Biruni University Institutional Repository
Not a member yet
2908 research outputs found
Sort by
Development of the parenting regret scale
No full textTürkçe Özet ve Anahtar Kelimeler
Çalışkan, B. (2024). Anne Babalıktan Pişmanlık Ölçeğinin Geliştirilmesi. Yüksek
Lisans Tezi, Biruni Üniversitesi Lisansüstü Eğitim Enstitüsü, İstanbul.
Bu araştırmanın temel amacı anne ve babaların anne veya babalıktan pişmanlık
durumlarını değerlendirebilen geçerli ve güvenilir bir ölçme aracı geliştirmektir. Bu
amaç doğrultusunda nicel bilimsel araştırma modellerinden genel tarama modeli
kullanılmıştır. Araştırmanın örneklemi basit seçkisiz örnekleme yöntemiyle
belirlenmiştir. Örneklem Türkiye’de yaşayan, en az bir öz çocuğa sahip olan ve
araştırmaya katılmayı gönüllü olarak kabul eden 721 katılımcıdan oluşmaktadır.
Araştırmada geçerli ve güvenilir sonuçlar elde edebilmek için benzer özellikteki üç
farklı gruptan veri toplanmıştır. Ölçme aracının geçerliğini tespit etmek için birinci
uygulama (N= 370) verileri üzerinde Açımlayıcı Faktör Analizi (AFA), ikinci
uygulama (N= 250) verileri üzerinde Doğrulayıcı Faktör Analizi (DFA) ile Yakınsama
(convergent) – Ayrışma (discriminant) geçerliği ve üçüncü uygulama (N= 101) verileri
üzerinde Ölçüt Bağıntılı Geçerlik analizi yapılmıştır. Ölçme aracının güvenirliğini
incelemek için ise Cronbach’s Alpha (α) katsayısı, eşdeğer yarılar (split-half) yönetimi
ve madde toplam test korelasyonu ile alt %27- üst %27 bağımsız gruplar t-testi
sonuçları incelenmiştir. AFA sonucunda varyansın %59.64’ünü açıklayan, 21
maddeden oluşan iki boyutlu ölçek elde edilmiştir. DFA sonucunda elde edilen
indeksler (χ2= 551.08, sd(df)=182, χ2/sd=3.02, p=.00, RMSEA=.090, SRMR=.091,
GFI=.83, AGFI=.78, NFI=.95, NNFI.96, PGFI=.65, CFI=.97, RFI=.95, IFI=.97)
model ile uyumludur. Analiz sonuçları yapıya ilişkin yakınsama-ayrışma ve ölçüt
bağıntılı geçerliğin (r=.697) anlamlı olduğunu göstermektedir. Ölçme aracının iç
tutarlılık güvenirliği için hesaplanan Cronbach’s Alpha (α) değeri .943, Spearman
Brown değeri .778 olarak hesaplanmıştır. Madde analizi kapsamında elde edilen
madde toplam test korelasyonu değerleri (.554 - .784) ile t-değerlerinin (p<.01)
anlamlı olduğu tespit edilmiştir. Araştırma bulguları “Anne-Babalıktan Pişmanlık
Ölçeği”nin geçerli ve güvenilir bir ölçme aracı olduğunu göstermektedir.İngilizce Özet ve Anahtar Kelimeler
Çalışkan, B. (2024). Development of the Parenting Regret Scale. Master’s Thesis,
Biruni University, Graduate Education Institute, Istanbul.
The aim of this study is to create a valid and reliable tool for measuring parental regret.
The general screening model, a quantitative research method, was used for this
purpose. The sample consisted of 721 participants living in Turkey who has at least
one child and voluntarily agreed to participate in the study, selected through simple
random sampling. To ensure the validity and reliability of the study's results, data were
collected from three distinct groups with similar characteristics. To assess the
measurement tool's validity, we conducted an Exploratory Factor Analysis (EFA) on
the first application's data (N= 370), Convergence-Dissociation validity with
Confirmatory Factor Analysis (CFA) on the second application's data (N= 250), and
Criterion Related Validity analysis on the third application's data (N= 101). To assess
the reliability of the measurement tool, we examined Cronbach's Alpha (α) coefficient,
equivalent halves management, and item total test correlation, as well as the results of
the lower 27% - upper 27% independent groups t-test. The results of the exploratory
factor analysis (EFA) yielded a two-dimensional scale comprising of 21 items, which
accounted for 59.64% of the variance. The confirmatory factor analysis (CFA)
produced indices (χ2= 551.08, sd(df)=182, χ2/sd=3.02, p=.00, RMSEA=.090,
SRMR=.091, GFI=.83, AGFI=.78, NFI=.95, NNFI=.96, PGFI=.65, CFI=.97,
RFI=.95, IFI=.97) that are consistent with the model. The analyses indicate that the
construct has significant convergent-divergent and criterion-related validity (r=.697).
The measurement tool also demonstrates high internal consistency reliability with a
Cronbach's Alpha (α) value of .943 and a Spearman Brown value of .778. The item
analysis revealed significant item total test correlation values ranging from .554 to .784
and t-values (p<.01). The research findings indicate that the 'Parenting Regret Scale'
is a valid and reliable tool for measurement
Otizm spektrum bozukluğu olan çocuklarda kardeş beceri destek eğitimi programı (KABEP)’nın etkililiği
Get PDFAbstract
The research aims to examine the efficacy of The Sibling Skills Support Training Program (SSSTP) concerning both children with Autism Spectrum Disorder (ASD) and their typically developing (TD) siblings. Specifically designed for TD siblings with a family member diagnosed with ASD, SSSTP is under scrutiny in this study. The research cohort encompasses three individuals, aged 7-20, diagnosed with ASD and receiving education at a Special Education and Rehabilitation Centre in Istanbul, T & uuml;rkiye. Additionally, the study includes three TD siblings within the same age range as the individuals with ASD. In the study, multiple probe design was used to investigate the effectiveness of The Sibling Skills Support Training Program (SSSTP). Developed as a skill teaching program, SSSTP is specifically designed for typically developing (TD) siblings. Its primary objective is to aid these siblings in instructing their brothers or sisters with Autism Spectrum Disorder (ASD) in acquiring self-care and daily living skills. In line with this program, the training process of siblings with typical development was carried out in two stages: awareness training and skills training program. The implementation process was completed in an average of 18 sessions with each participant pair. According to the findings of the study, it was concluded that SSSTP was effective in helping children diagnosed with ASD learn the target skill. The results obtained from the follow up sessions were consistent with the results of the instructional sessions. The social validity results of the study illustrated that the opinions of the participants and their families were positive.Özet
Araştırmanın amacı ailesinde OSB’li birey bulunan tipik gelişim
gösteren kardeşlere yönelik hazırlanan Kardeş Beceri Destek
Eğitimi Programı (KABEP)’nın OSB’li çocuğa ve kardeşine
etkisini incelemektir. Araştırmanın çalışma grubu, İstanbul
ilinde Özel Eğitim ve Rehabilitasyon Merkezi’nden eğitim alan
7-20 yaş aralığında üç OSB’li birey ve bu bireylerin aynı yaş
aralığında tipik gelişim gösteren üç kardeşi olmak üzere
toplam altı katılımcıdan oluşmaktadır. Araştırmada denekler
arası yoklama evreli çoklu yoklama modeli kullanılmıştır.
KABEP, tipik gelişim gösteren kardeşler tarafından OSB’li
kardeşlerine uygulanan öz bakım ve günlük yaşam becerilerin
öğretimine yardımcı olmak için hazırlanmış olan bir beceri
öğretim programıdır. Bu program doğrultusunda tipik gelişim
gösteren kardeşlerin eğitim süreci; farkındalık eğitimi ve beceri
öğretim programı olmak üzere iki aşamada gerçekleştirilmiştir.
Uygulama süreci her bir katılımcı çift ile ortalama 18 oturumda
tamamlanmıştır. Araştırma bulgularına göre KABEP’in OSB
tanılı çocukların hedef beceriyi öğrenmelerinde etkili olduğu
sonucuna ulaşılmıştır. İzleme oturumlarından elde edilen
sonuçlar, öğretim oturumlarındaki sonuç ile tutarlılık
göstermektedir. Araştırmaya ilişkin sosyal geçerlilik sonuçları
ise çalışmaya yönelik ailelerinin ve katılımcıların görüşlerinin
olumlu olduğu yönündedir
Anti-inflammatory immunomodulatory activity of valacyclovir on the in vitro activated mammalian macrophages
Get PDFAbstract
Background: Aciclovir, often known as acyclovir, is a nucleoside analog that exhibits antiviral activity in vitro against human
herpesvirus 6 (HHV-6), cytomegalovirus (CMV), varicella-zoster virus (VZV), and herpes simplex virus (HSV). Valacyclovir is an
amino acid ester prodrug of acyclovir. We examined valacyclovir, which is also an anti-viral agent, for its effects on inflammation.
Methods: Mammalian Macrophages were activated by lipopolysaccharide (LPS) in the presence of a concentration range of
Valacyclovir. Tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), granulocyte-macrophage colony-stimulating factor (GMCSF) and IL-12p40 enzyme-linked immunosorbent assay (ELISA) was performed to measure the production levels of these
pro-inflammatory cytokines.
Results: Our results suggest that Valacyclovir had anti-inflammatory activity on the LPS-activated mammalian macrophages.
Conclusion: Valacyclovir has the potential to be utilized in the clinical setting as an anti-viral drug molecule with antiinflammatory properties. Future studies are needed to further confirm its activities on different immune system cell types.
Keywords: anti-inflammatory activity; immunomodulatory activity; valacyclovir; macrophages; inflammatio
Recipient Site Necrosis After Follicular Unit Excision Technique For Hair Transplantation: Evaluation of 18 Patients
Get PDFAbstract
Background Hair transplantation is a widely performed
cosmetic procedure for hair restoration. While generally
safe, it carries the risk of complications, including recipient
site necrosis (RSN). RSN is a rare but serious complication. This study aims to conduct a detailed analysis of 18
patients who had necrosis in the recipient area after hair
transplantation.
Methods A retrospective review of medical records was
conducted on 18 consulted patients who developed RSN
following hair transplantation between 2017 and 2023.
Data collected included patient demographics, medical
history, surgical details, treatment modalities, and outcomes. Treatment involved surgical intervention (debridement), and conservative measures (wound care) in all
cases.
Results The mean age of patients was 36.06 years (range:
22–48). The most common risk factors identified were
smoking 66.7% (n = 10), hypertension 20% (n = 3), and
diabetes mellitus 13.3% (n = 2). All patients (n = 18)
underwent single-session hair transplantation using the
follicular unit excision technique, and an average of
3899.44 ± 93.76 follicular units were transplanted. Outcomes such as scarring and graft failure occurred in all
patients.
Conclusion The presented study is the largest complication series in the literature. RSN is a rare but significant
complication of hair transplantation. Identifying and
managing risk factors, such as smoking, diabetes and
hypertension, is crucial for prevention. Early recognition
and prompt treatment are essential for optimal outcomes.
While conservative management is often successful, surgical intervention may be necessary in severe cases.
Level of Evidence IV This journal requires that authors
assign a level of evidence to each article. For a full
description of these Evidence-Based Medicine ratings,
please refer to the Table of Contents or the online
Instructions to Authors www.springer.com/00266
The effect of in-water sensory-based activities on sensory-motor skills, sleep and quality of life of children diagnosed with asd with sleep problems
No full textAbstract
Çoban, Z. C. (2023). Su İçi Duyu Temelli Aktivitelerin Uyku Sorunu Olan OSB Tanılı Çocukların Duyu- Motor Becerileri, Uyku ve Yaşam Kalitesi Üzerine Etkisi. Yüksek lisans Tezi, Biruni Üniversitesi Lisansüstü Eğitim Enstitüsü, İstanbul. Bu çalışma, Otizm Spektrum Bozukluğu (OSB) tanısı almış ve uyku sorunu yaşayan çocuklarda su içi duyu temelli aktivitelerin duyu-motor becerileri, uyku düzeni ve yaşam kalitesi üzerindeki etkisini incelemeyi amaçlamaktadır. Araştırma, Cangüleç Özel Eğitim ve Rehabilitasyon Merkezi'nde takip edilen 3-10 yaş aralığındaki OSB'li çocuklar arasında gerçekleştirilmiştir. Araştırmaya dahil edilme kriterlerini karşılayan 15 otizmli çocuk dahil edildi. Çocuklar müdahaleden önce, müdahaleden hemen sonra ve müdahaleden sekiz hafta sonra olmak üzere toplamda üç kez değerlendirildi. Çalışma grubundaki çocuklara 8 hafta boyunca haftada iki kez 40'ar dakikalık seanslar uygulandı. Veri toplama araçları olarak Sosyodemografik Bilgi Formu, Çocukluk Otizmini Derecelendirme Ölçeği, Dunn Duyu Profili, Çocuk Uyku Alışkanlıkları Anketi, Çocuk Yaşam Kalitesi Ölçeği ve Nöromotor Performansın Klinik Gözlemi Kontrol Listesi kullanılmıştır. Bu ölçekler, çocukların duyu-motor becerileri, uyku alışkanlıkları ve yaşam kalitelerini değerlendirmek için kullanılmıştır. Araştırma sonuçları, su içi duyu temelli aktivitelerin çalışma grubundaki çocuklarda duyu-motor becerileri, uyku alışkanlıkları ve yaşam kalitesi üzerinde olumlu etkiler yarattığını göstermektedir. Bu çalışmanın bulguları, su içi duyu temelli aktivitelerin OSB tanısı almış çocuklar için potansiyel bir müdahale yöntemi olarak düşünülebileceğini ve duyu-motor becerileri, uyku düzeni ve yaşam kalitesi üzerinde olumlu etkiler sağlayabileceğini işaret etmektedir. Bu nedenle, OSB'li çocuklara yönelik daha fazla araştırma ve uygulama bu alandaki çalışmaları desteklemek için gereklidir. Anahtar Kelimeler: Otizm Spektrum Bozukluğu, Su İçi Duyu Temelli Aktiviteler, Duyu-Motor Beceriler, Uyku Sorunu, Yaşam Kalitesi, Çocuklar
This study aims to examine the effects of in-water sensory-based activities on sensorimotor skills, sleep patterns and quality of life in children diagnosed with Autism Spectrum Disorder (ASD) and having sleep problems. The research was conducted among children with ASD between the ages of 3-10 who were followed at Cangüleç Special Education and Rehabilitation Center. 15 children with autism who met the inclusion criteria were included in the study. Children were evaluated three times in total: before the intervention, immediately after the intervention, and eight weeks after the intervention. Children in the study group were given 40-minute sessions twice a week for 8 weeks. Sociodemographic Information Form, Childhood Autism Rating Scale, Dunn Sensory Profile, Child Sleep Habits Questionnaire, Child Quality of Life Scale and Clinical Observation of Neuromotor Performance Checklist were used as data collection tools. These scales were used to evaluate children's sensorimotor skills, sleep habits, and quality of life. Research results show that in-water sensory-based activities have positive effects on sensorimotor skills, sleep habits and quality of life in the children in the experimental group. It was stated that similar developments were not observed in the children in the control group. The findings of this study indicate that in-water sensory-based activities can be considered as a potential intervention method for children diagnosed with ASD and may provide positive effects on sensorimotor skills, sleep patterns and quality of life. Therefore, further research and practice for children with ASD is necessary to support studies in this area. Keywords: Autism Spectrum Disorder, In-Water Sensory-Based Activities, Sensory-Motor Skills, Sleep Problems, Quality of Life, Childre
The connection between anemia and limitations in daily activities among older males: the critical role of dynapenia
No full textAbstract
Aim: The aim of the present study was to examine the relationship between anemia and basic and instrumental activities of daily living in older male patients.
Methods: A total of 223 older males attending one geriatric outpatient clinic were included in this cross-sectional study. Anemia was defined as a hemoglobin level below 13 g/dL. Patients' demographic characteristics, comorbidities, and comprehensive geriatric assessment parameters were also recorded. Handgrip strength of < 27 kg for males was accepted as dynapenia. Basic Activities of Daily Living (BADL) and Instrumental Activities of Daily Living (IADL) questionnaires were used to evaluate functional capacity.
Results: The mean age (standard deviation) of the participants was 80.17 (7.69) years. The prevalence of patients with anemia was 43.9%. There was differences between anemic and non-anemic groups in terms of presence of diabetes mellitus (DM), congestive heart failure (CHF), chronic kidney disease (CKD), malnutrition, dynapenia, geriatric depression, BADL and IADL scores (all p 0.05).
Conclusion: Close to one in two older outpatient men had anemia. Anemic men had a higher incidence of DM, CHF, CKD, malnutrition, geriatric depression and dynapenia. Anemia was associated with dependence in both BADL and IADL in older men. However, comorbidities, nutritional status, depressive mood and, specifically muscle strength, were important contributors to this association
Inhibition of SARS-CoV-2 infection by Porphyromonas gingivalis and the oral microbiome
No full textAbstract
The COVID-19 pandemic persists despite the availability of vaccines, and it is, therefore, crucial to develop new therapeutic and preventive approaches. In this study, we investigated the potential role of oral microbiome in SARS-CoV-2 infection. Using an in vitro SARS-CoV-2 pseudovirus infection assay, we found a potent inhibitory effect exerted by Porphyromonas gingivalis on SARS-CoV-2 infection mediated by known P. gingivalis compounds such as phosphoglycerol dihydroceramide (PGDHC) and gingipains as well as by unknown bacterial factors. We found that the gingipain-mediated inhibition of infection is likely due to cytotoxicity, whereas PGDHC inhibited virus infection by an unknown mechanism. Unidentified factors present in P. gingivalis supernatant inhibited SARS-CoV-2 likely via the fusion step of the virus life cycle. We addressed the role of other oral bacteria and found certain periodontal pathogens capable of inhibiting SARS-CoV-2 pseudovirus infection by inducing cytotoxicity on target cells. In the human oral cavity, we observed that the modulatory activity of oral microbial communities varied among individuals, in that some saliva-based cultures were capable of inhibiting while others were enhancing infection. These findings contribute to our understanding of the complex relationship between the oral microbiome and viral infections, offering potential avenues for innovative therapeutic strategies in combating COVID-19.
Importance: The oral microbiome is important in health and disease, and in this study, we addressed the potential role of the oral microbiome in COVID-19 infection. Our in vitro studies suggest that certain bacteria of the oral microbiome such as P. gingivalis produce compounds that could potentially inhibit SARS-CoV-2 infection. These findings elucidating the interactions between the oral microbiome and SARS-CoV-2 infection will be important in our understanding of COVID-19 pathogenesis and the development of innovative therapeutic and preventive strategies against COVID-19 infection
New targets and biomarkers for doxorubicin-induced cardiotoxicity in humans: implications drawn from toxicogenomic data and molecular modelling
Get PDFABSTRACT
The doxorubicin-induced cardiotoxicity continues to be a life-threatening adverse effect in the clinic.
Doxorubicin-induced acute cardiotoxicity is reversible, whereas chronic cardiotoxicity is irreversible,
leading to dilated cardiomyopathy and heart failure. The aim of this study was to identify the molecular mechanisms associated with doxorubicin metabolites in doxorubicin-induced chronic cardiotoxicity.
For this purpose, literature searches and in silico toxicogenomic analyses were conducted using various
tools, including the Comparative Toxicogenomic Database, GeneMANIA, Metascape, MIENTURNET,
ChEA3, and AutoDock. Additionally, molecular dynamics simulations were performed for 500 ns using
Schro€dinger software to assess the stability and dynamics of the representative docked complexes. We
observed that doxorubicin biotransformed into five metabolites in the human heart and identified 11
common genes related to doxorubicin, its metabolites, dilated cardiomyopathy, and heart failure. Our
findings revealed that doxorubicin and its metabolites primarily exhibited binding affinity to the beta1 adrenergic receptor and fatty acid synthase. Furthermore, we identified several key transcription factors, especially the Homeobox protein Nkx-2.6, and hsa-miR-183-3p associated with this cardiotoxicity.
Finally, we observed that, in addition to doxorubicinol, 7-deoxidoxorubicinone, another metabolite of
doxorubicin, may also contribute to this cardiotoxicity. These findings contribute to our understanding
of the processes underlying doxorubicin-induced chronic cardiotoxicit
Genç yetişkinlerde psikolojik sağlamlık düzeyi ile internet bağımlılığı arasındaki ilişkinin incelenmesi
No full textÖzet
Bu çalışma genç yetişkin bireylerin psikolojik sağlamlık düzeyi ile internet bağımlılığı arasındaki ilişkiyi araştırmayı amaçlamaktadır. Araştırmada, genç yetişkinlerin internet bağımlılığı düzeyi ve psikolojik sağlamlık düzeyi ölçülmüş ve bu iki faktör arasındaki ilişki istatiksel yöntemlerle analiz edilmiştir. Ayrıca genç yetişkinlerin psikolojik sağlamlık düzeyi ve internet bağımlılığı değişkenlerinin cinsiyet, çalışma durumu, yaş, eğitim düzeyi, doğum sırası, ekonomik durum, sosyal medya platformu ve sosyal medyada geçirilen süre gibi değişkenler arasındaki ilişki incelenmiştir. Araştırma ilişkisel tarama modelindedir. Çalışma grubunu 18-40 yaş aralığında, 437 (292 Kadın, 145 Erkek)kişi oluşturmaktadır. Araştırmanın verileri Kişisel Bilgi Formu, Kısa Psikolojik Sağlamlık Ölçeği ve Young İnternet Bağımlılığı Testi Kısa Formu ile toplanmıştır. Verilerin analizi için Pearson Korelasyon Testi, Bağımsız Örneklem T Testi ve Anova testi uygulanmıştır. Gruplar arasında anlamlı fark çıkması durumunda, anlamlılığın hangi gruplar arasında olduğunu belirlemek amacıyla LCD testi kullanılmıştır. Yapılan analizler sonucunda Psikolojik sağlamlık düzeyi ve internet bağımlılığı arasında negatif yönlü ve anlamlı bir ilişki olduğu bulunmuştur. Bu durumda psikolojik sağlamlık düzeyi arttıkça internet bağımlılığı düzeyi azalmakta ya da bunun tam tersidir. Psikolojik sağlamlık düzeyi ve internet bağımlılığı demografik değişkenlerden; cinsiyet, yaş, sosyal medyada geçirilen süre ve en çok kullanılan sosyal medya platformu ile farklılık gösterdiği, ancak; çalışma durumu, doğum sırası, ekonomik durum ve eğitim durumu değişkenlerinde farklılık göstermediği bulunmuştur
Novel spiroindoline derivatives targeting aldose reductase against diabetic complications: Bioactivity, cytotoxicity, and molecular modeling studies
Get PDFABSTRACT
Despite significant developments in therapeutic strategies, Diabetes Mellitus remains an increasing concern,
leading to various complications, e.g., cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular diseases. The polyol pathway, which involves Aldose reductase (AR) as a critical enzyme, has been focused
on by many researchers as a target for intervention. On the other hand, spiroindoline-based compounds possess
remarkable biological properties. This guided us to synthesize novel spiroindoline oxadiazolyl-based acetate
derivatives and investigate their biological activities. The synthesized molecules’ structures were confirmed
herein, using IR, NMR (
1
H and 13C), and Mass spectroscopy. All compounds were potent inhibitors with KI
constants spanning from 0.186 ± 0.020 μM to 0.662 ± 0.042 μM versus AR and appeared as better inhibitors
than the clinically used drug, Epalrestat (EPR, KI: 0.841 ± 0.051 μM). Besides its remarkable inhibitory profile
compared to EPR, compound 6k (KI: 0.186 ± 0.020 μM) was also determined to have an unusual pharmacokinetic profile. The results showed that 6k had less cytotoxic effect on normal mouse fibroblast (L929) cells (IC50
of 569.58 ± 0.80 μM) and reduced the viability of human breast adenocarcinoma (MCF-7) cells (IC50 of 110.87
± 0.42 μM) more than the reference drug Doxorubicin (IC50s of 98.26 ± 0.45 μM and 158.49 ± 2.73 μM,
respectively), thus exhibiting more potent anticancer activity. Moreover, molecular dynamic simulations for 200
ns were conducted to predict the docked complex’s stability and reveal significant amino acid residues that 6k
interacts with throughout the simulation