Biruni University Institutional Repository
Not a member yet
2908 research outputs found
Sort by
Manufacturing an advanced synthetic graft for gingival tissue engineering
No full textAlhalees, R.L. (2025). Dişeti çekilmesini tedavi etmek için yumuşak doku mühendisliği tekniklerindeki son gelişmeler. Yüksek Lisans Tezi, Biruni Üniversitesi Lisansüstü Eğitim Enstitüsü, İstanbul. Yumuşak doku mühendisliği, yara iyileşmesine katkıda bulunan ve otogreftler, allogreftler ve ksenograftlar gibi birincil yumuşak doku mühendisliği tekniklerine etkili bir alternatif olan bir hidrojel geliştirerek dişeti çekilmesini tedavi etmek için karmaşık çözümler bulmayı hedefleyen yeni yeniliklere sahip genişletilmiş bir araştırma alanıdır. Çalışma, mekanik özellikler ve bozunma oranı gibi fiziksel özellikleri artırmak için dişeti doku mühendisliğinde kullanılabilecek doğal ve sentetik polimerlerden bir greft oluşturmayı amaçlamaktadır. Bunu yapmak için, bu tezde ayrıntılı bozunma ve mekanik analizler yürütülmüştür. Şişme testi de yapılmış ve kimyasal analizi yapmak ve hidrojel kimyasının mekanik, bozunma ve şişme sonuçlarıyla ilişkisini araştırmak için Fourier Dönüşümlü Kızılötesi Spektroskopisi (FTIR) alınmıştır. Polimerler olarak jelatin, dişeti içindeki kolajeni taklit etmek için seçilmiştir. Diş etinin mekanik dayanıklılığını artırmak için genipin ve glutaraldehit gibi farklı çapraz bağlayıcı ajanlar optimize edildi ve glutaraldehitin polietilen glikol (PEG) varlığında jelatini çapraz bağlamak için daha etkili olduğu bulundu. Ayrıca PEG'in basınç dayanıklılığını ve modülünü ve şişme/bozunma oranını da artırdığı bulundu. Doğal diş eti dokusunu simüle etmek ve esnek greftler elde etmek için Fibrin ile gelecekte araştırma yapılması gerekiyor. Anahtar kelimeler: Diş Eti Çekilmesi; Jelatin – PEG Hidrojelleri; Yumusak Doku Mühendisliği.Alhalees, R.L. (2025). Recent advances in soft tissue engineering techniques for treating gingival recession. Master Thesis, Biruni University Graduate Education Institute, Istanbul. Soft tissue engineering is an expanded research field that has new innovations that aspire to find complex solutions to treat the gingival recession by innovating a hydrogel that contribute to wound healing and be an effective alternative to the primary soft tissue engineering techniques such as autografts, allografts, and xenografts. The study aims to create a graft from natural and synthetic polymers that may be employed in gingival tissue engineering to boost the physical properties such as mechanical properties and degradation rate. To do so, detailed degradation and mechanical analyses have been conducted in this thesis. Swelling test was also done and Fourier Transform Infrared Spectroscopy (FTIR) has been taken to do the chemical analysis and investigate the relationship of hydrogel chemistry with mechanical, degradation and swelling results. As polymers, gelatin was chosen to mimic the collagen in gingiva. To increase the mechanical strength of gingiva\ different crosslinking agents including genipin and glutaraldehyde have been optimized and glutaraldehyde (GTA) have been found more efficient for crosslinking gelatin in the presence of polyethylene glycol (PEG). It was also found that PEG increased the compressive strength and modulus and swelling/degradation rate as well. Future research with Fibrin is needed to simulate natural gingival tissue and obtain flexible grafts. Keyword: Gingival Recession; Gelatin-PEG Hydrogel; Soft-Tissue Engineering
Deniz doğal ürünlerinin anti-inflamatuar ve antimikrobiyal özelliklerinin İn Siliko çalışmalar ile belirlenmesi ve gıda içeriği olarak potansiyel kullanımları
No full textDeniz organizmaları, çeşitli biyolojik aktivitelere sahip geniş bir kimyasal bileşik yelpazesi üretmektedir. Bu çalışma, deniz doğal ürünlerinin anti-inflamatuar ve antimikrobiyal özelliklerini in silico yöntemlerle değerlendirerek fonksiyonel gıda ve bileşen olarak potansiyel kullanımını araştırmaktadır. CMNPD veritabanı kullanılarak deniz kaynaklı biyoaktif bileşikler, bu süreçlerle ilişkili 7 ve 1 kritik enzim üzerinde incelenmiştir. Bilgisayar destekli ilaç tasarımı (CADD) kapsamında moleküler kenetleme ve dinamik simülasyon teknikleri uygulanarak hedef proteinlere bağlanma afiniteleri analiz edilmiştir. Schrödinger yazılımında LigPrep modülüyle 31.561 ligand hazırlanmış ve OPLS4 force field ile optimize edilmiştir. Her enzime en iyi bağlanan ligand ile doğal ligandlar karşılaştırılmıştır. Grid Generation modülüyle bağlanma bölgeleri belirlenmiş, Glide XP, SP ve HTVS modülleriyle kenetlenme gerçekleştirilmiştir. RMSD değerleri doğrulama amacıyla kullanılmıştır. QikProp modülüyle ligandların ADMET parametreleri değerlendirilmiştir. Sonuçlar, üç hedefe bağlanan bazı bileşiklerin doğal ligandlardan daha yüksek afinite gösterdiğini ortaya koymuştur. Bulgular, bu bileşiklerin terapötik ajanlar ve fonksiyonel gıda bileşenleri olarak önemli potansiyele sahip olduğunu göstermektedir. Anahtar Kelimeler: Besin Destekleri; Bilgisayar Destekli Tasarım; Biyoaktif Bileşikler; Denizel Canlılar; Moleküler KenetlemeMarine organisms produce a wide range of chemical compounds with various biological activities. This study aims to evaluate the anti-inflammatory and antimicrobial properties of marine natural products using in silico methods and to investigate their potential use as functional foods and ingredients. Using the CMNPD database, marine-derived bioactive compounds were examined on seven and one critical enzymes related to these processes, respectively. Within the scope of computer-aided drug design (CADD), molecular docking and dynamic simulation techniques were applied to analyze the binding affinities to target proteins. In Schrödinger software, 31,561 ligands were prepared with the LigPrep module and optimized using the OPLS4 force field. The best-binding ligands for each enzyme were compared with their natural ligands. Binding sites were defined using the Grid Generation module, and docking was performed with the Glide XP, SP, and HTVS modules. RMSD values were used for validation. ADMET parameters of the ligands were evaluated with the QikProp module. Results showed that certain compounds had higher binding affinities than natural ligands for three targets. Findings suggest that these compounds have significant potential as therapeutic agents and functional food ingredients. Key Words: Bioactive Compounds; Computer Aided Design; Dietary Supplements; Marine Organisms; Molecular Dockin
Technical use of intravascular ultrasound in chronic total occlusion percutaneous coronary interventions: insights from the Euro-CTO registry
No full textBackground Intravascular ultrasound (IVUS) plays a central role in complex percutaneous coronary interventions (PCI). While guidance for stenting and optimization is the most common reason for IVUS use, the technical application of IVUS for greater procedural efficiency is becoming increasingly important. The impact of IVUS has been only partially investigated in its technical aspect. Methods We analyzed 15,226 CTO-PCIs from the EuroCTO registry between January 2022 and December 2023. We compared CTO PCI procedures performed with or without IVUS and further categorized IVUS use based on its application (technical reasons or stent optimization). Results IVUS was used in 22% (n = 3393) of cases and increased consistently from 12 to 24% between 2016 and 2023. Guidance for stenting and optimization remained the most common indication (86.4% of IVUS cases). Importantly, IVUS was utilized in 7.2% (n = 1092) of cases for technical reasons, mainly to identify the proximal cap (55.7% of technical indications, n = 608). IVUS-guided CTO-PCIs showed higher J-CTO scores (2.46 +/- 1.20 vs. 2.19 +/- 1.25; p < 0.001) and greater use of the retrograde approach (28% vs. 19%; p < 0.001). Technical success rates were comparable between the IVUS and angiographic groups (90% vs. 92%; p = ns). High-experience IVUS users achieved greater technical success compared to low- and intermediate-experience users (p < 0.010). On multivariable analysis, IVUS use was an independent predictor of technical success (odds ratio 1.39, 95% CI from 1.07 to 1.82, p value = 0.016). Conclusions IVUS in CTO PCI is primarily used for stent optimization. However, there is an increasing use of IVUS for technical reasons resulting in similar technical success rates even in more complex lesions and standing out as an independent predictor of success. Experience seems to play a role, with an advantage for highly experienced users
The prevalence of functional urinary incontinence and its association with comprehensive geriatric assessment parameters in older women
No full textAim The study aims to examine the prevalence of functional urinary incontinence (FUI) and its comparative frequency with other types of incontinence. Moreover, this study also aims to explore its relationship with key geriatric assessment parameters in older women. Methods Older women over the age of 65 years from one geriatrics outpatient clinic were included in the cross-sectional study. UI subtypes were classified based on participants' responses to the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form. FUI is the involuntary leakage of urine resulting from physical or cognitive limitations in reaching or using toilet facilities. The relationships between UI subtypes and comprehensive geriatric assessment parameters were determined Results The study included 1628 participants (mean age 79.6 +/- 8.2 years). Prevalence rates were identified as follows: control group (no continence) (37.2%), Urge UI (31.9%), Stres UI (4.6%), FUI (7.6%), Mixt UI (urge and stress, 12.3%), Urge UI and FUI (4.9%), and Stress UI with FUI (1.5%). In mult & imath;nominal lojistik regression, Basic Activities of Daily Living scores were low across all types of urinary UI (p<0.05). Patients with FUI exhibited significantly lower Mini Nutritional Assessment scores, Tinetti balance and gait scores, and handgrip strength compared to those with other UI subtypes, whereas their Timed Up and Go times and age were higher (p<0.05). Conclusion FUI is associated with several geriatric conditions, including increased functional dependency, nutritional deterioration, reduced muscle strength, and impaired balance and gait functions. Therefore, when approaching an older woman with incontinence, it is essential to be aware of FUI, rather than focusing solely on Urge UI or Stress UI
The impact of pre-labor delivery room visits and companion support during labor on pregnant women's comfort and adaptation to childbirth
No full textAraştırma, doğum öncesi doğumhane ziyareti ve travay sürecinde sağlanan refakatçi desteğinin gebelerin konfor düzeyine ve doğum sürecine uyumlarına etkisini değerlendirmek amacıyla, Aralık 2024-Mayıs 2025 tarihleri arasında randomize kontrollü deneysel nitelikte gerçekleştirildi. Araştırmaya 158 gebe (79 müdahale ve 79 kontrol) dahil edildi. Araştırmada veri "Kişisel Bilgi Formu", "Doğum Konforu Ölçeği", "Doğum Uyumu Ebe Değerlendirme Ölçeği" ve "Doğum Uyumu Öz Değerlendirme Ölçeği" ile toplandı. Grupların sosyodemografik ve obstetrik özellikleri ile travay sürecindeki tüm uygulamalarının benzer olduğu; tüm gebelerin refakatçi olarak en sık annesini istediği bulundu. Müdahale grubundaki gebelerin toplam konfor puanları kontrol grubuna kıyasla anlamlı düzeyde daha yüksek bulundu (p=0.006). Doğum uyumuna ilişkin hem ebelerin hem de gebelerin değerlendirmeleri dikkate alındığında, müdahale grubundaki uyum puanlarının daha yüksek olduğu gözlendi (sırasıyla: p=0.028; p=0.009). Doğum ortamına uyumun anlamlı düzeyde daha yüksek olması, doğumhane ziyaretinin doğum ortamına yönelik adaptasyonu kolaylaştırdığını gösterdi (p=0.001). Ayrıca, konfor ile doğum uyumu arasında pozitif ve anlamlı ilişki tespit edildi. Sonuç olarak, doğum öncesi doğumhane ziyareti ile refakatçi desteğinin kadınların doğum sürecine daha sağlıklı, bilinçli ve güvenli şekilde uyum sağlamalarına katkı sunduğu anlaşıldı. Anahtar Kelimeler: Doğumhane Ziyareti, Doğum Uyumu, Ebe, Konfor, Refakatçi DesteğiThe study was conducted as a randomized controlled experimental research between December 2024 and May 2025 to evaluate the effect of pre-delivery delivery room visits and companion support during labor on pregnant women's comfort levels and their adaptation to the birth process. A total of 158 pregnant women (79 intervention, 79 control) were included in the study. Data were collected using the "Personal Information Form," "Birth Comfort Scale," "Midwife Evaluation Scale of Birth Adaptation," and "Self-Evaluation Scale of Birth Adaptation." It was found that the sociodemographic and obstetric characteristics of the groups, as well as all practices during labor, were similar; and that all pregnant women most frequently preferred their mothers as companions. The total comfort scores of the women in the intervention group were significantly higher than those in the control group (p=0.006). Considering both the midwives' and pregnant women's evaluations regarding birth adaptation, the adaptation scores were higher in the intervention group (p=0.028 and p=0.009, respectively). The significantly higher level of adaptation to the birth environment indicated that delivery room visits facilitated adaptation to the birth setting (p=0.001). Furthermore, a positive and significant correlation was found between comfort and birth adaptation. As a result, it was concluded that pre-delivery delivery room visits and companion support contribute to a healthier, more conscious, and safer adaptation of women to the childbirth process. Keywords: Delivery Room Visit, Birth Adaptation, Midwife, Comfort, Companion Suppor
Bir sağlık üniversitesinde öğrenim gören öğrencilerin mikrobiyota farkındalık düzeylerinin ölçülmesi
No full textBu çalışmanın amacı, geleceğin sağlık çalışanları olan beslenme ve diyetetik, ebelik, hemşirelik, eczacılık ve tıp öğrencilerinin mikrobiyota farkındalık düzeylerini belirlemek ve bazı değişkenler ile arasındaki ilişkiyi ortaya koymaktır. Çalışmaya, 2023-2024 akademik yılında Biruni Üniversitesi Eczacılık Fakültesi, Sağlık Bilimleri Fakültesi (Beslenme ve Diyetetik, Ebelik, Hemşirelik) ve Tıp Fakültesinde öğrenim gören 270 kadın 57 erkek olmak üzere toplamda 327 öğrenci dahil edilmiştir. Öğrencilere Bilgi Formu ve Mikrobiyota Farkındalık Ölçeği (MFÖ)'nde yer alan sorular Kasım 2023 - Mart 2024 tarihleri arasında yüz yüze görüşme tekniği kullanılarak uygulanmıştır. Öğrencilerin %39.8'i daha önce mikrobiyota kavramını duymamıştır, %47.1'inin sinbiyotiklerin ne olduğu hakkında bilgisi bulunmamaktadır. Ayrıca %76.5'inin ve %81.3'ünün sırasıyla psikobiyotikler ve postbiyotikler hakkında bilgisini bulunmamaktadır. Öğrencilerin cinsiyet, bölüm ve sınıfları ile MFÖ toplam puanı karşılaştırılması sonucunda, bölüm ve sınıfın istatistiksel olarak önemli olduğu bulunmuştur (p<.05). MFÖ ile bölüm arasındaki önemlilik beslenme ve diyetetik ile hemşirelik, beslenme ve diyetetik ile ebelik, tıp ile hemşirelik ve tıp ile ebelik bölümleri arasından kaynaklandığı görülmüştür. MFÖ ile sınıf arasındaki önemlilik ise 1. sınıf ile 4. sınıf, 1.sınıf ile 5. sınıf ve 1. sınıf ile 6. sınıf arasından kaynaklanmaktadır. Kefir, yoğurt tüketimi ve daha önce probiyotik destek kullanımı ile MFÖ toplam puanı ve alt boyut puanları arasında istatistiksel olarak önemli farklılık bulunmuştur (p<.05). Bağırsak mikrobiyotası ile hastalıklar arasındaki ilişki her geçen gün daha fazla anlam kazanmaktadır. Koruyucu önlemlerin alınması ve hastalıkların tedavisi için sağlık çalışanlarının bu konuda bilgi düzeyinin artırılması gerekmektedir. Bu çalışma mikrobiyota kavramı ve hastalıklarla ilişkisine, öğrencilerin eğitim dönemlerinde daha ayrıntılı şekilde yer verilmesinin gerekliliğini ortaya koymuştur. Anahtar Kelimeler: Disbiyozis; Mikrobiyota Farkındalığı; Prebiyotik; Probiyotik; SinbiyotikThe aim of this study was to determine the microbiota awareness levels of nutrition and dietetics, midwifery, nursing, pharmacy and medical students, who are the future healthcare professionals, and to examine the relationship with certain variables. A total of 327 students (270 females and 57 males) enrolled in Biruni University Faculty of Pharmacy, Faculty of Health Sciences (Nutrition and Dietetics, Midwifery, Nursing) and Faculty of Medicine in the 2023-2024 academic year were included in the study. The questions in the Information Form and the Microbiota Awareness Scale (MAS) were administered to the students using the face-to-face interview technique between November 2023 and March 2024. Of the students participating in this study, 39.8% had never heard of the concept of microbiota before, and 47.1% had no knowledge of synbiotics. Additionally, 76.5% and 81.3% of the students had no knowledge of psychobiotics and postbiotics, respectively. As a result of the comparison of the MAS total score with the gender, department and year of study of the students, it was found that the department and year of study were statistically significant (p<.05). The significance between the MAS and the department was found to be between the departments of nutrition and dietetics and nursing, nutrition and dietetics and midwifery, medicine and nursing, and medicine and midwifery. The significance between the MAS and the year of study was found to be between 1st year and 4th year, 1st year and 5th year, and 1st year and 6th year. The intake of kefir, yogurt, as well as previous probiotic supplementation, was found to be statistically significant difference between the MAS total score and sub-dimension scores (p<.05). The relationship between gut microbiota and diseases is gaining increasing importance every day. For preventive measures and diseases to be treated, the level of knowledge of healthcare professionals on this subject should be increased. This study revealed that the concept of microbiota and its relationship with diseases should be included in more detail in the education of students. Keywords: Dysbiosis; Microbiota Awareness; Prebiotic; Probiotic; Synbioti
Global Disproportionality Analysis of Adverse Event Reports on Interstitial Lung Diseases for Cancer-Targeted Therapies, 1968-2024
No full textBackground and Objectives The increasing complexity of interstitial lung disease (ILD) related to cancer-targeted monoclonal antibodies (mAbs) has emerged as a significant clinical concern. Thus, this study aimed to investigate reporting signals of four ILD subtypes detected with cancer-targeted mAbs.Methods This global pharmacovigilance study conducted disproportionality analyses to detect signals of ILD subtypes reported with cancer-targeted mAbs. ILD subtypes were classified into eight categories according to previous studies, of which four with a low number of reports were excluded. Five cancer-targeted monoclonal antibodies (VEGF/VEGFR, CD20, PD-1/PD-L1, HER2, and EGFR inhibitors) were included according to ATC code (L01F). Reporting signals were evaluated using reporting odds ratio (ROR) with 95% CI and information component (IC) with IC025.Results Interstitial pneumonitis and pulmonary fibrosis showed significant disproportionate reporting signals across all drugs. Notably, interstitial pneumonitis showed significant signals with EGFR inhibitors (ROR, 47.46 [95% CI, 44.67-50.42]; IC, 5.47 [IC0.25, 5.37]) and PD-1/PD-L1 inhibitors (45.20 [43.49-46.97]; 5.36 [5.30]), while pulmonary fibrosis showed higher signals with CD20 inhibitors (12.71 [11.30-14.31]; 3.61 [3.42]). Organising pneumonia exhibited significant signals with PD-1/PD-L1 inhibitors (ROR, 44.48 [95% CI, 39.05-50.67]; IC, 5.26 [IC0.25, 5.04]), followed by CD20 (17.45 [13.88-21.94]; 3.95 [3.57]), and HER2 (15.95 [11.88-21.40]; 3.76 [3.26]), with the strongest signal observed with PD-1/PD-L1 inhibitors. Eosinophilic pneumonia showed significant signals with all drugs except CD20 inhibitors.Conclusions Although causal inference cannot be drawn, this global disproportionality study highlights reporting signals between cancer-targeted mAbs and ILD subtypes, underscoring the importance of strengthening adverse event reporting systems before and after mAb administration
A neuro-fuzzy model for evaluating and predicting computational thinking skills of students
No full textComputational thinking skill is an important skill individuals should acquire to meet the requirements of the digital age. The aim of the study is to predict the computational thinking skills of middle school students through ANFIS approach, which is an adaptive neural network-based fuzzy logic. Students' computational thinking skill scores were predicted by creating a model based on grade level and academic achievement variables. Grade level and academic achievement served as the model's input variables, and computational thinking skill scores served as the model's output variable. Data were collected using personal information form and computational thinking scale. A comparison was made between students' real and artificial computational thinking skill scores using statistical methods. In the study, a strong and favorable association between the artificial scores produced using the ANFIS technique and the actual scores was discovered. Furthermore, there was no statistically significant difference between the real and artificial scores for computational thinking skills. These results indicate that the ANFIS approach is a suitable alternative analysis method for predicting students' computational thinking skills. The study provides a good example in the field of education where artificial intelligence can be used to predict students' educational characteristics
Radiologic and Clinical Anatomy of the Zygomatic Bone in Terms of Zygomatic Implant
No full textThe zygomatic bone is crucial in dental implantology,
wherein zygomatic implants are increasingly used for patients
with insufficient maxillary bone. A comprehensive understanding
of the complex anatomy of the zygomatic bone is essential
for minimizing surgical complications and optimizing
implant success. This study aimed to provide morphometric
data through cone-beam computed tomography (CBCT) and
microcomputed tomography (μCT) to assist dental radiologists
and surgeons in preoperative planning and implant placement.
In addition, it seeks to provide physicians with comprehensive
insights into the anatomy of the zygomatic bone and associated
structures, enhancing the use of zygomatic implants in implantology.
CBCT images from 3087 patients at Istanbul University,
were scanned to examine the canals and foramina of the zygomatic
bone. Their trajectories canals were assessed to identify
their canal types (T-shaped or V-shaped). Forty-three dry bone
samples were manually examined to classify zygomatic bone
types, and μCT was utilized to observe the canal routes. The
foramen zygomaticofacial, foramen zygomaticotemporale, and
foramen zygomaticoorbitale revealed distinctive patterns. Most
cases (n=414, 62%) had single zygomaticofacial canals,
whereas 27 (4%) had double zygomaticofacial canals; 41 canals
(6%) originated from the zygomaticotemporal canal, 174 (26%)
had T-shaped canals, and 13 (1.9%) had V-shaped canals. Using
μCT, their trajectories were observed by analyzing 43 dry bone
samples. The 43 dry bone samples were scanned, and Y-shaped
canal systems were observed in 6 of them. The canals entering
from FZF exited FZO with a Y-shaped canal system. In 3
bones, the canals were straight. The zygomaticofacial canal
entering from FZF exited FZO. The use of CBCT to map the
zygomatic bone before zygomatic implant procedures provides
valuable insights into routine dental imaging and enhances
preoperative evaluations. This approach aids in scrutinizing
anatomic variations and intrabone canals, ultimately reducing
complications
The Effect of Music and Mandala Activity on Stress and Stress-Coping Levels of Infertile Women Who Had an Embryo Transfer: A Randomized Clinical Trial
No full textThis study aimed to evaluate the effects of mandala activity combined with two different types of music on the stress and stress-coping levels of infertile women who recently underwent an embryo transfer. The research was conducted as a single-blind randomized controlled trial between July 1, 2021, and July 31, 2022, with a total of 120 infertile women at an infertility clinic in Turkey. Data were collected using the Descriptive Information Form, the COMPI Fertility Problem Stress Scales (COMPI-FPSS), and the COMPI Coping Strategy Scales (COMPI-CSS). Participants in the two intervention groups performed a mandala activity immediately after embryo transfer, accompanied by either meditation music or music of their choice, until one day before the Beta Human Chorionic Gonadotropin (BetaHcg) test. Stress and coping levels were assessed pre- and post-intervention. Statistical analyses were conducted using SPSS. Results showed that infertility-related stress levels significantly decreased and stress-coping abilities significantly improved among women in the intervention groups compared to the control group (p < 0.05). The group performing mandala activity with meditation music exhibited the most pronounced improvements. This study concludes that mandala activity, especially when combined with meditation music, has positive effects on stress and stress-coping among infertile women undergoing embryo transfer