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The impact of oral health literacy on periodontal health
No full textBireylerin sağlığının, sağlık davranışlarının ve sağlık çıktılarının güçlü belirleyicilerinden birinin sağlık okuryazarlığı olduğu bilinmektedir. Ağız sağlığı okuryazarlığı ise ağız sağlığını belirleyici faktörlerden biri olarak ağız sağlığı ile ilgili karar alabilmek için gereken temel sağlık bilgilerinin tedarik edilmesi ve anlaşılması olarak ifade edilmektedir. Bu araştırmanın amacı ağız sağlığı okuryazarlığının periodontal sağlık üzerine etkisinin incelenmesidir. Araştırmada nicel araştırma yöntemlerinden ilişkisel tarama modeli kullanılmıştır. Araştırma, 2021-2022 yılında İstanbul Biruni Üniversitesi Diş Hekimliği Fakültesi Periodontoloji Anabilim Dalına tedavi için başvuran ve çalışmayı kabul eden 176 hastadan elde edilen veriler ile yürütüldü. Araştırmada ağız sağlığı okuryazarlığının ölçülmesi amacıyla "Diş Hekimliğinde Yetişkin Okuryazarlığının Hızlı Tahmini Türkçe Versiyonu (TREALD-30)" kullanıldı. Periodontal durum, tüm ağız plak skoru, sondlamada kanama, sondlama derinliği ve klinik ataşman kaybı gibi standart klinik parametreler kullanılarak değerlendirildi. Katılımcıların sosyodemografik özellikleri ve ağız hijyeni alışkanlıklarına ilişkin veriler, yapılan görüşmeler aracılığıyla toplanmıştır. Elde edilen tüm veriler, Mann–Whitney U testi, Kruskal–Wallis testi ve Spearman's korelasyon analizi ile istatistiksel olarak analiz edilmiştir. İstatistiksel anlamlılık düzeyi p<0.05 olarak kabul edilmiştir. Yapılan çalışma sonucunda, ağız sağlığı okuryazarlığı düzeyinin artmasıyla periodontal sağlığın olumlu etkilendiği görülmüştür. Ayrıca yaş, medeni durum, çocuk sayısı, eğitim durumu, meslek faktörlerinin ağız sağlığı okuryazarlığı seviyesini ve periodontal sağlık düzeyini etkiledikleri belirlenmiştir.It is known that one of the strong determinants of individuals' health, health behaviors and health outcomes is health literacy. Oral health literacy, on the other hand, is expressed as the acquisition and understanding of basic health information required to make decisions about oral health, as one of the determining factors of oral health. The aim of this research is to examine the effect of oral health literacy on periodontal health. Relational survey model, one of the quantitative research methods, was used in the research.The research was conducted with data obtained from 176 patients who applied to Istanbul Biruni University Faculty of Dentistry Department of Periodontology in 2021-2022 for treatment and accepted the study. In order to measure oral health literacy in the study, "Quick Estimation of Adult Literacy in Dentistry Turkish Version (TREALD-30)" was used. Periodontal status was evaluated using standard clinical parameters, including full-mouth plaque score, bleeding on probing, probing depth, and clinical attachment loss. Sociodemographic data and oral hygiene behaviors were collected through structured interviews. Statistical analyses were performed using the Mann–Whitney U test, Kruskal–Wallis test, and Spearman's correlation analysis. A p-value of <0.05 was considered statistically significant. As a result of the study, it has been observed that periodontal health is positively affected by increasing the level of oral health literacy with a weak correlation. In addition, it was determined that age, marital status, number of children, educational status, and occupational factors affect the level of oral health literacy and periodontal health
The relationship between perinatal attachment levels and maternal functional status of women conceiving naturally and with art treatment
No full textİnfertilite tedavilerinin artmasıyla gebeliğin elde ediliş şeklinin anne adayının psikolojik durumu, bağlanma süreci ve anneliğe geçiş süreci üzerindeki etkileri önemli bir araştırma alanı olmuştur. Bu araştırma, doğal yolla ve yardımcı üreme teknikleri (YÜT) ile gebe kalan kadınların perinatal bağlanma düzeylerini, annelik fonksiyonel durumlarını ve bunların sosyodemografik, obstetrik ve psikososyal faktörlerle ilişkisini incelemek amacıyla gerçekleştirildi. YÜT ile gebe kalan kadınların deneyimlerinin, dgebe kalanlarla karşılaştırıldığında nasıl farklılaştığını ve bu farklılığın bağlanma, ruhsal sağlık ve annelik fonksiyonlarına etkisini belirlemek hedeflendi. Örneklem grubunu, bir kamu hastanesi ve özel bir tüp bebek merkezine başvuran toplam 106 kadın (53'ü YÜT, 53'ü doğal yolla) oluşturdu. Veriler yapılandırılmış anket, Prenatal Bağlanma Envanteri, Maternal Bağlanma Ölçeği, Barkin Annelik Fonksiyonu Ölçeği ve Depresyon, Anksiyete, Stres Ölçeği kullanılarak Aralık 2021-Şubat 2023 tarihleri arasında toplandı. YÜT grubunda yaş ortalamasının daha yüksek olduğu, cerrahi oranlarının ve gebelik öncesi bilgi alma oranlarının daha fazla olduğu bulundu. Maternal Bağlanma puanları YÜT grubunda anlamlı şekilde yüksek (YÜT: 99.47 ± 5.09, Doğal Yolla: 96.98 ± 6.89; Z = -2.079; p = .038) çıkarken, diğer ölçeklerde grup farkı saptanmadı (p>0.05). Her iki grupta da doğum sonrası depresyon puanlarında doğum öncesine kıyasla azalma gözlemlendi. (YÜT: 9.64 ± 6.75, Doğal Yolla: 10.08 ± 6.26; Z = -0.491; p = .624). Ancak gruplar arasında istatistiksel olarak anlamlı bir fark bulunamadı. Sosyodemografik özelliklerin bağlanma düzeylerini etkilediği ve eğitim düzeyinin bağlanmada önemli bir faktör olduğu belirlendi. Sonuçlar, sağlık hizmetlerinin bireyselleştirilmesi ve psikososyal desteklerin artırılması gerektiğini gösterdi. Bu çalışma, perinatal dönemde bütüncül sağlık hizmetleri sunulması ve kadınların bireysel ihtiyaçlarına odaklanılması gerektiğine dair önemli veriler sundu. Anahtar Kelimeler: Annelik Fonksiyonel Durumu; Doğal Yolla Gebelik; Perinatal Bağlanma; Yardımcı Üreme Teknikleri.With the growing use of infertility treatments, the psychological impact of pregnancy origin on maternal bonding and transition to motherhood has become increasingly important. This study aimed to compare the perinatal attachment levels and maternal functional status of women who conceived through natural conception and through assisted reproductive technologies (ART), and to explore how these outcomes relate to sociodemographic, obstetric, and psychosocial factors. The sample consisted of 106 pregnant women (53 ART, 53 natural conception) treated at a public hospital and a private IVF clinic. Data were collected between December 2021 and February 2023 using structured questionnaires, the Prenatal Attachment Inventory, the Maternal Attachment Scale, the Barkin Maternal Functioning Scale, and the Depression, Anxiety, and Stress Scale. The ART group showed significantly higher maternal attachment scores compared to the natural conception group (ART: 99.47 ± 5.09; natural conception: 96.98 ± 6.89; p = .038). No significant group differences were found in other scales. Both groups experienced a decrease in postpartum depression scores compared to pre-birth levels, though this change was not statistically significant. Findings indicated that sociodemographic characteristics, particularly education level, were influential in attachment outcomes. The study highlights the necessity of individualized perinatal care and enhanced psychosocial support for pregnant women, especially those undergoing ART. These findings underscore the importance of tailoring healthcare services to meet the psychological and emotional needs of expectant mothers. Keywords: Assisted Reproductive Technologies; Maternal Functional Status; Natural Conception; Perinatal Attachment
The effect of emotional intelligence levels of female healthcare workers on their marital relationship beliefs
No full textBu çalışma, kadın sağlık çalışanlarının duygusal zeka düzeylerinin evlilik ilişkisi inançları üzerindeki etkisini göstermek amacıyla yapılmıştır. Araştırmanın özelliği ilişki arayıcı ve tamamlayıcı bir araştırma olmasıdır. Çalışmaya, bir devlet hastanesinde çalışan 211 evli kadın sağlık çalışanı dahil edilmiştir. Veriler, Duygusal Zeka Değerlendirme Ölçeği (DZDÖ) ve Evlilik İlişkisi İnançları Ölçeği (EİİÖ) kullanılarak toplanmıştır. Verilerin analizinde bağımsız örneklem t-testi, ANOVA ve korelasyon analizi kullanılmıştır. Bulgular, kadın sağlık çalışanlarının duygusal zeka düzeyleri ile evlilik ilişkisi inançları arasında anlamlı bir ilişki olduğunu göstermiştir (p<0.05). Sonuç olarak, duygusal zeka düzeyi yüksek olan kadın sağlık çalışanlarının evlilik ilişkisi inançlarının daha olumlu olduğu evliliğe uyum sağlama oranlarının daha yüksek olduğu tespit edilmiştir. Araştırmanın bulgularına göre Duygusal zeka düzeyi yüksek olan kadın sağlık çalışanlarının evlilik ilişkisine dair inançlarının daha olumlu olduğu ve evliliğe uyum sağlama düzeylerinin daha yüksek olduğu ortaya konmuştur. Bu sonuç, duygusal zekanın bireylerin romantik ilişkilerdeki tutum ve davranışlarını şekillendirmede önemli bir rol oynadığını göstermektedir. Evlilik süresi arttıkça evlilik inancına yönelik (ölçeğin geneli ile kök aileye bağlılık ve cinsel hayat alt boyutunda) çatışma riskinin de arttığı; evlilik süresinin duygusal zekanın kendini motive etme alt boyutunda anlamlılık teşkil edecek şekilde değiştiği sonucuna ulaşılmıştır.This study was conducted to examine the impact of emotional intelligence (EI) levels on marital relationship beliefs among female healthcare workers. The research is characterized as a correlational and complementary study. The sample consisted of 211 married female healthcare workers employed at a public hospital. Data were collected using the "Emotional Intelligence Assessment Scale (EIAS)" and the "Marital Relationship Beliefs Scale (MRBS)". The data were analyzed using independent samples t-test, ANOVA, and correlation analysis. The findings revealed a statistically significant relationship (p < 0.05) between the emotional intelligence levels of female healthcare workers and their marital relationship beliefs. The results indicate that female healthcare workers with higher emotional intelligence levels tend to have more positive marital relationship beliefs and higher marital adjustment rates. According to the study's findings, female healthcare workers with higher emotional intelligence levels exhibit more positive beliefs about marital relationships and demonstrate greater marital adjustment. These results suggest that emotional intelligence plays a significant role in shaping individuals' attitudes and behaviors in romantic relationships. The study concluded that as the duration of marriage increases, the risk of conflict in marital beliefs (both in the overall scale and in the sub-dimensions of attachment to the family of origin and sexual life) also increases. Additionally, it was found that the duration of marriage significantly changes the self-motivation sub-dimension of emotional intelligence
Global, regional and national burden of epilepsy in children and adolescents, 1990-2021: A systematic analysis for the Global Burden of Disease Study 2021
No full textBackground Epilepsy is a common neurological disease that heavily impacts children and adolescents and carries serious physical, cognitive, psychological, social and economic consequences for patients and their caregivers.Methods Data was obtained via the Global Burden of Disease Study 2021. We reported numbers, rates and percentage changes of prevalence, mortality and disability-adjusted life years (DALYs).Results In 2021, there were 18.15 million [95% UI: 14.61-21.85] prevalent cases of epilepsy in children and adolescents worldwide, 8.24 million [5.77-11.13] of which were idiopathic epilepsy and 9.91 million [8.72-11.06] of which were secondary epilepsy. While mortality and DALY rates of idiopathic epilepsy declined between 1990 and 2021, the burden of secondary epilepsy remained substantial and, in some cases, increased-particularly in low-SDI regions. The prevalence rate of secondary epilepsy increased by 16.14% [4.28-29.24], driven by increases in epilepsy attributable to neonatal encephalopathy (82.02%), neonatal jaundice (18.45%) and malaria (77.03%). There were notable geographic variations in the burden of epilepsy, with the burden generally concentrated in Sub-Saharan Africa, Latin America and the Caribbean and Southeast Asia.Conclusions While efforts to reduce premature mortality of epilepsy have been successful, the burden on children and adolescents living with epilepsy is still significant. A healthcare gap remains for vulnerable populations with increased risk of infectious diseases, perinatal insults, poor sanitation and limited access to healthcare. Global and national action is needed to improve access to specialist care and medication, manage comorbidities, address stigma and discrimination and strengthen primary prevention initiatives
Evaluation of the effect of face mask treatment and RPE application on blood oxygen level in skeletal class III individuals with continued growth
No full textBu kontrollü klinik çalışmada, iskeletsel Sınıf III maloklüzyona sahip büyüme çağındaki bireylerde hızlı üst çene genişletme (HÜÇG) ve yüz maskesi (YM) tedavisinin üst hava yolu genişliği ve kandaki oksijen saturasyonu (SpO₂) üzerindeki bireysel ve kombine etkileri değerlendirilmiştir. Yaşları 6–10 arasında değişen toplam otuz katılımcı rastgele olarak üç gruba ayrılmıştır: HÜÇG+YM, yalnızca YM ve kontrol. HÜÇG+YM grubuna bonded tip Hyrax genişletici ardından Petit tipi yüz maskesi, YM grubuna ise ekspansiyon özelliği olmayan apareylerle yüz maskesi uygulanmıştır. Kontrol grubuna herhangi bir ortopedik müdahale yapılmamıştır. Tedavi öncesi ve sonrası SpO₂ düzeyleri pulse oksimetre ile, iskeletsel ve hava yolu değişiklikleri ise lateral sefalogramlar ile değerlendirilmiştir. Anlamlı SpO₂ artışı yalnızca HÜÇG+YM grubunda saptanmıştır (p=0.044). HÜÇG+YM ve YM gruplarında SNA, ANB, Wits analizi, üst hava yolu genişliği ve efektif maksiller uzunluk parametrelerinde anlamlı artışlar gözlenmiştir (p<0.01). Kombine tedavi grubunda bu etkiler daha belirgin olmuştur. YM tedavisi özellikle hava yolu genişliğini artırırken, HÜÇG tedavisi nazal oksijenlenme üzerinde daha fazla katkı sağlamıştır. Elde edilen bulgular, HÜÇG ve YM tedavisinin birlikte uygulanmasının hem iskeletsel hem de solunumsal iyileşmeyi en üst düzeye çıkarabileceğini ve erken dönem Sınıf III tedavisinde etkili bir yaklaşım olabileceğini göstermektedir.This controlled clinical study aimed to evaluate the individual and combined effects of rapid maxillary expansion (RME) and facemask (FM) therapy on upper airway width and blood oxygen saturation (SpO₂) in growing individuals with skeletal Class III malocclusion. Thirty participants aged between 6 and 10 were randomly assigned to three groups: RME+FM, FM only, and control. The RME+FM group received a bonded-type Hyrax expander followed by a Petit-type facemask, while the FM group received facemask therapy with bonded appliances that did not include expansion. The control group received no orthopedic intervention. SpO₂ levels were recorded using a pulse oximeter, and skeletal and airway changes were assessed via lateral cephalograms. A significant increase in SpO₂ was observed only in the RME+FM group (p=0.044). Both the RME+FM and FM groups showed significant increases in SNA, ANB, Wits appraisal, upper airway width, and effective maxillary length parameters (p<0.01), with more pronounced effects in the combined treatment group. FM therapy was more effective in increasing airway width, while RME therapy contributed more significantly to oxygen saturation. These findings suggest that RME enhances nasal oxygenation through transverse expansion, while FM improves airway width via maxillary protraction. Therefore, the combined RME+FM treatment protocol may offer a highly effective early-phase therapeutic approach for achieving both skeletal and respiratory benefits in patients with Class III malocclusion
Evaluation of a cost-effective gating strategy for CD4+T lymphocyte enumeration in HIV-infected individuals via flow cytometry
No full textBackground: Monitoring CD4+ T lymphocyte levels is a cornerstone in managing HIV infection, essential for assessing immune status and determining treatment strategies. However, the high cost of standard flow cytometry methods limits access to these diagnostic tools in low-income settings. This study evaluates a costeffective alternative method (AM) with a simplified gating strategy and reduced antibody use compared to the standard method (SM), which is based on PanLeucogating (PLG). Methods: This multicenter study analyzed 1,001 HIV-positive patient samples in a central laboratory serving six hospitals in Istanbul. SM used four antibodies (CD45/CD3/CD4/CD8), while AM utilized only CD4/CD8. Flow cytometric analysis was performed on a BD FACS Canto II system, and CD4* T cell percentages were compared between methods using Pearson's correlation coefficient and the Mann-Whitney U test. Results: A strong correlation (r = 0.993, p < 0.001) was observed between AM and SM, with no statistically significant difference (p = 0.339). However, AM systematically reported lower CD4* percentages, likely due to the absence of CD3-based gating and the use of FS/SS plots instead of CD45 for gating lymphocytes. Conclusion: With one of the largest datasets among similar studies, our findings suggest that AM, which uses 50 % fewer antibodies, is a cost-effective and viable alternative for CD4* enumeration in HIV monitoring. However, further validation in diverse epidemiological settings and clinical impact assessments are required before widespread clinical implementation
Riskli gebelerde olumlama ile bilgilendirmenin stres ve tahammülsüzlüğe etkisi
No full textGebelik sürecinde genellikle herhangi bir sorun olmadan devam etse de bazen riskli gebelikler de yaşanabilmektedir. Acil servise gelen gebelerin acilin stres ve temposunda özellikle riskli gebelere bilgilendirme yapılması emosyonel olarak onları rahatlatmaktadır. Riskli gebeliklerde kadınların ebelerden ve sağlık çalışanlarından beklentisi emosyonel destek ve güzel telkindir. Olumlama güzel telkin anlamına gelmektedir (Cohen ve ark., 2009; Cohen and Sherman, 2014). Bu çalışmanın amacı, acil servise başvuran riskli gebe tanılı gebelere yapılan olumlama ve bilgilendirmenin gebenin stres ve belirsizliğe tahammülsüzlüğüne etkisini incelemektir. Çalışma, İstanbul'da bir devlet hastanesinin kadın doğum acil servisine başvuran 51 olumlama ve 51 kontrol olmak üzere toplam 102 riskli gebe ile randomize kontrollü deneysel tasarımda gerçekleştirildi. Olumlama grubundakilerin tümü kendilerine bilgilendirme yapıldığını belirtirken kontrol grubundakilerin %47.1'i bilgilendirme yapıldığını ifade etti. Her iki grupta da belirsizliğe tahammülsüzlük puan ortalamalarının başlangıçta benzer olduğu (xolumlama=37.37±5.82, xkontrol=39.76±7.20); bilgilendirme ve olumlama sonrası, olumlama grubunda belirsizliğe tahammülsüzlükte anlamlı bir düşüş (xson=28.25±3.61) görüldüğü saptandı. İlk değerlendirmede kontrol grubundaki gebelerin algıladıkları stres puan ortalamalarının olumlama grubundan daha düşük olduğu (xolumlama=98.35±7.16, xkontrol=86.33±13.36); bilgilendirme ve olumlama sonrası grupta stres düzeyinde de ciddi ve anlamlı bir düşüş (xson=70.86±4.30) olduğu gözlendi. Acil servise başvuran riskli gebeleri olumlama ile bilgilendirmenin gebelerin stres ve belirsizliğe tahammülsüzlüğü önemli derecede azalttığı düşünülmektedir. Anahtar kelimeler: Riskli Gebelik, Stres, Bilgilendirme, Olumlama.Although pregnancy usually continues without any problems during pregnancy, risky pregnancies can sometimes occur. Because the stress level of women increases even more as a result of risky pregnancies (Evcili ve Dağ lar, 2019). In addition, informing the pregnant women who come to the emergency service, especially the risky pregnant women, in the intense stress and tempo of the emergency, emotionally relieves them. In risky pregnancies, women's expectations from midwives and health workers are emotional support and good suggestion. Affirmation means good suggestion (Cohen ve ark., 2009; Cohen and Sherman, 2014). The aim of this study was to examine the effect of affirmation and information given to pregnant women diagnosed with risky pregnancy who applied to the emergency department on the stress and intolerance to uncertainty of pregnant women. The study was carried out in a randomised controlled experimental design with a total of 102 high-risk pregnant women (51 affirmation and 51 control) who applied to the obstetric emergency department of a state hospital in Istanbul. Data were collected between July 2024 and January 2025. It was determined that 13.7% of the pregnant women in the affirmation group and 11.8% of theAlthough pregnancy often progresses without complications, high-risk pregnancies may also occur. In the fast-paced and stressful environment of emergency departments, providing information to pregnant women especially those at high risk can offer emotional relief. In such cases, women expect emotional support and positive reassurance from midwives and healthcare professionals, a practice referred to as affirmation (Cohen et al., 2009; Cohen & Sherman, 2014).This study aimed to examine the effects of affirmation and informational support on stress levels and intolerance of uncertainty among high-risk pregnant women admitted to the emergency department. The research was conducted with 102 participants (51 affirmation group, 51 control group) using a randomized controlled experimental design at the obstetric emergency department of a public hospital in Istanbul. While all participants in the affirmation group reported receiving information, only 47.1% of the control group stated that they had been informed.Baseline scores for intolerance of uncertainty were similar between groups (x̄ _affirmation = 37.37±5.82; x̄ _control = 39.76±7.20). However, post-intervention results revealed a significant decrease in the affirmation group (x̄ _post = 28.25±3.61). Additionally, although initial perceived stress scores were higher in the affirmation group (x̄ _affirmation = 98.35±7.16; x̄_control = 86.33±13.36), a notable and statistically significant reduction was observed following the intervention (x̄ _post = 70.86±4.30).These findings suggest that affirmation and informational support significantly reduce stress and intolerance of uncertainty in high-risk pregnant women who present to emergency departments. Keywords: High Risk Pregnancy, Stres, İnformation, Affirmation
Effects of psychotropic medications on electrocardiography
No full textBackground and aim: In recent years number of psychiatric patients has increased and psychotropic medications are becoming mostly used drugs. These drugs may affect cardiovascular system and we can check
side effects with electrocardiography (ECG). In this study we aimed to analyse psychiatric medications’ side
effects on ECG.
Objective and methods: Eighty-fi ve patients included in this study have psychiatric diagnosis and have used
psychoactive medications. Forty-fi ve of these patients are male and 40 of them are female. Age varies from
23 to 94 years. ECG has been taken from the patients and PR duration, QRS duration, and corrected QT measured from each ECG. Twenty-two kinds of drugs (Akineton, Haldol, Zyprexia, Prolixin, Dogmatil, Risperdal, Diazem, Artane, Tegretol, Sulpirid, Cipram, Seroquel, Depaqin, Stelazin, Anafranil, Rivotril, Clopiksol, Largactil, Melleril, Epanutin, Nurodol, Desyrel) were analyzed statistically and PR duration, QRS duration, and
cQT checked if there is an association with these drugs.
Results: All statistical analysis was performed with the IBM SPSS software package (version 24.0, IBM, Armong, NY, USA) at the 95% confi dence interval level and p <0.05 level of signifi cance. Quantitative variables
were analyzed by Friedman analysis for dependent group. Moreover the independent groups were compared with Mann–Whitney U test. In this study with univariate analyses we found that Haldol, Epanutin and
Nurodol may cause long PR, risperdal, Seroquel, clopiksol, and Nurodol may cause long QRS duration, depakin, stelazin, Melleril, Nurodol may cause long QT. On the other hand with multivariate analyses Tegretol is
associated with QRS duration at a level of signifi cance of 0.05 (p = 0.044). Diazem is effective for increasing
the PR duration at a level of signifi cance of 0.05 (p = 0.037) and Desyrel is effective for increasing the QTC
time at a signifi cance level of 0.05 (p = 0.023).
Conclusion: In this study we showed that among psychoactive medications, Nurodol is the most related drug
that affects ECG and may cause long PR, long QRS duration and long QT. So while using psychiatric tablets
physicians, nurses, families should be aware of cardiovascular side effects and regular ECG controls should
be checke
Identifying the therapeutic role of CD90 as a key player in cancer treatment for aggressive tumours
No full textObjective: In this study, it was aimed to investigate the role of one of the cancer stem cell biomarkers, CD90 (THY-1) that plays a crucial role in drug efflux and therapy resistance in different types of cancer.Methods: CD90 knockout cells were generated by using CRISPR/Cas9 technology. Colony formation, scratch assay, Boyden chamber and sphere formation were assessed. Chemoresistant cell lines were formed by using the most common therapeutics such as cisplatin, etoposide, cytarabine and paclitaxel and CD90 levels were measured by flow cytometry.Results: Suppression of CD90 led to decreased tumour proliferation, invasion, and migration, colony formation and tumour sphere generation in all cell lines and enhanced sensitivity to chemotherapeutic agents. Elevated CD90 levels were observed in chemoresistant cancer cell lines.Conclusion: These findings underscore CD90's significant contribution to drug resistance in addition to tumour malignancy and suggest that targeting CD90 could enhance the efficacy of cancer therapies
Machine learning analysis based on Bayesian regularization algorithm for the thermal bioconvection flow of Boger nanofluid in the presence of gyrotactic microbes: enzyme-based biosensor applications
No full textThe impact of heat generation and Soret-Dufour effects on bioconvection stagnation point flow of MHD Boger nanofluid around a spinning sphere in the occurrence of gyrotactic microbes is examined. This paper presents a numerical solution of this impact using back-propagation intelligent Bayesian regularization with the neural network domain (BPIBR-NNs), which is novel with convergent stability. Using a dataset for the proposed (BPIBR-NNs) for many MHD-BNF-TRDS scenarios, the Bvp4c numerical technique. This model may be useful for a variety of systems, including bacterial-powered micromixers, chip-scale micro-devices like bio-microsystems, microbial fuel cells, enzyme-based biosensors, and micro-scale environments like microfluidic devices. Gyrotactic microbes added to nanoparticles increase their thermal efficiency. Reactors and spinning machines need to be built and adjusted for industrial processes to work because reliable mixing and effective heat transmission are essential. This model may be used by environmental engineers to forecast the distribution of nutrients and contaminants in water bodies. To assess the accuracy of the proposed model, the data are processed, correctly tabulated, and its validity is examined. The BPIBR-NNs training, testing, and validation methods were used to evaluate the estimate solutions for specific occurrences and compare the suggested model for verification