzeylerinin düşük ve iş tatmin düzeylerinin iyi olduğu, iş yeri zorbalığının hemşirelerin iş tatmini üzerinde olumsuz bir etkiye sahip olduğu saptandı.This study is a descriptive-cross-sectional research conducted to evaluate the impact of workplace bullying on job satisfaction among nurses. Our study was carried out with nurses working at a foundation university hospital in Istanbul. The sample consisted of 350 nurses working between March and May 2024. The data were collected using the Introductory Information Form, Workplace Bullying Scale, and Job Satisfaction Scale. The average age of the nurses was 29.26±4.93. The majority of the nurses were female (62.9%), single (59.4%), and had a bachelor's degree (67.7%). Among the sample, 25.7% worked in the operating room, and 48.3% had 1-5 years of work experience. Most of the nurses stated that they were satisfied with their profession (67.4%) and that they did not consider leaving the institution (73.4%). The average score of the Workplace Bullying Scale was 31.451±6.435 (Min=22; Max=66), and the average score of the Job Satisfaction Scale was 18.586±2.738 (Min=10; Max=25). A weak negative correlation was found between the total workplace bullying and total job satisfaction scores (r= -0.238). Additionally, the regression analysis conducted to determine the cause-and-effect relationship between workplace bullying and job satisfaction yielded significant results (F=20.952; p=0.000<0.05). The total variance in job satisfaction level is explained by workplace bullying by 5.4% (R2=0.054). The study found that workplace bullying negatively impacts job satisfaction (β = -0.238). Specifically, operating room nurses, staff nurses, those working shifts, overtime workers, and those contemplating leaving the institution reported significantly higher workplace bullying scores (p < 0.05) and lower job satisfaction scores (p < 0.05). Despite overall low levels of workplace bullying, nurses at the hospital exhibited good job satisfaction. In conclusion, workplace bullying was identified as having a detrimental effect on nurses' job satisfaction levels
In silico discovery of diagnostic/vaccine candidate antigenic epitopes and a multi-epitope peptide vaccine (NaeVac) design for the brain-eating amoeba Naegleria fowleri causing human meningitis
No full textNaegleria fowleri, the brain-eating amoeba, is a free-living amoeboflagellate with three different life cycles (trophozoite, flagellated, and cyst) that lives in a variety of habitats around the world including warm freshwater and soil. It causes a disease called naegleriasis leading meningitis and primary amoebic meningoencephalitis (PAM) in humans. N. fowleri is transmitted through contaminated water sources such as insufficiently chlorinated swimming pool water or contaminated tap water, and swimmers are at risk. N. fowleri is found all over the world, and most infections were reported in both developed and developing countries with high mortality rates and serious clinical findings. Until now, there is no FDA approved vaccine and early diagnosis is urgent against this pathogen. In this study, by analyzing the N. fowleri vaccine candidate proteins (Mp2CL5, Nfa1, Nf314, proNP-A and proNP-B), it was aimed to discover diagnostic/vaccine candidate epitopes and to design a multi-epitope peptide vaccine against this pathogen. After the in silico evaluation, three prominent diagnostic/vaccine candidate epitopes (EAKDSK, LLPHIRILVY, and FYAKLLPHIRILVYS) with the highest antigenicities were discovered and a potentially highly immunogenic/antigenic multi-epitope peptide vaccine (NaeVac) was designed against the brain-eating amoeba N. fowleri causing human meningitis
Examination of the mediating role of emotion regulation difficulties on the relationship between childhood trauma and misophonia
No full textBu çalışmanın amacı, çocukluk çağı travmaları ve mizofoni arasındaki ilişkide duygu düzenleme güçlüğünün aracılık rolünün incelenmesidir. Araştırmanın çalışma grubunu, ortaya çıkan seslerden rahatsız olan 18 yaş ve üstü 486 birey oluşturmaktadır. Betimleyici bir çalışma olan bu araştırmada çocukluk çağı travması ile mizofoni ve duygu düzenleme güçlüğünün bu ilişkideki etkisini ortaya koymak adına ilişkisel tarama yöntemine uygun şekilde düzenleme yapılmıştır. Çalışmanın modeli ise teorik yapıları test etmek için kullanılan yapısal eşitlik modelidir. Araştırmaya katılan bireylerin seçimi, olasılıksız örnekleme yönteminden olan amaçlı örnekleme yöntemiyle gerçekleştirilmiştir. Çalışmada veri toplama araçları olarak; Demografik Bilgi Formu, Çocukluk Çağı Travmaları Ölçeği, Mizofoni Ölçeği, Duygu Düzenleme Güçlüğü Ölçeği kullanılmıştır. Veriler sosyal medya aracılığıyla Google Forms üzerinden toplanmış, elde edilen veriler değerlendirilmiştir. Yapılan analizlerde cinsiyet değişkeni açısından bakıldığında; katılımcıların Çocukluk Çağı Travması Ölçeğinden almış oldukları puanlar açısından, kadınlar lehine anlamlı bir farklılık bulunmuştur. Benzer şekilde mizofoni açısından yapılan karşılaştırmada da kadınlar lehine anlamlı farklılık bulunmuştur. Profesyonel ruhsal yardım alma açısından bakıldığında; çocukluk çağı travması ve mizofoni açısından profesyonel ruhsal yardım alanlar lehine anlamlı fark bulunmuştur. Yapılan yapısal Eşitlik Modelin analizde, duygu düzenleme güçlüklerinin çocukluk çağı travması ile mizofoni arasındaki ilişkide kısmi aracılık rolü oynadığını bulunmuştur.The aim of this study is to examine the mediating role of emotion regulation difficulties on the relationship between childhood trauma and misophonia. The participants of this study consists of 486 individuals aged 18 and over who are disturbed by specific sounds. This descriptive study is designed in accordance with the relational screening model to reveal the impact of childhood trauma on misophonia and the effect of emotion regulation difficulties on this relationship. The model used in the study is the structural equation model, which is employed to test theoretical constructs. Participants are selected using purposive sampling, a type of non-probability sampling. Data collection tools include the Demographic Information Form, Childhood Trauma Questionnaire, Misophonia Questionnaire, and Difficulties in Emotion Regulation Scale. Data were collected via Google Forms through social media and obtained data is analyzed subsequently. The analysis revealed a significant relationship between Childhood Trauma Questionnaire scores and Misophonia Questionnaire scores. From a gender perspective, there was a higher rate in the Childhood Trauma Questionnaire scores of women participants in comparison to men, indicating that women are more affected by childhood traumas. Similarly, comparisons in terms of misophonia also showed a significant difference in women. In terms of professional psychological support, those who received such support showed significant differences in childhood trauma and misophonia compared to those who did not. The analysis using the Structural Equation Model found that emotion regulation difficulties play a partial mediating role in the relationship between childhood trauma and misophonia
Cameo and intaglio surface stability and variability of additively, subtractively, and conventionally manufactured occlusal devices after long-term storage
No full textABSTRACT
Statement of problem. Additive and subtractive manufacturing have become alternative technologies for fabricating occlusal devices.
However, knowledge of the long-term stability of occlusal devices fabricated using these recent technologies is limited.
Purpose. The purpose of this in vitro study was to evaluate the cameo and intaglio surface stability and variability of additively,
subtractively, and conventionally manufactured occlusal devices after 18 months of storage.
Material and methods. A standard tessellation language (STL) file of a dentate maxillary typodont was used to design a master occlusal
device. The STL file of this design was used to fabricate occlusal devices additively either with a digital light processing (AM-1) or a
continuous liquid interface production (AM-2) printer, subtractively with 2 different 5-axis milling units (SM-1 and SM-2), and conventionally
(TM-HP) (n=10). STL files of each device's cameo and intaglio surfaces were generated using a laboratory scanner after fabrication and after
18 months of storage in a moist environment. These generated files were imported into an analysis software program (Geomagic Control X)
to analyze the dimensional stability of tested devices by using the root mean square method. The average deviation values defined the
variability of measured changes over time. Cameo and intaglio surface deviations were analyzed using the Kruskal-Wallis and Dunn tests,
while the variability of measured deviations was analyzed with 1-way analysis of variance and the Tukey HSD tests (α=.05).
Results. Significant differences were observed among tested devices when the intaglio surface deviations and the cameo surface variability
were considered (P<.001). SM-2 had significantly higher intaglio surface deviations than AM-1, SM-1, and AM-2 (P≤.036). Among the test
groups, AM-1 had the greatest cameo surface variability (P≤.004).
Conclusions. SM-2 resulted in lower intaglio surface stability than the additive and the other subtractive manufacturing technologies,
while AM-1 led to the highest cameo surface variability among the test groups. (J Prosthet Dent 2024;132:604.e1-e7
The relationship of leap motion-supported occupationaltherapy intervention with occupational competence andhand function in individuals with parkinson's disease
No full textParkinson hastalığı hareket, zihinsel sağlık, uyku, ağrı ve diğer sağlık sorunlarıyla presente olan ilerleyici nörodejeneratif bir hastalıktır. Parkinson hastalığında bazal ganglionlarda dopaminin tükenmesi sonucunda el fonksiyon becerisi, rol-aktivite yeterliliği, yürüme, denge, duruş ve fonksiyonel hareketlilik ile ilgili zorluklar dahil olmak üzere çoklu motor veya motor olmayan bozukluklar görülebilmektedir. Bu çalışmamızda amaç parkinsonlu bireylerde leap motion destekli ergoterapi müdahalesinin bozulan el fonksiyonlarına ve rol-aktivite yeterliliğine etkisini araştırmaktır. Çalışmaya Parkinsonlu 26 kişi katıldı. Katılımcılar müdahale (n=13) ve kontrol (n=13) grubu olarak iki gruba ayrıldılar. Hastaların ayırt edici bilişsel düzeylerini belirlemek için "Mini Mental Durum Değerlendirmesi"; bilişsel ve fiziksel durumlarını değerlendirmek için "Birleşik Parkinson Hastalığı Değerlendirme Ölçeği(BPHDÖ)"; el fonksiyon becerilerini değerlendirmek için "Jebsen El Fonksiyon Testi(JEFT)''; rol-aktivite yeterliliğini değerlendirmek için "Aktivite Öz Değerlendirme Ölçeği(AÖDÖ)'', ayırt edici depresyonu değerlendirmek için "Geriatrik Depresyon Ölçeği(GDÖ)'' uygulanmıştır. Değerlendirme sonuçlarına göre, müdahale ve kontrol grubunda el fonksiyon, rol-aktivite yeterliliğinde ilk ve son değerlendirme sonuçları istatistiksel olarak anlamlı bulunmuştur.(p0.05) Sonuç olarak Parkinsonlu hastalara yapılan ergoterapi ve leap motion destekli ergoterapi müdahalesinin kontrol ve müdahale gruplarında el fonksiyon becerileri ve rol-aktivite yeterliliğindeki etkisi istatiksel olarak kanıtlanmıştır. Anahtar Kelimeler:El Becerisi,Ergoterapi,Video Oyunu Tabanlı Eğitim,ParkinsonParkinson's disease is a progressive neurodegenerative disorder presenting with movement disorders, mental health, sleep, pain, and other health problems. As a result of dopamine depletion in the basal ganglia in Parkinson's disease, multiple motor or non-motor impairments can be seen, including difficulties with hand function, role-activity competence, gait, balance, posture, and functional mobility. This study investigated the effect of leap motion-assisted occupational therapy intervention on impaired hand function and occupational competence in individuals with Parkinson's disease. 26 individuals with Parkinson's disease participated in the study. Participants were divided 2 groups into intervention (n=13) and control (n=13) groups. "Mini-Mental State Examination" was administered to determine the differential cognitive level of the patients; "Unified Parkinson's Disease Rating Scale (UPDRS)" was administered to assess cognitive and physical status; "Jebsen Hand Function Test(JHFT)" was administered to assess hand function skills; "Ocupational Self-Assessment (OSA)" was administered to assess role-activity competence; and "Geriatric Depression Scale (GDS)" was administered to assess differential depression. According to the evaluation results, the initial and final evaluation results in hand function and occupational competence in the intervention and control groups were statistically significant (p<0.05). In conclusion, the effect of occupational therapy and leap motion-supported occupational therapy intervention on hand function skills and occupational competence in control and intervention groups was statistically proven. Keywords: Hand function ,Occupational Therapy, Parkinson's disease, Video Game-Based Trainin