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Impact of multi-stacking and resin type on dimensional stability of dentate casts
Get PDFABSTRACT
Objective: To evaluate the effects of multi-stacking and resin type on the dimensional stability of additively
manufactured (AM) dentate casts.
Methods: A master maxillary dentate model file was used to AM casts in a multi-stacked manner, consisting of
four layers (L1–L4), using two different resins (DentaMODEL [DM] and KeyModel Ultra Ivory [KM], n = 10).
Each cast was digitized one day, one week, two weeks, three weeks, four weeks, and three months after fabrication (T0–T5). The scan files were superimposed over the master file to evaluate the dimensional stability of the
casts (anterior, posterior, and entire arch) using the root mean square method. Data were analyzed with a
generalized linear model (α = 0.05).
Results: KM casts had their highest anterior and entire arch deviations when printed at L4 (P < 0.001). DM casts
mostly had lower deviations than KM casts across tested layers and storage durations (P < 0.001). DM casts
showed the highest anterior deviations at T1 and T2, while KM casts showed the highest at T0, T3, and T4 (P ≤
0.009). Casts printed at L4 showed the highest anterior deviations at T0 and greater deviations than L1 at T3 and
T5, regardless of resin (P ≤ 0.044). KM casts had lower entire arch deviations at T5 than at T3 (P = 0.027).
Conclusions: While the differences due to stacking were minimal and clinically negligible, the DM casts mostly
had higher stability. All casts remained within clinically acceptable limits over three months.
Clinical Significance: Multi-stacking during printing may be an efficient method for large-scale of plateless dentate
casts with clinically acceptable dimensional stability for diagnostic and orthodontic use over three months, when
tested resins and three-dimensional printer are used
Intranasal Terpene Treatment for Glioblastoma: the Neuro-Oncological Potential of Perillyl Alcohol
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Glioblastoma is the most aggressive and fatal primary brain tumor in adults, characterized by poor prognosis and limited
treatment efficacy due to the impermeability of the blood-brain barrier (BBB) and its treatment-resistant nature. This
review aims to evaluate the potential of intranasal terpene treatment (ITT) as a novel and non-invasive strategy to bypass
the BBB and improve glioblastoma treatment outcomes. A review of recent preclinical and clinical studies on intranasally
administered compounds (especially terpenes such as Perillyl alcohol (POH)) is presented in terms of their molecular
mechanisms, bioavailability, and clinical effects in the central nervous system (CNS)
Sensitive, low cost and disposable electrochemical dopamine sensor based on Ag-NP/f-MWCNT/Poly (L-Cysteine)/ PGE
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In this study, a single-step electrochemical method was employed to coat the electrode surface with a hybrid material comprising silver nanoparticles (AgNPs), functionalised multi-walled carbon nanotubes (f-MWCNTs) and poly(Lcysteine). This material was used for the electrochemical determination of dopamine (DA). The electrocatalytic effect
of the AgNPs/f-MWCNT/Poly(L-cysteine) hybrid material in DA determination exhibited superior performance in the
sensitive and selective determination of DA, due to its well-designed morphology and surface functional groups. The
spectroscopic, structural and morphological analyses of the AgNPs/f-MWCNT/Poly(L-cysteine)/PGE sensor electrode
were conducted using XRD, FT-IR, Raman and SEM-EDS. The electrochemical properties and sensitivity of the sensor
electrode employed in the determination of DA were investigated through the utilisation of cyclic voltammetry (CV),
electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV) methodologies. The limit of
detection (LOD) value of the DA sensor was calculated to be 0.068 µM, while the limit of quantification (LOQ) value
was determined to be 0.23 µM. Furthermore, linear ranges of 0.1 µM to 5.0 µM and 10 µM to 1000 µM were obtained.
The repeatability test of the sensor electrode was also performed, and the RSD value was found to be 4.14%
Assessment of mastoid emissary foramen morphology: a multidetector computed tomography study
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Objectives This study aimed to assess the occurrence and morphological features of the mastoid emissary foramen (MEF)
using multidetector computed tomography (MDCT) images. The analysis highlights the clinical signifcance of these structures and their implications for surgical procedures.
Methods A total of 357 patients were evaluated using MDCT in bone window mode with a high-resolution technique
(1 mm). The presence, number, and mean diameter of the MEFs were recorded. Statistical analyses compared data between
both sides and sexes.
Results 714 sides from 357 patients (177 male, 180 female) were analyzed. The patients’ ages ranged from 7 to 83 years, with
a mean age of 25.6. MEFs were found in 329 patients, representing 92.15% of the total. The diameters of the MEFs ranged
from 0.6 mm to 5.0 mm on the right side (mean 1.80 mm) and from 0.6 mm to 4.4 mm on the left side (mean 1.96 mm). Up
to 3 MEFs were identifed on the right side, and a maximum of 6 on the left. No signifcant diferences in MEF presence
were observed between sexes or between the left and right sides (p>0.05).
Conclusion This study reveals a high prevalence and notable anatomical variations in the MEF, with MEFs larger than
previously reported. At least one MEF was detected in 92.15% of cases, emphasizing the importance of comprehensive
preoperative evaluation
An investigation into EFL mentors' preferred mentoring approaches through feedback practices
No full textAbstract
PurposeThis case study provides an account of eight mentor teachers' mentoring approaches based on their reported feedback practices.Design/methodology/approachIn an interpretative phenomenological design, the data were obtained through in-depth individual interviews with mentor teachers in different practicum schools in Istanbul, T & uuml;rkiye. The study draws upon the mentoring approaches in the literature (Orland-Barak and Wang, 2020), and the mentor teachers' reports on their feedback behaviors were analyzed accordingly.FindingsDuring the interviews, the mentors' emphasis on issues such as the use of positive language, encouraging reflection and the evaluative nature of feedback indicated that their feedback behaviors were mainly influenced by personal growth and situated learning mentoring approaches.Practical implicationsThe results suggest that mentors' awareness on mentoring approaches and how to give feedback should be enhanced. It also suggests that teacher education programs should pay more attention to providing accurate information about mentoring approaches. A more accurately structured evaluation process should be ensured, and mentors should be instructed on how to give constructive feedback through training.Originality/valueThis study contributes to the existing literature by offering a nuanced exploration of mentoring approaches in relation to teachers' feedback practices
The effect of high-intensity versus photobiomodulation therapy (PBM) on the regeneration of the sciatic nerve following crush injury: an animal study
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The purpose of this research was to evaluate the therapeutics effects of photobiomodulation and high intensity laser therapy after a sciatic nerve crush injury. Following the crush injuries of sciatic nerve, 33 rats were randomly divided into three groups. The injured sciatic nerves of the rats in the control group were left to heal spontaneously, whereas HILT (120 J/session and 1064 nm) and photobiomodulation therapy (PBM) (2.4 J/session and 650 nm) were started immediately after surgery and performed once every 3 days (10 session in total) during the postoperative period. Electrophysiological evaluations were conducted before surgery and at the end of the healing period. The Sciatic Functional Index (SFI) was assessed before surgery and at the end of the healing period. The ratio of the inner axonal diameter to the total outer axonal diameter (g-ratio) and schwann cells per square micrometer were histomorphometrically evaluated. At the end of the 30-day healing period, significantly better SFI scores were noted in the HILT group compared with PBM (p=0.002) and control (p < 0.001) groups. HILT exhibited positive effects on latency and duration values when compared PBM (p=0.002, p=0.014) and control (p=0.003, p < 0.001) groups. The number of nerves with an optimum g-ratio was higher in the HILT group which indicates a better rate of myelination. Functional, histomorphometric, and electrophysiological investigations of the present study revealed that HILT seems to be a superior treatment modality for peripheral nerve regeneration
An investigation of pre-service english language teaching students' opinions about their practicum at schools on the basis of sustainable development goals (SDGS)
No full textABSTRACT
Objective: The aim of this study is to investigate the views of pre-service English language
teaching students about their practicum at schools on the basıs of SDGS.
Theoretical Framework: Concerns about personal, perceptual, and motivational issues that
arise during the teaching process can be linked to instructors' emotional and affective states,
which in turn can lead to anxiety in foreign language instruction.
However, pre-service teachers' motivations are intrinsic, altruistic, and service-oriented
related to their desire to study work with the students.
Method: This qualitative study involves 50 pre-servive English language teaching teachers
studying at a foundation university in İstanbul/Türkiye. The data collection instruments include
in-depth interviews, student reflection papers, and a questionnaire with open-ended questions.
Results and Discussion: The findings indicated that their worries stemmed from their own
assessments of their foreign language ability, their lack of teaching experience, the students'
disinterest in the classes, their concern of receiving poor feedback from both students and
observers, and their inability to manage their time well.
The sources of motivation for the pre-service teachers were working with supportive teachers,
the evaluation of the mentors, relationships with students, respect from students, and feeling
useful and valuable.
Research Implications: Pre-service teachers had the chance to consider what teaching and
learning meant to them personally and to assess their own performance during their teaching
practicum. Pre-service training program curriculum have to be changed with an eye on
improving their applicability to teaching practicums
A Waterborne, Flexible, and Highly Conductive Silver Ink for Ultra-Rapid Fabrication of Epidermal Electronics
Get PDFAbstract: Epidermal electronics provide a promising solution to key challenges in wearable
electronics, such as motion artifacts and low signal-to-noise ratios caused by an imperfect
sensor–skin interface. To achieve the optimal performance, skin-worn electronics require
high conductivity, flexibility, stability, and biocompatibility. Herein, we present a nontoxic,
waterborne conductive ink made of silver and child-safe slime for the fabrication of skincompatible electronics. The ink formulation includes polyvinyl acetate (PVAc), known
as school glue, as a matrix, glyceryl triacetate (GTA) as a plasticizer, sodium tetraborate
(Borax) as a crosslinker, and silver (Ag) flakes as the conducting material. Substituting
citric acid (CA) for GTA enhances the deformability by more than 100%. With exceptional
conductivity (up to 1.17 × 104 S/cm), we demonstrate the ink’s potential in applications
such as an epidermal near-field communication (NFC) antenna patch and a wireless ECG
system for motion monitoring
Furoic acid-doped-over-oxidized poly (3, 4-ethylenedioxythiophene)-based electrochemical sensor for selective, sensitive and concurrent quantification of paracetamol, codeine phosphate and caffeine in pharmaceutical formulation
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Herein, furoic acid-doped-over-oxidized poly(3,4-ethylenedioxythiophene)-modified pencil graphite electrode (furoic acid-doped-oo-PEDOT/PGE) was firstly prepared and then employed for the simultaneous and sensitive electrochemical determination of paracetamol (PAR), codeine phosphate (COD-P) and caffeine (CAF). Distinctive functional properties of the furoic acid-doped-oo-PEDOT electrode exhibit selective, sensitive and rapid analysis of the target drugs. The electrochemical performance of the prepared sensor electrode was investigated using differential pulse voltammetry (DPV), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) methods. The calibration curves of the drugs show excellent linearity over a concentration ranges: 0.5-100 mu mol L-1 for PAR, 0.75-100 mu mol L-1 for COD-P and 25-5000 mu mol L-1 for CAF and limit of detection (LOD) values of 0.075, 0.36 and 9.41 mu mol L-1for the analytes, respectively. Finally, the fabricated sensor was successively used for the simultaneous determination of PAR, COD-P, and CAF in commercial pharmaceutical samples and displayed appreciable recoveries.Graphical abstractElectrochemical Sensor Design for Paracetamol, Codeine phosphate and Caffein
Terpene-Centered Olfactory Training in Postinfectious Olfactory Dysfunction: A Dual-Route Approach
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Objective: To compare the efficacy of classical olfactory training (COT) protocols with a novel dual-route method targeting
both orthonasal and retronasal pathways in the management of postinfectious olfactory dysfunction (PIOD), and to explore the
neurotherapeutic potential of terpene-based odorants.
Methods: One hundred and seventeen patients diagnosed with PIOD received either conventional olfactory training or a modi-
fied protocol that integrates retronasal stimulation. The terpene profile of administered odorants was evaluated for its contribu-
tion to olfactory and cognitive outcomes.
Results: This study had five major findings: (1) The Terpene-Centered Orthonasal and Retronasal Olfactory Training (TCOT)
group showed significantly greater improvements in Sniffin' Sticks TDI and odor identification scores at the 9th and 12th months
compared to the COT and Modified Olfactory Training (MOT) groups (p<0.001); (2) Retronasal olfactory scores improved sig-
nificantly more in the TCOT group at the 9th and 12th months (p<0.001); (3) Clinically meaningful improvement (≥6-point TDI
gain) was most frequent in TCOT participants at all time points beyond 6months; (4) TCOT participants exhibited the greatest re-
ductions in parosmia severity at 6, 9, and 12months (p<0.05); (5) Cognitive complaints, as measured by CFQ-5 scores, improved
most markedly in the TCOT group, with significant differences at the 6th (p<0.001) and 12th (p=0.02) months.
Conclusion: Incorporating retronasal training and terpene-rich odorants in olfactory rehabilitation may improve outcomes
in PIOD. These findings support the integration of terpene-centered, multimodal olfactory training into clinical rehabilitation
strategies for PIOD.
Level of Evidence: Level 2