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Supraorbital bone shaving (SOS procedure) in restoration of upper lateral convexity in sunken eyes
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BackgroundSunken eyes have become a most important target of periorbital area aesthetics. Throughout history, the aesthetics of the periorbital region have been emphasized, and various surgical techniques related to this region have been described. Most of these techniques provide only soft tissue solutions; therefore, additional surgical interventions may be required. The aim of our study was to introduce an endoscopic supraorbital shaving (SOS) technique for the treatment of individuals with sunken eyes.MethodsBetween 2020 and 2021, 34 patients (30 females, 4 males; mean age 36.2 years) with sunken eyes were treated with our described technique. All patients underwent an endoscopic SOS procedure under general anesthesia.ResultsA total of 34 patients (30 women and four men), aged 23-59 years old (mean = 36.2 years), underwent the endoscopic SOS procedure. The mean follow-up period was 13 months (range: 12-16 months). Postoperatively, significant improvement in lateral convexity was achieved in all patients. Physical examinations performed at the control visits revealed no functional problems in any patients and no visible or palpable irregularities or contour deformities. No complications were encountered regarding the SOS procedure.ConclusionsThe technique described here provides significant improvement in lateral convexity compared to other techniques used in patients with sunken eyes. No additional eyelid intervention is needed. Unlike the techniques previously described in the literature, intervention is made in the bone structure, thereby providing more accurate results.Level of Evidence VThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266
Computational analysis of heat transfer for hybrid nanofluid flow within a wavy lid-driven cavity with entropy generation and non-uniform heating
No full textABSTRACT
This study investigates entropy generation, mixed convection, and magnetohydrodynamic (MHD) effects in
hybrid nanofluid flow within a wavy lid-driven cavity with non-uniform heated wall. This research addresses a
significant problem in heat transfer system efficiency which is essential for uses such as solar energy collection,
medical devices, and microelectronics cooling. The nondimensional governing equations are solved using the
Finite Element Method (FEM) for various key parameters including Hartmann number (Ha), Grashof number
(Gr), Reynolds number (Re), volume fraction (ϕ), number of undulations (N), wave amplitude (A), radius of
cylinder (r) and inclined magnetic field (γ). Findings show that the enhancement of Grashof number, inclined
angle, volume fraction and Reynolds number depict increasing flow magnitude but the number of undulations,
radius of cylinder and Hartmann number cause a decay in flow strength. Increasing Re and Gr enhances heat
transfer, with an average Nusselt number increase of 5.4 times when Re = 300 and Gr = 106 compared to Re =
10 and Gr = 103. Entropy generation is significantly influenced by N with the highest total entropy observed at
N = 4. In contrast to previous studies, the novelty of this investigation lies in the unique geometric configuration
featuring a wavy lid-driven cavity with an embedded cylinder and non-uniformly heated walls. This study of
hybrid nanofluids and an angled magnetic field provides new paths for improving heat transfer and decreasing
entropy generation. This study enhances previous literature by providing comprehensive quantitative insights
into how they interact between those parameters opening the way for more efficient heat management in modern
technological systems
Evaluation of the Awareness and Anxiety Levels and Oral Hygiene Habits of University Students During the Coronavirus Disease 2019 (COVID-19) Pandemic
No full textMaterials and methods: A total number of 560 university students were included at different education levels. Sociodemographic data regarding age, gender, current school level, family income, and smoking frequency status were obtained. Anxiety levels were evaluated through the Coronavirus Anxiety Scale and awareness levels through the Coronavirus Awareness Scale. Oral hygiene habits before and during the COVID-19 pandemic were also recorded. In addition, the participants were asked to evaluate their oral hygiene and general health status before and after the pandemic. Data were collected online using a data collection form consisting of five sections via the Google Forms (Google Inc., Mountain View, California, United States) platform. The data were statistically analyzed. p<0.05 was considered statistically significant. Results: The statistical analysis revealed that there is a statistically significant difference in COVID-19 anxiety levels according to the current school level and family income (all with p<0.05). COVID-19 awareness levels differed significantly according to the current school level and family income (all with p<0.05). A statistically significant discrepancy was identified in the oral hygiene habits of the examined population according to gender, smoking frequency status, and family income prior to the onset of the pandemic (all with p<0.05). The examination of oral hygiene habits during the pandemic revealed statistically significant differences in accordance with the subjects' gender, smoking frequency status, current school level, and family income (all with p<0.05). During the pandemic, there was an increase in the frequency of tooth brushing, tongue brushing, toothbrush change, dental floss use, and acidic beverage consumption compared to the pre-pandemic period (all with p<0.05).
Conclusion: The present study examined the impact of the ongoing pandemic on oral hygiene habits among university students. The findings revealed a notable increase in the frequency of many oral hygiene habits during the pandemic compared to pre-pandemic levels. However, the study also observed that while anxiety levels were low, awareness levels were high. This study is the first to evaluate awareness and anxiety levels and oral hygiene habits in this context
Development of silver nanoparticles based on the method using quince seed mucilage for ascorbic acid determination
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Introduction: Nanoparticles are used in various fields such as chemistry, pharmacy,
biotechnology, and food science since they provide higher sensitivity than traditional
optical detection methods. Recently, synthesis of nanomaterials using green
chemistry has become popular. Many phytochemical components are used in the
synthesis of nanoparticles, including vitamins, proteins, polysaccharides, glycosides,
essential oils and phenolic compounds.
Objective: A novel green nanotechnology-based method using quince seed mucilage
(QSM) was designed for the determination of ascorbic acid in pharmaceutical preparations. QSM, a natural polysaccharide, was used as a bioreducing and stabilizing
reagent in the proposed silver nanoparticle (SNP)-based method.
Method: In the first stage of the developed method, silver(I) is reduced to silver(0) via
QSM and spherical, homogeneous SNPs were prepared (QSM-SNPs). In the second
stage of the developed method, SNPs nuclei were enlarged with the addition of
ascorbic acid. The developed method was validated by performance parameters
(linearity, recovery, and precision). Ascorbic acid determination was performed by
measuring increase in absorbance at 420 nm.
Results: The limit of detection and limit of quantification for ascorbic acid were,
respectively, found to be at 0.27 and 0.90 μM. The QSM-SNP-based method was
successfully applied to effervescent tablets containing ascorbic acid. The standards
of the excipients frequently used in pharmaceutical preparations did not interfere
with the developed method.
Conclusion: The developed QSM-SNP-based method satisfies the requirements
of green nanotechnology. The developed QSM-SNP-based method is simple, fast,
eco-friendly and low-cost
Publication Trends on Infective Endocarditis: Comprehensive Bibliometric Analysis and Visualization Between 1892 and 2022
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Background: In recent years, studies reported that the incidence of infective endocarditis (IE) has increased despite the decrease in rheumatic heart diseases, great advances
in medical and surgical treatment methods, and prophylactic antibiotic therapies.
However, there is no bibliometric analysis based on the visual mapping method in the literature. In the study, we aimed to analyze the hot topics in IE, the distribution of publications in terms of country, institution, journal, author, and their relationships by assessing
IE articles published in the 130 years between 1892 and 2022.
Methods: Publications before 2023 were analyzed using the keywords “infective” and
“endocarditis” in the Scopus database.
Results: Approximately 25% of the publications on IE were from the USA followed by
Japan, France, and the UK. A total of 116 keywords were used at least 15 times and the
keywords were categorized into 9 clusters by the VOSviewer program. The keywords
used more than 100 times except “infective endocarditis” were “echocardiography,”
“mortality,” “surgery,” “Staphylococcus aureus,” “cardiac surgery,” “epidemiology,” and
“prognosis” 247, 191, 152, 142, 130, 122, and 119 times, respectively. To the best of our knowledge, the study is the most comprehensive study globally on IE with the widest time range
including the visual mapping method.
Conclusion: Since our study reveals the changes in the literature related to infective endocarditis, we think that it will be a guide in planning new research studies. We believe that
periodic repetition of bibliometric analyses and keyword mapping studies will contribute
to the quantitative and qualitative development of scientific productivity globall
Bioactivity, cytotoxicity, and molecular modeling studies of novel sulfonamides as dual inhibitors of carbonic anhydrases and acetylcholinesterase
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In the present medical epoch, the prevailing approach of drug discovery, which focuses on inhibiting a single
target, has been superseded by the concept of designing drugs that target more than one specific site. Herein, we
present the design and synthesis of a novel series of 1-oxo-3,4-dihydronaphthalene substituted sulfonamides (5aj) with human carbonic anhydrase (hCA) and acetylcholinesterase (AChE) inhibitory activities as potential dualtarget agents. The design of target compounds 5a-j incorporated two key elements: i) The sulfonamide group,
which is widely recognized for its high affinity for the active site of hCAs, and ii) the effectiveness of 2-benzylidene-1-tetralone class compounds in some neurodegenerative disorders. All reported sulfonamides were evaluated for their inhibitory effect against hCA I, II isoforms, and AChE. Both hCAs, and AChE were potently inhibited
by 5a-j with KI constants in the nanomolar range; 47.71–113.20 nM, 28.05–206.60 nM, and 87.38–136.60 nM,
respectively, compared to standard inhibitors, acetazolamide (KIs of 439.17 and 98.28 nM for hCA I and hCA II,
respectively) and tacrine (KI of 159.61 nM). 5i exhibited the best multi-target inhibitory activity against hCA I (KI
of 47.71 nM), hCA II (KI of 30.75 nM), and AChE (KI of 88.97 nM), while 5b showed a selectivity index (hCA I/II)
of 3.61. Moreover, a cytotoxic activity assay for sulfonamides 5a-j was applied on the human breast adenocarcinoma MCF-7 cell line as well as on the non-tumoral mouse fibroblast L929 cell. Thereafter, extensive
molecular dynamics simulations revealed the dynamic behavior of ligand/enzyme complex and predicted vital
ligand contacts in the binding pocket
Investigating the diagnostic potential of IL-1β, IL-10, and IL-36γ in gingival crevicular fluid in patients with different periodontal conditions
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BackgroundThe study aimed to analyze cytokine levels, including interleukin (IL)-1 beta, IL-10, and IL-36 gamma, to investigate the link between pro- and anti-inflammatory responses in periodontal conditions and assess their potential as diagnostic biomarkers for distinguishing between different types of periodontal conditions.Methods80 systemically healthy non-smokers (25 periodontally healthy, 25 with gingivitis, 30 with periodontitis) were included. Clinical periodontal parameters were recorded, and gingival crevicular fluid (GCF) samples were obtained. Receiver operating characteristic (ROC) curve analysis was applied to determine the diagnostic value of cytokines. Results: IL-36 gamma had the highest sensitivity for diagnosing periodontitis, although its specificity for identifying those without periodontitis was relatively low. The combination of IL-1 beta and IL-36 gamma was the most effective in differentiating periodontitis from periodontal health. IL-10 was found to be an acceptable discriminator for distinguishing gingivitis from healthy conditions. However, its sensitivity and specificity for identifying gingivitis were lower. The combination of the three cytokines showed the highest ability to distinguish between periodontitis and gingivitis.ResultsIL-36 gamma had the highest sensitivity for diagnosing periodontitis, although its specificity for identifying those without periodontitis was relatively low. The combination of IL-1 beta and IL-36 gamma was the most effective in differentiating periodontitis from periodontal health. IL-10 was found to be an acceptable discriminator for distinguishing gingivitis from healthy conditions. However, its sensitivity and specificity for identifying gingivitis were lower. The combination of the three cytokines showed the highest ability to distinguish between periodontitis and gingivitis.ConclusionThe levels of IL-1 beta, IL-10, and IL-36 gamma in GCF may provide insights into periodontal health and disease status. Further studies are needed to validate these results and explore the potential of these cytokines in periodontal disease management.
All three of these cytokines exhibit exceptional diagnostic accuracy, particularly in distinguishing between chronic periodontitis and periodontal health.Moreover, the combination of IL-1 beta and IL-36 gamma stands out as the most accurate diagnostic indicator for periodontitis. This combination could serve as a robust biomarker panel for the early detection and monitoring of periodontal disease, potentially allowing for timely interventions to prevent disease progression
Effect of Biphenyl Derivative of Coumarin Compounds Photodynamic Therapy on The Expression of Carcinoma-Associated Genes
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Photodynamic Therapy (PDT) is a cancer treatment. Singlet oxygen is produced as a result of the photochemical reaction
between light, photosensitizer (PS), and molecular oxygen, which kills cells. Colon cancer, affecting 1.23 million people
worldwide, often requires surgery but has high recurrence and metastasis rates. Photodynamic therapy (PDT) represents an alternative treatment for colon cancer. This study used MTT assays to evaluate cell viability and applied Zinc
(II) Phthalocyanine (ZnPc) photosensitizers to the colorectal adenocarcinoma (HT-29) cell line to investigate cancer
pathways via flow cytometry and q-PCR. The results showed that PDT with ZnPc significantly reduced cell viability in
HT-29 cells and induced apoptosis at a rate of 53%. According to q-PCR results, CT values of ten out of thirty genes were
significant, and their association with cancer was evaluated
Examination of nurses' ethical and professional attitudes
No full textAraştırma hemşirelerin etik ve mesleki tutumları arasındaki ilişkinin incelenmesi amacıyla yapıldı. Araştırmanın evrenini, Ekim-Aralık 2022 tarihleri arasında Bursa ilinde bulunan iki devlet hastanesinde çalışan 665 hemşire, örneklemi ise çalışmaya katılmayı kabul eden 156 hemşire oluşturdu. Veriler; bilgi formu, Hemşirelik Bakımında Etik Tutum Ölçeği ve Hemşirelik Mesleğine Yönelik Tutum Ölçeği ile toplandı. %95 güven seviyesinde ve %5 anlamlılık düzeyinde değerlendirilen verilerin analizinde Kolmogorov Smirnov/Shapiro-wilk Testi, Spearman Korelasyonu analizi, Kruskal-Wallis ve Mann Whitney-U testi kullanıldı. Araştırmada hemşirelerin, hemşirelik bakımında etik tutum ölçeğinden aldıkları puan ortalaması 152.76 ± 15.09; hemşirelik mesleğine yönelik tutum ölçeğinden aldıkları puan ortalaması 165.98 ± 17.47 ve her iki ölçek puan ortalamaları arasında pozitif yönde anlamlı ilişki olduğu belirlendi (p=0.000). Araştırmada hemşirelerin etik tutumlarının oldukça iyi olduğu; mesleki tutum düzeylerinin oldukça yüksek olduğu belirlendi. Hemşirelerin mesleklerine yönelik olumlu tutuma sahip oldukları ve etik tutumları arttıkça hemşirelik mesleğine yönelik tutumlarının da arttığı sonucuna varıldı.The research was conducted to examine the relationship between nurses' ethical and professional attitudes. The population of the study consisted of 665 nurses working in two public hospitals in Bursa between October and December 2022, and the sample consisted of 156 nurses who agreed to participate in the research. Data were collected with an information form, an ethical attitude scale in nursing care, and an attitude scale towards the nursing profession. Kolmogorov Smirnov/Shapiro-Wilk Test, Spearman Correlation analysis, Kruskal-Wallis, and Mann Whitney-U test were used to analyze the data evaluated at a 95% confidence level and 5% significance level. The study determined that the average score nurses received from the ethical attitude scale in nursing care was 152.76 ± 15.09, and the average score nurses received from the attitude scale towards the nursing profession was 165.98 ± 17.47. There was a positive significant relationship between the mean scores of both scales. In the research, it is observed that nurses' ethical attitudes and professional attitude levels were quite high, and they had a positive attitude towards the nursing profession (p=0.000). The study concluded that nurses' ethical attitudes and professional attitude levels are quite high. They have a positive attitude towards the nursing profession, and as their ethical attitudes increase their attitudes towards the nursing profession also increase
Lise öğrencilerinde tüketilen atıştırmalık paketli besinlerin sürdürülebilirlik kriterleri ve bireye özgü parametreler üzerine etkileri açısından incelenmesi
No full textÖZET
Yeni nesil diyetler sürdürülebilirliği vurgulamaktadır ve bu doğrultuda paketli besinlerdeki sürdürülebilirlik kriterleri önem kazanmakta olup adölesanlarda atıştırmalık paketli besin tüketimi diğer yaş gruplarına kıyasla daha yüksektir. Bu çalışma lise öğrencilerinde tüketilen atıştırmalık paketli besinlerin sürdürülebilir beslenme kriterlerine uygunluğunun incelenmesi ve bu ürünlerin tüketiminin bireye özgü bazı parametrelerle ilişkisini değerlendirilmesi amacıyla planlanmış ve yürütülmüştür. Çalışma Ocak-Mart 2024 tarihleri arasında İstanbul'un Beylikdüzü ilçesinde yer alan Beyfen Koleji'nde gerçekleştirilmiştir. Çalışmaya katılan öğrenciler ile yüz yüze görüşme sağlanmış ve veri toplama formu ve Biyoelektrik Impedans Analiz cihazı ile ölçüm yapılarak bireylerin sosyo-demografik özellikleri, beslenme alışkanlıkları , antropometrik ölçümleri, atıştırmalık paketli besinlerin tüketim sıklığı, 24 saatlik besin tüketimleri sorgulanmış; daha sonrasında öğrencilerin tükettikleri atıştırmalık paketli besinler nitel ve nicel sürdürülebilirlik kriterleri açısından incelenmiştir. Nitel ve nicel sürdürülebilirlik kriterleri açısından incelenen atıştırmalık paketler arasında en sürdürülebilir besinin süt olduğu tespit edilmiştir. Çalışmamızda öğrencilerin cinsiyete göre atıştırmalık paketli besin tüketim miktarları incelendiğinde bisküvi, siyah çay, granül kahve, ayran, limonata, maden suyu, gazlı içecek, granola, glutensiz ekmek tüketim miktarları istatistiksel açıdan önemli bulunmuştur (p<.05). Sonuç olarak öğrencilerin sürdürülebilirlik açısından atıştırmalık paketli besinler arasında daha az sürdürülebilirliğe sahip olan ürünleri tükettikleri ve bu tüketilen atıştırmalık paketli besinlerin bireylerin beslenme alışkanlıklarını ve vücut kompozisyonlarını etkilediği saptanmıştır